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Influence of automated driving on driver’s own localization:a driving simulator study

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Journal of Intelligent and Connected Vehicles

Journal of Intelligent and Connected Vehicles 2018年第3期1卷 99-106页

作者： Ryuichi Umeno Makoto Itoh satoshi Kitazaki University of Tsukuba IbarakiJapan National Institute of Advanced Industrial science and Technology Tsukuba CenterTsukuba CentralIbarakiJapan

Purpose–Level 3 automated driving,which has been defined by the society of Automotive Engineers,may cause driver drowsiness or lack of situation awareness,which can make it difficult for the driver to recognize where he/she is.Therefore,the purpose of this study was to conduct an experimental study with a driving simulator to investigate whether automated driving affects the driver’s own localization compared to manual driving.Design/methodology/approach–seventeen drivers were divided into the automated operation group and manual operation group.Drivers in each group were instructed to travel along the expressway and proceed to the specified destinations.The automated operation group was forced to select a course after receiving a Request to Intervene(RtI)from an automated driving system.Findings–A driver who used the automated operation system tended to not take over the driving operation correctly when a lane change is immediately required after the RtI.Originality/value–This is a fundamental research that examined how the automated driving operation affects the driver's own localization.The experimental results suggest that it is not enough to simply issue an RtI,and it is necessary to tell the driver what kind of circumstances he/she is in and what they should do next through the HMI.This conclusion can be taken into consideration for engineers who design automatic driving vehicles.

关键词： Automated vehicles Autonomous driving Advanced driver assistant systems Driver behaviors and assistance Human-machine interfaces Request to intervene

Using Machine Reading to Understand Alzheimer's and Related Diseases from the Literature

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Journal of Data and Information science 2017年第4期2卷 81-94页

作者： satoshi Tsutsui Yi Bu Ying Ding school of Informatics Computingand EngineeringIndiana UniversityBloomingtonIN 47408USA school of Information Management Wuhan UniversityWuhan 430072China

Purpose： This paper aims to better understand a large number of papers in the medical domain of Alzheimer＇s disease （AD） and related diseases using the machine reading approach. Design/methodology/approach： The study uses the topic modeling method to obtain an overview of the field, and employs open information extraction to further comprehend the field at a specific fact level. Findings： several topics within the AD research field are identified, such as the Human Immunodeficiency Virus （HIV）/Acquired Immune Deficiency syndrome （AIDs）, which can help answer the question of how A1Ds/HIV and AD are very different yet related diseases. Research limitations： some manual data cleaning could improve the study, such as removing incorrect facts found by open information extraction. Practical implications： This study uses the literature to answer specific questions on a scientific domain, which can help domain experts find interesting and meaningful relations among entities in a similar manner, such as to discover relations between AD and AIDs/HIV. Origlnality/value： Both the overview and specific information from the literature are obtained using two distinct methods in a complementary manner. This combination is novel because previous work has only focused on one of them, and thus provides a better way to understand an important scientific field using data-driven methods.

关键词： Machine reading Alzheimer＇s disease Knowledge discovery Data mining

Japan's experience of energy saving and business model for low-carbon economy

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Chinese Journal of Population,Resources and Environment 2013年第4期11卷 288-298页

作者： satoshi Watanabe Makoto Nishimura Graduate school of Economics Nagoya University

The purpose of this paper is to clarify the questions concerning stimulation of the innovation and the diffusion of energy saving or low-carbon.To do so,this paper explains using two cases of Japan-energy saving innovation after the Oil shock and the eco points system.For the case after the oil shock,we explain the energy saving trend after the Oil shock and the factors statistically.Then we put forward the business model for the low-carbon economy.Furthermore,we analyze the case of the eco points system from 2009-2011 in Japan and explain the significance of the business model for diffusion of the low-carbon products.

关键词： energy saving innovation eco-point system business model low-carbon economy Japan

Vaccine therapy for dysbiosis-related diseases

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World Journal of Gastroenterology 2020年第21期26卷 2758-2767页

作者： Kosuke Fujimoto satoshi Uematsu Department of Immunology and Genomics Osaka City University Graduate School of MedicineOsaka 545-8585Japan Division of Innate Immune Regulation International Research and Development Center for Mucosal VaccinesThe Institute of Medical ScienceThe University of TokyoTokyo 113-8654Japan Division of Metagenome Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyo 113-8654Japan Collaborative Research Institute for Innovative Microbiology The University of TokyoTokyo 113-8654Japan

