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Long-term efficacy of endoscopic coagulation for different types of gastric vascular ectasia

World Journal of Gastroenterology 2013年第18期19卷 2799-2805页

作者： Yukinori Imai Yoshie Mizuno Kiyoko Yoshino Kazuhiro Watanabe Kayoko Sugawara Daisuke Motoya Masashi Oka satoshi mochida Department of Gastroenterology and Hepatology Faculty of Medicine Saitama Medical University Saitama 350-0495 Japan

AIM: To examine the long-term therapeutic efficacies of endoscopic cauterization for gastric vascular ectasia, according to the type of lesion. METHODS: Thirty-eight patients with hemorrhagic gastric vascular ectasia (VE) were treated by endoscopic cauterization: 13 by heater probe coagulationand 25 by argon plasma coagulation. Depending on the number of lesions, 14 and 24 patients were classified into localized VE (≤ 10; LVE) and extensive VE (> 10; EVE), respectively. The patients were followedup by repeated endoscopic examinations after the therapy, and the incidences of VE recurrence and rebleeding from the lesions were evaluated. RESULTS: Although the VE lesions disappeared initially in all the patients after the therapy, the recurrence of VE developed in 25 patients (66%) over a mid-term observation period of 32 mo, and re-bleeding occurred in 15 patients (39%). The recurrence of VE was found in all patients with EVE, with re-bleeding occurring in 14 patients (58%). In contrast, only 1 patient (7%) with LVE showed recurrence of the lesions and complicating hemorrhage. Both the cumulative recurrence-free rates and cumulative re-bleeding-free rates were significantly lower in the EVE group than in the LVE group (P < 0.001 and P < 0.001, respectively). Moreover, the cumulative re-bleeding-free rate in the EVE group was 47.6% at 1 year and 25.4% at 2 years in patients with chronic renal failure, which were significantly lower than the rates in the patients without chronic renal failure (83.3% and 74.1%, respectively) (P < 0.05). CONCLUSION: The recurrence of VE and re-bleeding from the lesions was more frequent in the patients with EVE, especially in those with complicating renal failure.

关键词： Gastric vascular ectasia Heater probe coagulation Argon plasma coagulation Renal failure Recurrence

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Usefulness of anti-ulcer drugs for the prevention and treatment of peptic ulcers induced by low doses of aspirin

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World Journal of Gastroenterology 2009年第6期15卷 727-731页

作者： Sayaka Nakashima Shinichi Ota Shin Arai Kiyoko Yoshino Mie Inao Keiko Ishikawa Nobuaki Nakayama Yukinori Imai Sumiko Nagoshi satoshi mochida Department of Gastroenterology and Hepatology Faculty of Medicine Saitama Medical UniversitySaitamaJapan

AIM： To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin-induced peptic ulcer.METHODS： Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin （81 or 100 rag/day）. The endoscopic findings were classified according to the Lanza score, and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used. In another study, 31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled. The patients were randomly classified into the proton pump inhibitor （PPI）-treated group and the H2 receptor antagonist （H2RA）-treated group. The administration of low-dose aspirin was continued concomitantly, and endoscopic examinations were performed 8 wk later.RESULTS： The Lanza scores （mean ± SD） of the gastro-mucosal lesions were 1.0 ± 1.9 and 1.9 ± 2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA, respectively. Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy （4.7 ± 1.0） and in 10 patients receiving cytoprotective anti-ulcer drugs （4.3± 1.6）. In the prospective study, 18 and 13 patients received a PPI and an H2RA, respectively. Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients （92%） in the H2RA-treated group; no significant differences were observed between the groups.CONCLUSION： H2RA therapy was effective for both the prevention and treatment of low-dose aspirin-induced peptic ulcer, similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration.

