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Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-s2 cells is proceeded by the activation of protein kinase C

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中华医学杂志(英文版) 2005年第3期 23-28页

作者： AN Wei-wei, WANG Min-wei, Tashiro shin-ichi, Onodera satoshi and Ikejima TakashiChina-Japan Research Institute of Medical and Pharmaceutical sciences, shenyang Pharmaceutical University, shenyang 110016, China Department of Pharmacology, shenyang Pharmaceutical University, shenyang 110016, China Department of Clinical and Biomedical sciences, showa Pharmaceutical University, Tokyo 19-8543, Japan

Background We have reported that norcantharidin (NCTD) induces human melanoma A375-s2 cell apoptosis and that the activation of caspase and the mitochondrial pathway are involved in the apoptotic process. This study aimed at investigating the roles of mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) in A375-s2 cell apoptosis induced by NCTD.

关键词： norcantharidin · A375-s2 cells · mitogen-activated protein kinase · protein kinase C · staurosporine

Lentinan prolonged survival in patients with gastric cancer receiving s-1-based chemotherapy

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World Journal of Clinical Oncology 2011年第10期2卷 339-343页

作者： Kenji Ina Ryuichi Furuta Takae Kataoka satoshi Kayukawa Takashi Yoshida Takaya Miwa Yoshitaka Yamamura Yuuki Takeuchi Department of Medical Oncology Nagoya Memorial HospitalNagoya 468-8520Japan Department of Clinical Oncology Nagoya Memorial HospitalNagoya 468-8520Japan Department of surgery Nagoya Memorial HospitalNagoya 468-8520Japan

AIM:To examine whether administration of lentinan,purifiedβ-1,3-glucan,can prolong survival in advanced gastric cancer patients receiving s-1-based chemotherapy.METHODs:since 2004,78 patients with metastatic or recurrent gastric cancer have received s-1-based chemotherapy as first-line treatment.survival,side effects,and the ratio of granulocytes/lymphocytes(G/L ratio)were compared between 2 groups of patients who received chemo-immunotherapy using lentinan and chemotherapy alone.REsULTs:Median overall survival was significantly longer in the former group than in the latter group[689 d(95%CI:431-2339 d)vs 565 d(95%CI:323-662 d),P=0.0406].In addition,the G/L ratio in patients who received lentinan was maintained around or below 2,which was significantly lower than that in patients who received chemotherapy alone(PsION:Chemo-immunotherapy with lentinan offers a significant advantage over s-1-based chemotherapy alone in terms of survival in patients with advanced gastric cancer.

关键词： Gastric cancer Lentinan s-1-based chemotherapy

Gene Organization of F1F0-ATPase Complex in Yeast saccharomyces cerevisiae.

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Gene Organization of F1F0-ATPase Complex in Yeast Saccharomy...

Leukemogenic Fusion Gene (p190 BCR-ABL) Transduction into Hematopoietic stem/Progenitor Cells in the Common Marmoset

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作者： Katsunori Ohnishi Takuya Yamaguchi satoshi Nakano Masateru Wakamatsu Hideki satoh Masaharu Takeda Dept.Applied Microbial Tech. Kumamoto Inst. Tech.IkedaKumamoto 860-0082Japan Dept.Applied Microbial Tech. Kumamoto Inst. Tech.IkedaKumamoto 860-0082Japan Dept.Applied Microbial Tech. Kumamoto Inst. Tech.IkedaKumamoto 860-0082Japan Dept.Applied Microbial Tech. Kumamoto Inst. Tech.IkedaKumamoto 860-0082Japan Dept.Applied Microbial Tech. Kumamoto Inst. Tech.IkedaKumamoto 860-0082Japan Dept.Applied Microbial Tech. Kumamoto Inst. Tech.IkedaKumamoto 860-0082Japan

＜正＞In yeast s. cerevisiae, five different subunit genes of F1 are encoded by nuclear genomes. The subunit stoichiometry of F1 is generally α3β3γ1δ1ε1 in all organisms although the genetic system is different f...

