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Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer

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World Journal of Gastroenterology 2011年第15期17卷 2003-2006页

作者： Takaaki Fujii Yuichi Tabe Reina Yajima satoru Yamaguchi Soichi Tsutsumi Takayuki Asao Hiroyuki Kuwano Depart ment of General Surgical Science Graduate School of Medicine Gunma University Gunma 371-8511 Japan

AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive ***: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.

关键词： Extracapsular invasion Lymph node Metastasis Colorectal cancer Risk factor Adjuvant therapy

Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C:A randomized controlled clinical trial

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World Journal of Gastroenterology 2006年第8期12卷 1265-1269页

作者： Hideyuki Suzuki Hitoshi Takagi Naondo Sohara Daisuke Kanda satoru Kakizaki Ken Sato Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineShowa-machi 3-39MaebashiGunma 371-8511Japan

AIM： To study the therapeutic effect of interferon （IFN） and ribavirin with zinc supplement on patients with chronic hepatitis C viral （HCV） infection. METHODS： A total of 102 patients confirmed histologically to have chronic HCV infection with genotype lb and more than 100 KIU/mL of HCV were randomly assigned to each arm of the study and each received 10 million units of pegylated interferon （IFN- alpha-2b） daily for 4 wk followed by the same dose every other day for 20 wk plus ribavirin （600 or 800 mg/d depending on body weight）, with or without polaprezinc （150 mg/d） orally for 24 wk. The primary endpoint was sustained virological response （SVR） defined as negative HCV-RNA in the serum 6 mo after treatment. RESULTS： There were no differences in the clinical background between the two groups except for more females in the dual therapy group than in the other group （P〈 0.05）. SVR was observed in 33.3% of the triple therapy group and 33.3% of the dual therapy group. The side effects were almost the same in both groups except for gastrointestinal symptoms, which were less in the triple therapy group （P= 0.019）. CONCLUSION： Considered together, triple therapy of zinc plus IFN and ribavirin for HCV infection patients with genotype lb and high viral load is not better than dual therapy except for lower incidence of gastrointestinal side effects.

关键词： HCV Zinc Interferon Ribavirin

Initial 3-month dynamics of dehydroepiandrosterone sulfate can predict responsiveness to primary androgen deprivation therapy in patients with metastatic prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 635-636页

作者： Akihiro Yano Makoto Kagawa Hideki Takeshita Yohei Okada Makoto Morozumi satoru Kawakami Department of Urology Saitama Medical CenterSaitama Medical UniversityKawagoeSaitama 350-8550Japan.

Dear Editor,Intensive treatments such as primary androgen deprivation therapy(pADT)plus docetaxel or abiraterone acetate are reportedly beneficial in metastatic prostate cancer(mPCa)patients with high-volume disease or high-risk features,respectively.1,2 High-volume or high-risk features are determined exclusively via pretreatment *** patient responsiveness to pADT,which is one of the major determinants of survival in these patients,would be advantageous with regard to making primary treatment *** an initial 3-month period is possible,short-term serum parameter dynamics can be used to predict pADT ***-specific antigen(PSA)and alkaline phosphatase(ALP)dynamics have been indicated as potential predictors.3,4 Although pADT can reportedly cause a 20%-30%decrease in adrenal androgen levels,5 it is not known whether the dynamics of adrenal androgens shortly after the initiation of pADT can predict pADT *** aim of the current study was to identify predictors of pADT responsiveness among pretreatment parameters and 3-month dynamics(D3m)of serum parameters including the adrenal androgen,dehydroepiandrosterone sulfate(DHEAS).

