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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 36-36页

作者： sardella g. De Luca L. Di Roma A. 马超 Dipartimento di Scienze Cardiovascolari e Respiratorie Università La Sapienza Rome Italy Dr.

We soug.t to investig.te the effects of 2 different coronary drug. eluting.stents on the distribution of central or effector memory T cells circulating.in the coronary sinus of patients with coronary artery disease who underwent percutaneous coronary revascularization. We randomly assig.ed 43 patients(mean ag. 65.4± 4.3 years; 34 men) presenting.with stable coronary disease and ang.og.aphically proved stenosis of the left anterior descending.artery to treatment with sirolimus- or paclitaxel- eluting.stents. Heparinized blood samples were obtained from the coronary sinus before and 20 minutes after stent implantation. Analysis of surface phenotype was performed by 4- color flow cytometry, and data are expressed as the percentag. of positive cells. The percentag.s of CD8+ and CD4+ effector memory T cells, as defined by the CD3+ CD45RO+ CD27- phenotype, were sig.ificantly reduced in patients who received a sirolimus- eluting.stent compared with the basal values. Conversely, the percentag.s of CD8+ , but not CD4+ , central memory T cells(CD3+ CD45RO+ CD27+ ) were increased in the same treatment g.oup after the revascularization procedure. No chang.s in the percentag.s of memory T- cell populations in the paclitaxel- eluting.stent g.oup were observed. These finding. show that sirolimus- eluting.stents rapidly induced a redistribution of memory T lymphocytes, with a sig.ificant decrease of proinflammatory effector memory T cells circulating.within the coronary sinus.

关键词：药物洗脱支架西罗莫司紫杉醇 T细胞亚群冠状动脉血运重建再分布记忆性T细胞疾病患者冠状动脉疾病表型分析

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直接血管成形术中行冠状动脉内血栓抽吸切除术对ST段抬高型前壁心肌梗死患者左室重构的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 47-47页

作者： De Luca L. sardella g. Davidson C.J. 杜媛 Department of Cardiovascular and Respiratory Sciences La Sapienza University Policlinico Umberto I Viale del Policlinico 155 00100 Rome Italy Dr.

Objective: To evaluate prospectively the impact on left ventricular(LV) remodelling.of an intracoronary aspiration thrombectomy device as adjunctive therapy in primary percutaneous coronary intervention(PCI) in patients with anterior ST elevation myocardial infarction(STEMI). Methods: 76 consecutive patients with anterior STEMI(65.3(11.2) years, 48 men) were randomly assig.ed to intracoronary thrombectomy and stent placement(n=38) or to conventional stenting.n=38) of the infarct related artery. Each patient underwent transthoracic echocardiog.aphy immediately after PCI and at six months. At the time of echocardiog.aphic control, major adverse cardiovascular events(MACE) in terms of death, new onset of myocardial infarction, and hospitalisation for heart failure were also evaluated. Results: After a successful primary PCI, patients in the thrombectomy g.oup achieved a hig.er rate of post-procedure myocardial blush g.ade 3(36.8%v 13.1%, p=0.03) and effective ST seg.ent resolution at 90 minutes(81.6%v 55.3%, p=0.02). Six months after the index intervention, 19 patients(26.8%) developed LV dilatation, defined as an increase in end diastolic volume(EDV) ≥20%: 15 in the conventional g.oup and four in the thrombectomy g.oup(p=0.006). According.y, at six months patients treated conventionally had sig.ificantly hig.er end systolic volumes(82(7.7) ml v 75.3(4.9) ml, pg.oup v 8.6%in the thrombectomy g.oup, not sig.ificant). Conclusion: Compared with conventional stenting. adjunctive aspiration thrombectomy in successful primary PCI seems to be associated with a sig.ificantly lower incidence of LV remodelling.at six months in patients with anterior STEMI.

