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A complete reference genome for th. soybean ***

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Plant Communications 2024年第2期5卷 19-22页

作者： Yich.ng h.ang Dal-h.e Koo Yizh.u Mao Eliot M.h.rman Jianwei Zh.ng Monica A.schmidt National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Wh.at Genetics Resource Center Department of Plant PathologyKansas State UniversityManhattanKS 66506USA BIO5 Institute School of Plant SciencesUniversity of ArizonaTucsonAZ 85721USA

Dear Editors,Soybeans are a global commodity for th.ir edible protein and vegetable *** global population is predicted to be 9.7 billion by 2050(UN,2022),with.a concomitant drastic increase in protein *** already 2.4 billion people suffering from food insecurity(FAO et al.,2023),th.re is an urgent need to meet future production demands for plant-based proteins.

关键词： commodity soybean urgent

循环酪氨酸酶和MART-1mRNA不能独立预测AJCCI-II期黑色素瘤患者的复发或存活

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 15-15页

作者： schmidt h. Sorensen B.S. Sjoegren P. 朱国兴 Department of Oncology Aarhus University Hospital Norrebrogade 44 8000 Aarhus C Denmark Dr.

Th. detection of melanoma cells in periph.ral blood h.s been proposed to select patients with.a h.gh.risk of relapse. In th.s study, tyrosinase and melanoma antigen recognized by T cells 1 (MART-1) mRNA expression was evaluated in serial samples obtained before definitive surgery and during follow-up in patients with.American Joint Committee on Cancer stage I-II melanoma. Serial samples (n = 2,262) were collected from 236 patients from 1997 to 2002. Analyses of th. RNA samples were performed with.a calibrated reverse transcriptase-PCR assay. Gender, age, primary tumor site, ulceration, th.ckness, Clark level, and h.stological subtype were analyzed togeth.r with.tyrosinase and MART-1 mRNA treated as updated covariates in a Cox proportional-h.zard model. After a median follow-up time of 66 month., 42 out of 236 patients (18%) h.d relapsed. Th. following variables were significantly associated with.relapse free survival in th. univariate analyses: tyrosinase, MART-1, gender, ulceration, th.ckness, Clark level, and h.stological subtype. Entering th.se covariates into a multivariate Cox analysis resulted in th.ckness as th. single independent prognostic factor (P h.reas MART-1 (P = 0.07) approach.d significance at th. 5%significance level. Th. serial measurements of tyrosinase and MART-1 mRNA in periph.ral blood of stage I-II melanoma patients cannot be demonstrated to h.ve independent prognostic impact on relapse free survival.

关键词：黑色素瘤细胞 MART-1 酪氨酸酶 mRNA 预测因素无复发患者 AJCC 存活 Ⅱ期

Mitoch.ndrial dysfunction as a target in spinal cord injury:intimate correlation between path.logical processes and th.rapeutic approach.s

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Neural Regeneration Research 2023年第10期18卷 2161-2166页

作者： Julieta schmidt h.ctor Ramiro Quintá Universidad de Buenos Aires CABAArgentina Laboratorio de Medicina Experimental“Dr.J.Toblli” Hospital AlemánCABAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas-CONICET CABAArgentina Reh.bilitation Medicine Department University of MinnesotaTwin CitiesMINUSA

Traumatic spinal cord injuries interrupt th. connection of all axonal projections with.th.ir neuronal targets below and above th. lesion site. Th.s interruption results in eith.r temporary or permanent alterations in th. locomotor, sensory, and autonomic functions. Damage in th. spinal tissue prevents th. re-growth.of severed axons across th. lesion and th.ir reconnection with.neuronal targets. Th.refore, th. absence of spontaneous repair leads to sustained impairment in voluntary control of movement below th. injury. For decades, axonal regeneration and reconnection h.ve been considered th. opitome of spinal cord injury repair with.th. goal being th. repair of th. damaged long motor and sensory tracts in a complex process th.t involves:(1) resealing injured axons;(2) reconstructing th. cytoskeletal structure inside axons;(3) re-establish.ng h.alth. growth.cones;and(4) assembling axonal cargos. Th.se biological processes require an efficient production of adenosine triph.sph.te, wh.ch.is affected by mitoch.ndrial dysfunction after spinal cord injury. From a path.logical standpoint, during th. secondary stage of spinal cord injury, mitoch.ndrial h.meostasis is disrupted, mainly in th. distal segments of severed axons. Th.s result in a reduction of adenosine triph.sph.te levels and subsequent inactivation of adenosine triph.sph.te-dependent ion pumps required for th. regulation of ion concentrations and reuptake of neurotransmitters, such.as glutamate. Th. consequences are calcium overload, reactive oxygen species formation, and excitotoxicity. Th.se events are intimately related to th. activation of necrotic and apoptotic cell death.programs, and furth.r exacerbate th. secondary stage of th. injury, being a h.llmark of spinal cord injury. Th.s is wh. restoring mitoch.ndrial function during th. early stage of secondary injury could represent a potentially effective th.rapeutic intervention to overcome th. motor and sensory failure produced by spinal cord injury. Th.s

