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International Journal of Ophthalmology(English edition) 2024年第3期17卷 509-517页

作者： Umay Güvenç Gülizar Demirok Güner Üney Selma Uzman Ophthalmology Department Ankara Training and Research HospitalAnkara 06230Turkey

●AIM:To assess the necessity of neuroimaging in patients with neurological or atypical findings of normal tension glaucoma(NTG)who do not exhibit typical glaucoma manifestations.●METHODS:A retrospective analysis was conducted on 90 atypical NTG patients who underwent cranial magnetic resonance imaging(MRI)due to atypical *** demographic characteristics,clinical parameters,and radiological findings were recorded.●RESULTS:Among the patients,66.7%had abnormal radiology results,with the most common findings being gliosis(34.4%),sequelae of cerebrovascular events and vascular malformations(14.4%),and benign intracranial mass lesions(11%).Non-glaucomatous visual field defects were more frequently observed in patients with abnormal neuroimaging ***,there were no significant differences in intraocular pressure,optic disc parameters,retinal nerve fiber layer thickness,and visual field indices between patients with normal and abnormal radiological *** mean age of the patients was ***,there was a significant age difference,with the abnormal radiology group having a higher median age(P=0.021).●CONCLUSION:The study highlights the importance of cranial imaging in older NTG patients to detect underlying pathologies and prevent *** suggests that neuroimaging may be warranted in NTG patients with atypical visual field defects incompatible with ***,routine neuroimaging in all NTG patients without classic neurological signs may not be necessary.

关键词： normal tension glaucoma neuroimaging atypical visual field defects

The Pichia pastoris enzyme production platform:From combinatorial library screening to bench-top fermentation on residual cyanobacterial biomass

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Journal of Bioresources and Bioproducts 2024年第1期9卷 43-57页

作者： Korbinian Sinzinger Ulrike Obst Samed Güner Manuel Döring Magdalena Haslbeck Doris Schieder Volker Sieber Chair of Chemistry of Biogenic Resources Campus Straubing for Biotechnology and SustainabilityTechnical University of MunichStraubing 94315Germany Catalysis Research Center Technical University of MunichGarching 85748Germany SynBiofoundry@TUM Technical University of MunichStraubing 94315Germany School of Chemistry and Molecular Biosciences The University of QueenslandSt.Lucia 4072Australia

The demand for industrial enzymes is continually rising,fueled by the growing need to shift towards more sustainable industrial ***,making efficient enzyme production strains and identifying optimal enzyme expression conditions remains a ***,the production of the enzymes themselves comes with unavoidable impacts,e.g.,the need to utilize secondary ***,we take a more holistic view of bioprocess development and report an integrative approach that allows us to rapidly identify improved enzyme expression and secretion conditions and make use of cyanobacterial waste biomass as feed for supporting Pichia pastoris *** demonstrate these capabilities by producing a phytase secreted by *** that is grown on cyanobacterium hydrolysate and buffered glycerol-complex(BMGY)medium,with genetic expression conditions identified by high-throughput screening of a randomized se-cretion *** our best-performing strain is grown in a fed-batch fermentation on BMGY,we reach over 7000 U/mL in three days.

关键词： Protein secretion Phytase Cyanobacterial biomass Fed-batch fermentation Pichia pastoris

Relation between dysbiosis and inborn errors of immunity

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World Journal of Methodology 2024年第4期14卷 104-109页

作者： Öner Özdemir Department of Pediatric Allergy and Immunology Sakarya UniversityMedical FacultyAdapazarı54100SakaryaTürkiye

Inborn errors of immunity(IEI)disorders,formerly primary immune deficiency diseases,are a heterogeneous group of disorders with variable hereditary transitions,clinical manifestations,complications and varying disease *** of the clinical symptoms,signs and complications in IEI patients can be attributed to inflammatory and immune dysregulatory processes due to loss of microbial diversity(dysbiosis).For example,in common variable immunodeficiency patients,the diversity of bacteria,but not fungi,in the gut microbiota has been found to be reduced and significantly ***,this was associated with a more severe disease *** of the STAT3/Th17 pathway in hyper-IgE syndrome may lead to dysbiosis of the oral microbiota in these patients,causing Candida albicans to switch from commensal to *** of the microbiota can be used as a therapeutic approach in patients with ***,probiotics,postbiotics and fecal microbiota transplantation can be used to restore the balance of the gut microbiota and reduce pathogenicity in IEI *** trials are currently underway to understand the impact of this dysbiosis on the phenotype of IEI diseases and its role in their treatment.

