Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C

作     者：AN Wei-wei, WANG Min-wei, Tashiro Shin-ichi, Onodera Satoshi and Ikejima TakashiChina-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University, Tokyo 19-8543, Japan 

出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)

年 卷 期：2005年第3期

页      面：23-28页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：norcantharidin · A375 S2 cells · mitogen activated protein kinase · protein kinase C · staurosporine 

摘      要：Background We have reported that norcantharidin (NCTD) induces human melanoma A375-S2 cell apoptosis and that the activation of caspase and the mitochondrial pathway are involved in the apoptotic process. This study aimed at investigating the roles of mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) in A375-S2 cell apoptosis induced by NCTD.