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World Journal of Gastroenterology 2015年第12期21卷 3741-3745页

作者： Hisatake Matsumoto Hiroshi Ogura Masafumi Seki Mitsuo ohnishi Takeshi Shimazu Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine Division of Infection Control and Prevention Osaka University Graduate School of Medicine

We report a case of phlegmonitis of the esophagus, stomach, and duodenum in patient in an immunocompromised state. Culture of gastric juice and blood yielded Bacillus thuringiensis. This case showed that even low-viru... 详细信息

关键词： Phlegmonous gastritis Esophagus Duodenum Bacillus

Normalization of Serum Alkaline Phosphatase in Primary Sclerosing Cholangitis Associated with Ulcerative Colitis

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Health 2014年第10期6卷 969-974页

作者： Mitsuro Chiba Hidehiko Tsuda Satoko Tsuda Masafumi Komatsu Yasuo Horie Hirohide ohnishi Depatment of Gastroenterology Akita University School of Medicine Akita Japan Division of Gastroenterology Akita City Hospital Akita Japan Division of Gastroenterology Akita Kumiai General Hospital Akita Japan

Primary sclerosing cholangitis (PSC) is commonly associated with ulcerative colitis (UC). PSC progresses independently of UC ultimately resulting in liver failure. There is no established medical treatment to improve the natural course of PSC. Normalization of serum alkaline phosphatase (ALP) in early stage might delay the progress of PSC. A 20-year-old female, had a sudden attack of right hypochondralgia with high fever and abnormal liver function tests without elevation of bilirubin: ALP 478 IU/L, aspartate aminotransferase 360 IU/L, alanine aminotransferase 174 IU/L. Abnormal liver function tests returned to normal after the attacks. Morphological examinations initially indicated then confirmed a diagnosis of PSC. One month after displaying PSC symptoms administration of ursodeoxycholic acid was initiated. Similar attacks of cholangitis were repeated several times over the following two years. Even in the absence of these attacks, she always suffered postprandial hypochondralgia. There was no acute cholangitis in the year prior to the last hospitalization due to abdominal pain and bloody diarrhea. Findings were consistent with UC in the form of entire colitis. Sulfasalazine, metronidazole and semi-vegetarian diet (SVD) were initiated. Metronidazole is routinely used in inflammatory bowel disease (IBD) in our practice with the expectation of elimination of any potentially pathogenic bacteria. SVD was designed for IBD hoping to increase beneficial bacteria. A remission of UC was ascertained during hospitalization. Elevated ALP, in the absence of clinical cholangitis, was decreased to normal after the therapy for UC.

关键词： Primary Sclerosing Cholangitis Ulcerative Colitis Alkaline Phosphatase Metronidazole Vegetarian Diet

A Computation Model of Echo Avoidance in Human Audition

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A Computation Model of Echo Avoidance in Human Audition

Crystallization of Cellobiohydrolase in the Presence of Cellulose-Degraded Cellobiose: Analysis of Intermolecular Interactions and Association Dynamics

1998 International Conference on Neural Networks and Brain(ICNN&B’98)

作者： Jie Huang Noboru ohnishi Xiaolan Guo Noboru Sugie Bio-Mimetic Control Research Center The Institute of Physical and Chemical Research(RIKEN)2271-130 AnagahoraShimoshidamiMoriyama-kuNagoya 463Japan Department of Information Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya464-01 Japan

＜正＞The precedence effect being a topic of continuous theoretical interest in hearing research,however,cannot be predicted explicitly by a model until so *** this paper,an acho-avoidance mechanism is proposed by assuming that the precedence effect is caused by the inhibition of sound localization which depends on the estimated soundto -echo *** assume there is a neural echo estimation mechanism in the human auditory *** is found that a temporal pattern of aftereffect with delay and decay features,which is adopted from the previous psychological tests on the increase of the perceptual threshold of interaural time difference following a preceding impulsive sound, can be used for echo *** results of psychological experiments,***-level and unequal-level paired click tests,Haas’s tests,Franssen’s tests and others,can be interpreted consistently.