关键词： Hemorrhagic ulcer H2 receptor Antagonist Low-dose aspirin Peptic ulcer Proton pump inhibitor

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Biology and treatment of cervical adenocarcinoma

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Chinese Journal of Cancer Research 2016年第2期28卷 254-262页

作者： satoshi Takeuchi Department of Obstetrics and Gynecology School of MedicineIwate Medical University

Uterine cervical adenocarcinoma （ADC） has been increasing in its prevalence world widely despite the decrease of squamous cell carcinoma （SCC）. It comprises nearly 20-25% of the all cervical malignancy in developed countries. The worse biological behavior had been reported in patients with intermediateand high risk factors after surgery, and in advanced stage over III, radiotherapy （RT） alone and concurrent chemo-radiotherapy （CCRT） with cisplatin was not always effective. As for chemotherapy （CT）, the iaduction CT has not established, as well. Further molecular targeted therapy （MTT） has been studied. The targets of oncogenic driver mutations were vascular endothelial growth factor （VEGF） in SCC, or tyrosine kinase （TK） of endothelial growth factor receptor 2 （EGFR2, Her2/neu）-Ras-MAPK-ERK pathway. Bevacizumab （Bey, anti-VEGF monoclonal antibody） is considered as one of key agent with paclitaxel and carboplatin in SCC, but not for ADC. This article focuses on up-to-date knowledge of biology and possible specific therapeutic directions to explore in the management of cervical ADC.

关键词： Cervical cancer adenocarcinoma (ADC) atypical glandular cell (AGC) gastric type adenocarcinoma (GAS)

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Advances in quantum dots for classical and non-classical light sources Invited Paper

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Chinese Optics Letters 2008年第10期6卷 718-723页

作者： Yasuhiko Arakawa satoshi Iwamoto satoshi Kako Masahiro Nomura Denis Guimard Research Center for Advanced Science and Technology Institute for Nano Quantum Information ElectronicsThe University of Tokyo4-6-1 Meguro-ku153-8505 TokyoJapan

Recent advances in quantum dots （QDs） for classical and non-classical light sources are presented. We have established metal organic chemical vapor deposition （MOCVD） technology for InAs-based QD lasers at 1.3 μm and achieved ultralow threshold in QD lasers with photonic crystal （PhC） nanocavity. In addition, single photon emitters at 1.55 μm, GaN-based single photon sources operating at 200 K, and high-Q PhC nanocavity have been demonstrated.

关键词： QDs Advances in quantum dots for classical and non-classical light sources Invited Paper AIN InAs

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Application of 3D Scanned Big Data of Large-scale Cultural Heritage Objects Based on Noise-robust Transparent Visualization

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系统仿真学报 2023年第8期35卷 1635-1650页

作者： Tanaka satoshi College of Information Science and Engineering Ritsumeikan UniversityShiga 525-8577Japan

Three-dimensional(3D) scanning technology has undergone remarkable developments in recent *** acquired by 3D scanning have the form of 3D point *** 3D scanned point clouds have data sizes that can be considered big *** also contain measurement noise inherent in measurement *** properties of 3D scanned point clouds make many traditional CG/visualization techniques *** paper reviewed our recent achievements in developing varieties of high-quality visualizations suitable for the visual analysis of 3D scanned point *** demonstrated the effectiveness of the method by applying the visualizations to various cultural heritage *** main visualization targets used in this paper are the floats in the Gion Festival in Kyoto(the float parade is on the UNESCO Intangible Cultural Heritage List) and Borobudur Temple in Indonesia(a UNESCO World Heritage Site).

关键词： 3D scanning point cloud transparent visualization noise transparentization cultural heritage object

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Posture Maintenance Control of 2-Link Object By Nonprehensile Two-Cooperative-Arm Robot Without Compensating Friction

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IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1397-1403页

作者： Changan Jiang satoshi Ueno Department of Mechanical Engineering Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan

In this paper, a method to posture maintenance control of 2-link object by nonprehensile two-cooperative-arm robot without compensating friction is proposed. In details, a mathematical model of the 2-link object is firstly built. Based on the model, stable regions for holding motion of nonprehensile two-cooperative-arm robot are obtained while the 2-link object is kept stable on the robot arms with static friction. Among the obtained stable regions, the robust pairs of orientation angles of the 2-link object are found. Under the robust orientation angles, a feedback control system is designed to control the arms to maintain the 2-link object's posture while it is being held or lifted up. Finally, experimental results are shown to verify the effectiveness of the proposed method.