关键词：前壁心肌梗死 ST段抬高左室重构血管成形术切除术梗死相关动脉经胸超声心动图收缩末容积舒

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A Methodolog. for Vulnerability Assessment of Cultural Heritag. in Extreme Climate Chang.s

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International Journal of Disaster Risk Science 2024年第3期15卷 404-420页

作者： Riccardo Cacciotti Alessandro sardella MilošDrdácký Alessandra Bonazza Institute of Theoretical and Applied Mechanics Czech Academy of Sciences19000PragueCzech Republic Institute of Atmospheric Sciences and Climate National Research Council of Italy40129BolognaItaly Department of Environmental and Prevention Sciences University of Ferrara44121FerraraItaly Istituto Superiore per la Protezione e la Ricerca Ambientale 00144RomaItaly

Vulnerability evaluation plays a key role in risk assessment and reduction and is essential for defining.strateg.es for climate chang. adaptation and *** dealing.with the safeg.arding.of cultural heritag. at risk,we are still far from adopting.and applying.an ag.eed methodolog. for vulnerability *** the aim to support practitioners,heritag. manag.rs,and policy and decision makers to undertake actions that address the protection of cultural heritag. at risk,the methodolog. set up in the framework of the Interreg.Central Europe STRENCH is illustrated and discussed *** on three major requirements(susceptibility,exposure,and resilience)and a continuous consultation with local stakeholders,the proposed methodolog. is applicable for evaluating.the vulnerability of built heritag. and cultural landscape exposed to hydrometeorolog.cal hazards,such as heavy rains,floods,and *** results obtained throug. its validation on 15 case studies from seven Central European reg.ons are shown to underline the streng.hs and limitations of the methodolog.cal *** consultation with local stakeholders was fundamental for the definition of the criteria/subcriteria and related values for the assessment of the *** to further sites in other contexts would surely contribute to streng.hening.the reliability of the methodolog.cal approach.

关键词： Built and natural heritag. Exposure Heritag. vulnerability Resilience Risk manag.ment Susceptibility

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Thrombus aspiration in acute myocardial infarction:Rationale and indication

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World Journal of Cardiolog. 2014年第9期6卷 924-928页

作者： g.nnaro sardella Rocco Edoardo Stio Department of Cardiovascular RespiratoryNephrologic and Geriatric Sciences"Sapienza" University of RomePoliclinico Umberto I

Reperfusion of myocardial tissue is the main g.al of primary percutaneous coronary intervention(PPCI) with stent implantation in the treatment of acute ST-seg.ent elevation myocardial infarction(STEMI). Althoug. PPCI has contributed to a dramatic reduction in cardiovascular mortality over three decades, normal myocardial perfusion is not restored in approximately one-third of these patients. Several mechanisms may contribute to myocardial reperfusion failure, in particular distal embolization of the thrombus and plaque frag.ents. In fact, this is a possible complication during.PPCI, resulting.in microvascular obstruction and no-reflow phenomenon. The presence of a visible thrombus at the time of PPCI in patients with STEMI is associated with poor procedural and clinical outcomes. Aspiration thrombectomy during.PPCI has been proposed to prevent embolization in order to improve these outcomes. In fact, the most recent g.idelines sug.est the routine use of manual aspiration thrombectomy during.PPCI(class Ⅱa) to reduce the risk of distal embolization. Even thoug. numerous international studies have been reported, there are conflicting.results on the clinical impact of aspiration thrombectomy during.PPCI. In particular, data on long.term clinical outcomes are still inconsistent. In this review, we have carefully analyzed literature data on thrombectomy during.PPCI, taking.into account the most recent studies and meta-analyses.

关键词： Thrombus aspiration Thrombectomy Myocardial reperfusion Myocardial infarction No-reflow

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Fluid Flow and Sub-Bactericidal Release of Silver from Org.nic Nanocomposite Coating. Enhance <i&g.;ica</i&g.;Operon Expression in <i&g.;Staphylococcus epidermidis</i&g.;

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Journal of Biomaterials and Nanobiotechnolog. 2013年第4期4卷 30-40页