关键词： precedence effect sound localization echo estimation echo avoidance reverberant environment

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Journal of Crystallization Process and Technology 2014年第1期4卷 1-13页

作者： Kazuo Onuma Naoki Furubayashi Fujiko Shibata Yoshiko Kobayashi Sachiko Kaito Yuki ohnishi Koji Inaka Maruwa Foods and Biosciences Inc. Tsutsui-cho Yamatokoriyama Nara Japan National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Ibaraki Japan

Crystallization of enzymes in presence of impurities is important for clarifying the role of enzymes in natural world. Although it is proposed that impurities inhibit nucleation of enzyme crystallization, details are unclear. In this study, crystallization of cellobiohydrolase from Aspergillus niger was investigated by dynamic and time-resolved static light scattering using cellobiose as an impurity. We aimed to clarify how cellobiose inhibits cellobiohydrolase crystallization and to crystallize cellobiohydrolase in concentrated cellobiose without using seeds. The contribution of attractive forces to total intermolecular interactions of cellobiohydrolase monomers increased with the molar ratio of cellobiose/cellobiohydrolase (R(cb/ce)). Association dynamics of cellobiohydrolase using lithium sulfate, however, showed that the initial aggregation rate decreased with an increase in R(cb/ce). Because binding sites of cellobioses to cellobiohydrolase molecules differed from those for the growth of protein crystals, the binding of cellobioses would increase the chemical potential of the cellobiohydrolase monomers, which gradually reduced supersaturation for growth as the aggregate size increased. This result was in contrast with the conventional idea that cellobiose inhibits the nucleation of cellobiohydrolase crystals. Gentle agitation of cellobiose-containing cellobiohydrolase solutions during sitting-drop vapor-diffusion growth resulted in the growth of cellobiohydrolase single crystals for all R(cb/ce) conditions without using seeds.

关键词： Enzyme Crystallization Inhibitor Hamaker Constant Light Scattering

AUTORADIOGRAPHIC STUDY OF THE ATTRITION OF MIGRATING SCHISTOSOMULA IN THE SKIN OF MICE *** CHALLENGED WITH NORMAL *** CERCARIAE AFTER IMMUNIZATION WITH HIGHLY IRRADIATED CERCARIAE

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Chinese Medical Sciences Journal 1990年第1期8卷 30-36页

作者： S.Y.Li Hsu H.F.Hsu J.W.Osborne W.R.Clarke C.K.Hawk Y.ohnishi College of Medicine University of IowaIowaUSA

The migratory pattern and attrition of75Se-labelled *** challenge cercariae in CF1mice immunized 0,1,3, or 5 times with 12kR-or 48kR-irradiated cercariae were investigatedby compressed organ *** were percutaneously inoculated with 500-1000 cer-cariae for each immunization and with a known count of approximately 90 cercariae at adifferent site for *** skin,lungs,liver,other organs,and catrcass were processedfor *** and mesenteric perfusions for worm collection were alsosampled from day 19 through *** naive tnice,25% of challenge cercariae died in *** attrition of challenge cercariae in mice immunized with 12kR-irradiated cercariaewas 43% with 1 immunization,54% with 3,and 58% with 5,whereas in mice immunized with48kR-irradiated cercariae,skin,attrition was48% with 1,63% with 3,and 76% with 5 *** all immunized mice,a high percentage of migrating sehistosomula died in the skinwithin 24 hours of a challenge *** autoradiography,it was found that thesilver foci created by single labelled worms were difficult to differentiate from those of *** study documents the induction of acquired resistance against a challenge infectionin the skin by vaccination with highly irradiated cercariae,with the degree of attemtation ofimmunizing cercariae and the number of immunizations being closely related to the *** in the ***,we discuss the contradictory views concerning the site of attritiotn ofchallenge cercariae.

