男性痤疮患者血清17-羟黄体酮升高

作     者：Placzek M. Arnold B. Schmidt H. K. Degitz 李晓莉 

作者机构：Department of Dermatology Ludwig-Maximilian University Frauenlobstr 9- 11 D- 80337M¨ unchen Germany Dr 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第3期

页      面：9-10页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：痤疮患者 黄体酮 男性 升高 促肾上腺皮质激素 促黄体生成激素 硫酸脱氢表雄酮 血清 病例对照研究 雄激素 

摘      要：Background: Androgen excess may provoke or aggravate acne by inducing seborrhea. In women, androgen disorders are frequently suspected when acne is accompanied by hirsutism or irregularities of the menstrual cycle. In men, however, acne may be the only sign of androgen excess. Objective: Our aim was to investigate whether male patients with acne display pathologic androgen blood values. Methods: This case-control study at a university dermatology department with referred and unreferred patients investigated male acne patients (n = 82, consecutive sample) in whom the diagnosis of mild to severe acne was made, as well as a control group of men without acne (n= 38). The main outcome measures were androgen parameters including morning values of testosterone, luteinizing hormone, follicle-stimulating hormone, dehydroepiandrosterone sulfate, androstenedione, and 17-hydroxyprogestero-ne; as well as a corticotrophin stimulation test. Results: 17-Hydroxyprogesteronelevels were significantly higher (P = .01) in acne patients than in the control group, whereas the other parameters did not differ significantly. In addition, the corticotropin stimulation test revealed abnormal 17-hydroxyprogesterone induction values in 10 of 82 patients. Limitations: The analysis is limited to a selection of androgen parameters. Conclusion: The results suggest that in men irregularities of adrenal steroid metabolism may be a factor contributing to acne.