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2.0 Ga orogenic graphite deposits and associated 13C-enriched meta-carbonate rocks from South China Craton:Implications for global Lomagundi event

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Geoscience Frontiers 2022年第4期13卷 181-192页

作者： Yihe Li Madhusoodhan Satish-Kumar sasidharan kiran Chuanhui Wan Jianping Zheng Institute of Geophysics and Geomatics Hubei Subsurface Multi-scale Imaging Key LaboratoryChina University of GeosciencesWuhan 430074China Department of Geology Faculty of ScienceNiigata UniversityNiigata 950-2181Japan Graduate School of Science and Technology Niigata UniversityNiigata 950-2181Japan Eighth Geological Brigade of Hubei Xiangyang 441000China School of Earth Sciences State Key Laboratory of Geological Processes and Mineral ResourcesChina University of GeosciencesWuhan 430074China

The Lomagundi(-Jatuli)event,characterized by extremely high positive global inorganic carbon isotope excursion at about 2.2 billion years ago,is pivotal in investigating the causes and consequences of great oxygenation event,inventory and sequestration of carbon on the Earth’s surface,evolution of life,and more profoundly tectonic control on Earth’s ***,the reasons that caused the isotopic excursion are not resolved ***,we report the discovery of meta-carbonate rocks with distinct positive carbon isotopic excursion from the Paleoproterozoic continental collision zone of the Kongling Complex,South China *** δ^(13)C_(V-PDB) values for meta-carbonate rocks show positive values in the range from+5.5‰to+11.6‰,whereas the δ^(13)C_(V-PDB) values of associated graphite deposits range from-25.8‰to-9.5‰.Zircon U-Pb-Hf isotopes from zircon-bearing meta-carbonate sample yielded weighted average _(207)Pb/_(206)Pb age of 2001.3±9.5 Ma,with correspondingε_(Hf)(t)range from-7.05 to-3.16,comparable to the values of local 2.9–2.6 Ga basement *** characteristics of meta-carbonate rocks,such as their rare earth element patterns and the trace element parameters of La,Ce,Eu,and Gd anomalies and Y/Ho ratio,suggest that the carbonate deposition took place in passive continental margin in association with large volumes of organic *** extensive graphite deposits from Kongling Complex in South China Craton,their equivalents in the North China Craton and elsewhere across the globe prove that the burial of ^(12)C-enriched organic carbon has eventually resulted in the global enrichment of ^(13)C in the atmospheric CO_(2),which is recorded in the marine carbonate *** mass balance estimates indicate that more than half of the organic carbon was buried during the oceanic ***,the observed global shift could be directly related to the continent collision event in greater China,thus resolving the long-standing paradox of the Lomag

关键词： Positive carbon isotope excursion Lomagundi(-Jatuli)event Kongling Complex South China Craton Marine carbonate

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MicroRNA deregulation and cancer and medicinal plants as microRNA regulator

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 47-53页

作者： Nathan Shanmugapriya Sreenivasan sasidharan Institute for Research in Molecular Medicine Universiti Sains Malaysia11800 GelugorPulau PinangMalaysia

MircroRNAs(mi RNAs)are short non-coding RNAs with a length of approximately 20-22 nucleotides,which interact with their target mRNAs at 3’-untranslated region by partial *** miRNAm-RNA interaction leads to induction of mRNA degradation and eventually translational ***,mi RNAs play an important role in virtually all cellular processes,especially differentiation,proliferation,migration,and *** deregulation of miRNAs may lead to serious diseases including *** is mounting evidence demonstrating the participation of mi RNA regulation during *** this review,we discuss an updated miRNA biogenesis,mechanisms involved in their deregulation,and their role in cancer *** review also summarizes updated information on potential medicinal plants which regulate miRNA expression as a promising molecular miRNA therapeutic approach for cancers.

