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Development of the nervous system in mouse liver

World Journal of Hepatology 2022年第2期14卷 386-399页

作者： Naoto Koike Tomomi Tadokoro Yasuharu Ueno satoshi okamoto Tatsuya Kobayashi Soichiro Murata Hideki Taniguchi Department of Surgery Seirei Sakura Citizen HospitalSakura 285-8765ChibaJapan Department of Regenerative Medicine Yokohama City University Graduate School of MedicineYokohama 236-0004KanagawaJapan Division of Regenerative Medicine Center for Stem Cell Biology and Regenerative MedicineThe Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan

BACKGROUND The role of the hepatic nervous system in liver development remains *** previously created functional human micro-hepatic tissue in mice by co-culturing human hepatic endodermal cells with endothelial and mesenchymal ***,they lacked Glisson’s sheath[the portal tract(PT)].The PT consists of branches of the hepatic artery(HA),portal vein,and intrahepatic bile duct(IHBD),collectively called the portal triad,together with autonomic *** To evaluate the development of the mouse hepatic nervous network in the PT using *** Liver samples from C57BL/6J mice were harvested at different developmental time periods,from embryonic day(E)10.5 to postnatal day(P)*** sections of the surface cut through the hepatic hilus were examined using protein gene product 9.5(PGP9.5)and cytokeratin 19(CK19)antibodies,markers of nerve fibers(NFs),and biliary epithelial cells(BECs),*** numbers of NFs and IHBDs were separately counted in a PT around the hepatic hilus(center)and the peripheral area(periphery)of the liver,comparing the average values between the center and the periphery at each developmental ***-IHBD and NF-HA contacts in a PT were counted,and their relationship was *** high mobility group-box gene 9(SOX9),another BEC marker;hepatocyte nuclear factor 4α(HNF4α),a marker of hepatocytes;and Jagged-1,a Notch ligand,were also immunostained to observe the PT *** HNF4αwas expressed in the nucleus,and Jagged-1 was diffusely positive in the primitive liver at E10.5;however,the PGP9.5 and CK19 were negative in the fetal ***9-positive cells were scattered in the periportal area in the liver at *** Jagged-1 was mainly expressed in the periportal tissue,and the number of SOX9-positive cells increased at ***9-positive cells constructed the ductal plate and primitive IHBDs mainly at the center,and SOX-9-positive IHBDs partly acquired CK19 positivity at the same perio

关键词： Nervous system Liver Portal tract Hepatic artery Immunohistochemistry Tissue engineering

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Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2006年第2期12卷 322-326页

作者： Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki satoshi okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru Aoshima Naoyuki Miyokawa Masakazu Haneda Masashi Yoneda Second Department of Medicine Asahikawa Medical CollegeAsahikawaJapan Department of Surgical Pathology Asahikawa Medical CollegeAsahikawaJapan Health Care Administration Center Obihiro University of Agriculture and Veterinary MedicineObihiroJapan Department of Gastroenterology Dokkyo University School of MedicineMibuJapan

AIM： To investigate the efficacy of angiotensin Ⅱ receptor antagonist on hepatic stellate cells （HSCs） activation in the patients with non-alcoholic steatohepatitis （NASH）. METHODS： Seven patients with NASH were prescribed Iosartan, a selective angiotensin Ⅱ type 1 receptor antagonist （50 mg/d） for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 and α-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver （NAFL） were also examined as controls. RESULTS： In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk Iosartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION： Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensin Ⅱ receptor antagonist on patients with NASH.

关键词： NASH NAFLD Hepatic fibrosis HSC Losartan

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Increase in serum levels of phosphatidylserine-specific phospholipase A_(1) in COVID-19 patients

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Cellular & Molecular Immunology 2021年第9期18卷 2275-2277页

作者： Takuya Shimura Makoto Kurano Koh okamoto Daisuke Jubishi Kuniyuki Kano Koji Igarashi satoshi Shimamoto Junken Aoki Kyoji Moriya Yutaka Yatomi Department of Clinical Laboratory The University of Tokyo HospitalTokyoJapan Department of Clinical Laboratory Medicine Graduate School of MedicineThe University of TokyoTokyoJapan Department of Infectious Diseases The University of Tokyo HospitalTokyoJapan Department of Health Chemistry Graduate School of Pharmaceutical SciencesThe University of TokyoTokyoJapan Bioscience Division TOSOH CorporationKanagawaJapan

