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Tempering of exh.usted T cells to compreh.nd th.ir adaptive response for suitable clinical translation

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Cellular & Molecular Immunology 2023年第12期20卷 1401-1402页

作者： Amit Sh.rma Ingo G.h.schmidt-Wolf Department of Integrated Oncology Center for Integrated Oncology(CIO)BonnUniversity Hospital BonnBonnGermany

Alth.ugh.cancer immunoth.rapy h.s taken center stage,exh.ustion of T cells is undeniably one of th. major problems preventing it from being fully successful[1].Certainly,reversal of T-cell exh.ustion or dysfunction is of great importance for developing new strategies and restoring immune ***,counterarguments about th. adverse effect of reversing T-cell exh.ustion(leading to overactivation of T cells and cytotoxicity)and even th.ir irreversible properties h.ve been quite common in scientific *** more to be discovered about th. reasons for T-cell failure,a better understanding of th. molecular factors/determinants[2,3]th.t sh.pe/remodel“h.terogeneous”dysfunctional T cells in cancer makes clear ***,two recent publications in Nature immunology h.ve described th. intriguing perspective of T-cell exh.ustion[4,5].Of interest,Vignali et *** on th. h.poxia-driven CD39-dependent suppressor function of exh.usted T cells,wh.reas Saadey et *** restoring th. epigenetic balance of TGFβ1/BMP signaling in exh.usted T cells to unlock responsiveness to immune ch.ckpoint blockade th.rapy.

关键词： irreversible exh.ustion publications

Some Applications of Optimal Control in Sustainable Fish.ng in th. Baltic Sea

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Applied Math.matics 2011年第7期2卷 854-865页

作者： Dmitriy Stukalin Werner h. schmidt 不详

Issues related to th. implementation of dynamic programming for optimal control of a th.ee-dimensional dynamic model (th. fish.populations management problem) are presented. Th.y belong to a class of models called Lotka-Volterra models. Th. existence of bionomic equilibria will be considered. Th. problem of optimal h.rvest policy is th.n solved for th. control of various classes of its beh.viour. Th.refore th. focus will be th. optimality conditions by using th. Bellman principle. Moreover, we consider a different form for th. optimal value of th. control vector, namely th. feedback or closed-loop form of th. control. Academic examples are studied in order to demonstrate th. proposed meth.ds.

关键词： Optimal Control Problems Maximum Principle Piecewise Constant Optimal Control Bellman Principle

A Mercury Orbiter Mission Study

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紫金山天文台台刊 1996年第3期15卷 12-19页

作者： W.K.h.schmidt Max-Planck-Institut fur Aeronomie 37191 katl enburg- LindauGermany

A sh.rt review of th. Assessment Study results of a Mercury Obriter mission wh.ch.ws propoesd to ESA in 1993 is given.

关键词：侧切肠面吐血加成比压旧址田令幻山

Size and time dependent internalization of label-free nano-graph.ne oxide in h.man macroph.ges

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Nano Research 2017年第6期10卷 1980-1995页

作者： Rafael G. Mendes Angelo Mandarino Britta Koch.Anne K. Meyer Alicja Bach.atiuk Cordula h.rsch.Th.mas Gemming Oliver G. schmidt Zh.ngfan Liu Mark h. Rummeli College of Ph.sics Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215006 China IFW Dresden Institute for Solid State and Materials Research P.O. Box D-01171 Dresden Germany Centre of Polymer and Carbon Materials Polish Academy of Sciences M. Curie-Sklodowskiej 34 Zabrze 41-819 Poland EMPA - Swiss Federal Laboratories for Materials Science and Tech.ology Lerchenfeldstrasse 5 9014 St. Gallen Switzerland Material Systems for Nanoelectronics Chemnitz University of Technology Reichenhainer Sir. 70 09107 Chemnitz Germany ing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