关键词： autoradiography attrition—challenge cercariae immunization—highly X-irradiated cercariae Schistosoma mansoni

DEVELOPMENT OF THE 3D UNDERGROUND SPACE INFORMATION MANAGEMENT SYSTEM(USIMS) FOR THE MAINTENACE AND HEALTH ASSESSMENT OF TUNNELS Paper No.191

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DEVELOPMENT OF THE 3D UNDERGROUND SPACE INFORMATION MANAGEME...

Early Diagnosis of Spontaneous Spinal Epidural Hematoma with Echo-Planar Gradient-Echo T2*-Weighted MR Imaging

ISRM-Sponsored International Symposium on Rock Mechanics:"Rock Characterisation,Modelling and Engineering Design Methods"(SINOROCK2009)

作者： Meiji Ryu Takumi Nakai Tomofumi Koyama Satoshi Nishiyama Yuzo ohnishi Earthtech Toyo Co.Ltd. Department of Urban and Environmental Engineering Kyoto University

Due to the economical,political and social changes in Japan,the construction industry has to shift the focus from building new infrastructures to maintaining existing *** life of the infrastructures will be extended by regular maintenance considerably and this is especially true for tunnels and other underground ***,for the construction,maintenance and reinforcement of the tunnels,the new concept called asset management has been also introduced and paid *** of the key issues for asset management for tunnels is how to define,monitor and assess the performance of the *** is also important to register geological and construction related data and store them for the future use such as the maintenance and repair/reinforcement of the tunnels. At each stages(construction,maintenance and repair/reinforcement),large amount of data are gathered that should be stored and retrieved for the later *** newly developed three-dimensional Underground Space Information Management System (USIMS) enables to store and integrate all types of information related to the construction,inspection,maintenance and reinforcement systematically with a 3-D virtual world. In this study,for the purpose of the tunnel maintenance and health assessment of the tunnels,the comprehensive tunnel database was constructed using USIMS based on the geological data at the tunnel site,construction data,regular inspection records and photos,and etc.,which were stored as a hard copy and/or digital *** updating this tunnel database,time evolution of the tunnel status such as deformation,clacks *** be presented with clear 3D vision. The USIMS can help to optimize the process of regular inspections and maintenance and can be of great help to identify causes for accelerated *** USIMS can be a valuable asset management *** make a good inspection and maintenance program it is important to identify how fast and with what spread deterioration

关键词： Underground Space Information Management System(USIMS) tunnel regular inspection maintenance asset management 3-D vision

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Neuroscience & Medicine 2015年第1期6卷 20-23页

作者： Koichi Iwatsuki Toshiki Yoshimine Yu-Ichiro ohnishi Koshi Ninomiya Toshika Ohkawa Kousuke Iwaisako Department of Neurosurgery Osaka University Medical School Osaka Japan Department of Neurosurgery Kyoritu Hospital Hyogo Japan

Spontaneous spinal epidural hematoma (SSEH) is a rare idiopathic condition that leads to the acute onset of neurological deficits, which can have catastrophic consequences if not recognized early. It is important to make an early precise diagnosis. Spinal epidural hematoma has been increasingly recognized since the advent of magnetic resonance imaging (MRI). However, T1- and T2-weighted gradient-echo sequences are relatively less sensitive to the magnetic susceptibility effects of hemorrhage. Echo-planar gradient-echo T2*-weighted MR imaging (T2* MRI) is sensitive to these magnetic susceptibility effects and is commonly used for the detection of hemorrhage. We reported that the case of a 76-year-old man who presented with tetra paresis had an early diagnosis of spontaneous spinal epidural hematoma early diagnosed by T2* MRI.