The development of novel drugs to overcome the current global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an important *** antiviral agents have been investigated,one of the important goals of treatment is also to control the biological response to the infection.A series of elegant basic studies have revealed that lysophosphatidylserine(LysoPS)might play important roles in inflammation through three kinds of G protein-coupled receptors[1];LysoPS reportedly suppresses activation of T cells[2]and secretion of inflammatory cytokines from macrophages[3]and promotes phagocytosis of apoptotic cells,including apoptotic neutrophils,by macrophages[4].

关键词： drugs inflammation acute

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Sofosbuvir/Ribavirin therapy for patients experiencing failure of ombitasvir/paritaprevir/ritonavir + ribavirin therapy: Two cases report and review of literature

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World Journal of Clinical Cases 2019年第9期7卷 1043-1052页

作者： Ken Sato Yuichi Yamazaki Takeshi Kobayashi satoshi Takakusagi Norio Horiguchi Satoru Kakizaki Masayasu Andou Yoshihiro Matsuda Toshio Uraoka Hiroshi Ohnishi Hiroaki okamoto Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Department of Nephrology and Rheumatology Gunma University Graduate School of Medicine Department of Diagnostic Radiology and Nuclear Medicine Gunma University Graduate School of Medicine Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine

BACKGROUND The effectiveness of sofosbuvir/ribavirin(SOF/RBV) combination therapy,which is one of the 1 st-choice therapeutic options for patients with hepatitis C virus(HCV) genotype 2(HCV-G2) in Japan according to the most recent version of the Japan Society of Hepatology guideline, for patients who experienced failure of the ombitasvir/paritaprevir/ritonavir plus ribavirin(OBV/PTV/r+RBV) combination therapy, which was another option for patients with HCV-G2, is *** SUMMARY We evaluated the effects of SOF/RBV combination therapy in two patients with genotype 2 a who could not achieve a sustained virological response(SVR) by OBV/PTV/r+RBV combination therapy. One patient was complicated with VogtKoyanagi-Harada(VKH) disease. Resistance-associated variations before SOF/RBV combination therapy were not detected in two patients. Both patients had an SVR at 12 wk after the treatment(SVR12). Regarding adverse events(AEs), itching, chill, a dull feeling in the throat and cough as well as increase of alanine transaminase level were shown in one patient, while a headache and deterioration of light aversion probably due to the recurrence of VKH disease were shown in the other patients. In addition, the latter patient developed arthralgia and morning stiffness approximately 7 wk after the therapy and turned out to be diagnosed with rheumatoid *** SOF/RBV therapy might be effective for patients experiencing failure of OBV/PTV/r+RBV therapy, but caution should be taken regarding the AEs.

关键词： Direct-acting antiviral agent failure Hepatitis C Genotype 2 Ribavirin Sofosbuvir Case report

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Possible role of human cytomegalovirus in pouchitis after proctocolectomy with ileal pouch-anal anastomosis in patients with ulcerative colitis

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World Journal of Gastroenterology 2007年第7期13卷 1085-1089页

作者： Damian Casadesus Tatsuo Tani Toshifumi Wakai satoshi Maruyama Tsuneo iiai Haruhiko okamoto Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan

AIM: To detect the presence of human cytomegalovirus (HCMV) proteins and genes on the ileal pouch of patients with ulcerative colitis who have undergone proctocolectomy with ileal pouch-anal anastomosis (iPAA). METHODS: immunohistochemistry, polymerase chain reaction (PCR) and PCR sequencing methods were utilized to test the presence of HCMV in pouch specimens taken from 34 patients in 86 endoscopies. RESULTS: HCMV genes and proteins were detected in samples from 12 (35.2%) patients. The rate of detection was significant in the endoscopies from patients diagnosed with pouchitis (5 of 12, 41.6%), according to the Japanese classification of pouchitis, in comparison to patients with normal pouch (7 of 62, 11.2%; P = 0.021). in all patients with pouchitis in which the HCMV was detected, it was the first episode of pouchitis. The virus was not detected in previous biopsies taken in normal endoscopies of these patients. During the follow- up, HCMV was detected in one patient with recurrent pouchitis and in 3 patients whose pouchitis episodes improved but whose positive endoscopic findings persisted. CONCLUSION: HCMV can take part in the inflammatory process of the pouch in some patients with ulcerative colitis who have undergone proctocolectomy with iPAA.