Progress in genomic analysis has resulted in the proposal that the intestinal microbiota is a crucial environmental factor in the development of multifactorial diseases,such as obesity,diabetes,rheumatoid arthritis,and inflammatory bowel diseases represented by Crohn’s disease and ulcerative colitis.Dysregulated gut microbiome contributes to the pathogenesis of such disorders;however,there are few effective treatments for controlling only disease-mediating bacteria.Here,we review current knowledge about the intestinal microbiome in health and disease,and discuss a regulatory strategy using a parenteral vaccine with emulsified curdlan and CpG oligodeoxynucleotides,which we have recently developed.Unlike other conventional injectable immunizations,our vaccine contributes to the induction of antigen-specific systemic and mucosal immunity.This vaccine strategy can prevent infectious diseases such as streptococcus pneumoniae infection,and control metabolic symptoms mediated by intestinal bacteria(e.g.Clostridium ramosum)by induction of high titers of antigen-specific IgA at target mucosal sites.In the future,our vaccination approach could be an effective therapy for common infectious diseases and dysbiosis-related disorders that have been difficult to control so far.

关键词： Dysbiosis IgA Microbiome Mucosal immunity Pathobiont Vaccine

纯铜在低温和极低应变速率下的初始蠕变和粘弹性回复（英文）

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Transactions of Nonferrous Metals society of China 2016年第7期26卷 1729-1735页

作者：申俊杰 Ken-ichi IKEDA satoshi HATA Hideharu NAKAsHIMA 天津理工大学机械工程学院天津300191 Department of Electrical and Materials science Faculty of Engineering SciencesKyushu University

采用高应变分辨率的螺旋弹簧蠕变试验法,研究晶粒尺寸d_g为40μm纯铜在低温(Ts^(-1)条件下的蠕变和粘弹性回复行为。采用基于蠕变曲线尺度因子的数据解析法,代替传统基于外推的稳态蠕... 详细信息

采用高应变分辨率的螺旋弹簧蠕变试验法,研究晶粒尺寸d_g为40μm纯铜在低温(Ts^(-1)条件下的蠕变和粘弹性回复行为。采用基于蠕变曲线尺度因子的数据解析法,代替传统基于外推的稳态蠕变速率的蠕变数据解析法。结果表明:纯铜低温、低应力初始蠕变行为可由幂律蠕变方程描述,因为幂律蠕变方程初始参数不随蠕变时间改变而变化;粘弹性应变为弹性应变的1/6;粘弹性应变速率的对数和粘弹性应变的对数呈线性关系(斜率为1)。因此,纯铜低温、低应力蠕变可能由三维位错网的收缩机制控制。

关键词：纯铜蠕变位错粘弹性蠕变本构方程

Clinicopathological features and prognosis of surgical resected cases of biliary cancer with pancreaticobiliary maljunction

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 97-100页

作者： Tsukasa Takayashiki Hideyuki Yoshitomi Katsunori Furukawa satoshi Kuboki Masaru Miyazaki Masayuki Ohtsuka Department of General surgery Graduate School of MedicineChiba University Department of Gastroenterological surgery Mita HospitalInternational University of Health and Welfare

To the Editor:Pancreaticobiliary maljunction(PBM)is a congenital anomaly in which the pancreatic and bile ducts join anatomically outside of the duodenal wall away from the Oddi’s sphincter.This condition causes the reflux of pancreatic juice into the bile duct under high pressure,resulting in various pathologic changes.The features of PBM patients are common bile duct dilatation,long common channel,and high amylase levels in bile juice.Among them,one of the most significant problems is the development of biliary cancer,including extrahepatic bile duct and gallbladder cancers[1].A nationwide survey in Japan reported biliary cancer in 21.6%of adult patients with PBM concomitant with congenital biliary dilatation,32.1%and 62.3%extrahepatic bile duct and gallbladder cancers,respectively[2].

