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αB-crystallin mini-peptides support corneal healing in vitro and in vivo in rabbit model

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1772-1779页

作者： Namrata Maity Aditya Konar sarbani Hazra Department of Veterinary Surgery&Radiology West Bengal University of Animal and Fishery SciencesKolkata 700037India CSIR-IICB Kolkata 700032India

AIM:To evaluate if topical use ofαB-crystallin minipeptides supports corneal healing following flap ***:Cultured corneal cells were treated with fluorescent taggedαB-crystallin mini-peptides to assess its *** corneal cells pre-treated with or without the mini-peptides were exposed to H2O2 and cell viability was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of neurites of cultured trigeminal neurones was examined following treatment either withαB-crystallin mini-peptides or *** trigeminal neurones were pre-treated either withαB-crystallin mini-peptides or crystallin protein and exposed to H2O2 and presence of beading in the dendrites and axons was *** flap surgery was conducted on rabbit cornea and treated topically either withαB-crystallin peptide(0.5 mg/mL thrice daily for 14d)or phosphate-buffered saline(PBS).Corneal healing was evaluated under slit-lamp biomicroscope,mRNA expression of inflammatory cytokines were assessed and the corneas were evaluated by ***:Internalization ofαB-crystallin mini-peptides was ascertained by the detection of fluorescence within the corneal *** MTT assay revealed that treatment withαB-crystallin mini-peptide reduced cell death induced by H2O2 *** mini-peptides did not influence the elongation of trigeminal neurites,but significantly(P<0.05)reduced beading in the *** rabbit eye,the treated corneas showed reduced hyper-reflective zones(P<0.05)and suppression in the expression of inflammatory *** examination also revealed reduction of inflammatory response in treated ***:TheαB-crystallin mini-peptides restrict the damage to corneal cells and neurons and aids in corneal healing.

关键词： corneal healing αB-crystallin cytoprotection neuroprotection

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Quantized Redshift and its Significance for Recent Observation

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Research in Astronomy and Astrophysics 2024年第9期24卷 156-166页

作者： Arindam Mal sarbani Palit Christopher C.Fulton Sisir Roy Indian Space Research Organization Space Applications CentreAhmedabadIndia Indian Statistical Institute CVPR UnitKolkataIndia Protostar Inc.15652 Carrousel DriveCanyon CountryCA 91387USA National Institute of Advanced Studies IISC CampusBangaloreIndia

With the recent observational evidence in extragalactic astronomy,the interpretation of the nature of quasar redshift continues to be a research *** high redshifts are being detected for extragalactic objects that are presumably very distant and young while also exhibiting properties that are characteristic of a more mature galaxy such as *** to Halton Arp and Geoffrey Burbidge,redshift disparities consist of an intrinsic component and are related to an evolutionary *** observed redshift periodicity at integer multiples of0.089 in log scale and Burbidge observed redshift periodicity at integer multiples of 0.061 in linear *** Singular Value Decomposition based periodicity estimation is known to be superior for noisy data sets,especially when the data contain multiple harmonics and overtones,mainly irregular in nature,we have chosen it to be our primary tool for analysis of the quasar-galaxy pair redshift *** have observed a fundamental periodicity of0.051 with a confidence interval of 95%in linear scale with the site-available Sloan Digital Sky Survey Data Release 7(SDSS DR7)quasar-galaxy pair data *** have independently generated quasar-galaxy pair data sets from both 2d F and SDSS and found fundamental periodicities of 0.077 and 0.089,respectively,in log scale with a confidence interval of 95%.

关键词： galaxies:distances and redshifts (galaxies:)quasars:absorption lines cosmology:observations

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Dynamics of a delay-induced prey-predator system with interaction between immature prey and predators

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International Journal of Biomathematics 2024年第2期17卷 139-176页

作者： Soumik Pandey Abhijit Sarkar Debashis Das sarbani Chakraborty Department of Mathematics West Bengal State University Barasat-7000126West BengalIndia Department of Basic Science&Humanities JIS College of Engineering Kalyani-741235West BengalIndia

In biological pest control systems,several pests(including insects,mites,weeds,etc.)are controlled by biocontrol agents that rely primarily on *** this biocontrol management ecology,we have created a three-tier prey-predator model with prey phase structure and predator gestation *** studies have demonstrated that predators with Holling type-II functional responses sometimes consume immature prey.A study of the well-posedness and local bifurcation(such as saddle-node and transcritical)near the trivial and planer equilibrium points is carried *** any time lag,the prey development coeficient has a stabilizing impact,while increasing attack rate accelerates *** transformation rate and handling time are shown to cause multiple stability switches in the *** results demonstrate time delay is the key destabilizer that destroys *** model can replicate more realistic events by including time-dependent factors and exploring the dynamic behavior of nonautonomous *** the presence of time delay,sufficient conditions of permanence and global attractivity of the nonautonomous system are ***,MATLAB simulations are performed to validate the analytical findings.

