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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 209-213页

作者： Ashok Kumar Pannu Atul Saroch saurabh chandrabhan sharda Manoj Kumar Debnath Manisha Biswal Navneet Sharma Department of Internal Medicine Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Medical Microbiology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Objective:To study the spectrum and outcome of severe scrub typhus in adult patients and to predict the hospital mortality by organ failure on ***:This was a prospective observational cohort study conducted between July 2017 and October 2020 at the medical emergency centre of PGIMER,Chandigarh,*** hundred and twenty-six patients aged≥13 years were diagnosed with scrub *** disease was defined as the presence of organ failure based on the Sequential Organ Failure Assessment(SOFA)score on ***:About two-thirds of the patients were from geographic regions outside the endemic sub-Himalayan ***(99.21%)and dyspnea(79.36%)were the most frequent *** failure(81.75%)was the most common organ failure,followed by hepatic(52.38%),coagulative(47.62%),circulatory(33.33%),renal(21.43%),and cerebral dysfunction(13.49%).The median(Q1,Q3)SOFA score was 8(6,9),and 48.41%of the patients had a quick-SOFA score≥*** supports with invasive ventilation(40.48%),vasopressors(36.51%),and renal replacement therapy(7.14%)were frequently *** in-hospital mortality was 11.90% and was independently predicted by circulatory and hepatic failures on multivariate logistic regression(OR 11.12,95%CI 1.73-71.31 and OR 8.49,95%CI 1.18-61.41,respectively).Conclusions:Most patients had pulmonary dysfunction;circulatory or hepatic failure on admission strongly predicts death.

关键词： Scrub typhus Orientia tsutsugamushi Organ failure Mortality Prognosis

Translational products of adipose tissue-derived mesenchymal stem cells:Bench to bedside applications

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World Journal of Stem Cells 2021年第10期13卷 1360-1381页

作者： Shilpa Sharma Sathish Muthu Madhan Jeyaraman Rajni Ranjan saurabh Kumar Jha Department of Pediatric Surgery All India Institute of Medical SciencesNew Delhi 110029India Indian Stem Cell Study Group LucknowUttar Pradesh 226010India Department of Orthopaedics Government Medical College and HospitalDindigulTamil Nadu 624304India Research Scholar Department of BiotechnologySchool of Engineering and TechnologyGreater NoidaSharda UniversityUttar Pradesh 201306India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201306India

With developments in the field of tissue engineering and regenerative medicine,the use of biological products for the treatment of various disorders has come into the limelight among researchers and *** all the available biological tissues,research and exploration of adipose tissue have become more *** tissue engineering aims to develop by-products and their substitutes for their regenerative and immunomodulatory *** use of biodegradable scaffolds along with adipose tissue products has a major role in cellular growth,proliferation,and *** tissue,apart from being the powerhouse of energy storage,also functions as the largest endocrine organ,with the release of various *** progenitor cells among the heterogeneous population in the adipose tissue are of paramount importance as they determine the capacity of regeneration of these *** results of adipose-derived stemcell assisted fat grafting to provide numerous growth factors and adipokines that improve vasculogenesis,fat graft integration,and survival within the recipient tissue and promote the regeneration of tissue are *** tissue gives rise to various by-products upon *** article highlights the significance and the usage of various adipose tissue by-products,their individual characteristics,and their clinical applications.

关键词： Adipose tissue Stem cells Fat graft Clinical applications Mesenchymal stem cells

Nanofat: A therapeutic paradigm in regenerative medicine

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World Journal of Stem Cells 2021年第11期13卷 1733-1746页

作者： Madhan Jeyaraman Sathish Muthu Shilpa Sharma Charan Ganta Rajni Ranjan saurabh Kumar Jha Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater Noida 201306Uttar PradeshIndia Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater Noida 201306Uttar PradeshIndia Indian Stem Cell Study Group Lucknow 226010Uttar PradeshIndia Department of Orthopaedics Government Medical College and HospitalDindigul 624001Tamil NaduIndia Department of Pediatric Surgery All India Institute of Medical SciencesNew Delhi 110029New DelhiIndia Department of Stem Cells and Regenerative Medicine Kansas State UniversityManhattanUnited States 10002United States

Adipose tissue is a compact and well-organized tissue containing a heterogeneous cellular population of progenitor cells,including mesenchymal stromal *** to its availability and accessibility,adipose tissue is considered a“stem cell depot.”Adipose tissue products possess anti-inflammatory,anti-fibrotic,antiapoptotic,and immunomodulatory ***,being a compact bundle of stem cells with regenerative and tissue remodeling potential,has potential in translational and regenerative *** the wide range of applicability of its reconstructive and regenerative potential,the applications of nanofat can be used in various *** behaves on the line of adipose tissuederived mesenchymal stromal *** the site of injury,these stromal cells initiate a site-specific reparative response comprised of remodeling of the extracellular matrix,enhanced and sustained angiogenesis,and immune system *** properties of stromal cells provide a platform for the usage of regenerative medicine principles in curbing various *** about nanofat,including various preparation methods,characterization,delivery methods,evidence on practical applications,and ethical concerns are included in this ***,appropriate guidelines and preparation protocols for its optimal use in a wide range of clinical applications have yet to be standardized.

