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Precise tracking of tip-induced structural variation at the single-chemical-bond limit

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Light(Science & Applications) 2023年第1期12卷 15-16页

作者： sayantan Mahapatra Nan Jiang Department of Chemistry University of Illinois ChicagoChicagoIL 60607USA

Sub-nanometer-resolved TERS provides a systematic way for investigating tip-molecule interaction and molecular motions,enabling a promising approach to examine on-surface reaction mechanisms and catalysis at the micro... 详细信息

关键词： level. limit catalysis

Comparative architecture in monolithic perovskite/silicon tandem solar cells

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Science China(Physics,Mechanics & Astronomy) 2023年第1期66卷 60-84页

作者： sayantan Mazumdar Ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage CenterSolar Energy Conversion CenterNankaiUniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Tianjin 300350China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Tianjin 300350China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Inorganic-organic metal halide perovskite light harvester-based perovskite solar cells(PSCs)with widely tunable bandgap have achieved rapid growth in power conversion efficiency,which exceeds 25%*** is deliberated that if a semitransparent solar cell made of wider bandgap materials was placed on top of a narrow bandgap materials-based solar cell such as a silicon solar cell,with proper optical and electrical arrangements,the resultant tandem device consisting of two subcells could more effectively utilize the solar spectrum than a single junction solar *** a perovskite/silicon tandem solar cell(PSTSC),a semitransparent PSC with a wider bandgap is placed on top of a narrow bandgap silicon solar *** PSC efficiently harvests the higher energy photons in the ultraviolet and visible regions of the solar spectrum while the silicon solar cell can convert the photons of the infrared region to *** PSTSC is proposed as a potential candidate to overcome the Shockley-Queisser limit of single-junction silicon solar *** the theoretical limit of a PSTSC is calculated as~42%,its actual efficiency achieved until now is less than 30%.Therefore,a great scope of research exists in improving the efficiency of *** issues of stability and upscaling of the device in PSCs are also a matter of concern for PSTSCs.A tandem device consists of multiple parts,and different configurations can be applied,thus tuning the architecture of the *** various parts may result in significant changes in the efficiency of the *** this review,competing architectures of otherwise comparable devices are compared in terms of photovoltaic ***,future directions to improve the efficiency of the device based on architecture design are proposed *** particular,the influence of the polarity of PSCs and the surface morphology of silicon solar cells(both front and rear)on determining the properties of the PSTSC are discussed.

关键词： tandem solar cell silicon solar cell perovskite perovskite solar cell solar cell architecture polarity of tandem solar cell photoelectrochemical cells photoconduction and photovoltaic effects solar cells and arrays

A Stack-based Ensemble Framework for Detecting Cancer MicroRNA Biomarkers

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Genomics, Proteomics & Bioinformatics 2017年第6期15卷 381-388页

作者： Sriparna Saha sayantan Mitra Ravi Kant Yadav Department of Computer Science and Engineering Indian Institute of TechnologyPatna 801103India

MicroRNA （miRNA） plays vital roles in biological processes like RNA splicing and regulation of gene expression. Studies have revealed that there might be possible links between onco- genesis and expression profiles of some miRNAs, due to their differential expression between normal and tumor tissues. However, the automatic classification of miRNAs into different cate- gories by considering the similarity of their expression values has rarely been addressed. This article proposes a solution framework for solving some real-life classification problems related to cancer, miRNA, and mRNA expression datasets. In the first stage, a mulfiobjective optimization based framework, non-dominated sorting genetic algorithm II, is proposed to automatically determine the appropriate classifier type, along with its suitable parameter and feature combinations, pertinent for classifying a given dataset. In the second page, a stack-based ensemble technique is employed to get a single combinatorial solution from the set of solutions obtained in tke first stage. The performance of the proposed two-stage approach is evaluated on several cancer and RNA expression pro- file datasets. Compared to several state-of-the-art approaches for classifying different datasets, our method shows supremacy in the accuracy of classification.