关键词： biliary cancer congenital

细晶Al-5356合金在低应变速率下基于高分辨率应变测量的“异常瞬时蠕变”(英文)

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Transactions of Nonferrous Metals society of China 2013年第5期23卷 1209-1214页

作者：申俊杰 Kenichi IKEDA satoshi HATA Hideharu NAKAsHIMA 天津理工大学机械工程学院天津300191 Department of Electrical and Materials science Faculty of Engineering SciencesKyushu University

极低应变速率下(Tp,Tp为发生相变的温度,Tp=0.58Tm)或"中温弱化"(0.4Tm 详细信息

极低应变速率下(s-1)的瞬时蠕变仍然未知。由于应变分辨率低(～10-6),传统的单轴拉伸/压缩等蠕变测试技术并不能满足此蠕变区的测试要求。采用具有高应变分辨率的螺旋弹簧蠕变试验法,研究Al-5356合金在温度范围为0.4Tm^0.8Tm(Tm为熔点的绝对温度)、应变速率小于10-10s-1的瞬时蠕变行为。采用透射电子显微镜研究蠕变微观组织以揭示极低应变速率下的瞬时蠕变机制。实验结果首次显示了一些异常蠕变行为:"高温强化"(T>Tp,Tp为发生相变的温度,Tp=0.58Tm)或"中温弱化"(0.4Tm

关键词： Al-5356合金瞬时蠕变相变低应变速率

In situ backscattered electron imaging study of the effect of annealing on the deformation behaviors of Ni electroformed from additive-free and saccharin-containing sulfamate solutions

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International Journal of Minerals,Metallurgy and Materials 2019年第1期26卷 114-123页

作者： Kai Jiang Hiroaki Nakano satoshi Oue Tatsuya Morikawa Wen-huai Tian school of Materials science and Engineering University of Science and Technology Beijing Faculty of Engineering Kyushu University

The Ni samples were electroformed from additive-free(AF) and saccharin-containing(sC) sulfamate solutions, respectively. In situ backscattered electron(BsE) imaging, electron backscatter diffraction(EBsD), and electron-probe microanalysis(EPMA) were used to investigate the effect of annealing on the deformation behaviors of the AF and sC samples. The results indicate that columnar grains of the as-deposited AF sample had an approximated average width of 3 μm and an approximated aspect ratio of 8. The average width of columnar grains of the as-deposited sC sample was reduced to approximately 400 nm by the addition of saccharin to the electrolyte. A few very-large grains distributed in the matrix of the sC sample after annealing. No direct evidence indicated that s segregated at the grain boundaries before or after annealing. The average value of the total elongations of the sC samples decreased from 16% to 6% after annealing, whereas that of the AF samples increased from 18% to 50%. The dislocation recovery in grain-boundary areas of the annealed AF sample was reduced, which contributed to the appearance of microvoids at the triple junctions. The incompatibility deformation between very-large grains and fine grains contributed to the brittle fracture behavior of the annealed sC Ni.

关键词： backscattered electron imaging annealing electroformed Ni sulfamate solution deformation behaviors

PLosONE：研究揭示去甲肾上腺素改善视力机制

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现代生物医学进展 2017年第14期17卷 I0001-I0001页

作者： Ryo Mizuyama, satoshi shimegi Laboratory of Cognitive and Behavioral Neuroscience Graduate School of Frontier Bioscience Osaka University Suita Osaka Japan Laboratory of Cognitive and Behavioral Neuroscience Graduate School of Medicine Osaka University Toyonaka Osaka Japan Universidad de salamanca SPAINCompeting Interests: The authors have declared that no competing interests exist.Conceptualization: RM S. Shimegi.Data curation: RM.Formal analysis: RM.Funding acquisition: S. Shimegi.Investigation: RM S. Shimegi.Methodology: RM S. Soma NS.Project administration: S. Shimegi.Resources: S. Shimegi.Software: RM NS S. Soma.Supervision: S. Shimegi.Visualization: RM.Writing - original draft: RM S. Shimegi.Writing - review & editing: RM S. Shimegi. [¤a]Current address: Brain Science Institute Tamagawa University Tamagawa Tokyo Japan[¤b]Current address: Graduate School of Engineering Osaka University Suita Osaka Japan* E-mail: pj.ca.u-akaso.ssh.noisiv@igemihs

去甲肾上腺素是依赖于动物的行为环境和生理状态的大脑分泌出的一种神经调节物（neuromodulator，也被称作神经调质）。并且通过调控大脑活动来影响许多各种不同的生理功能。它可能最好被称作为一种调节心率和血液流量的激素。而且很多... 详细信息

去甲肾上腺素是依赖于动物的行为环境和生理状态的大脑分泌出的一种神经调节物（neuromodulator，也被称作神经调质）。并且通过调控大脑活动来影响许多各种不同的生理功能。它可能最好被称作为一种调节心率和血液流量的激素。而且很多药物，如广为人知的θ-阻断剂，靶向它的效应。它也调节视觉系统。

关键词：去甲肾上腺素机制视力神经调节大脑活动生理状态行为环境生理功能