关键词： Adipose tissue Nanofat Stem cells Regenerative medicine Adipose stem cells

Molecular basis of fluoride toxicities:Beyond benefits and implications in human disorders

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Genes & Diseases 2023年第4期10卷 1470-1493页

作者： Priyankar Pal Niraj Kumar Jha Debankur Pal saurabh Kumar Jha Uttpal Anand Abilash Valsala Gopalakrishnan Abhijit Dey Prabir Kumar Mukhopadhyay Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Department of Biotechnology School of Engineering and Technology(SET)Sharda UniversityGreater NoidaUttar Pradesh 201310India Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradun 248007India Department of Biotechnology Engineering and Food Technology Chandigarh UniversityMohali 140413India Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Biomedical Sciences School of Bio Sciences and TechnologyVellore Institute of Technology(VIT)VelloreTamil Nadu 632014India

Detrimental impacts of fluoride have become a global concern for several *** its beneficial role which is restricted only in skeletal tissues,deleterious effects are also observed in soft tissues and *** generation of enhanced oxidative stress is the commencement of excess fluoride exposure which may lead to cell *** causes cell death through autophagy via Beclin 1 and mTOR signaling *** these,several or-gan specific anomalies through different signaling pathways have been ***-drial dysfunction,DNA damage,autophagy and apoptosis are the damaging outcomes in case of hepatic *** concentration defects and cell cycle arrest have been reported in renal *** immune response has been characterized in the cardiac ***-tive dysfunction,neurodegenerative condition and learning impairment have also been *** steroidogenesis,gametogenic abnormalities,epigenetic alterations and birth defect are the major reprotoxic *** immune responses,altered immu-nogenic proliferation,differentiation as well as altered ratio of immune cells are well-defined anomalies in the immune *** the mechanistic approach of fluoride toxicity in phys-iological systems is common,it follows different signaling *** review emphasizes diverse signaling pathways which are the targets of overexposed fluoride.

关键词： Fluoride Autophagy Mitochondrial dysfunction Signaling cascades System disorders

Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman Naveen Jeyaraman Tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan saurabh Kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

Newer perspectives of coronary artery disease in young

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World Journal of Cardiology 2016年第12期8卷 728-734页

作者： Amitesh Aggarwal saurabh Srivastava M Velmurugan Department of Medicine University College of Medical Sciences and GTB Hospital Department of Medicine School of Medical Sciences and ResearchSharda University

Coronary artery disease(CAD) occurring in less than 45 years of age is termed as young *** studies show a prevalence of 1.2% of CAD cases in this age *** wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%.Conventional risk factors such as smoking,diabetes,hypertension,obesity and family history seems to be as important as in older CAD *** the prevalence of these risk factors seems to vary in younger *** far the most commonly associated risk factor is smoking in young *** genes associated with lipoprotein metabolism are now found to be associated with young CAD like cholesterol ester transfer protein(CETP) gene,hepatic lipase gene,lipoprotein lipase gene,apo A1 gene,apo E gene and apo *** such as lipoprotein(a),fibrinogen,D-dimer,serum Wnt,gamma glutamyl transferase,vitamin D2 and osteocalcin are seems to be associated with premature CAD in some newer *** general CAD in young has better prognosis than older *** terms of prognosis two risk factors obesity and current smoking are associated with poorer *** studies shows predominance of single vessel disease in young CAD *** CAD in older person primary and secondary prevention plays an important role in prevention of new and further coronary events.

