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EXIsTENCE,MULTIPLICITY AND sTABILITY REsULTs FOR POsITIVE sOLUTIONs OF NONLINEAR p-LAPLACIAN EQUATIONs

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Chinese Annals of Mathematics,series B 2004年第2期25卷 275-286页

作者： mali sUNING DepartmentofMathematicalsciences TsinghuaUniversityBeijing100084China.

This paper studies the existence of positive solutions of the Dirichlet problem for the nonlinear equation involving p-Laplacian operator: -△pu = λf(u) on a bounded smooth domain Ω in Rn. The authors extend part of the Crandall-Rabinowitz bifurcation theory to this problem. Typical examples are checked in detail and multiplicity of the solutions are illustrated. Then the stability for the associated parabolic equation is considered and a Fujita-type result is presented.

关键词： p-Laplacian operator Bifurcation Multiplicity Positive solutions

Event-Triggered sampled-Data Consensus of Nonlinear Multi-Agent systems with Control Input Losses

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Journal of systems science & Complexity 2018年第6期31卷 1469-1497页

作者： XING mali DENG Feiqi Department of Automation science and Engineering South China University of Technology

This paper investigates the leader-following consensus problem for multi-agent systems with event-triggered mechanism and control packet *** on the local synchronization error, event-triggered mechanisms are proposed in order to reduce the number of controller *** control packet may lose due to unreliability of communication *** the assumption that once the packet loss happens the controller will be set to zero,sufficient consensus criteria for multi-agent system with event-triggered mechanism and control packet losses is *** is also shown that the interplay among the allowable packet loss rate,event-triggered mechanism and sampling *** illustrative example is given to demonstrate the effectiveness of the theoretical results.

关键词： Consensus control packet losses event-triggered mechanism multi-agent systems

Pancreatitis in pregnancy: etiology, diagnosis, treatment, and outcomes

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 434-438页

作者： Padmavathi mali Department of Internal Medicine Marshfield Clinic

BACKGROUND：Acute pancreatitis in pregnancy is a rare and dangerous *** study aimed to examine the etiology,treatment,and outcomes of pancreatitis in ***：A total of 25 pregnant patients diagnosed with pancreatitis during the period of 1994 and 2014 was analyzed ***：The pregnant patients were diagnosed with pancreatitis during a period of 21 ***（60%）of the patients were diagnosed with pancreatitis in the third *** mean age of the patients at presentation was 25.7 years,with a mean gestational age of 24.4 *** pain occurred in most patients and vomiting in one patient was associated hyperemesis *** common cause of the disease was gallstone-related（56%）,followed by alcohol-related（16%）,post-ERCP（4%）,hereditary（4%）and undetermined conditions（20%）.The level of triglycerides was minimally high in three *** and wire-guided sphincterotomy were performed in 6（43%）of 14 patients with gallstone-related pancreatitis and elevated liver enzymes with no ***（84%）of the patients underwent a full-term,vaginal *** was no difference in either maternal or fetal outcomes after ***：Acute pancreatitis is rare in pregnancy,occurring most commonly in the third trimester,and gallstones are the most common *** laparoscopic cholecystectomy is not feasible and a common bile duct stone is highly suspected on imaging,endoscopic sphincterotomy or stenting may help to prevent recurrence and postpone cholecystectomy until after delivery.

关键词： pancreatitis alcoholic pancreatitis pregnancy complications diagnostic imaging

Euphorbia neriifolia L.:Review on botany,ethnomedicinal uses,phytochemistry and biological activities

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 408-417页

作者： Prashant Y.mali shital s.Panchal Department of Pharmacology Institute of PharmacyNirma UniversityAhmedabadGujaratIndia

