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Professor yuan Cheng (Bert) Fung:My Respected Mentor and Cherished Friend

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医用生物力学 2018年第S1期33卷 7-15页

作者：胡流源 Department of Bioengineering Swanson School of EngineeringUniversity of Pittsburgh

On September 14,2008,*** Chien,Peter Chen,Geert Schmid-Schonbein,Pin Tong and I had the great pleasure of organizing a beautiful event in San Diego,California to celebration ***’s 90thbirthday with his students,friends and family[1].The team gave me the honor and privilege to be the banquet speaker.I titled my speech as“***:My Respected Mentor and Cherished Friend”-something for those of you who have known *** well can“resonate”.Still,I would like to take this opportunity to share with you an excerpt of the story I told about this great gentle man.

关键词： Fung:My Respected Mentor and Cherished Friend Professor yuan Cheng

Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine life Science & Technology 2024年第1期6卷 84-92页

作者： yuna Jung Chaesun Kwon Taeyeon Kim Jin woo lee Min-Kyoo Shin Sang Hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea College of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROESy correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,SH-Sy5y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/l of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

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生物医学工程与肌腱、韧带的修复和再生

生命科学 2009年第2期21卷 198-200页

作者： woo savio l-y 美国匹兹堡大学Swanson工程学院生物工程系

肌腱韧带的损伤修复是临床医学实践中的热点和难点,其近几年的进展很大一部分应归功于生物医学工程与临床实践结合。本文主要介绍了当前生物医学工程领域对于韧带肌腱损伤研究的几大热点问题,并介绍了作者在膝关节前交叉韧带损伤的生物... 详细信息

肌腱韧带的损伤修复是临床医学实践中的热点和难点,其近几年的进展很大一部分应归功于生物医学工程与临床实践结合。本文主要介绍了当前生物医学工程领域对于韧带肌腱损伤研究的几大热点问题,并介绍了作者在膝关节前交叉韧带损伤的生物工程修复研究方面所取得的初步成果,后者对于临床实践具有重要意义。

关键词：生物医学工程肌腱韧带损伤前交叉韧带腱病

Hyperammonemia-induced encephalopathy: A rare devastating complication of bariatric surgery

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World Journal of Hepatology 2015年第7期7卷 1007-1011页

作者： Michelle l Kromas Omar y Mousa savio John Department of Anesthesiology SUNY Upstate Medical University Department of Medicine SUNY Upstate Medical University

The clinical manifestations of hyperammonemia are usually easily identifiable to the clinician when associated with liver disease and lead to prompt diagnosis and treatment. However, hyperammonemia-induced encephalopathy is rare in adults in the absence of overt liver disease, thus diagnosis is often delayed or missed leading to potentially life threatening complications. Without proper treatment, such patients can decompensate rapidly with poor outcomes including seizures, coma, and death. Early assessment of plasma ammonia levels in patients with normal hepatic function and characteristic symptoms of encephalopathy can lead to early intervention while investigating the underlying etiology. We describe a patient who presented with a 2-year progression of waxing and waning acute mental status changes after a Roux-en-y gastric bypass surgery. He was found to have elevated ammonia level as well as orotic aciduria; results consistent with a urea cycle disorder. After consulting neurology as well as toxicology, he ultimately improved after dietary protein restriction, sodium benzoate and lactulose therapy. While rare, clinicians should have a high index of suspicion for late onset urea cycle disorders in symptomatic patients presenting with encephalopathy secondary to hyperammonemia.

关键词： Hyperammonemia Urea cycle Bariatricsurgery Encephalopathy Hepatic

ClONING AND ORGANIZATION OF BOVINE METAllOTHIONEIN GENES

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Chinese Science Bulletin 1989年第11期34卷 953-956页

作者：沈孝宙杨卫民彭红 M.G.PETERSON J.F.B.MERCER savio l.C.woo laboratories of Reproductive Biology and Department of Endocrinology Institute of Zoology Academia Sinica Beijing Birth Defects Research Institute Royal Children's Hospital Parkville Australia Department of Cell Biology Baylor College of Medicine Texas Medical Center Houston TX 77030 USA

I. INTRODUCTIONMetallothioneins(MT) are ubiquitously distributed in animal and plant kingdoms. They are cysteine-rich proteins that specifically bind heavy metal ions, such as cadmium, zinc, mercury and copper. The high expression of the MT gene could be induced by heavy metals in vitro and in vivo. The first transgenic mice obtained by Palmiter et al. in 1982 were introduced with an exogenous growth hormnoe gene

关键词： bovine metallothionein gene gene organization genomic cloning.

Nucleotide Sequence and Characterization of Bovine Metallothionein Gene

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Chinese Science Bulletin 1993年第5期38卷 419-423页

作者：杨靖沈孝宙杨卫民 M.G.Peterson J.F.B.Mercer savio l.C.woo Institute of Developmental Biology Academia Sinica Beijing 100080 PRC. laboratory of Reproductive Biology Institute of Zoology Academia Sinica Beijing 100080 PRC Birth Defects Research Institute Poyal Children's Hospital Parkville Australia Department of Cell Biology Baylor College of Medicine Houston TX 77030 USA

1 Introduction Metallothioneins (MTs) are a family of low-molecular weight heavy metal binding proteins, unique in their high cystein content. MTs are ubiquitously distributed in the eukaryote from yeast to human. It is an experimental model emphasized during researching gene expression and regulation of animal cells. In order to provide inducible regulatory elements for transgenosis livestock, we cloned bovine MT genes. At least four members of bovine MT family have been discovered. In this note, one gene (bMTc) of

关键词： bovine metallothionein gene DNA sequence gene structure.

A STUDy ON CHINESE PHENylAlANINE HyDROXylASE GENE RESTRICTION SITE POlyMORPHISM

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Science China Chemistry 1988年第12期31卷 1447-1453页

作者：曾溢滔,黄淑帧,陈美珏,张美兰,任兆瑞,徐永华,彭素芬,savio l. C. woo,胡流清 laboratory of Medical Genetics Shanghai Children's Hospital laboratory of Medical Genetics Shanghai Children's Hospital laboratory of Medical Genetics Shanghai Children's Hospital laboratory of Medical Genetics Shanghai Children's Hospital laboratory of Medical Genetics Shanghai Children's Hospital Shanghai Institute of Cell Biology Academia Sinica Shanghai Institute of Cell Biology Academia Sinica Department of Cell Biology Baylor College of Medicine Houston Texas 77030 U.S.A. Department of Cell Biology Baylor College of Medicine Houston Texas 77030 U.S.A.

Human phenylalanine hydroxylase (PAH) cDNA was applied as a hybridization probe to analyzing the following 8 restriction fragment length polymorphisms (RFlP) in the PAH genes of 80 normal and 28 phenylketonuric Chinese patients: BgⅢ, 3.6kb/1.7kb; EcoRI, 17kb/11kb; EcoRV, 30kb/25kb; HindⅢ, 4.2kb/4.0kb; MspIa, 23kb/19kb; MspIb, 4.0kb/2.2kb; PvuIIa, 19kb/6.0kb and PvuIIb, 11.5kb/9.1kb. The frequencies of the above RFlP in normal Chinese and PKU patients are: 0.13, 0.83, 0.77, 0.81, 0.12, 0.04, 0.70, 0.10 and 0.12, 0.93, 0.89, 0.81, 0.04, 0, 0.69, 0.04, respectively. This study reveals significant differences between the frequencies of individual RFlPs when these values are compared with those of the Caucasians. Finally, the detection of RFlPs in the PAH gene in the Chinese population will permit prenatal diagnosis of PKU in China.

关键词： phenylketonuria Chinese PAH gene polymorphism.

缺氧培养骨髓内皮祖细胞移植对缺血性心脏病的治疗作用

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天津医药 2013年第2期41卷 145-147页

作者：简锴陶王联群王强郑宝荣 Joseph y.woo 刘建实天津市胸科医院 300051 宾夕法尼亚大学附属医院

目的探讨缺氧培养的骨髓内皮祖细胞心肌内移植治疗缺血性心脏病的效果。方法从8周龄同种系成年雄性Wistar大鼠长骨中获取骨髓内皮祖细胞,常规培养4d后,1%O2+5%CO2+94%N2培养3d。将26只8周龄同种系成年雄性Wistar大鼠随机分为对照组(n=8... 详细信息

目的探讨缺氧培养的骨髓内皮祖细胞心肌内移植治疗缺血性心脏病的效果。方法从8周龄同种系成年雄性Wistar大鼠长骨中获取骨髓内皮祖细胞,常规培养4d后,1%O2+5%CO2+94%N2培养3d。将26只8周龄同种系成年雄性Wistar大鼠随机分为对照组(n=8)、常规组(n=9)和缺氧组(n=9),建立急性心肌梗死动物模型。在心肌梗死边缘5个不同区域心肌内分别注射PBS溶液200μl,内皮祖细胞2×106个,缺氧培养内皮祖细胞2×106个,4周后应用压力-容量曲线分析评估实验动物血流动力学和心脏功能变化。结果缺氧培养骨髓内皮祖细胞心肌内移植4周后,缺氧组与对照组相比较,舒张末容积、收缩末容积、心搏量、射血分数以及每分心输出量改善明显,差异均有统计学意义;缺氧组与常规组相比,收缩末容积减小,心搏量、射血分数及每分心输出量提高,差异均有统计学意义;常规组与对照组比较,心搏量、射血分数和每分心输出量无明显改善,差异无统计学意义。结论缺氧培养大鼠骨髓内皮祖细胞较常规培养细胞对缺血性心脏病的治疗效果更加明显,限制了心室重构,改善了梗死后整体的心脏功能。

关键词：干细胞内皮细胞骨髓细胞干细胞移植心肌梗死心脏功能试验大鼠,Wistar

Spontaneous ethanol-water emulsification as a precursor for porous particle formation: Understanding the role of dissolved carbohydrates

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Particuology 2019年第3期17卷 44-53页

作者： P.l. Xiao s. Mansouri V. Suriya Hena y.K. Bong K. Hapgood M.W. woo Department of Chemical Engineering Faculty of Engineering Monash University Clayton Campus Australia Powder Metallurgy Research Institute Central South University China Faculty of Science Engineering &Bu ε Environment School of Engineering Deakin University Geelong Waum Ponds Campus Australia

Quiescent mixing of aqueous lactose solution with ethanol by gentle pouring allowed controlled observation of a transient, spontaneous emulsification process between ethanol and water. This phenomenon contrasts with the conventional stable phase-separation process for ethanol-water systems with other solutes. The presence of lactose in the dissolved state was deduced to be the key factor causing spontaneous emulsification. This explains the transitional behavior of the phenomenon. Further experiments with aqueous maltodextrin solution, using the same experimental technique, confirmed this phenomenon. The mechanisms determined in this work will form the basis of porous-particle synthesis via the antisolvent vapor-precipitation technique.

关键词： Spontaneous emulsification Ethanol lactose Precipitation Crystals Droplets