Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia:a case study from Malaysia

作     者：Ee Lean Thiang Choon Weng Lee Hideshige Takada Kanako Seki Ayaka Takei Satoru Suzuki Aijun Wang Chui Wei Bong 

作者机构：Institute of Ocean and Earth SciencesUniversity MalayaKuala LumpurMalaysia Institute for Advanced StudiesUniversity MalayaKuala LumpurMalaysia Institute of Biological SciencesUniversity MalayaKuala LumpurMalaysia Laboratory of Organic GeochemistryTokyo University of Agriculture and TechnologyFuchuTokyoJapan Center for Marine Environmental StudiesEhime UniversityMatsuyamaEhimeJapan Third Institute of OceanographyState Oceanic AdministrationXiamenChina 

出 版 物：《Ecosystem Health and Sustainability》 (生态系统健康与可持续性（英文）)

年 卷 期：2021年第7卷第1期

页      面：300-317页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 082803[工学-农业生物环境与能源工程] 08[工学] 0828[工学-农业工程] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

基　　金：This work was supported by a research grant from the Malaysian Ministry of Higher Education[HiCoE Phase II(IOES-2014D),FP048-2013A,SF022-2013] University Malaya[PG309-2016A,IF030A-2017] KAKENHI,JSPS[25257402,16H01782,17H04476] 

主　　题：Antibiotic residues resistance genes risk assessment aquaculture 

摘      要：Background and Objectives:One major source of antibiotic contamination in the sea is from *** monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes(tet(M),sul1,sul2 and sul3)in aquaculture farms in Peninsular ***:Antibiotic residues and resistance genes were quantified using high-performance liquid chromatography and real-time PCR *** quotients in European technical guidance document on risk assessment was used to assess the potential environmental ***:We detected 23 antibiotics with tetracyclines,sulfonamides and quinolones were the most frequently detected classes,indicating a wide distribution of antibiotics in Malaysian aquaculture *** dendrogram and heatmap revealed three groups of antibiotic concentration patterns but with no differences in the types of antibiotics usage among aquaculture *** ARGs(10^(−3)copies/16S)were detected in90%of the sites except for ***,enrofloxacin,norfloxacin and lincomycin posed risks to cyanobacteria and algae in Kelantan,Perak and ***:Relative to Asian aquaculture farms,the residues detected here were at low or moderate levels except for *** study will be useful to develop effective management of aquaculture wastewater in order to mitigate antibiotic pollution and transmission of ARGs to humans through the food chain.