关键词： patients metastatic cancer

Secretome-microRNA and anti-proliferative APRO family proteins as cancer prevention and stem cell research strategies

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BIOCELL 2022年第5期46卷 1163-1167页

作者： YUKA IKEDA NOZOMI NAGASE AI TSUJI KURUMI TANIGUCHI YASUKO KITAGISHI satoru MATSUDA Department of Food Science and Nutrition Nara Women’s UniversityNara630-8506Japan

Stemness of cancer cells contains limitless self-renewal *** the purpose of proliferation,secretome might exert its effects via the paracrine *** microRNAs enclosed in the secretome of cancer stem cells could regulate the expression of anti-proliferative APRO family *** biological functions of APRO family proteins seems to be quite intricate,however,which might be a key modulator of microRNAs,then could regulate the proliferation of cancer *** addition to affecting proliferation/differentiation during cellular development,APRO family proteins might also play an imperious role on keeping homeostasis in healthy stem cells under a physiological ***,relationship between the microRNAs and the APRO family proteins has attracted much attention in the field of cancer research and regenerative ***,we have described the molecular mechanism behind this interplay that have a potential role in the future promising tools with targeting APRO family proteins for the medical applications.

关键词： Cancer Stem cell Secretome Proliferation APRO family microRNA

Pyloric-gland metaplasia may be an origin of cancer and intestinal metaplasia with possible CDX2 expression

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Gastroenterology Report 2021年第4期9卷 370-373,I0003页

作者： Kazuyoshi Yagi Atsunori Tsuchiya satoru Hashimoto Taisuke Kato Osamu Onodera Shuji Terai Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalNiigataJapan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigataJapan Department of System Pathology for Neurological Disorders Brain Science BranchBrain Research InstituteNiigata UniversityNiigataJapan Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Introduction The majority of cases of gastric cancer are thought to develop due to chronic inflammation from Helicobacter pylori(***)infection leading to intestinal metaplasia,termed the intestinal metaplasia–dysplasia–cancer sequence[1].Chronic inflammation from *** infection causes mucin core protein 6-positive(MUC6t)pyloric-gland metaplasia;however,its origin is *** MUC6t pyloric-gland metaplasia is similar to spasmolytic polypeptide-expressing metaplasia in mouse studies[2–4].

关键词：肠上皮化生幽门腺 Helicobacter CDX2

利用强子探针研究奇特原子核的点质子分布半径及强子探针效应

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Science Bulletin 2024年第11期69卷 1647-1652页

作者：张寂潮孙保华 Isao Tanihata Rituparna Kanungo Christoph Scheidenberger satoru Terashima 王枫 Frederic Ameil Joel Atkinson Yassid Ayyad Soumya Bagchi Dolores Cortina-Gil Iris Dillmann Alfredo Estradé Alexey Evdokimov Fabio Farinon Hans Geissel Giulia Guastalla Rudolf Janik Satbir Kaur Ronja Knöbel Jan Kurcewicz Yury Litvinov Michele Marta Magdalena Mostazo Ivan Mukha Chiara Nociforo Hooi Jin Ong Stephane Pietri Andrej Prochazka Branislav Sitar Peter Strmen Maya Takechi Junki Tanaka Jossitt Vargas Helmut Weick John Stuart Winfield School of Physics Beihang UniversityBeijing 100191China Research Center for Nuclear Physics(RCNP) Osaka UniversityOsaka 567-0047Japan Astronomy and Physics Department Saint Mary’s UniversityHalifax B3H 3C3Canada TRIUMF Vancouver V6T 4A3Canada GSI Helmholtzzentrum für Schwerionenforschung Darmstadt D-64291Germany Justus-Liebig University Gießn 35392Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion ResearchGießn 35392Germany Universidad de Santiago de Compostela Santiago de Compostella E-15706Spain Department of Physics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India Faculty of Mathematics and Physics Comenius UniversityBratislava 84215Slovakia Department of Physics and Atmospheric Science Dalhousie UniversityHalifax B3H 4R2Canada

We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first *** from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both *** allows us to deduce proton radii(R_p)for the first time from the cross sections on *** identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen *** calls for further experimental and theoretical investigations.