The present review is intended to provide information on botany,ethnomedicinal uses,phytochemistry and biological activities of various parts of Euphorbia neriifolia(E. neriifolia). E. neriifolia has several ethnomedicinal uses. The latex of E. neriifolia is used as laxative,purgative,rubefacient,carminative and expectorant as well as in treatment of whooping cough,gonorrhea,leprosy,asthma,dyspepsia,jaundice,enlargement of the spleen,tumors,stone in the bladder,abdominal troubles and leucoderma. Leaves are brittle,heating,carminative,and good for improving the appetite and treatment of tumors,pains,inflammations,abdominal swellings and bronchial infections. Roots are used as symptomatic treatment of snake bite,scorpion sting and antispasmodic. Various plant parts or whole E. neriifolia extract and its isolates have been reported scientifically using various in-vivo and in-vitro experimental methods for anaesthetic,analgesic,anti-anxiety,anti-convulsant,anti-psychotic,anti-arthritis,anti-carcinogenic,antidiabetic,anti-diarrhoeal,anti-inflammatory,anti-thrombotic,antimicrobial,antioxidant,antiulcer,cytotoxic,death-receptor expression enhancing,dermal irritation,diuretic,hemolytic,immunomodulatory,radioprotective,scorpion venom and wound healing properties. It is reported to have chemical constituents like,neriifolin-s,neriifolin,neriifoliene,euphol,neriifolione,cycloartenol,nerifoliol,lectin,euphonerins A–G,3-O-acetyl-8-O-tigloylingol,taraxerol,antiquorin,etc. Identified chemical constituents are still required to be explored for their advanced isolation techniques and biological activities.

关键词： Euphorbia neriifolia Botany Ethnomedicinal uses Phytochemistry Anti-cancer

Euphorbia tirucalli L.:Review on morphology,medicinal uses,phytochemistry and pharmacological activities

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Asian Pacific Journal of Tropical Biomedicine 2017年第7期7卷 603-613页

作者： Prashant Y. mali shital s. Panchal Department of Pharmacology Institute of Pharmacy Nirma University Ahmedabad Gujarat India

The intention of current review is to make available up-to-date information on morphology, ecological biodiversity, medicinal uses, phytochemistry and pharmacolog-ical activities on different parts of Euphorbia tirucalli (E. tirucalli). This plant has a number of medicinal uses. Latex of E. tirucalli is vesicant and rubefacient which is used for rheumatism, warts, cough, asthma, ear-ache, tooth-ache and neuralgia. It acts as a purgative in small doses while in big doses it is bitter irritant and emetic. Milky juice is alexiteric, carminative and purgative. It is useful in whooping cough, gonorrhea, asthma, leprosy, dropsy, dyspepsia, enlargement of spleen, colic, jaundice and stone in bladder. The fresh milky juice is good alternative in syphilis and a good application in neuralgia. A decoction of branches is used in gastralgia and colic. Bark is used in treatment of fractures. Poultices prepared from the stem are useful to repair the broken bones. Boiled root liquid acts as an emetic in cases of snake-bite and for infertility in women. The wood is used for rafters, toys and veneering purposes. It is also useful against leprosy and foot paralysis subsequent to childbirth. E. tirucalli is reported to have euphol, β-sitosterol, euphorbol hexacosonate, cycloeuphordenol, cyclotirucanenol, tirucalicine, tri-methyl ellagic acid, gallic acids, terpenic alcohol, isoeuphorol, taraxasterol, tirucallol, euphor-one, euphorcinol, euphorbins, 12-deoxy-4β-hydroxyphorbol-13-phenyl acetate-20-acetate, 12, 20-dideoxyphorbol-13-isobutyrate, glut-5-en-3-β-ol, 3,3′-di-O-methylellagic acid, euphorbin-A (polyphenol), tirucallin-A (7) (tannin), tirucallin-B (11), euphorbin-F (14) (dimers), cycloartenol, 24-methylenecycloartenol, ingenol triacetate, 12-deoxy-4β-hydroxyphorbol-13-phenyl acetate-20-acetate, taraxerone, euphorginol, taraxerol, cam-pesterol, stigmasterol, palmitic acid, linoleic acid,β-amyrin, etc. active phytoconstituents. E. tirucalli have possessed activity in human-lymphocy

关键词： Euphorbia tirucalli Morphology Ecological biodiversity Medicinal uses Phytochemistry Anticancer

Bioconcentration of polycyclic aromatic hydrocarbons in roots of three mangrove species in Jiulong River Estuary

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Journal of Environmental sciences 2005年第2期17卷 285-289页

作者： LUZhi-qiang ZHENGWen-jiao mali schoolofLifesciences ResearchCentreforWetlandandEcologicalEngineeringXiamenUniversityXiamen361005China／／EnvironmentalScienceResearchCenterXiamenUniversityXiamen361005China schoolofLifesciences ResearchCentreforWetlandandEcologicalEngineeringXiamenUniversityXiamen361005China EnvironmentalscienceResearchCenter XiamenUniversityXiamen361005China

The polycyclic aromatic hydrocarbons(PAHs) concentrations were determined in the root of three mangrove species(Kandelia candel, Avicennia marina and Bruguiera gymnorrhiza) and their growing environment(sediment) in mangrove wetlands of Jiulong River Estuary, Fujian, China. The total PAHs(16 parent PAHs) in mangrove sediments ranged from 193.44 to 270.53 ng/g dw, with a mean value of 231.76±31.78 ng/g dw. Compared with other mangrove and coastal marine sediments, the PAHs concentrations of all the sampling areas in this study were at relatively lower level. The total PAHs(13 parent PAHs) values varied from 30.83 to 62.73 ng/g dw in mangrove roots. Benzo[a]pyrene(five-ring), fluoranthene(four-ring) and pyrene(four-ring) dominated in mangrove sediments. Based on ratios of phenathrene/anthracene, fluoranthene/pyrene and fluoranthene/pyrene + fluoranthene, the main possible sources of surface sediment PAHs were identified as grass, wood or coal combustion for mangrove wetlands of Jiulong River Estuary. Naphthalene(two-ring) and phenathrene(three-ring) were the most abundant compounds in mangrove roots. sediment-to-vegetation bioconcentration factors(BCF sV s) were calculated and their relationships with PAHs' physico-chemical properties were investigated. The average BCF sV s of PAHs for three mangrove species roots were almost all under the level of 1 except for naphthalene. Good linear relationship between BCF sV values for mangrove roots and PAHs water solubility, octanol-water partitioning coefficients was derived in present study. The solubility and the octanol-water partition coefficient were proved to be good predictors for the accumulation of PAHs in mangrove roots, respectively.

关键词： mangrove PAHs Jiulong River Estuary bioconcentration factors

Expression of Human Vascular Endothelial Growth Factor (VEGF_(165)) in Pichia pastoris and Its Biological Activity

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Biomedical and Environmental sciences 2001年第4期14卷 302-311页

作者： mali ZHANGZHI－QING 等 InstituteofMolecularImmunology theFirstMilitaryMedicalUniversityGuangzhou510515China stateKeyLaboratoryofMolecularVirologyandGeneticEnginering Beijing100052China

Objective To express human vascular endothelial growth factor (hVEGF-{165}) cDNA in %Pichia pastroris, %purify the expressed product and detect the biological activity of it. Methods By inserting hVEGF-{165} cDNA coding 165 amino acid residues into %Pichia pastoris% expression vector pPIC9K containing AOX1 promoter and the sequences of α secreting signal peptides, a recombinant expression plasmid pPIC9K/hVEGF-{165} was constructed and transformed to yeast host strain KM71, then multiple_copy insert transformants were screened out and cultured in flasks, and hVEGF-{165} was expressed under the induction of 1% methanol. Results sDs_PAGE showed that after being induced with 1% methanol for 4d, the expressed product existed in supernatant in the form of soluble molecule and contained 60% of total protein expressed. Western blot showed good antigenicity and specificity of expressed product. After being purified by Heparin_sepharose CL6B affinity chromatography, the purity of expressed product reached above 90%. Biological assays proved that the expressed product could stimulate the proliferation of HUVEC. Conclusion hVEGF-{165} was successfully expressed. The study opened up a wide prospect for the application of VEGF-{165} in the prevention and treatment of ischemic heart disease and other tissue ischemic diseases such as secondary arterial occlusion in limbs.