关键词： Sequential minimal optimizer Non-dominated sorting genetic algorithm Multiobjective optimization MicroRNA

Immunotherapy in type 1 diabetes:Novel pathway to the future ahead

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World Journal of Diabetes 2024年第10期15卷 2022-2035页

作者： sayantan Ray Rajan Palui Department of Endocrinology All India Institute of Medical SciencesBhubaneswar 751019India Department of Endocrinology The Mission HospitalDurgapur 713212India

Since the discovery of insulin over 100 years ago,the focus of research in the management of type 1 diabetes(T1D)has centered around glycemic control and management of complications rather than the prevention of autoimmune destruc-tion of pancreaticβ***,in recent years,there has been significant advancement in immune-targeted pharmacotherapy to halt the natural progres-sion of *** immune-targeted intervention aims to alter the underlying pa-thogenesis of T1D by targeting different aspects of the immune *** im-munotherapy can either antagonize the immune mediators like T cells,B cells or cytokines(antibody-based therapy),or reinduce self-tolerance to pancreaticβcells(antigen-based therapy)or stem-cell ***,the US Food and Drug Administration approved the first immunotherapy teplizumab to be used only in stage 2 of ***,the window of opportunity to practically implement this approved molecule in the selected target population is *** this Edito-rial,we briefly discuss the various promising recent developments in the field of immunotherapy research in ***,further studies of these newer thera-peutic agents are needed to explore their true potential for prevention or cure of T1D.

关键词： Type 1 diabetes Immunotherapy Teplizumab Antigen based therapy Stem cell immunotherapy

Non-exotic static spherically symmetric thin-shell wormhole solution in f(Q,T)gravity

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Chinese Physics C 2023年第7期47卷 173-189页

作者： Moreshwar Tayde sayantan Ghosh P.K.Sahoo Department of Mathematics Birla Institute of Technology and Science-PilaniHyderabad CampusHyderabad-500078India

In this study,we conduct an analysis of traversable wormhole solutions within the framework of linear f(Q,T)=αQ+βT gravity,ensuring that all energy conditions hold for the entire *** solutions presented in this paper are derived through a comprehensive analytical examination of the parameter space associated with the wormhole *** involves considering the exponents governing the redshift and shape functions,as well as the radius of the wormhole throat(r_(0)),the redshift function value at the throat(∅_(0)),and the model parameters(αandβ).Moreover,we establish bounds on these free parameters,which guarantee the satisfaction of the energy conditions throughout spacetime and also provide two ***,we use the Israel junction condition to observe the stability of a thin-shell around the ***,we calculate the null energy condition criteria as well as the potential for the thin-shell and how it varies with the chosen shape function.

关键词： wormhole energy conditions f(Q,T)gravity junction condition thin-shell

Dynamical system analysis of Dirac-Born-Infeld scalar field cosmology in coincident f(Q)gravity

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Chinese Physics C 2024年第9期48卷 199-209页

作者： sayantan Ghosh Raja Solanki P.K.Sahoo Department of Mathematics Birla Institute of Technology and Science-PilaniHyderabad CampusHyderabad-500078India

In this article,we present a dynamical system analysis of a Dirac-Born-Infeld scalar field in a modified f(Q)gravity *** considered a polynomial form of modified gravity,used two different types of scalar potential,polynomial and exponential,and found a closed autonomous dynamical system of *** analyzed the fixed points of such a system and evaluated the conditions under which deceleration to late-time acceleration occurs in this *** note the similarity of the two models and show that our result is consistent with a previous study on Einstein s *** also investigated the phenomenological implications of our models by plotting EoS(ω),energy density(Ω),and deceleration parameter(q)*** e-fold time and comparing to the present *** conclude the paper by observing how the dynamical system analysis differs in the modified f(Q)gravity,and present the future scope of our research.

关键词： Dirac-Born-Infeld field f(Q)gravity dark energy dynamical system analysis

Heterogeneity of non-alcoholic fatty liver disease: Implications for clinical practice and research activity

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World Journal of Hepatology 2021年第11期13卷 1584-1610页

作者： Partha Pal Rajan Palui sayantan Ray Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India Department of Endocrinology The Mission HospitalDurgapur 713212West BengalIndia Department of Endocrinology Jagannath Gupta Institute of Medical Sciences and HospitalKolkata 700137West BengalIndia Diabetes and Endocrinology Apollo ClinicBallygungeKolkata 700019West BengalIndia