关键词： Immunodeficiency Microbiome Microbiota Fecal microbiota transplantation Immunoglobulin

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质子磁荷半径:新疑难?

Science Bulletin 2024年第4期69卷 419-421页

作者：林勇辉 Hans-Werner Hammer Ulf-G.Meiûner Helmholtz Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnBonn D-53115Germany Technische Universität Darmstadt Department of PhysicsInstitut für KernphysikDarmstadt 64289Germany ExtreMe Matter Institute EMMI and Helmholtz Forschungsakademie Hessen für FAIR GSI Helmholtzzentrum für Schwerionenforschung GmbHDarmstadt 64291Germany Institute for Advanced Simulation and Institut für Kernphysik Forschungszentrum JülichJülich D-52425Germany Tbilisi State University Tbilisi 0186Georgia

The electric radius,rE,and the magnetic radius,rM,of the proton are fundamental quantities of low-energy QCD,as they are a measure of the probe-dependent size of the proton.

关键词： radius quantities fundamental

Mast cell activation syndrome:An up-to-date review of literature

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World Journal of Clinical Pediatrics 2024年第2期13卷 104-113页

作者： ÖnerÖzdemir Gökçe Kasımoğlu Ayşegül Bak Hüseyin Sütlüoğlu Süreyya Savaşan Department of Pediatric Allergy and Immunology Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Kocaeli City HospitalKocaeli 50123Türkiye Department of Pediatrics Children’s Hospital of MichiganHematology/OncologyCentral Michigan University College of MedicineMount PleasantMI 48859United States Barbara Ann Karmanos Cancer Institute Wayne State UniversityDetroitMI 12345United States

Mast cells are a subtype of white blood cells and are involved in the immune *** cells contain many chemical substances called mediators,which are involved in the allergic *** fact that mast cells play a role in many events that require urgent intervention,especially anaphylaxis,has led to a more detailed study of these *** diseases also caused by dysfunctions of mast cells have been examined in many *** instance,mast cell activation syndrome is known as an augmented number of cells due to decreased cell death,resulting in clinical symptoms affecting many *** main common symptoms include flushing,hypotension,urticaria,angioedema,headache,vomiting and *** the underlying mechanism is not yet clearly known,we aim to review the literature in a broad perspective and bring together the existing knowledge in the light of the literature due to the diversity of its involvement in the body and the fact that it is a little known syndrome.

关键词： Mast cell Mast cell activation syndrome Tryptase Histamine

On ε-Derivations and Local ε-Derivations

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1555-1566页

作者： Ajda FOner Maja FOner Faculty of Management University of Primorska Faculty of Logistics University of Maribor

In this paper, we describe ∈-derivations in certain graded algebras by their actions on elements satisfying some special conditions. One of the main results is applied to local ∈-derivations on some certain graded a... 详细信息

关键词： Graded algebras graded prime algebras graded semiprime algebras ∈-derivations local ∈-derivations

Changes in carbon stocks of soil and forest floor in black pine plantations in Turkey

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Journal of Forestry Research 2021年第1期32卷 339-347页

作者： SükrüTeoman Güner Dilek Güner General Directorate of Forestry Research Institute for Forest Soil and Ecology26160 EskisehirTurkey

The objectives of this study were:(1)to determine carbon stock changes in the soil and forest floor of black pine(Pinus nigra ***)plantations in Turkey;(2)to determine the effects of thinning on annual carbon accumulation in both;and,(3)to investigate relationships between annual carbon storage in soil and forest floor and stand characteristics of black *** were taken in 90 plots from stands at the pole(dbh=11.0–19.9 cm)and sawlog(dbh=20.0–35.9 cm)*** analyses of soil and forest floor samples showed that in unthinned plantations signifi cant organic carbon was sequestered an average of 1.47 Mg ha^−1 a^−1 in the soil and 0.20 Mg ha^−1 a^−1 in the forest *** carbon sequestered annually in the soil was signifi cantly lower in thinned than in unthinned stands,while diff erences in the forest floor were insignifi *** were positive correlations between carbon sequestered in the soil and stand age,average DBH,mean stand height,basal area,and site *** sequestered the forest floor increased with basal *** a result,carbon sequestered in the soil should not be ignored in greenhouse gas inventories because carbon stored belowground was approximately 70%of the aboveground pool.

