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An autopsy case of granulocyte-colony-stimulating-factor- producing extrahepatic bile duct carcinoma

World Journal of Gastroenterology 2008年第18期14卷 2924-2927页

作者： satoru matsuyama Tomonori Shimonishi Hirofumi Yoshimura Kensaku Higaki Kenji Nasu Mariko Toyooka Shigehisa Aoki Keiko Watanabe Hajime Sugihara Department of Surgery Takagi Hospital141-11Sakemi Ohkawa-CityFukuoka 831-0016Japan Department of Pathology Takagi Hospital141-11SakemiOhkawa-City Fukuoka 831-0016 Japan Department of Pathology and Biodefence Faculty of Medicine Saga University 5-1-1 Nabeshima Saga-City Saga 849-8501 Japan

A 79-year-old man was referred to this department due to the presence of extrahepatic bile duct carcinoma with a tumor at the left chest wall. The lesion was suspected to be a metastasis of bile duct carcinoma to the left wall, however, computed tomography (CT) revealed no regional lymph node or liver metastases. In addition, cytological and pathological examinations did not show malignancy. At the time of admission, the white blood cell count was 21 460 cells/μL (neutrophils, 18 240 cells/μL) and this elevated to 106 040 before death. In addition, serum granulocyte colony-stimulating factor (G-CSF) was elevated. At 28 d after admission, the patient died. An autopsy showed a poorly differentiated adenocarcinoma with sarcomatous change, which had slightly invaded into the pancreas around the bile duct, and was found in the distal bile duct with multiple metastases to the chest wall, lung, kidney, adrenal body, liver, mesentery, vertebra and mediastinal and para-aortic lymph nodes, without locoregional lymph node and liver metastasis. The cancer cells showed positive immunohistochemical staining for anti-G-CSF antibody. This is believed to be the first report of an extrahepatic bile duct carcinoma that produces G-CSF. Since G-CSF-producing carcinoma and sarcomatous change of the biliary tract leads to poor prognosis, early diagnosis and treatment are needed. When infection is ruled out, the G-CSF in serum should be examined. In addition, examinations such as bonescintigraphy and chest CT should also be considered for distant metastasis.

关键词： Bile duct carcinoma Granulocyte colony-stimulating factor Multiple metastases Autopsy

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Evaluation of <i>in vivo</i>migration of chondrocytes from tissue-engineered cartilage that was subcutaneously transplanted in mouse model

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Open Journal of Regenerative Medicine 2013年第4期2卷 93-98页

作者： Mariko matsuyama Yuko Fujihara Ryoko Inaki satoru Nishizawa satoru Nagata Tsuyoshi Takato Kazuto Hoshi Department of Cartilage & Bone Regeneration (Fujisoft) Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Sensory and Motor System Medicine The University of Tokyo Hospital Tokyo Japan NAGATA Microtia and Reconstructive Plastic Surgery Clinic Toda Saitama Japan Translational Research Center The University of Tokyo Hospital Tokyo Japan

For regenerative medicine, clarification of in vivo migration of transplanted cells is an important task to secure the safety of transplanted tissue. We had prepared tissue-engineered cartilage consisting of cultured chondrocytes with collagen hydrogel and a biodegradable porous polymer, and we clinically applied it for treatment of craniofacial anomaly. To verify the safety of this tissue-engineered cartilage, we had syngenically transplanted the tissue-engineered cartilage using chondrocytes harvested from EGFP-transgenic mice into subcutaneous pocket of wild type mice, and investigated localizations of transplanted chondrocytes in various organs including cerebrum, lung, liver, spleen, kidney, auricle, gastrocnemius, and femur. After 8 to 24 weeks of the transplantation, accumulation of cartilaginous matrices was observed in tissue-engineered cartilage, while EGFP-positive transplanted chondrocytes were localized in this area. Otherwise, no EGFP was immunohistochemically detected in each organ, suggesting that subcutaneously-transplanted chondrocytes do not migrate to other organs through the circulation. In cartilage tissue engineering using cultured chondrocytes, risk for migration and circulation of transplanted cells seemed negligible, and that ectopic growth of the cells was unlikely to occur, showing that this is safe technique with regard to the in vivo migration of transplanted cells.