关键词： Exotic nuclei Nuclear size Reaction cross section Glauber model Radioactive ion beam

Flexible Evanescent Wave Interference Lithography System for Sub-half-Wavelength Complex Relief Structures Fabrication

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Nanomanufacturing and Metrology 2021年第4期4卷 256-270页

作者： Yuki Torii Shuzo Masui Yuki Matsumoto Kunikazu Suzuki Masaki Michihata Kiyoshi Takamasu satoru Takahashi Department of Precision Engineering The University of TokyoHongo 7-3-1BunkyoTokyo 113-8656Japan Research Center for Advanced Science and Technology The University of TokyoKomaba 4-6-1MegroTokyo 153-8904Japan

Surface microstructures impart various useful properties to objects,for example,improving optical characteristics,wettability,and sliding *** is well known that biomimicking relief structures are effective in making such properties arise and have been studied to be applied to various ***,they are expected to be utilized not only for improving a particular property but also for adding more complex functions on a device's urface by fabricating different multi-functional structures on a single surface in the ***,to begin with,artificially fabricating such biomimicking special functional relief is *** typical feature of biomimicking surfaces is the dual-scale structure,the smaller one of which is less than 200 ***,in the case of realizing the more complex devices,it is necessary to fabricate various forms as changing process conditions *** this study,we proposed and developed a flexible evanescent wave interference lithography system as a novel fabrication method,which allows us to realize the fabrication of sub-half-wavelength complex relief ***,we theoretically analyzed the fundamental behavior of the fabricated structure and found that the proposed concept has the potential to realize one of the target complex ***,we developed the proposed system with high process flexibility,in which the number of beams,the azimuth angles,and the polarization can be simply ***,we validated the concept of the designed system by some experiments,where we fabricated dual-scale structures with 840-nm and 190-nm fringe patterns simultaneously.

关键词： Evanescent wave Biomimetics Interference lithography Micro fabrication Surface structure

Effects of Ethephon and Abscisic Acid Application on Ripening-Related Genes in ‘Kohi' Kiwifruit (Actinidia chinensis) on the Vine

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Horticultural Plant Journal 2017年第1期3卷 29-33页

作者： Kongsuwan Ampa Takanori Saito Katsuya Okawa Hitoshi Ohara satoru Kondo Graduate School of Horticulture Chiba University

The effects of ethephon and abscisic acid(ABA) application on ripening-related genes of pre-harvest ‘Kohi' kiwifruit(Actinidia chinensis) were studied to clarify the possibility of the fruit ripening on the vine. The fruits were treated on the vine at mature stage with 250 μL·L^(-1)ethephon or 100 μmol·L^(-1)ABA, and the expression levels of chlorophyll synthase(Ac CLS), chlorophyllase1(Ac CLH1), polygalacturonase(Ac PG), expansin(Ac EXP),β-amylase(Acβ-AM), sucrose synthase(Ac SUSY), MADS-box SEPALLATA4/RIPENING INHIBITOR-like(Ac SEP4/RIN) and FRUITFUL-like(Ac TDR4/FUL) genes were analyzed. The expression levels of Ac PG, Ac EXP, Acβ-AM, and Ac SUSY increased in the ethephon-treated fruit, but those of Ac CLH1 at 6and 9 days after treatment and Ac CLS decreased. Moreover, the expression levels of Ac SEP4/RIN and Ac TDR4/FUL, the latter of which is associated with ethylene biosynthesis, were higher in the ethephon-treated fruit. The expression level of each gene in ABA-treated fruit was not significantly different from that of the untreated control. The results suggest that ethephon application increases the expression levels of Ac PG,Ac EXP, Acβ-AM, Ac SUSY, Ac SEP4/RIN, and Ac TDR4/FUL in ‘Kohi' kiwifruit on the vine.

关键词： kiwifruit Actinidia chinensis ethephon ABA fruit ripening ethylene

Conjunctival cyst with apocrine hidrocystoma-like features:a case report

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 465-467页

作者： Takafumi Igarashi satoru Kase Yuka Suimon Emi Takakuwa Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 0608638Japan Department of Surgical Pathology Hokkaido University HospitalSapporo 0608638Japan

Dear Editor,I am Takafumi Igarashi from Hokkaido University Hospital,*** hidrocystoma is a benign cystic tumor arising in the apocrine sweat glands proposed by Mehregan^([1])in *** is likely that apocrine hidrocystoma arises in the uvula,ears,chest,and shoulders,as well as the (peri)ocular regions such as the eyelid,and sclera^([2-4]).

关键词： apo ocular likely