关键词： MiRNA Biogenesis Cancer Medicinal plants

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Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines

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Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 826-829页

作者： Soundararajan Vijayarathna Sreenivasan sasidharan Institute for Research in Molecular Medicine(INFORMM) Universiti Sains Malaysia

Objective:To investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7and Vero ***:In vitro cytotoxicity was evaluated in by MTT *** morphological changes were observed by using light ***:The MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on *** alteration of the cell lines after exposure with lilaeis guineensis extract were observed under phase contrast microscope in the dose dependent ***:The results suggest the probable use of the Elaeis guineensis methanol extract in preparing recipes for cancer-related *** studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.

关键词： Cytotoxicity Growth inhibitory Elaeis guineensis Cell morphology

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In vivo toxicity study of Lantana camara

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 230-232页

作者： Badakhshan Mahdi Pour Sreenivasan sasidharan Department of Biotechnology Faculty of Applied SciencesAIMST University Institute for Research in Molecular Medicine(INFORMM) Universiti Sains Malaysia

Objective:To investigate the toxicity of methanol extract of various parts(Root,Stem,Leaf, Flower and Fruit) of Lantana camara(***) in Artemia ***:The methanol extracts of *** were tested for in vivo brine shrimp lethality ***:All the tested extract exhibited very low toxicity on brine shrimp *** results showed that the root extract was the most toxic part of *** and may have potential as anticancer ***: Methanolic extract of *** is relatively safe on short-term exposure.

关键词： Lantana camara Artemia salina Toxicity

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Pharmacological activity,phytochemical analysis and toxicity of methanol extract of Etlingera elatior(torch ginger) flowers

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 769-774页

作者： Subramanion Jo Thy Lachumy Sreenivasan sasidharan Velio Sumathy Zakaria Zuraini School of Distance Education Universiti Sains MalaysiaMinden 11800Pulau PinangMalaysia Institute for Research in Molecular Medicine(INFORMM) Universiti Sains MalaysiaMinden 11800Pulau PinangMalaysia

Objective:To elucidate its pharmacological activities and medicinal potential of extract of Etlingera elatior（***）.Methods:Phytochemical screening of the flower extract was done to determine the phytochemical in the *** pharmacological study included the determination of antimicrobial activity and minimum inhibitory concentration（MIC） of metabolic flower *** antimicrobial activity of the extract was tested against medically important bacterial,yeast and fungal *** from that,the methanolic extract of *** flower was further tested in vivo toxicity using the brine shrimp lethality ***,the flower extract was qualitatively screened for their free radical scavenging activity by 2,2-diphenyl-1- picrylhydrazyl radical（DPPH） ***:The extract was effective on tested microorganisms and MIC values were in the range of 1.563-50.000 mg/*** brine shrimp lethality test exhibited no significant toxicity(LC50= 2.52 mg/mL) against Artemia *** *** flower extract with high LC50 value signified that this plant is not toxic to *** the phytochemical screening of the flower extract revealed the presence of the following compounds: flavonoids,terpenoids,saponin,tannins and carbohydrates whereas,alkaloids,anthraquinone and reducing sugars were *** concentration of the flower extract required for 50% inhibition of DPPH radical scavenging effect(IC50) were 9.14 mg/mL and 8.08 mg/mL for butylated hydroxytoluene 8.08 mg/***:These findings indicate that the extract of *** flower possesses pharmacological properties and potential to develop natural products based pharmaceuticals products.

关键词： Etlingera elatior Pharmacological activity Phytochemical analysis Artemia salina

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Antioxidant activity and phytochemical screening of the methanol extracts of Euphorbia hirta L

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 386-390页

作者： Abu Arra Basma Zuraini Zakaria Lacimanan Yoga Latha Sreenivasan sasidharan Biology Division School of Distance EducationUniversiti Sains MalaysiaUSM 11800Pulau PinangMalaysia Institutes for Research in Molecular Medicine(INFORMM) Universiti Sains MalaysiaUSM 11800Pulau PinangMalaysia