关键词： Nursing care nonprehensile robot posture maintenance static friction two-cooperative-arm robot

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A pH-dependent molecular switch for virion uncoating

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Protein & Cell 2014年第9期5卷 653-654页

作者： satoshi Koike Neurovirology Project Tokyo Metropolitan Institute of Medical Science 2-1-6 Kamikitazawa Setagaya-ku Tokyo 156-8506Japan

Enterovirus 71, belonging to human enterovirus speCies A in the genus Enterovirus of the family Picornaviridae, is one of the main causative agents of hand-foot-mouth disease. It can also cause severe neurological diseases such as acute encephalitis, polio-like paralysis, and neurogenic pulmonary edema, and it has become a serious public health concern especially in the Asia-Pacific region.

关键词： Enterovirus Picornaviridae Asia-Pacific

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Hepatic pseudolesions caused by alterations in intrahepatic hemodynamics

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World Journal of Gastroenterology 2021年第46期27卷 7894-7908页

作者： satoshi Kobayashi Department of Quantum Medical Technology Kanazawa University Graduate School of Medical SciencesKanazawa 9200942IshikawaJapan

Hepatic pseudolesion may occur in contrast-enhanced computed tomography and magnetic resonance imaging due to the unique haemodynamic characteristics of the *** concept of hepatic arterial buffer response(HABR)has become mainstream for the understanding of the mechanism of the reciprocal effect between hepatic arterial and portal venous *** HABR is thought to be significantly related to the occurrence of the abnormal imaging findings on arterial phase of contrast enhanced images,such as hepatic arterial-portal vein shunt and transient hepatic attenuation difference,which mimic hypervascular tumor and may cause clinical *** inflow to the liver also cause hepatic pseudolesion,and some of the cases may show histopathologic change such as focal hyperplasia,focal fatty liver,and focal sparing of fatty liver,and called *** understand these phenomena might be valuable for interpreting the liver imaging findings.

关键词： Pseudolesion Focal sparing of fatty liver Computed tomography Hepatic blood flow Hepatic hemodynamics Hyperplastic change

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Surface roughness and its role in mediating cell adhesion on cobalt-chromium-molybdenum alloys

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Biosurface and Biotribology 2023年第4期9卷 161-168页

作者： satoshi Migita Graduate School of Science and Engineering Yamagata UniversityYonezawaJapan

Co-Cr-Mo ally(CCM)is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion ***,the influence of surface roughness on cell attachment and proliferation remains *** study aimed to elucidate the impact of surface roughness of CCM on the attachment and proliferation of *** samples with different values of surface rouges were prepared by ***3T3-E1 mouse osteoblasts were used for cell culture *** attachment,morphology,and the expression of actin stress fibres,vinculin,and distri-bution of yes-associated protein were *** results suggest that surface rough-ness does not significantly affect cell attachment and proliferation on CCM,unlike on *** implies that other properties of CCM,such as physicochemical properties,may play a more substantial role in modulating cell *** study provides important insights into the design of CCM implants,suggesting that approaches beyond tuning surface roughness may be necessary to improve biocompatibility and osseointegration.

关键词： biointerface biological reaction biological response biomaterials biomedical application biosurface

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Artificially frozen ground and related engineering technology in Japan

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Research in Cold and Arid Regions 2021年第2期13卷 77-86页

作者： satoshi Akagawa Cryosphere Engineering Laboratory TokyoJapan

Since the 1970's, frozen ground has been developing near the Tokyo Bay area around liquefied natural gas(LNG) inground storage tanks. For disaster prevention purposes, the tanks are constructed below the ground surface. Since the temperature of the liquid stored in the tanks is -162℃ the soil surrounding the tanks freezes. Since this frozen ground has existed for almost half a century, we have permafrost near Tokyo. The development of artificial frozen ground may cause frost heaving, resulting in frost heave forces that may cause structural damage of adjacent LNG in-ground storage ***, the demand for frozen ground engineering increased and consequently we now have advanced technology in this area. Fortunately, we use this engineering technology and artificial ground freezing for civil engineering, especially in big and crowded cities like Tokyo. This paper provides a summary of the testing apparatus, test methods, and assessment methods for frost heaving.

关键词： artificial ground freezing frost heave frozen ground engineering

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