Graph.ne oxide sh.ws great promise as a material for biomedical applications, e.g., as a multi-drug delivery platform. With.th.s in view, reports of studies on th. interaction between nanosized graph.ne oxide flakes and biological cells are beginning to emerge. h.wever, th. number of studies remains limited, and most used labeled graph.ne oxide samples to track th. material upon endocytosis. Unfortunately, th. labeling process alters th. surface functionality of th. graph.ne oxide, and th.s additional funcfionalization h.s been sh.wn to alter th. cellular response. h.nce, in th.s work we used label-free graph.ne oxide. We carefully tracked th. uptake of th.ee different nanoscale graph.ne oxide flake size distributions using scanning/transmission electron microscopy. Uptake was investigated in undifferentiated h.man monocyte cells （Th.-1） and differentiated macroph.ge cells. Th. data sh.w clear size dependence for uptake, such.th.t larger graph.ne oxide flakes （and clusters） are more easily taken up by th. cells compared to smaller flakes. Moreover, uptake is sh.wn to occur very rapidly, with.n two min of incubation with.Th.-1 cells. Th. data h.gh.igh.s a crucial need for cellular incubation studies with.nanoparticles, to be conducted for sh.rt incubation periods as certain dependencies （e.g., size and concentration） are lost with.longer incubation periods.

关键词： graph.ne oxide Th.-1 cells label-free uptake size dependence

SOURCES OF PRECIPITABLE MOISTURE IN Th. Ch.h.Ah.AN DESERT:POSSIBILITIES FOR IMPROVED UTILIZATION OF RAINFALL

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干旱区资源与环境 1993年第Z1期7卷 219-220页

作者： Robert h.schmidt Department of Geological Sciences The University of Texas at EI PasoU.S.A.

As a result of increased pressure being exerted upon arid, and particularly semiaridzones to improve th. use of renewable resources, regional climatological analysis, and par-ticularly information pertaining to warm season rainfall, h.lps provide a significant contri-bution for better utilization pertaining to warm season rainfall, h.lps provide a

关键词： Ch.h.ah.an Deset Precipitation Renewable Resources

On a Fast Integral Equation Meth.d for Diffraction Gratings

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Communications in Computational Ph.sics 2006年第6期1卷 984-1009页

作者： A.Rath.feld G.schmidt B.h.Kleemann Weierstrass Institute for Applied Analysis and Stoch.stics Mohrenstr.3910117 BerlinGermany Carl Zeiss AG Corporate Research and TechnologyOptical Design73446 OberkochenGermany

Th. integral equation meth.d for th. simulation of th. diffraction by optical gratings is an efficient numerical tool if profile gratings determined by simple crosssection curves are *** meth.d in its recent version is capable to tackle profile curves with.corners,gratings with.th.n coated layers,and diffraction scenarios with.unfavorably large ratio period over *** discuss special implementational issues including th. efficient evaluation of th. quasi-periodic Green kernels,th. quadrature algorith.,and th. iterative solution of th. arising systems of linear ***,as an example we present th. simulation of ech.lle gratings wh.ch.demonstrates th. efficency of our approach.

关键词： Diffraction gratings integral equation meth.d preconditioning

Entangled-ph.tons generation with.quantum dots

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Ch.nese Ph.sics B 2018年第2期27卷 140-153页

作者：李远丁飞 Oliver G schmidt Institute for Integrative Nanosciences IFW Dresden HelmholtzstraBe 20. 01069 Dresden. Germany Integrative for Solid State Ph.sics. Leibniz University of h.nnover. AppelstBe 2.30 167 h.nnovel Germany

Entanglement between particles is a crucial resource in quantum information processing, an important example of wh.ch.is th. exploitation of entangled ph.tons in quantum communication protocols. Among th. different available sources of entangled ph.tons, semiconductor quantum dots （QDs） excel owing to th.ir deterministic emission properties, potential for electrical injections, and direct compatibility with.semiconductor manufacturing tech.iques. Despite th. great promises, QD-based sources at＇e far from being ideal. In particular, such.sources present several critical issues, wh.ch.require th. overcoming of ch.llenges pertaining to spectral tunability, entanglement fidelity, ph.ton indistinguish.bility and brigh.ness. In th.s article, we will discuss th. potential solutions to th.se problems and review th. recent progress in th. field.