关键词： Cartilage Tissue Engineering Chondrocyte Migration

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Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia:a case study from Malaysia

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Ecosystem Health and Sustainability 2021年第1期7卷 300-317页

作者： Ee Lean Thiang Choon Weng Lee Hideshige Takada Kanako Seki Ayaka Takei satoru Suzuki Aijun Wang Chui Wei Bong Institute of Ocean and Earth Sciences University MalayaKuala LumpurMalaysia Institute for Advanced Studies University MalayaKuala LumpurMalaysia Institute of Biological Sciences University MalayaKuala LumpurMalaysia Laboratory of Organic Geochemistry Tokyo University of Agriculture and TechnologyFuchuTokyoJapan Center for Marine Environmental Studies Ehime UniversityMatsuyamaEhimeJapan Third Institute of Oceanography State Oceanic AdministrationXiamenChina

Background and Objectives:One major source of antibiotic contamination in the sea is from *** monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes(tet(M),sul1,sul2 and sul3)in aquaculture farms in Peninsular ***:Antibiotic residues and resistance genes were quantified using high-performance liquid chromatography and real-time PCR *** quotients in European technical guidance document on risk assessment was used to assess the potential environmental ***:We detected 23 antibiotics with tetracyclines,sulfonamides and quinolones were the most frequently detected classes,indicating a wide distribution of antibiotics in Malaysian aquaculture *** dendrogram and heatmap revealed three groups of antibiotic concentration patterns but with no differences in the types of antibiotics usage among aquaculture *** ARGs(10^(−3)copies/16S)were detected in>90%of the sites except for ***,enrofloxacin,norfloxacin and lincomycin posed risks to cyanobacteria and algae in Kelantan,Perak and ***:Relative to Asian aquaculture farms,the residues detected here were at low or moderate levels except for *** study will be useful to develop effective management of aquaculture wastewater in order to mitigate antibiotic pollution and transmission of ARGs to humans through the food chain.

关键词： Antibiotic residues resistance genes risk assessment aquaculture

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减少向环境中释放抗生素和抗生素耐药基因的管理措施

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环境与职业医学 2014年第1期31卷 72-77页

作者： Amy Pruden D.G.Joakim Larsson Alejandro Amézquita Peter Collignon Kristian K.Brandt David W.Graham James M.Lazorchak satoru Suzuki Peter Silley Jason R.Snape Edward Topp Tong Zhang Yong-Guan Zhu 何蓉汪源张伊人金泰廙 Department of Civil and Environmental Engineering Virginia TechBlacksburgVirginiaUSA Institute for Biomedicine The Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden Unilever-Safety & Environmental Assurance Centre SharnbrookUnited Kingdom Australian National University CanberraAustralia Canberra Hospital CanberraAustralia Department of Plant and Environmental Sciences University of CopenhagenFrederiksbergDenmark School of Civil Engineering and Geosciences Newcastle UniversityNewcastle upon TyneUnited Kingdom Office of Research and Development U.S. Environmental Protection AgencyCincinnatiOhioUSA Center for Marine Environmental Studies Ehime UniversityMatsuyamaEhimeJapan MB Consult Limited SouthamptonUnited Kingdom University of Bradford BradfordUnited Kingdom AstraZeneca Brixham Environmental LaboratoryBrixhamUnited Kingdom Agriculture and Agri-Food Canada LondonOntarioCanada Department of Civil Engineering University of Hong Kong Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of Sciences

[背景]全球越来越关注污染土壤、水环境对抗生素耐药性产生和蔓延的作用。[目的]本研究的目的是确定那些可以减少抗生素和抗生素耐药性经环境途径传播影响因素的管理措施,以最终达到延长抗生素使用寿命的目标。此外还研究了实施这些措... 详细信息

[背景]全球越来越关注污染土壤、水环境对抗生素耐药性产生和蔓延的作用。[目的]本研究的目的是确定那些可以减少抗生素和抗生素耐药性经环境途径传播影响因素的管理措施,以最终达到延长抗生素使用寿命的目标。此外还研究了实施这些措施的激励和阻碍因素。[方法]着重研究有关农业源头限制,生活、医院和工业废水处理,以及水产养殖三方面的管理措施。[讨论]我们确定了若干措施,如养份管理、径流控制和基础设施升级。凡适当处,可提供世界不同地区的典型实例。研究还强调了监测和验证管理策略有效性的重要性。最后,介绍了一则瑞典的案例研究,展示了通过沟通来发动利益相关方参与和促进行动的重要作用。[结论]在许多情况下,可以花费很少或根本不花费成本来减少抗生素和抗生素耐药性细菌的环境释放。一些管理措施与现有的政策和目标协同作用。预期的效益是延长现有和未来的抗生素使用寿命。虽然往往难以量化所降低的风险,但是全球抗生素耐药性相关发病率和死亡率加速增长,这一情况的严重程度强烈表明采取行动的必要性。

关键词：农业抗生素制造抗生素耐药性水产养殖畜牧粪便管理政策废水处理

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