关键词： Spinal Epidural Hematoma T2* MRI Diagnosis Hemorrhage

Makeup Activates Brain Activity in Visually Impaired Persons: Evaluation by Functional Magnetic Resonance Imaging

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第2期11卷 140-154页

作者： Katsushi Taomoto Kaho Oishi Hiroshi Matsunaka Yumi Murakami Yoshihiro Kuga Shinsuke Hashimoto Hideyuki ohnishi Koji Abe ohnishi Neurological Center Akashi Japan International Caremake Association Tokyo Japan NOV Academic Research TOKIWA Pharmaceutical Co. Ltd. Tokyo Japan Department of Neurology Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan

Cosmetics are used to improve physical appearance, but the benefits may be limited to people without visual impairment. The importance of attractiveness among blind persons has not been assessed. We investigated the influence of makeup on brain activity of blind persons using functional magnetic resonance imaging (fMRI). Participants were 7 blind females (BFs) who learned to fully apply makeup and 9 mostly age-matched normally sighted females (NSFs). Brain activity was measured using fMRI before and after application of makeup and during a makeup image task in each state. In the default mode network at rest, there was no difference between the BFs and NSFs. However, a lateral visual network to the opposite side was observed in the NSFs, whereas no such network was noted in the BFs. A weak network was noted in the BFs in the occipital fusiform gyrus and temporal occipital fusiform cortex, and an extensive visual area network defect was noted. Also, activity after makeup application was significantly higher in the nucleus accumbens, pallidum, and hippocampus. Activity in the right middle cingulate gyrus, right cerebral white matter, and right anterior cingulate gyrus was higher before makeup in both BFs and NSFs, and the activity was significantly higher and more extensive in the BFs. In conclusion, applying makeup is a personally rewarding activity, even for BFs, as it strongly activates the reward system and the reward/memory system network, even in the absence of a visual area network.

关键词： Functional Magnetic Resonance Imaging Visually Impaired Persons Brain Activity Makeup Female

Comparison of Anticancer Drug Preparation Techniques between Chemotherapy Specialist Pharmacists and Non-Chemotherapy Pharmacists Using Eye-Tracking Techniques

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Pharmacology & Pharmacy 2023年第8期14卷 229-238页

作者： Yuka Miyachi Yukina Miyagi Saori Gocho Chika Nakayama Masayuki Ejiri Masayuki Takeuchi Masafumi ohnishi Taeyuki Oshima College of Pharmacy Kinjo Gakuin University Nagoya Japan Graduate School of Medicine Aichi Medical University Nagakute Japan Department of Pharmacy Nagoya Ekisaikai Hospital Nagoya Japan Faculty of Pharmacy Gifu University of Medical Science Kani Japan Department of Pharmacy Aichi Medical University Hospital Nagakute Japan

Anticancer drug preparation by pharmacists is a critical task directly related to medical incidents. This study examined the factors influencing medical errors in chemotherapy, that is, errors by specialist pharmacists (CPh) and pharmacists in other departments (NCPh), by measuring their gaze during the preparation of anticancer drugs. The eye-tracking results showed that the gazing time of NCPh was significantly longer than that of CPh for items such as “preparation of a closed-system device” and “preparation of the syringe” and all preparation times (P < 0.05). The NCPh were not assigned to prepare drugs on a regular basis, indicating their lack of familiarity with the process. There was no significant difference in gaze ratio between CPh and NCPh. This outcome was suggested to be a result of the use of an anticancer drug preparation support system. The results for the pupil diameter variation rate showed that NCPh were significantly more mydriatic in the “mixing injections” category than CPh. However, CPh tended to be more mydriatic in the “checking” category. CPh exhibited a smooth workflow and focused on the important items to be checked. This study showed that the differences in procedure flow and concentration points may lead to errors. Furthermore, the results are of interest from the perspective of medical incident prevention. They will be useful in identifying potential human factors, such as where the pharmacist focuses their attention by measuring eye movements.

关键词： Eye Tracking Medicine Inspection Anticancer Drug Pharmacists