Non-alcoholic fatty liver disease(NAFLD)is a heterogeneous condition with a wide spectrum of clinical presentations and natural history and disease *** is also substantial inter-individual variation and variable response to a different *** heterogeneity of NAFLD is in turn influenced by various factors primarily demographic/dietary factors,metabolic status,gut microbiome,genetic predisposition together with epigenetic *** differential impact of these factors over a variable period of time influences the clinical phenotype and natural *** to address heterogeneity partly explains the sub-optimal response to current and emerging therapies for fatty liver ***,leading experts across the globe have recently suggested a change in nomenclature of NAFLD to metabolic-associated fatty liver disease(MAFLD)which can better reflect current knowledge of heterogeneity and does not exclude concomitant factors for fatty liver disease(***,viral hepatitis,etc.).Precise identification of disease phenotypes is likely to facilitate clinical trial recruitment and expedite translational research for the development of novel and effective therapies for NAFLD/MAFLD.

关键词： Non-alcoholic fatty liver disease Metabolic-associated fatty liver disease Heterogeneity Phenotypes nomenclature Clinical trial Effective therapies

MicroRNAs:a new ray of hope for diabetes mellitus

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Protein & Cell 2012年第10期3卷 726-738页

作者： Munish Kumar sayantan Nath Himanshu K Prasad G D Sharma Yong Li Department of Biotechnology Assam UniversitySilchar 788011 India 2 Department of Life Science and Bioinformatics Assam UniversitySilchar 788011 India 3 Department of Biochemistry and Molecular Biology University of LouisvilleKY 40292USA

Diabetes mellitus has become one of the most common chronic diseases,thereby posing a major challenge to global *** by high levels of blood glucose(hyperglycemia),diabetes usually results from a loss of insulin-producing β-cells in the pancreas,leading to a deficiency of insulin(type 1 diabetes),or loss of insulin sensitivity(type 2 diabetes).Both types of diabetes have serious secondary complications,such as microvascular abnormalities,cardiovascular dysfunction,and kidney *** complex factors,such as genetic and environmental factors,are associated with the pathophysiology of *** the past two decades,the role of small,single-stranded noncoding microRNAs in various metabolic disorders,especially diabetes mellitus and its complications,has gained widespread attention in the scientific *** first as an endogenous regulator of development in the nematode Caenorhabditis elegans,these small RNAs post-transcriptionally suppress mRNA target *** this review,we discuss the potential roles of different microRNAs in diabetes and diabetes-related complications.

关键词： diabetes diabetic complications dicer glucose insulin microRNA pancreas

Critical review of bone health,fracture risk and management of bone fragility in diabetes mellitus

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World Journal of Diabetes 2021年第6期12卷 706-729页

作者： Rajan Palui Subhodip Pramanik Sunetra Mondal sayantan Ray Department of Endocrinology The Mission HospitalDurgapur 713212West BengalIndia Department of Endocrinology Neotia Getwel Healthcare CentreSiliguri 734010West BengalIndia Department of Endocrinology Institute of Post Graduate Medical Education and Research(IPGMER)Kolkata 700020West BengalIndia Department of Endocrinology Medica Superspeciality Hospital and Medica ClinicKolkata 700099West BengalIndia

The risk of fracture is increased in both type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM).However,in contrast to the former,patients with T2DM usually possess higher bone mineral ***,there is a considerable difference in the pathophysiological basis of poor bone health between the two types of *** bone strength due to poor bone microarchitecture and low bone turnover along with increased risk of fall are among the major factors behind elevated fracture ***,some antidiabetic medications further enhance the fragility of the *** the other hand,antiosteoporosis medications can affect the glucose homeostasis in these *** is also difficult to predict the fracture risk in these patients because conventional tools such as bone mineral density and Fracture Risk Assessment Tool score assessment can underestimate the ***-based recommendations for risk evaluation and management of poor bone health in diabetes are sparse in the *** the advancement in imaging technology,newer modalities are available to evaluate the bone quality and risk assessment in patients with *** purpose of this review is to explore the patho-physiology behind poor bone health in diabetic *** to the fracture risk evaluation in both T1DM and T2DM as well as the pragmatic use and efficacy of the available treatment options have been discussed in depth.

关键词： Diabetes Fracture risk Bone mineral density Microarchitecture Antidiabetic drugs Antiosteoporosis therapy