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Open Journal of Blood Diseases 2012年第1期2卷 1-10页

作者： Yan Dong seiichiro Kobayashi Yamin Tian Manabu Ozawa Takafumi Hiramoto Kiyoko Izawa Yuansong Bai Yasushi soda Erika sasaki Toshio Itoh Yoshiro Maru satoshi Takahashi Kaoru Uchimaru Naoki Oyaizu Arinobu Tojo Chieko Kai Kenzaburo Tani Central Institute for Experimental Animals Kawasaki Japan Department of Laboratory Medicine Research Hospital Institute of Medical Science the University of Tokyo Tokyo Japan Department of Molecular Genetics Medical Institute of Bioregulation Kyushu University Fukuoka Japan Department of Pharmacology Tokyo Woman’s Medical University Japan Division of Molecular Therapy Institute of Medical Science the University of Tokyo Tokyo Japan Laboratory Animal Research Center Institute of Medical Science the University of Tokyo Tokyo Japan.

Patients with Philadelphia chromosome (p190 BCR-ABL fusion gene)-positive acute lymphoblastic leukemia have a poor prognosis despite intensive therapeutic intervention.In this study, we attempted to develop a leukemia nonhuman primate model that mimics various human systems. Hematopoietic stem/progenitor cells in the common marmoset were transduced with a lentiviral vector containing the p190 BCR-ABL fusion gene by ex vivo transduction or in vivo direct bone marrow injection. In the latter model, BCR-ABL gene expression was maintained for more than one and a half years. One marmoset unexpectedly developed myelofibrosis-like disease. However, none of the marmosets have developed leukemia to date. In conclusion, we successfully achieved sustained p190 BCR-ABL gene expression in vivo. However, a genetic mutation in addition to p190 BCR-ABL may be required for the malignant transformation of hematopoietic stem/progenitor cells in the common marmoset during the short observation period. This novel in vivo approach will help develop a marmoset leukemia model in the future.

关键词： Leukemia Lentiviral Vector Myelofibrosis Common Marmoset

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日本生活废水的土壤处理

世界环境 1985年第2期 29-31页

作者：松本聪许明

生活废水和工业废水不同,它和人类的日常生活有着密切的联系。排出的生活废水进入陆地生态系统后,形成植物—土壤—生物良性循环。为了找到安全合理的处理方法,世界上早就开展了大量的研究工作。近年来,为了更好地保护水域水质和解决富... 详细信息

生活废水和工业废水不同,它和人类的日常生活有着密切的联系。排出的生活废水进入陆地生态系统后,形成植物—土壤—生物良性循环。为了找到安全合理的处理方法,世界上早就开展了大量的研究工作。近年来,为了更好地保护水域水质和解决富营养化问题,在日本展开了更加广泛的研究。美国宾西法尼亚大学和西德布兰纠巴伊库开展的以生活废水进行灌溉

关键词：生活废水透水性拉西试验器土壤处理毒饵净化率沙质土壤日本

Mn-Cu系高阻尼合金的凝固组织控制及阻尼特性的改善(英文)

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物理学进展 2006年第3期26卷 323-331页

作者：殷福星岩崎智坂口琢哉长井寿日本物质材料研究机构丰田汽车公司第三材料研究部

Mn—Cu系阻尼合金兼有较高的阻尼特性和良好的力学性质，因而具有较大的实用前景。这类合金通常经过铸造，塑性加工和热处理来获得要求的性能和组织。加工后的Mn—Cu合金存在一个特定温度，在此温度以上合金的阻尼性能将会消失，因而影... 详细信息