关键词： quantum information entangled-ph.ton source quantum dots

Incorporating sh.pe constraints in generalized additive modelling of th. h.igh.-diameter relationsh.p for Norway spruce

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Forest Ecosystems 2016年第2期3卷 112-125页

作者： Natalya Pya Matth.as schmidt Department of Math.matics School of Science and TechnologyNazarbayev University Th. North.est German Forest Research.Station Department of Forest Growth

Background： Measurements of tree h.igh.s and diameters are essential in forest assessment and modelling. Tree h.igh.s are used for estimating timber volume, site index and oth.r important variables related to forest growth.and yield, succession and carbon budget models. h.wever, th. diameter at breast h.igh. （dbh. can be more accurately obtained and at lower cost, th.n total tree h.igh.. h.nce, generalized h.igh.-diameter （h.d） models th.t predict tree h.igh. from dbh. age and oth.r covariates are needed. For a more flexible but biologically plausible estimation of covariate effects we use sh.pe constrained generalized additive models as an extension of existing h.d model approach.s. We use causal site parameters such.as index of aridity to enh.nce th. generality and causality of th. models and to enable predictions under projected ch.ngeable climatic conditions. Meth.ds： We develop unconstrained generalized additive models （GAM） and sh.pe constrained generalized additive models （SCAM） for investigating th. possible effects of tree-specific parameters such.as tree age, relative diameter at breast h.igh., and site-specific parameters such.as index of aridity and sum of daily mean temperature during vegetation period, on th. h.d relationsh.p of forests in Lower Saxony, Germany. Results： Some of th. derived effects, e.g. effects of age, index of aridity and sum of daily mean temperature h.ve significantly non-linear pattern. Th. need for using SCAM results from th. fact th.t some of th. model effects sh.w partially implausible patterns especially at th. boundaries of data ranges. Th. derived model predicts monotonically increasing levels of tree h.igh. with.increasing age and temperature sum and decreasing aridity and social rank of a tree with.n a stand, Th. definition of constraints leads only to marginal or minor decline in th. model statistics like AIC An observed structured spatial trend in tree h.igh. is modelled via 2-dimensional surface fitting. Conclusions： We

关键词： h.igh.-diameter curve Norway spruce Sh.pe constrained additive models Impact of climate ch.nge,Varying coefficient models

Perceived damage and areas of needed research.for wildlife pests of California agriculture

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Integrative Zoology 2014年第3期9卷 265-279页

作者： Roger A.BALDWIN Terrell P.SALMON Robert h.schmidt Robert M.TIMM Statewide IPM Program University of California Cooperative ExtensionParlierCAUSA University of California Cooperative Extension San DiegoCAUSA Department of Environment and Society Utah State UniversityLoganUTUSA h.pland Research.and Extension Center University of CaliformniaHoplandCAUSA

Many wildife species cause extensive damage to a variety of agricultural commodities in California,with.es-timates of damage in th. h.ndreds of millions *** th. limited availability of resources to solve all h.man-wildlife conficts,we sh.uld focus management efforts on issues th.t provide th. greatest benefit to ag-ricultural commodities in *** survey provides quantitative data on research.needs to better guide future efforts in developing more effective,practical and appropriate meth.ds for managing th.se *** found th.t ground squirels,pocket goph.rs,birds,wild pigs,coyotes and voles were th. most common agricul-tural wildlife pest species in *** damage caused by th.se species could be quite h.gh.but varied by agricultural *** most species,common forms of damage included loss of crop production and di-rect death.of th. plant,alth.ugh.livestock depredation was th. greatest concern for *** meth.ds used most frequently and th.se deemed most effective varied by pest species,alth.ugh.greater advancements in control meth.ds were listed as a top research.priority for all ***,th. use of toxicants,biocon-trol and trapping were th. most preferred meth.ds for control,but th.s varied by *** general,integrated pest management practices were used to control wildlife pests,with.a special preference for th.se approach.s th.t were efficacious and quick and inexpensive to *** information and survey design sh.uld be useful in establish.ng research.and management priorities for wildlife pest species in California and oth.r similar re-gions.

关键词： agriculture California h.man-wildlife conflict integrated pest management survey