西罗莫司与紫杉醇药物洗脱支架在T细胞亚群再分布方面作用的比较

作     者：Sardella G. De Luca L. Di Roma A. 马超 

作者机构：Dipartimento di Scienze Cardiovascolari e Respiratorie Università La Sapienza Rome Italy Dr. 

出 版 物：《世界核心医学期刊文摘（心脏病学分册）》 (Digest of the World Core Medical Journals(Cardiology))

年 卷 期：2006年第2卷第6期

页      面：36-36页

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：药物洗脱支架 西罗莫司 紫杉醇 T细胞亚群 冠状动脉血运重建 再分布 记忆性T细胞 疾病患者 冠状动脉疾病 表型分析 

摘      要：We sought to investigate the effects of 2 different coronary drug- eluting stents on the distribution of central or effector memory T cells circulating in the coronary sinus of patients with coronary artery disease who underwent percutaneous coronary revascularization. We randomly assigned 43 patients(mean age 65.4± 4.3 years; 34 men) presenting with stable coronary disease and angiographically proved stenosis of the left anterior descending artery to treatment with sirolimus- or paclitaxel- eluting stents. Heparinized blood samples were obtained from the coronary sinus before and 20 minutes after stent implantation. Analysis of surface phenotype was performed by 4- color flow cytometry, and data are expressed as the percentage of positive cells. The percentages of CD8+ and CD4+ effector memory T cells, as defined by the CD3+ CD45RO+ CD27- phenotype, were significantly reduced in patients who received a sirolimus- eluting stent compared with the basal values. Conversely, the percentages of CD8+ , but not CD4+ , central memory T cells(CD3+ CD45RO+ CD27+ ) were increased in the same treatment group after the revascularization procedure. No changes in the percentages of memory T- cell populations in the paclitaxel- eluting stent group were observed. These findings show that sirolimus- eluting stents rapidly induced a redistribution of memory T lymphocytes, with a significant decrease of proinflammatory effector memory T cells circulating within the coronary sinus.