Objective:To assess antioxidant activities of different parts of Euphorbia hirta（***）,and to search for new sources of safe and inexpensive ***:Samples of leaves,stems, flowers and roots from *** were tested for total phenolic content,and flavonoids content and in vitro antioxidant activity by diphenyl-1-picrylhydrazyl（DPPH） assay and reducing power was measured using cyanoferrate ***:The leaves extract exhibited a maximum DPPH scavenging activity of（72.96±0.78）%followed by the flowers,roots and stems whose scavenging activities were（52.45±0.66）%,（48.59±0.97）%,and（44.42±0.94）%,*** standard butylated hydroxytoluene（BHT） was（75.13±0.75）%.The IC50,for leaves,flowers,roots,stems and BHT were 0.803,0.972,0.989,1.358 and 0.794 mg/mL,*** reducing power of the leaves extract was comparable with that of ascorbic acid and found to be dose dependent. Leaves extract had the highest total phenolic content[（206.17±1.95） mg GAE/g],followed by flowers,roots and stems extracts which were（117.08±3.10） mg GAE/g,（83.15±1.19） mg GAE/g,and （65.70±1.72） mg GAE/g,*** the other hand,total flavonoids content also from leave had the highest value[（37.970±0.003） mg CEQ/g],followed by flowers,roots and stems extracts which were（35.200±0.002） mg CEQ/g,（24.350±0.006） mg CEQ/g,and（24.120±0.004） mg CEQ/ g,*** bioautography analysis of phenolic and antioxidant substance revealed phenolic *** screening of *** leaf extract revealed the presence of reducing sugars,terpenoids,alkaloids,steroids,tannins,flavanoids and phenolic compounds. Conclusions:These results suggeste that *** have strong antioxidant *** study is necessary for isolation and characterization of the active antioxidant agents,which can be used to treat various oxidative stress-related diseases.

关键词： Antioxidant Euphorbia hirta L DPPH scavenging Reducing power Total phenolics content Total flavonoids content Phytochemical screening

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A transmission electron microscopy study of the diversity of Candida albicans cells induced by Euphorbia hirta *** extract in vitro

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 20-22页

作者： Abu Arra Basma Zakaria Zuraini Sreenivasan sasidharan Biology Division School of Distance EducationUniversiti Sains Malaysia Institutes for Research in Molecular Medicine(INFORMM) Universiti Sains Malaysia

Objective:To determine the major changes in the microstructure of Candida albicans(C. albicans) after treatment with Euphorbia hirta(***) *** ***:Transmission electron microscopy was used to study the ultrastructural changes caused by *** extract on C. albicans cells al various exposure ***:It was found that the main abnormalities were the alterations in morphology,lysis and complete collapse of the yeast cells after 36 h of exposure to the *** the control cultures showed a typical morphology of Candida with a uniform central density,typically structured nucleus,and a cytoplasm with several elements of endomembrane system and enveloped by a regular,intact cell ***:The significant antifungal activity shown by this methanol extract of *** *** its potential against infections caused by *** extract may be developed as an anticandidal agent.

关键词： Candida albicans Euphorbia hirta L. Transmission electron microscopy Anticandidal agent

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Antimicrobial drug resistance of Staphylococcus aureus in dairy products

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 130-132页

作者： sasidharan S Prema B Yoga Latha L Institute for Research in Molecular Medicine(INFORMM) Universiti Sains Malaysia Department of Biotechnology Faculty of Applied SciencesAIMST UniversityJalan Bedong-SemelingBatu 3 1/2Bukit Air Nasi

Objective:To evaluate the prevalence of multidrug resistant Staphylococcus aureus(***) in dairy ***:Isolation and identification of *** were performed in 3 dairybased food *** isolates were tested for their susceptibility to 5 different common antimicrobial ***:Of 50 samples examined,5(10%) were contaminated with 5. ***,the 5 isolates were subjected to antimicrobial resistance pattern using five antibiotic discs(methicillin,vancomycin,kanamycin,chloramphenicol and tetracycline).Sample 29 showed resistance to methicillin and *** 18 showed intermediate response to *** other samples were susceptible to all the antibiotics ***:The results provide preliminary data on sources of food contamination which may act as vehicles for the transmission of antimicrobial-resistant ***,it enables us to develop preventive strategies to avoid the emergence of new strains of resistant ***.