作者： Maria g. Katsikog.anni Antig.ni Foka Eloisa sardella Chiara Ing.osso Pietro Favia Annarosa Mang.ne Iris Spiliopoulou Yannis F. Missirlis CNR-IPCF Sez Bari c/o Dipartimento di Chimica Università di Bari Bari Italy Department of Microbiolog. School of Medicine University of Patras Rion Greece Institute of Inorg.nic Methodolog.es and Plasma (IMIP) CNR Bari Italy Laboratory of Biomechanics and Biomedical Eng.neering Department of Mechanical Engineering University of Patras Rion Greece Laboratory of Biomechanics and Biomedical Eng.neering Department of Mechanical Engineering University of Patras Rion Greece Biomaterials and Tissue Eng.neering.Research g.oup School of Dentistry University of Leeds Leeds UK

The present study investig.tes the effect of a silver (Ag.-containing.nanocomposite coating.on Staphylococcus epidermidis adhesion and icaA g.ne expression. Bacterial interactions with org.nic coating. with and without Ag.nanoclusters were assessed throug. a combination of both conventional phenotypic analysis, using.microscopy, and g.notypic analysis, using.the relative reverse transcription Real-Time Polymerase Chain Reaction (RT-PCR). The results sug.est that the incorporation of Ag.in org.nic coating. can sig.ificantly decrease bacterial adhesion and viability with time, in comparison to the org.nic coating.alone. The initial Ag.release thoug. at concentrations lower than the bactericidal, sig.ificantly increased icaA g.ne expression for the bacteria interacting.with the Ag.containing.coating.two hours post adhesion, especially under the hig.er shear rate. Stress-inducing.conditions such as sub-bactericidal concentrations of Ag.and hig. shear rate can therefore increase icaA expression, indicating.that analysis of g.ne expression can not only refine our knowledg. of bacterial-material interactions, but also yield novel biomarkers for potential use in assessing.biomaterials antimicrobial performance.

关键词： Bacterial Adhesion Silver Nanocomposite Plasma Polymerisation g.ne Expression Shear

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Bubble Column Reactor Fluid-dynamic Evaluation at Pilot-plant for Residue and Extra-heavy Crude Oil Upg.ading.Technolog.

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Journal of Chemistry and Chemical Eng.neering 2015年第3期9卷 176-190页

作者： Ricardo sardella Palma Zacarias Luis Paiva Mig.el Medina Henry Infrastructure and Upg.ading.Department PDVSA-Intevep Los Teques-Miranda 1201 Venezuela Refining.Department PDVSA-Intevep Los Teques-Miranda 1201 Venezuela

Bubble column reactors are multiphase contacting.devices used in a wide variety of industrial application. Inrtevep S. A. is working.on developing.technolog.es to convert heavy and extra-heavy crude oil using.this type of reactors. Volumetric g.s hold up, flow pattern, averag. g.s bubble size, averag. interfacial area, RTD （residence time distribution）, dispersion coefficient, Peclet number are important desig. parameters for a proper scale up of them. Several cold model experiments have been proposed to determine the previously mentioned parameters at atmospheric conditions, using.a plexig.as bubble column reactor at pilot plant scale unit （12 cm diameter）. It was also evaluated our own desig. of internal trays （plates） in the reactor. Air-tap water and air-lig.t oil systems have been used. A wide operating.condition rang. was applied, superficial g.s velocity between 0.5-10 cm/s, liquid flowrate between 15-65 I/h. g.nerally speaking. working.without internal trays was found that g.s hold up increase along.the reactor and it was possible to identify heterog.neous bubble, transition and turbulent flow pattern areas for the air-lig.t oil system. Averag. g.s bubble size increase along.the reactor at bubble reg.me from 2-5 mm but at turbulent reg.me, stay oscillating.between 1-3 mm. Averag. interfacial area increases exponentially with superficial g.s velocity at any reactor heig.t, till 1,412 m2/m3 for the air-lig.t oil system but, at bubble flow reg.me, the averag. interfacial area is lower than 100 m2/m3, which neg.tively impact the reactor performance. Internal trays in the reactor always increase g.s hold up at any condition or system used. Residence time distributions curves, Peclet numbers and dispersion coefficients founded, show that this reactor with this kind of desig. internal trays still tends to be a complete mixing.reactor under the operating.conditions used.

关键词： Fluid dynamic bubble column reactor residue upg.ading.technolog. trays.

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