Mn—Cu系阻尼合金兼有较高的阻尼特性和良好的力学性质，因而具有较大的实用前景。这类合金通常经过铸造，塑性加工和热处理来获得要求的性能和组织。加工后的Mn—Cu合金存在一个特定温度，在此温度以上合金的阻尼性能将会消失，因而影响了合金的在较高温度下的使用。该温度和合金的Mn含量有关，然而提高合金的Mn含量有会降低合金的加工性及力学性能。一般Mn-Cu合金的热处理都是利用400℃附近的时效来获得相分解后的局部高Mn组织。但是目前的时效处理后的Mn—Cu阻尼合金的最高使用温度只在80℃以下。为解决Mn—Cu阻尼合金使用温度的局限性，本研究选用凝固过程控制的方法在铸造组织中来获得较大幅度的Mn含量分布。从而在Mn-Cu合金得到较高的高阻尼特性温度。本工作利用铸型温度控制的方法，将M2052（Mn-20Cu-5Ni-2Fe）合金在250～0．1K／s冷却速度范围内控制凝固。随凝固冷却速度的降低在合金的铸态组织中观察到二次枝晶间距和晶粒尺寸的明显增大。同时还发现缓冷凝固的合金的成分比快冷凝固有较大的分布幅度。铸态下的合金阻尼性能评价也证实了凝固冷却速度对合金的凝固组织有很大的影响。尽管铸态组织的合金的高温阻尼性能并没有很大的改善，然而通过对铸态组织实施时效处理后发现缓冷凝固合金的高温阻尼性能有很大的改善。凝固冷却速度对时效处理后合金的阻尼性能有明显的影响。实验结果表明0．1K／s的冷却速度下缓慢凝固的合金在时效处理后高阻尼特性可持续高达120℃．

关键词： Mn-Cu系高阻尼合金阻尼行为凝固组织控制

streptomyces griseochromogenes菌株milbemycin生物合成基因簇的筛选

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沈阳药科大学学报 2001年第5期18卷 345-349页

作者：阎浩林 IKEDA Haruo MURA satoshi 沈阳药科大学制药工程学院辽宁沈阳110016 日本国北里研究所

经BamHI酶切的柯氏质粒pku4 0 3与MboⅠ部分消化并经碱性磷酸酶处理的streptomycesgriseochromogenes染色体DNA片段相连接 ,体外包装后 ,转化大肠杆菌E .coliJM1 0 8,挑取转化子1 1 5 2个 ,构建streptomycesgriseochromogenes的基因文... 详细信息

经BamHI酶切的柯氏质粒pku4 0 3与MboⅠ部分消化并经碱性磷酸酶处理的streptomycesgriseochromogenes染色体DNA片段相连接 ,体外包装后 ,转化大肠杆菌E .coliJM1 0 8,挑取转化子1 1 5 2个 ,构建streptomycesgriseochromogenes的基因文库。分别以avermectin聚酮体合成酶 (PKs)的酰基转移酶基因 (AT)、酮基合成酶基因 (Ks)及参与avermectin生物合成的内酯化酶基因(aveE)、C5 O 甲基转移酶基因 (aveD)为探针 ,利用菌落原位杂交、核酸杂交和以烯酰基还原酶基因(ER)引物的PCR扩增等手段 ,从文库中筛选出 2 4个阳性克隆。根据克隆DNA之间的重叠关系 ,将阳性克隆分为 7组 ,这

关键词：柯氏质粒pku403 包装蛋白转化基因文库聚酮体合成酶菌落原位杂交核酸杂交 PCR 链霉菌

Near-infrared polarimetry of the GG Tauri A binary system

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Research in Astronomy and Astrophysics 2014年第11期14卷 1438-1446页

