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Unfolded protein response in myelin disorders

Neural Regeneration Research 2020年第4期15卷 636-645页

作者： Wensheng Lin sarrabeth stone Department of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Translational Neuroscience University of MinnesotaMinneapolisMNUSA

Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions.Nevertheless,persistent,unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells.Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin,including multiples sclerosis,Charcot-Marie-Tooth disease,Pelizaeus-Merzbacher disease,vanishing white matter disease,spinal cord injury,tuberous sclerosis complex,and hypoxia-induced perinatal white matter injury.In this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders.

关键词： axon ER multiples sclerosis myelin oligodendrocyte Schwann cell spinal cord injury UPR

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Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2018年第9期13卷 1507-1515页

作者： Yuan Yue sarrabeth stone Wensheng Lin Department of Neuroscience University of Minnesota Institute for Translational Neuroscience University of Minnesota

The transcription factor nuclear factor κB（NF-κB） plays major roles in inflammatory diseases through regulation of inflammation and cell viability.Multiple sclerosis（MS） is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system（CNS）.It has been shown that NF-κB is activated in multiple cell types in the CNS of MS patients,including T cells,microglia/macrophages,astrocytes,oligodendrocytes,and neurons.Interestingly,data from animal model studies,particularly studies of experimental autoimmune encephalomyelitis,have suggested that NF-κB activation in these individual cell types has distinct effects on the development of MS.In this review,we will cover the current literature on NF-κB and the evidence for its role in the development of MS and its animal model experimental autoimmune encephalomyelitis.

关键词： multiple sclerosis experimental autoimmune encephalomyelitis nuclear-factor κB T cell macrophage microglia astrocyte oligodendrocyte neuron

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