关键词： Antimicrobial drug resistance Staphylococcus aureus Milk Dairy product

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Complementary and Alternative Medicine-related Drug-induced Liver Injury in Asia

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Journal of Clinical and Translational Hepatology 2019年第3期7卷 263-274页

作者： Cyriac Abby Philips Philip Augustine sasidharan Rajesh Praveen Kumar Y Deepak Madhu The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Gastroenterology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Gastroenterology Government Medical CollegeThrissurKeralaIndia Gastroenterology Aster MIMSCalicutKeralaIndia

The use of complementary and alternative medicines(CAMs)for treatment of acute and chronic diseases is on the rise world over,especially in Asian countries,and mostly in China and ***-induced liver injury(DILI)due to CAM is increasingly reported in the literature from multiple centers all around the world and with large-number patient series published from the West,mostly based on nation-wide DILI networks and multicenter *** DILI networks are lacking among major Asian countries with high incidence of CAM *** medical societies dealing with drug toxicity,CAM practice and hepatobiliary disease have adopted an integrated approach to establishing identification,diagnosis and treatment of CAM-related DILI,representing a systematic approach that could be iterated by other countries for improving patient *** this exhaustive review,we provide published data on CAM-related DILI in Asia,with detail on incidences along with analysis of patient population and their clinical *** and clear discussion on commonly implicated CAM agents in major Asian countries and associated chemical and toxicology analyses as well as descriptions of liver biopsy findings are discussed with future directions.

关键词： CAM Herbals Ayurveda Chinese DILI Hepatitis Cirrhosis ACLF Liver biopsy

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Outcomes and Toxicology of Herbal Drugs in Alcoholic Hepatitis-A Single Center Experience from India

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 329-340页

作者： Cyriac Abby Philips sasidharan Rajesh Tom George Rizwan Ahamed Sandeep Kumbar Philip Augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia Interventional Radiology Department of Gastroenterology and HepatologyCochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia Gastroenterology and Advanced G.I.Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterKochiKeralaIndia

Background and Aims:We aimed to study clinical out-comes and liver biopsy features of alcoholic hepatitis(AH)patients on complementary and alternative medicines(CAMs)and to analyze the retrieved drugs for chemical and toxic components linked to drug-induced liver ***:We retrospectively assessed clinical,biochemical and liver bi-opsy features of AH patients on CAM with drug-induced liver injury(AH-CAM,n=27)and compared them to a control group(classical AH,n=29)on standard of *** without liver biopsy evaluation and other causes for liver dis-ease were *** of the CAMs(n=42)from pa-tients were retrieved and assessed for chemical and ***:All were males,and significantly worse clinical pre-sentation,biochemical severity,and liver disease scores were notable in patients with *** Ayurve-dic-polyherbal formulations were the most commonly used *** liver histology,varying grades of severe-necrosis,severe hepatocellular,canalicular,cholangiolar cholestasis with predominant lymphocytic-portal-inflammation and varying grades of interface-hepatitis were noted in *** of CAMs revealed presence of heavy metals up to 100,000 times above detectable range and adulter-ants,such as antibiotics,chemotherapy agents,nonsteroi-dal anti-inflammatory drugs,alcohols,antidepressants,anxiolytics,and recreational *** follow up,a signifi-cantly higher number of patients with AH on CAM died at end of 1,3-and-6-months compared to controls(37%vs.83%,29%vs.62%,18%vs.52%respectively;p<0.001).Conclusions:Patients with AH and CAM-related drug-induced liver injury have extremely poor short-term survival in the absence of liver transplantation compared to those patients with AH on evidence-based *** transplant referral and educating on and curbing of CAM use in severe liver disease through strict monitoring of unregulated traditional health practices can help ease the burden of liver-related death.

关键词： Hepatitis Alcohol CAM DILI Ayurveda

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