作者： Yoichi Itoh Yumiko Oasa Tomoyuki Kudo Nobuhiko Kusakabe Jun Hashimoto Lyu Abe Wolfgang Brandner Timothy D.Brandt Joseph C.Carson sebastian Egner Markus Feldt Carol A.Grady Olivier Guyon Yutaka Hayano Masahiko Hayashi saeko s.Hayashi Thomas Henning Klaus W.Hodapp Miki Ishii Masanori Iye Markus Janson Ryo Kandori Gillian R.Knapp Masayuki Kuzuhara Jungmi Kwon Taro Matsuo Michael W.McElwain shoken Miyama Jun-Ichi Morino Amaya Moro-Martin Tetsuo Nishimura Tae-soo Pyo Eugene serabyn Takuya suenaga Hiroshi suto Ryuji suzuki Yasuhiro H.Takahashi Naruhisa Takato Hiroshi Terada Christian Thalmann Daigo Tomono Edwin L.Turner Makoto Watanabe John Wisniewski Toru Yamada satoshi Mayama Thayne Currie Hideki Takami Tomonori Usuda Motohide Tamura Nishi-Harima Astronomical Observatory Center for AstronomyUniversity of Hyogo407-2NishigaichiSayoHyogo 679-5313Japan Faculty of Education Saitama University255 Shimo-OkuboSakuraSaitamaSaitama338-8570Japan subaru Telescope National Astronomical Observatory of Japan650 North Ahoku PlaceHiloHI 96720USA National Astronomical Observatory of Japan 2-21-1OsawaMitakaTokyo181-8588Japan H.L.Dodge Department of Physics & Astronomy University of Oklahoma440 W Brooks St.NormanOK 73019USA Laboratoire Lagrange (UMR 7293) Universit de Nice-Sophia AntipolisCNRSObservatoire de la Cote d’Azur28 avenue Valrose06108 Nice Cedex 2France Max Planck Institute for Astronomy Knigstuhl 1769117 HeidelbergGermany Department of Astrophysical science Princeton UniversityPeyton HallIvy LanePrincetonNJ 08544USA Department of Physics and Astronomy College of Charleston58 Coming St.CharlestonSC29424USA subaru Telescope National Astronomical Observatory of Japan650 North A’ohoku PlaceHiloHI 96720USA Exoplanets and stellar Astrophysics Laboratory Code 667Goddard Space Flight CenterGreenbeltMD 20771USA Eureka scientific 2452 DelmerSuite 100Oakland CA 96002USA Goddard Center for Astrobiology GreenbeltMD 20771USA Institute for Astronomy University of Hawaii640 N.Aohoku PlaceHiloHI 96720USA Department of Earth and Planetary sciences Tokyo Institute of TechnologyOokayamaMeguro-kuTokyo 152-8551Japan Department of Astronomy Kyoto UniversityKitashirakawa-Oiwake-choSakyo-kuKyotoKyoto 606-8502Japan Hiroshima University 1-3-2KagamiyamaHigashihiroshimaHiroshima 739-8511Japan Department of Astrophysics CAB-CSIC/INTA28850 Torrejón de ArdozMadridSpain Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA91109USA Department of Astronomical science The Graduate University for Advanced Studies2-21-1OsawaMitakaTokyo181-8588Japan Department of Astronomy The University of Tokyo7-3-1HongoBunkyo-kuTokyo113-0033Japan Astronomical Institute "Anton Pannekoek" University

A high angular resolution near-infrared image that shows the intensity of polarization for the GG Tau A binary system was obtained with the subaru Telescope. The image shows a circumbinary disk scattering the light from the central binary. The azimuthal profile of the intensity of polarization for the circumbinary disk is roughly reproduced by a simple disk model with the Henyey-Greenstein phase function and the Rayleigh function, indicating there are small dust grains at the surface of the disk. Combined with a previous observation of the circumbinary disk, our image indicates that the gap structure in the circumbinary disk orbits counterclockwise, but material in the disk orbits clockwise. We propose that there is a shadow caused by material located between the central binary and the circumbinary disk. The separations and position angles of the stellar components of the binary in the past 20 yr are consistent with the binary orbit with a = 33.4 AU and e = 0.34.

关键词： stars individual （GG Tauri） -- stars pre-maln sequence - techniques high angular resolution

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一个估算积云中夹卷率的新方法

一个估算积云中夹卷率的新方法