关键词： Human cytomegalovJrus Pouchitis Inflammatory bowel disease Ileal pouch-analanastomosis

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A preliminary study on rectal dose reduction associated with hyaluronic acid implantation in brachytherapy for prostate cancer

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Asian Journal of Urology 2024年第2期11卷 286-293页

作者： Tairo Kashihara Yuka Urago Hiroyuki okamoto Mihiro Takemori Hiroki Nakayama Shohei Mikasa Tetsu Nakaichi Kotaro Iijima Takahito Chiba Junichi Kuwahara satoshi Nakamura Weishan Chang Yoshiyuki Matsui Hiroshi Igaki Department of Radiation Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Radiation Safety and Quality Assurance Division National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Radiological Sciences Graduate School of Human Health SciencesTokyo Metropolitan University7-2-10 Higashi-OguArakawa-kuTokyoJapan Department of Radiological Technology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Urological Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan

Objectives: Hydrogel spacer (HS) was developed to reduce rectal toxicities caused by radiotherapy, but has been reported to cause major adverse events. Our institute has attempted to introduce a hyaluronic acid (HA) as an alternative spacer. This study aimed to compare rectal doses and geometric distributions between the HS and HA implantation in prostate ***: HS and HA were inserted in 20 and 18 patients undergoing high-dose brachytherapy, respectively. The rectum spacer volumes injected were 10 mL and 22 mL, respectively. In the treatment planning system, 13.5 Gy was administered with common catheter positions. The rectal dose indices were assessed between the spacer groups for dosimetry evaluation. Distances between the prostate and rectum and configurations of the spacers were ***: The mean doses irradiated to 0.1 and 2 mL of the rectum were 10.45 Gy and 6.71 Gy for HS, and 6.73 Gy and 4.90 Gy for HA (p<0.001). The mean minimum distances between the prostate and rectum were 1.23 cm and 1.79 cm for HS and HA, respectively (p<0.05). Geometrical configuration comparisons revealed that HA has a higher ability to expand the space than ***: The rectal dose reduction ability of HA is significantly greater than that of HS, suggesting its potential as a new spacer.

关键词： Brachytherapy Hyaluronicacid Hydrogel Prostaticneoplasm Radiotherapy

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Sonodynamic Antitumor Effect of Benzoporphyrin Derivative Monoacid Ring A on KLN205 Cells

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Journal of Cancer Therapy 2011年第2期2卷 99-104页

作者： Tomohiro Osaki Motoshi Tajima Yoshiharu okamoto satoshi Takagi Takeshi Tsuka Tomohiro Imagawa Saburo Minami 不详

Sonodynamic therapy is a new cancer treatment based on the synergetic effect of ultrasound and a drug. In this study, ultrasonically induced antitumor effects of benzoporphyrin derivative monoacid ring A (BPD-MA) on KLN205 cells were investigated. KLN205 cells were irradiated at an ultrasonic frequency of 3 MHz with 10 μg/ml BPD-MA. The ultrasonically induced cell damage significantly increased as an ultrasonic intensity and ultrasound exposure time increased. Confocal microscopic examination revealed that the irradiated cells were induced chromatin condensation and phosphatidylserine exposure. The synergistic effect of the ultrasound exposure and BPD-MA on the tumor cell adhesion rate was significant.

