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Magnesium based implants for functional bone tissue regeneration–A review

Journal of Magnesium and Alloys 2022年第2期10卷 384-419页

作者： Gavish Uppal Amit Thakur Amit Chauhan saroj bala University Institute of Engineering and Technology Panjab Universitysector-14ChandigarhIndia Sri Guru Gobind Singh College Panjab Universitysector-26ChandigarhIndia

Magnesium(Mg)has emerged as one of the third-generation biomaterials for regeneration and support of functional bone *** is a better choice over permanent implants such as titanium,stainless steel,cobalt-chrome as magnesium is biodegradable and does not require a second surgery for its removal after bone tissue *** also reduces the risk of stress shielding as its elastic modulus is closer to human bone in comparison to permanent implants and other biodegradable metallic implants based on Iron and *** importantly,Mg is osteoconductive thus stimulates new bone formation and possess anti-bacterial properties hence reducing the risk of failure due to *** its advantages,a major concern with pure Mg is its rapid bio-corrosion in presence of body fluids due to which the mechanical integrity of the implant deteriorates before healing of the tissue is *** properties of Mg-based implants can be enhanced by mechanical processing,alloying,and topology *** reduce the corrosion/degradation rate,Mg has been alloyed with metals,reinforced with ceramics,and surface coatings have been applied so that the degradation rate of Mg-based implant matches with that of healing rate of bone *** present review discusses the effect of alloying elements and reinforcing ceramics on microstructure,mechanical,and corrosion properties of Mg-based orthopedic *** addition,the biocompatibility of Mg-based alloys,composites,and coatings applied on Mg implants has been ***,different methods of fabricating porous implants have been highlighted as making the implant porous facilitates the growth of new bone tissue through the pores.

关键词： Magnesium Biodegradable orthopedic implant Porous structure Osteo-conductive Antibacterial

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