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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 209-213页

作者： Ashok kumar Pannu Atul Saroch saurabh Chandrabhan Sharda Manoj kumar Debnath Manisha Biswal Navneet Sharma Department of Internal Medicine Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Medical Microbiology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Objective:To study the spectrum and outcome of severe scrub typhus in adult patients and to predict the hospital mortality by organ failure on ***:This was a prospective observational cohort study conducted between July 2017 and October 2020 at the medical emergency centre of PGIMER,Chandigarh,*** hundred and twenty-six patients aged≥13 years were diagnosed with scrub *** disease was defined as the presence of organ failure based on the Sequential Organ Failure Assessment(SOFA)score on ***:About two-thirds of the patients were from geographic regions outside the endemic sub-Himalayan ***(99.21%)and dyspnea(79.36%)were the most frequent *** failure(81.75%)was the most common organ failure,followed by hepatic(52.38%),coagulative(47.62%),circulatory(33.33%),renal(21.43%),and cerebral dysfunction(13.49%).The median(Q1,Q3)SOFA score was 8(6,9),and 48.41%of the patients had a quick-SOFA score≥*** supports with invasive ventilation(40.48%),vasopressors(36.51%),and renal replacement therapy(7.14%)were frequently *** in-hospital mortality was 11.90% and was independently predicted by circulatory and hepatic failures on multivariate logistic regression(OR 11.12,95%CI 1.73-71.31 and OR 8.49,95%CI 1.18-61.41,respectively).Conclusions:Most patients had pulmonary dysfunction;circulatory or hepatic failure on admission strongly predicts death.

关键词： Scrub typhus Orientia tsutsugamushi Organ failure Mortality Prognosis

Palaeobotanical and biomarker evidence for Early Permian(Artinskian) wildfire in the Rajmahal Basin, India

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Journal of Palaeogeography 2021年第1期10卷 55-75页

作者： Srikanta Murthy Vinod Atmaram Mendhe Dieter Uhl Runcie Paul Mathews Vivek kumar Mishra saurabh Gautam Birbal Sahni Institute of Palaeosciences 53University RoadLucknow 226007India CSIR-Central Institute of Mining and Fuel Research Dhanbad 826015JharkhandIndia Senckenberg Forschungsinstitut und Naturmuseum Frankfurt Senckenberganlage 2560325 Frankfurt am MainGermany

This study provides a combined analysis on the palynology, fossil charcoal and biomarkers of the subsurface coal deposits from a borehole RMB #2 drilled at the Dhulia Coal Block, Rajmahal Basin, India, in attempts to establish the chronology of sedimentation and to propose palaeobotanical as well as geochemical evidence for the occurrence of wildfires in these sediments. The palynological investigation suggests a Scheuringipollenites barakarensis palynoassemblage from the lower Barakar Formation, dated as Artinskian(Early Permian) in age. This assemblage reveals the dominance of Glossopteridales and sub-dominance of taxa belonging to Cordaitales and *** charcoal in sediments is usually recognized as a direct indicator for the occurrence of palaeo-wildfires. More data involving the anatomical features of fossil charcoal analyzed by Field Emission Scanning Electronic Microscope broaden our knowledge on Early Permian wildfires from the peninsula of India. The studied macroscopic charcoal fragments exhibit anatomical details such as homogenized cell walls, uniseriate simple and biseriate alternate pitting on tracheid walls and rays of varying heights pointing to a gymnospermous wood affinitity. The excellent preservation of charcoal fragments, shown by their large sizes and almost unabraded edges, suggests a parautochthonous origin. The embedded biomarker study performed for charcoal sediments and its characterization demonstrate the presence of n-alkanes, isoprenoids, terpenoids and aromatic compounds. A bimodal distribution pattern of n-alkanes with a Cmaxat n-C25 is identified. Diterpenoids and pentacyclic terpenoids are identified, indicating the input of an early conifer vegetation and bacterial activity, respectively. The identified polyaromatic hydrocarbon(PAH) compounds, together with the charcoal fragments, clearly suggest that repeated wildfire events occurred during the deposition of these Artinskian sediments in the Rajmahal Basin.