关键词： BPD-MA Cell Damage Sonodynamic Therapy Sonosensitizer Ultrasound

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Dose escalation of external beam radiotherapy for high-risk prostate cancerdImpact of multiple high-risk factor

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Asian Journal of Urology 2019年第2期6卷 192-199页

作者： Rei Umezawa Koji Inaba satoshi Nakamura Akihisa Wakita Hiroyuki okamoto Keisuke Tsuchida Tairo Kashihara Kazuma Kobayashi Ken Harada Kana Takahashi Naoya Murakami Yoshinori Ito Hiroshi Igaki Keiichi Jingu Jun Itami Department of Radiation Oncology National Cancer Center HospitalChuo-kuTokyoJapan Department of Radiation Oncology Tohoku University Graduate School of MedicineSendaiJapan

Objective:To retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADT)in high-risk prostate cancer in three radiotherapy dose ***:Between 1998 and 2013,patients with high-risk prostate cancer underwent threedimensional conformal radiotherapy or intensity-modulated radiotherapy of 66 Gy,72 Gy,or 78 Gy with ***-specific antigen(PSA)relapse was defined using the Phoenix *** relapse-free survival(PRFS)was evaluated in each radiotherapy dose ***,high-risk patients were divided into H-1(patients with multiple high-risk factors)and H-2(patients with a single high-risk factor)as risk ***:Two hundred and eighty-nine patients with a median follow-up period of 77.3 months were analyzed in this *** median duration of ADT was 10.1 ***,Gleason score,T stage,and radiotherapy dose influenced PRFS with statistical significance both in univariate and multivariate *** 4-year PRFS rates in Group-66 Gy,Group-72 Gy and Group-78 Gy were 72.7%,81.6%and 90.3%,*** rates in the H-1 subgroup differed with statistical significance with an increasing radiotherapy dose having a more favorable PRFS,while PRFS rates in H-2 subgroup did not differ with increase in radiotherapy ***:Dose escalation for high-risk prostate cancer in combination with ADT improved *** for patients in the H-1 subgroup was poor,but dose escalation in those patients was beneficial,while dose escalation in the H-2 subgroup was not proven to be effective for improving PRFS.

关键词： Prostate cancer External beam radiotherapy Dose escalation Biochemical control

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Mathematical Modeling and Computational Analysis of Underwater Topography with Global Positioning and Echo Sounder Data

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Journal of Applied Mathematics and Physics 2021年第5期9卷 1171-1179页

作者： satoshi Iwakami Masahiko Tamega Masahide Sanada Michiaki Mohri Yoshitaka Iwakami Naoki okamoto Ryousuke Asou Shuji Jimbo Masaji Watanabe Earth Rise Company Inc. Okayama Japan Visiting Researcher Okayama University Okayama Japan Specially Appointed Professor Okayama University Okayama Japan

This study focuses on change of topography in a water area. Output data from a GPS unit and an echo sounder data were incorporated into analysis for construction of underwater topography. Comparison of two data sets ... 详细信息

关键词： Underwater Topography RTK-GPS Echo Sounder

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Study on Change of Topography in Water Area with Field Measurement

Study on Change of Topography in Water Area with Field Measu...

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作者： satoshi Iwakami Masahiko Tamega Masahide Sanada Michiaki Mohri Yoshitaka Iwakami Naoki okamoto Shuji Jimbo Masaji Watanabe Earth Rise Company Inc. Okayama University

Disastrous flood events in recent years include 2018 Japan floods（July 2018）,Typhoon 19（Hagibis, October 2019） and the following heavy rain event, and July 2020 heavy rain disaster. Such disastrous flood events are expected to occur more frequently as the climate change progresses, and it is indispensable to update information regarding water areas such as rivers, reservoirs, and coastal waters. This study demonstrates practical techniques to analyze underwater topography. Longitude and latitude components of ellipsoidal data recorded by a GPS receiver are projected to a rectangular coordinate system,and results are combined with vertical components including data recorded by an echo sounder unit so that tracks on an underwater floor are obtained. A mapping on a finite dimensional space of continuous functions over a triangular mesh is formulated, and its fixed point gives rise to an underwater floor that fits the tracks. Our techniques are illustrated with data obtained in measurement conducted in a reservoir called Kojima Lake located in Okayama Prefecture, Japan.

关键词： Underwater Topography RTK-GPS Echo Sounder Triangular Mesh Fixed Point Iteration

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