关键词： Pinus nigra Belowground Forest floor Carbon sequestration Thinning

Exact solutions of nonlinear fractional differential equations by (G'/G)-expansion method

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Chinese Physics B 2013年第11期22卷 140-145页

作者： Ahmet Bekir zkan Güner Eskisehir Osmangazi University Art-Science Faculty Department of Mathematics-Computer Dumlup nar University School of Applied Sciences Department of Management Information Systems

In this paper, we use the fractional complex transform and the （G＇/G）-expansion method to study the nonlinear fractional differential equations and find the exact solutions. The fractional complex transform is proposed to convert a partial fractional differential equation with Jumarie＇s modified Riemann-Liouville derivative into its ordinary differential equation. It is shown that the considered transform and method are very efficient and powerful in solving wide classes of nonlinear fractional order equations.

关键词： (G'/G)-expansion method time-fractional Burgers equation fractional-order biological popula-tion model space-time fractional Whitham-Broer-Kaup equations

Current and efficiency of Brownian particles under oscillating forces in entropic barriers

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Chinese Physics B 2015年第4期24卷 82-89页

作者： Ferhat Nutku Ekrem Aydιner Theoretical Physics Research Group Department of Physics Faculty of Sciencestanbul University

In this study, considering the temporarily unbiased force and different forms of oscillating forces, we investigate the current and efficiency of Brownian particles in an entropic tube structure and present the numerically obtained results. We show that different force forms give rise to different current and efficiency profiles in different optimized parameter intervals. We find that an unbiased oscillating force and an unbiased temporal force lead to the current and efficiency, which are dependent on these parameters. We also observe that the current and efficiency caused by temporal and different oscillating forces have maximum and minimum values in different parameter intervals. We conclude that the current or efficiency can be controlled dynamically by adjusting the parameters of entropic barriers and applied force.

关键词： entropic barrier Brownian motion Fick-Jacobs equation efficiency of Brownian motor stochastic processes

Immunosurveillance function of human mast cell?

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World Journal of Gastroenterology 2005年第44期11卷 7054-7056页

作者： ner zdemir Department of Pediatrics

Mast cell (MC) is so widely recognized as a critical effector in allergic disorders that it can be difficult to think of MC in any other context. Indeed, MCs are multifunctional and recently shown that MCs can also act as antigen presenters as well as effector elements of human immune system. First observations of their possible role as anti-tumor cells in peri- or intra-tumoral tissue were mentioned five decades ago and a high content of MCs is considered as a favorable prognosis,consistent with this study. Believers of this hypothesis assumed them to be inhibitors of tumor development through their pro-apoptotic and -necrolytic granules e.g.,granzymes and TNF-α. However, some still postulate them to be enhancers of tumor development through their effects on angiogenesis due to mostly *** are also some data suggesting increased MC density causes tumor development and indicates bad prognosis. Furthermore, since MC-associated mediators have shown to influence various aspects of tumor biology, the net effect of MCs on the development/progression of tumors has been difficult to evaluate. For instance, chymase induces apoptosis in targets; yet,tryptase, another MC protease, is a well-known *** with these various enzyme expression patterns may mediate different functions and the predominant MC type in tissues may be determined by the environmental needs. The coexistence of tryptase-expressing MCs(MCT) and chymase and tryptase-expressing MCs (MCTC)in physiological conditions reflects a naturally occurring balance that contributes to tissue homeostasis. We have recently discussed the role and relevance of MC serine proteases in different bone marrow diseases.

关键词： Mast cell Immunosurveillance Tryptasechymase Cytotoxicity Tumors