关键词： Young Coronary artery disease Risk factors Epidemiological trends Prognosis

Remission is not maintained over 2 years with hematopoietic stem cell transplantation for rheumatoid arthritis:A systematic review with meta-analysis

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World Journal of Biological Chemistry 2021年第6期12卷 114-130页

作者： Sathish Muthu Madhan Jeyaraman Rajni Ranjan saurabh Kumar Jha Department of Biotechnology School of Engineering and TechnologySharda UniversityDelhi 201306Uttar PradeshIndia Department of Orthopaedics Government Medical College and HospitalDindigul 624001Tamil NaduIndia Department of Orthopaedics Faculty of MedicineSri Lalithambigai Medical College and HospitalChennai 600095Tamil NaduIndia Department of Orthopaedics School of Medical Sciences and ResearchGreater Noida 201306Uttar PradeshIndia

BACKGROUND Hematopoietic stem cell(HSC)transplantation(HSCT)is being accepted as a standard of care in various inflammatory *** treatment of rheumatoid arthritis(RA)has been closely evolving with the understanding of disease *** the rising resistance to the traditional disease-modifying antirheumatic drugs and targeted biological therapy,researchers are in pursuit of other methods for disease *** the ultimate goal of the ideal treatment of RA is to restore immune tolerance,HSCT attracts much attention considering its reparative,paracrine,and anti-inflammatory ***,a systematic review of studies on HSCT in RA is *** To investigate the role of HSCT in the management of *** A detailed search of PubMed,Scopus,EMBASE,Cochrane,and the Web of Science databases was made to identify the relevant articles till September 2020 following Cochrane and PRISMA *** extracted data including the number of patients,source of hematopoietic stem cells,their mobilization and conditioning regimens,results,and complications from the eligible *** were dichotomized into success(ACR 50/70)and failure(ACR 20)based on the improvement from baseline *** methodological quality of the included studies was also *** was performed using OpenMeta[Analysis]*** We included 17 studies(1 randomized controlled trial,11 prospective,and 5 retrospective studies)with 233 patients for *** provided a significantly beneficial overall improvement in the clinical grades of ACR criteria(Z=11.309,P<0.001).However,the remission was noted only till 24 mo and later on the significance of the result was lost(Z=1.737,P=0.082).A less than 1%treatmentrelated mortality was noted from the included *** major drug-related toxicities were noted in any of the included *** patients who underwent allogeneic HSCT received immunosuppression in the conditioning regimen to counteract the

关键词： Hematopoietic stem cell Rheumatoid arthritis Disease-modifying antirheumatic drug Biological therapy Systematic review Meta-analysis

Analyzing the Prebiotic Potential of Glucosamine for Targeting the Gut Microbiome Health

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Food and Nutrition Sciences 2023年第2期14卷 119-134页

作者： Pranav Pancham Divya Jindal Archita Gupta Deepshikha Yadav Shriya Agarwal saurabh Jha Manisha Singh Department of Biotechnology Jaypee Institute of Information Technology (JIIT) Noida India Neuroimmunology Laboratory School of Medicine Western Sydney University Campbelltown Australia Birla Institute of Technology Mesra India Indian Institute of Technology-Kanpur Kanpur India Bhartiya Nirdeshak Dravya Division CSIR-National Physical Laboratory New Delhi India Physico-Mechanical Metrology Division CSIR-National Physical Laboratory New Delhi India Academy of Scientific and Innovation Research (AcSIR) Ghaziabad India School of Natural Sciences Macquarie University Sydney Australia Department of Biotechnology School of Engineering and Technology Sharda University Greater Noida India

Recognizing the composition and modulation of the microbiome, a viable therapeutic tool for multi-targeted therapy is a new strategy that has recently been explored. Glucosamine (GS) is being studied for its prebiotic potential in addition to being the most abundant and naturally occurring amino monosaccharide. The current study focuses on glucosamine’s prebiotic potential by assessing the stability of various GS concentrations (1% - 5%) in the gastrointestinal tract (GIT) and its ability to be fermented by the gut microbiota. The results showed that GS stimulated the most growth in L. acidophilus even after a longer incubation time than B. bifidum and L. acidophilus growth was concentration-dependent, with maximum growth at 3% with a simultaneous decrease in pH (5.6 - 1.7). The decrease in GS concentration with time also represented the growth of bacterial species, demonstrating the species’ utilization of GS. Furthermore, at 3%, GS also represented the prebiotic index of 1.9. In addition, the concentration of GS in various simulated GIT fluids was estimated in both fast and fed conditions to examine GS stability at various levels in the gut. The results showed that GS remained unaffected and non-digestible in all of the simulated GIT fluids (salivary, gastric, intestinal, and colonic), but there was a slight decrease in GS concentration (2.8%) in the fasted state of gastric fluid due to low pH levels (1.6). As a result, the findings are conclusive and suggest that GS possesses prebiotic properties.

关键词： Microbiome Enteric Nervous System (ENS) Prebiotic Index Hexosamine Biosynthetic Pathway (HBP) Vagal Afferents Phosphotransferase System

Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva saurabh Kumar Jha Shreesh Ojha Dinesh Kumar Niraj Kumar Jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine