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估测卵泡期早期卵泡刺激素(FSH)水平增高的患者卵泡发育终末期初始化的FSH阈值

世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 28-29页

作者： De Koning C.H. schoemaker j. Lambalk C.B. 石磊

To test the hypothesis that the folli cle -stimulating hor-mone(FSH)threshold in patients with elevated FSH levels in the early follicular phase(EFP)is higher than in *** *** *** patients with elevated EFP FSH(>10IU /L)and ***-ment with a GnRH agonist in the midlut eal phase before IV administration of recombinant FSH w as started in an ul-tra -low -dose step -up *** FSH threshold was determined by the mean of FSH levels o f the above threshold value and the below thresh old *** -stimulating hormone threshold,FSH screening value,E 2,number of *** FSH threshold in the elevated EFP FSH group was 6.75IU /L and was significantly higher than the FSH threshold of the controls(4.65IU /L).The FSH screening value on day 3was 12.0I U /L in the pa-tient group and 5.0IU /L in the contro *** significantly lower on the day that t he largest follicle was 18mm in the elevated EFP FSH group compared with controls(277vs.491pmol /L,respectively)-.On the day of hCG administration,the number of sm aller(10-13mm)follicles was equal but the number of larger(>14mm)follicles was higher in the control g roup compared with the elevated FSH *** the contro l group,the basal FSH levels correlated highly with th e FSH threshold levels(r =0.8),but in the patients with elevated EFP FSH this correlation was *** normal wo men,basal FSH day 3values represent the ovarian thresh old for *** womenwith elevated day 3FSH,the FSH threshold is higher but not as high as basal FSH *** postulate that the FSH threshold in patients with elevated EFP FSH is higher be-cause of intraovarian *** l FSH overshoots the threshold,probably because of the l imited feedback by the ovary.

关键词：卵泡发育 FSH 卵泡刺激素卵泡数目黄体中期小卵泡大卵泡高阈激动剂试点研究

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具有类固醇代谢酶缺陷的XY女性患者

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国际遗传学杂志 1980年第4期03卷 189-190页

作者： Modan K schoemaker j.戴德林

单纯性腺发育不全和睾丸女性化的XY女性病例已有大量报导,具有酶缺陷阻碍雄激素和雌激素合成的XY女性病例的报导相对较少。最近作者发现一例17α-羟化酶缺陷的XY女性患者,促使作者复习关于具有酶缺陷的XY女性患者的文献。检查胆固醇代谢... 详细信息

单纯性腺发育不全和睾丸女性化的XY女性病例已有大量报导,具有酶缺陷阻碍雄激素和雌激素合成的XY女性病例的报导相对较少。最近作者发现一例17α-羟化酶缺陷的XY女性患者,促使作者复习关于具有酶缺陷的XY女性患者的文献。检查胆固醇代谢(图1)发现20,22-碳链酶,3β-羟类固醇脱氢酶、17α-羟化酶、17,20-碳链酶和17β-还原酶中任何一种酶缺乏都将阻碍睾丸酮和雌二醇的合成。

关键词：碳链酶雄激素雌激素性甾体雌性激素酶缺陷 XY 女性患者

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