Surface roughness and its role in mediating cell adhesion on cobalt-chromium-molybdenum alloys

作     者：Satoshi Migita 

作者机构：Graduate School of Science and EngineeringYamagata UniversityYonezawaJapan 

出 版 物：《Biosurface and Biotribology》 (生物表面与生物摩擦学（英文）)

年 卷 期：2023年第9卷第4期

页      面：161-168页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：Japan Society for the Promotion of Science Grant/Award Number:JP19K12798 

主　　题：biointerface biological reaction biological response biomaterials biomedical application biosurface 

摘      要：Co-Cr-Mo ally(CCM)is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion ***,the influence of surface roughness on cell attachment and proliferation remains *** study aimed to elucidate the impact of surface roughness of CCM on the attachment and proliferation of *** samples with different values of surface rouges were prepared by ***3T3-E1 mouse osteoblasts were used for cell culture *** attachment,morphology,and the expression of actin stress fibres,vinculin,and distri-bution of yes-associated protein were *** results suggest that surface rough-ness does not significantly affect cell attachment and proliferation on CCM,unlike on *** implies that other properties of CCM,such as physicochemical properties,may play a more substantial role in modulating cell *** study provides important insights into the design of CCM implants,suggesting that approaches beyond tuning surface roughness may be necessary to improve biocompatibility and osseointegration.