关键词： Base sequence Blotting Western Chromatography Affinity DNA Primers Electrophoresis Polyacrylamide Gel Endothelial Growth Factors Humans Lymphokines Pichia Plasmids Polymerase Chain Reaction Recombinant Proteins Research support Non-U.s. Gov't Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors

Expression of Human Vascular Endothelial Growth Factor Receptor Flt-1 Extracellular Domain 1-3 Loop cDNA in Pichia pastoris, Purification of the Expressed Product and Detection of Its Biological Activity

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Biomedical and Environmental sciences 2001年第4期14卷 292-301页

作者： mali ZHANGZHI－QING 等 InstituteofMolecularImmunology ThefirstMilitaryMedicalUniversityGuangzhou510515China stateKeyLaboratoryofMolecularVirologyandGeneticEngineering Beijing100052China

Objective To express human vascular endothelial growth factor receptor Flt-1 extracellular domain 1-3 loop cDNA in Pichia. pastroris, and to purify the expressed product and detect its biological activity. Methods By inserting human Flt-1 (1-3 loop) cDNA coding 316 amino acid residues into Pichia pastoris expression vector pPIC9K containing AOX1 promoter and the sequences of α secreting signal peptides, a recombinant expression plasmid pPIC9K/Flt-1 (1-3) was constructed and transformed to yeast host strain Gs115, then His + Mut s phenotype transformant was screened out and cultured in flasks, and Flt-1 (1-3) was expressed under the induction of 1% methanol. Results sDs-PAGE showed that after being induced with 1% methanol for 4d, the expressed product existed in supernatant in the form of soluble molecule and contained 60% of total protein expressed. Western blot showed good antigenicity and specificity of expressed product. After being purified by CM-sepharose FF and sephacryl s-100 chromatography, the purity of the expressed product reached above 90%. Biological assay proved that the expressed product could bind to hVEGF 165 and inhibit the proliferation of HUVEC stimulated by hVEGF 165. Conclusion Human vascular endothelial growth factor receptor Flt-1 extracellular domain 1-3 loop was successfully expressed. The study lays a foundation for further application of the expressed product in the treatment of vasoformation related diseases, such as tumor and diabetic retinopathy.

关键词： Base sequence Blotting Western Cells Cultured Cloning Molecular DNA Primers DNA Complementary Electrophoresis Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Humans Phenotype Pichia Plasmids Polymerase Chain Reaction Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases Recombinant Proteins Research support Non-U.s. Gov't Vascular Endothelial Growth Factor Receptor-1

Entropy Generation and Thermal Radiation Effects on Nanofluid over Permeable stretching sheet

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Journal of Mathematical Research with Applications 2022年第5期42卷 523-538页

作者： s.K.AsHA G.mali Department of Mathematics Karnatak University

In the present paper, effects of entropy generation and nonlinear thermal radiation on Jeffery nanofluid over permeable stretching sheet with partial slip effect were analyzed. The suitable similarity transformation is utilized for the reduction of a set of governing equations,which are solved by using Differential Transformation Method(DTM) with the help of symbolic software MATHEMATICA. The accuracy of impact of slip parameter on coefficient of skin friction by using DTM and numerical method(shooting technique with fourth-order RungeKutta) is illustrated and good agreement is found. Further, velocity, temperature, nanoparticle volume fraction and entropy generation profiles are shown graphically and studied in detail for various physical parameters. We notice that, as slip parameter rises the velocity and entropy generation profile rises. Enhancement in the effect of nonlinear thermal radiation reduces the entropy generation.

关键词： stretching sheet partial slip permeable nonlinear thermal radiation entropy generation Jeffrery nanofluid