Newer perspectives of coronary artery disease in young

作     者：Amitesh Aggarwal Saurabh Srivastava M Velmurugan 

作者机构：Department of MedicineUniversity College of Medical Sciences and GTB Hospital Department of MedicineSchool of Medical Sciences and ResearchSharda University 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2016年第8卷第12期

页      面：728-734页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Young Coronary artery disease Risk factors Epidemiological trends Prognosis 

摘      要：Coronary artery disease(CAD) occurring in less than 45 years of age is termed as young *** studies show a prevalence of 1.2% of CAD cases in this age *** wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%.Conventional risk factors such as smoking,diabetes,hypertension,obesity and family history seems to be as important as in older CAD *** the prevalence of these risk factors seems to vary in younger *** far the most commonly associated risk factor is smoking in young *** genes associated with lipoprotein metabolism are now found to be associated with young CAD like cholesterol ester transfer protein(CETP) gene,hepatic lipase gene,lipoprotein lipase gene,apo A1 gene,apo E gene and apo *** such as lipoprotein(a),fibrinogen,D-dimer,serum Wnt,gamma glutamyl transferase,vitamin D2 and osteocalcin are seems to be associated with premature CAD in some newer *** general CAD in young has better prognosis than older *** terms of prognosis two risk factors obesity and current smoking are associated with poorer *** studies shows predominance of single vessel disease in young CAD *** CAD in older person primary and secondary prevention plays an important role in prevention of new and further coronary events.