关键词： Palaeo-wildfire Palynology Fossil charcoal Biomarker Barakar Formation Rajmahal Basin

Silibinin and colorectal cancer chemoprevention:a comprehensive review on mechanisms and efficacy

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The Journal of Biomedical Research 2016年第6期30卷 452-465页

作者： Komal Raina Sushil kumar Deepanshi Dhar Rajesh agarwal Department of Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Cancer Center University of Colorado Anschutz Medical Campus

Globally,the risk of colorectal cancer（CRC） as well as the incidence of mortality associated with CRC is ***,it is imperative that we look at alternative approaches involving intake of non-toxic natural dietary/non-dietary agents,for the prevention of *** ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC,and use these natural agents as a safe intervention strategy during the clinical course of this deadly *** the years,pre-clinical studies have shown that silibinin（a flavonolignan isolated from the seeds of milk thistle,Silybum marianum） has strong preventive and therapeutic efficacy against various epithelial cancers,including *** focus of the present review is to provide a comprehensive tabular summary,categorically for an easy accessibility and referencing,pertaining to the efficacy and associated mechanisms of silibinin against CRC growth and progression.

关键词： colorectal cancer silibinin cancer chemoprevention milk thistle

Randomized controlled trial of topical EMLA and vapocoolant spray for reducing pain during wDPT vaccination

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World Journal of Pediatrics 2017年第3期13卷 236-241页

作者： Navratan kumar Gupta Amit Upadhyay Ajeet kumar Dwivedi Astha agarwal Vijay Jaiswal Abhishek Singh Department of Pediatrics LLRMMedical CollegeMeerut(UP)India

Background:Intramuscular vaccination is among the most common source of iatrogenic pain in *** sprays are rapid-acting alternative to topical *** provide transient anesthesia via evaporation induced skin cooling,and reduce pain due to vaccine injection in children and *** objective was to compare the synergistic analgesic effect of eutectic mixture of local anesthetics (EMLA) with breastfeeding (EB group) and vapocoolant spay with breastfeeding (VB group) to that of only breastfeeding (BO group) during whole cell diptheria,pertussis and tetanus (wDPT) ***:A double blind randomized controlled trial was done to include infants up to 3 months of age who came for their first wDPT *** primary outcome variable was the duration of cry after *** outcome variables were Modified Facial Coding Score,Neonatal Infant Pain Scale and latency of onset of ***:Of the 201 eligible participants,111 babies were excluded and remaining 90 babies were randomized into three groups of thirty *** groups did not differ significantly in baseline *** (interquartile range,IQR) of duration of cry was lesser [35.86 (21.07-107.75) seconds] in babies receiving EMLA cream with breast feeding (EB group) and in babies receiving vapocoolant spray with breast feeding (VB group) [32.58 (21.25-106.21) seconds] as compared to babies receiving only breast feeding (BO group) [67.5 (27.6-180) seconds] (P=-0.147).Difference in median (IQR) of latency of cry was not statistically *** Facial Coding Score and Neonatal Infant Pain Scale at 1 minute and 3 minutes was significantly lower in the EB and VB group,as compared to the BO group (P<0.05).Conclusions:Addition of topical EMLA application or vapocoolant spray to breastfeeding during wDPT vaccination does not reduce duration of cry in infants up to 3 months of ***,they are able to show reduction in pain score and further studi

关键词： diptheria,pertussis and tetanus vaccine eutectic mixture of local anesthetics Modified Facial Coding Score Neonatal Infant Pain Scale

Comparison of surgically induced astigmatism in various incisions in manual small incision cataract surgery

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 1001-1004页

作者： Nidhi Jauhari Deepak Chopra Rajan kumar Chaurasia Ashutosh agarwal Department of Ophthalmology Vivekananda Polyclinic and Institute of Medical SciencesVivekanandpuriLucknowUttar Pradesh 226001India Department of Community Medicine Integral University of Medical Sciences and ResearchKursi RoadLucknowUttar Pradesh 226026India

AIMTo determine the surgically induced astigmatism (SIA) in Straight, Frown and Inverted V shape (Chevron) incisions in manual small incision cataract surgery (SICS).

关键词： manual small incision cataract surgery incisions surgically induced astigmatism

A multiwavelength view of a classical T Tauri star CV Cha

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Research in Astronomy and Astrophysics 2019年第1期19卷 75-86页

作者： Jeewan Chandra Pandey Subhajeet Karmakar Arti Joshi saurabh Sharma Shashi Bhushan Pandey Anil kumar Pandey Aryabhatta Research Institute of Observational Sciences (ARIES)

Using long-term optical, ultraviolet(UV) and X-ray data, we present a study of a classical T Tauri star CV Cha. The V-band light curve obtained from the All Sky Automated Survey(ASAS) shows short as well as long-term variability. The short-term variability could be due to rotational modulation of CV Cha. We derive the rotational period of 3.714 ± 0.001 d for CV Cha. UV light curves obtained from Swift also show the variations. X-ray light curves from XMM-Newton and Swift do not show any significant short as well as long-term variability. However, the light curve from Chandra appears to be variable, which could be due to the emergence of flaring activities. X-ray spectra from all observations are explained well by the single temperature plasma of 0.95 keV with X-ray luminosity of 1030.4erg s-1in the 0.5–7.5 keV energy band. It appears that variability in optical and UV bands could be due to the presence of both hot and cool spots on the surface, while X-ray emission is dominated by magnetic processes.

关键词： stars:activity stars:individual(CV Cha) stars:pre-main sequence stars:variable:T Tauri X-ray:stars

Nanofat: A therapeutic paradigm in regenerative medicine

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World Journal of Stem Cells 2021年第11期13卷 1733-1746页

作者： Madhan Jeyaraman Sathish Muthu Shilpa Sharma Charan Ganta Rajni Ranjan saurabh kumar Jha Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater Noida 201306Uttar PradeshIndia Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater Noida 201306Uttar PradeshIndia Indian Stem Cell Study Group Lucknow 226010Uttar PradeshIndia Department of Orthopaedics Government Medical College and HospitalDindigul 624001Tamil NaduIndia Department of Pediatric Surgery All India Institute of Medical SciencesNew Delhi 110029New DelhiIndia Department of Stem Cells and Regenerative Medicine Kansas State UniversityManhattanUnited States 10002United States

Adipose tissue is a compact and well-organized tissue containing a heterogeneous cellular population of progenitor cells,including mesenchymal stromal *** to its availability and accessibility,adipose tissue is considered a“stem cell depot.”Adipose tissue products possess anti-inflammatory,anti-fibrotic,antiapoptotic,and immunomodulatory ***,being a compact bundle of stem cells with regenerative and tissue remodeling potential,has potential in translational and regenerative *** the wide range of applicability of its reconstructive and regenerative potential,the applications of nanofat can be used in various *** behaves on the line of adipose tissuederived mesenchymal stromal *** the site of injury,these stromal cells initiate a site-specific reparative response comprised of remodeling of the extracellular matrix,enhanced and sustained angiogenesis,and immune system *** properties of stromal cells provide a platform for the usage of regenerative medicine principles in curbing various *** about nanofat,including various preparation methods,characterization,delivery methods,evidence on practical applications,and ethical concerns are included in this ***,appropriate guidelines and preparation protocols for its optimal use in a wide range of clinical applications have yet to be standardized.

关键词： Adipose tissue Nanofat Stem cells Regenerative medicine Adipose stem cells

A Reliable and Accurate Calculation of Excitation Capacitance Value for an Induction Generator Based on Interval Computation Technique

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International Journal of Automation and computing 2011年第4期8卷 429-436页

作者： Rajesh kumar Thakur Vivek agarwal Paluri S. V. Nataraj Systems and Control Engineering Interdisciplinary Programme (IDP)Mumbai 400076 India Department of Electrical Engineering IIT-Bombay Powai Mumbai 400076 India

A squirrel cage induction generator （SCIG） offers many advantages for wind energy conversion systems but suffers from poor voltage regulation under varying operating conditions. The value of excitation capacitance （C exct ） is very crucial for the selfexcitation and voltage build-up as well as voltage regulation in SCIG. Precise calculation of the value of C exct is, therefore, of considerable practical importance. Most of the existing calculation methods make use of the steady-state model of the SCIG in conjunction with some numerical iterative method to determine the minimum value of C exct . But this results in over estimation, leading to poor transient dynamics. This paper presents a novel method, which can precisely calculate the value of C exct by taking into account the behavior of the magnetizing inductance during saturation. Interval analysis has been used to solve the equations. In the proposed method, a range of magnetizing inductance values in the saturation region are included in the calculation of C exct , required for the self-excitation of a 3-φ induction generator. Mathematical analysis to derive the basic equation and application of interval method is presented. The method also yields the magnetizing inductance value in the saturation region which corresponds to an optimum C exct（min） value. The proposed method is experimentally tested for a 1.1 kW induction generator and has shown improved results.

关键词： d-q model hull consistency induction generator interval analysis interval arithmetic optimization range of interval realpaver self-excitation transients.

Functional Role of miRNAs: Key Players in Soybean Improvement

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Phyton-International Journal of Experimental Botany 2021年第5期90卷 1339-1362页

作者： Kapil Gupta Sujit kumar Mishra Shubhra Gupta saurabh Pandey Jogeswar Panigrahi Shabir Hussain Wani CSIR-Central Institute of Medicinal and Aromatic Plants Lucknow226015India Department of Zoology School of Applied SciencesCenturion University of Technology and ManagementBhubaneswar751009India Department of Biotechnology Central University of RajasthanAjmer305817India Plant Molecular Biology International Center for Genetic Engineering&BiotechnologyNew Delhi110067India Department of Biosciences and Bioinformatics Khallikote UniversityBerhampur761008India Mountain Research Center for Field Crops KhudwaniSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirAnantnag192101India

Soybean(Glycine max(L.)Merr)is an agro-economic crop growing across the world to cater nutrition for both human and animal feed due to the high oil and protein content in its edible *** genes and QTLs associated with important agronomic traits in this crop have already been identified and validated for soybean cyst nematode(SCN),Phytophthora root and stem rot,Pythium root rot and aphid resistance,seed quality,nutrient values,and also employed for genetic improvement in *** the last decade,micro RNAs(miRNAs)have been considered the effector molecules,so the detection and characterization of novel miRNAs in soybean have been taken up by several *** advancement in the strategy of sequencing and tools of bioinformatics during last decade has contributed to the discovery of many soybean miRNAs,thus miRNA can be used as a tool in molecular breeding studies,and this has opened new vistas for miRNA mediated genetic improvement of soybean to augment crop productivity as well as nutritional *** review addresses the current state of understanding of miRNAmediated stress responses,nutrient acquisition,plant development and crop production processes in soybean.

关键词： Soybean miRNA quality improvement plant development genetic engineering molecular breeding

Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 866-869页

作者： Shashi Kant Singh saurabh K Sinha SK Prasad R kumar Bhawani S Bithu S Sadish kumar P Singh Varanasi College of Pharmacy Uttar PradeshVaranasiIndia Department of Pharmaceutics Institute of TechnologyBanaras Hindu UniversityVaranasiUttar PradeshIndia Institute of Technology and Sciences Paramedical College(Pharmacy)MuradnagarUttar PradeshIndia Uday Pratap College VaranasiUttar PradeshIndia

Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera *** was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin *** synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/*** and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral ***:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 ***:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.

关键词： Mangifera indica Mangiferin Antipyretic