关键词： adenosine triph.sph.te axonal regeneration creatine mitoch.ndria dysfunction mitoch.ndria spinal cord injury

Multi-material additive manufacturing-functionally graded materials by means of laser remelting during laser powder bed fusion

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Frontiers of Mech.nical Engineering 2023年第4期18卷 183-193页

作者： Alexander schmidt Felix JENSCh.Sebastian h.RTEL Ch.ir of h.brid Manufacturing Brandenburg University of TechnologyCottbus 03046Germany

Many processes may be used for manufacturing functionally graded *** th.m,additive manufacturing seems to be predestined due to near-net sh.pe manufacturing of complex geometries combined with.th. possibility of applying different materials in one *** adjusting th. powder composition of th. starting material layer by layer,a macroscopic and step-like gradient can be *** furth.r improve th. step-like gradient,an enh.ncement of th. in-situ mixing degree,wh.ch.is limited according to th. state of th. art,is *** th.s paper,a novel tech.ique for an enh.ncement of th. in-situ material mixing degree in th. melt pool by applying laser remelting(LR)is *** effect of layer-wise LR on th. formation of th. interface was investigated using pure copper and low-alloy steel in a laser powder bed fusion *** cross-sectional selective electron microscopic analyses were carried *** applying LR,th. mixing degree was enh.nced,and th. reaction zone th.ckness between th. materials was ***,an additional copper and iron-based ph.se was formed in th. interface,resulting in a smooth.r gradient of th. ch.mical composition th.n th. case with.ut *** Marangoni convection flow and th.rmal diffusion are th. driving forces for th. observed effect.

关键词： multi-material additive manufacturing(MMAM) functionally graded materials(FGMs) laser powder bed fusion(L-PBF) laser remelting(LR) pure copper

Neoadjuvant treatment for advanced esoph.geal cancer: response assessment before surgery and h.w to predict response to ch.moradiation before starting treatment

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Ch.nese Journal of Cancer Research 2015年第3期27卷 221-230页

作者： Elfriede Bollsch.eiler Arnulf h.h.lsch.r Matth.as schmidt Ute Warnecke-Eberz Department of General Visceral and Cancer SurgeryUniversity of Cologne Institute of Nuclear Medicine University of Cologne

Patients with.advanced esoph.geal cancer（T3-4, N） h.ve a poor prognosis. Ch.moradiation or ch.moth.rapy before esoph.gectomy with.adequate lymph.denectomy is th. standard treatment for patients with.resectable advanced esoph.geal carcinoma. h.wever, only patients with.major h.stopath.logic response（regression to less th.n 10% of th. primary tumor） after preoperative treatment will h.ve a prognostic benefit of preoperative ch.moradiation. Using current th.rapy regimens about 40% to 50% of th. patients sh.w major h.stopath.logical response. Th. remaining coh.rt does not benefit from th.s neoadjuvant approach.but migh. benefit from earlier surgical resection. Th.refore, it is an aim to develop tools for response prediction before starting th. treatment and for early response assessment identifying responders. Th. current review discusses th. different imaging tech.iques and th. most recent studies about molecular markers for early response prediction. Th. results sh.w th.t [^18F]-fluorodeoxyglucose-positron emission tomograph.（FDGPET） h.s a good sensitivity but th. specificity is not robust enough.for routine clinical use. Newer positron emission tomograph. detector tech.ology, th. combination of FDG-PET with.computed tomograph., additional evaluation criteria and standardization of evaluation may improve th. predictive value. Th.re exist a great number of retrospective studies using molecular markers for prediction of response. Until now th. clinical use is missing. But th. results of first prospective studies are promising. A future perspective may be th. combination of imaging tech.ics and special molecular markers for individualized th.rapy. Anoth.r aspect is th. response assessment after finish.ng neoadjuvant treatment protocol. Th. different clinical meth.ds are discussed. Th. results sh.w th.t until now no non-invasive meth.d is valid enough.to assess complete h.stopath.logical response.

关键词： Esoph.geal cancer squamous cell carcinoma adenocarcinoma neoadjuvant ch.moradiation response prediction response assessment