关键词： Holling type-II functional response stage-structure bifurcation time delay seasonality

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Clinical outcomes for nasopharyngeal cancer with intracranial extension after taxanebased induction chemotherapy and concurrent chemo-radiotherapy in the modern era

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 25-33页

作者： sarbani ghosh-laskar Avinash Pilar Carlton Johnny Kumar Prabhash Amit Joshi Jai Prakash Agarwal Tejpal Gupta Ashwini Budrukkar Vedang Murthy Monali Swain Vanita Noronha Vijay Maruthi Patil Prathamesh Pai Deepa Nair Devendra Arvind Chaukar Shivakumar Thiagarajan Gouri Pantvaidya Anuja Deshmukh Pankaj Chaturvedi Sudhir Nair Anil D’Cruz Department of Radiation Oncology Tato Memorial HospitalHomi Bhobho National InstituteMumbaiIndia Department of Medical Oncology Tata Memorial HospitalHomi Bhobha Notional InstituteMumbaiIndia Department of Surgical Oncolosy Tota Memorial HospitalHomi Bhabha Notional InstituteMumbait India

Objective:To evaluate the survival outcomes for a cohort of nasopharyngeal cancer with intracranial extension(ICE)treated with induction chemotherapy(ICT)followed by chemo-intensity-modulated radiotherapy(CTRT)at a tertiary cancer ***:We retrospectively analyzed 45 patients with histologically proven,non-metastatic NPC with ICE treated at our institute between October 2008 and October *** were classified as minor ICE or major ICE,based on the extent of *** the patients received 2-3 cycles of a taxane-based ICT regimen followed by *** was delivered with"riskadapted"intensity-modulated radiotherapy(IMRT)technique in all ***:After a median follow up of 45 months(range:8-113 months),the estimated 5-year DFS,LRFS,DMFS,and OS of the entire cohort was 58%,82%,67%and 74%*** multivariate analysis,histological subtype was an independent predictor of LRFS,and age was an independent predictor of *** extent of ICE showed only a trend towards worse DFS(P=0.06).None of the factors significantly predicted for DMFS or ***,N-stage,and response to ICT did not significantly affect any of the *** 2 or worse subcutaneous fibrosis was seen in 22%of patients and grade 2 or worse xerostomia was seen in 24%of patients at last follow ***-three percent of the patients developed clinical hypothyroidism at last follow *** of the patients experienced any neurological or vascular ***:Taxane-based induction chemotherapy followed by chemo-intensity modulated radiotherapy resulted in excellent locoregional control and survival with acceptable toxicities in patients of nasopharyngeal cancer with intracranial *** metastasis continues to be the predominant problem in these patients.

关键词： Nasopharyngeal cancer Intracranial extension Clinical outcomes Induction chemotherapy and intensity-modulated radiotherapy

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Adaptive Execution of Jobs in Computational Grid Environment

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Journal of Computer Science & Technology 2009年第5期24卷 925-938页

作者： sarbani Roy Nandini Mukherjee Department of Computer Science and Engineering Jadavpur University

In a computational grid, jobs must adapt to the dynamically changing heterogeneous environment with an objective of maintaining the quality of service. In order to enable adaptive execution of multiple jobs running concurrently in a computational grid, we propose an integrated performance-based resource management framework that is supported by a multi-agent system （MAS）. The multi-agent system initially allocates the jobs onto different resource providers based on a resource selection algorithm. Later, during runtime, if performance of any job degrades or quality of service cannot be maintained for some reason （resource failure or overloading）, the multi-agent system assists the job to adapt to the system. This paper focuses on a part of our framework in which adaptive execution facility is supported. Adaptive execution facility is availed by reallocation and local tuning of jobs. Mobile, as well as static agents are employed for this purpose. The paper provides a summary of the design and implementation and demonstrates the efficiency of the framework by conducting experiments on a local grid test bed.

关键词： grid environment multi-agent system adaptive execution Jini mobile agent

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Comparison of design of intraocular lens versus the material for PCO prevention

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 59-63页

作者： sarbani Hazra Himangshu Palui Geeta K Vemuganti Department of Veterinary Surgery & Radiology West Bengal University of Animal and Fishery Sciences Kolkata India Prof & Dean Medical Sciences University of Hyderabad India Hyderabad India

AIM: To evaluate the influence of different intraocular lens(IOL) designs made of PMMA on posterior capsular opacification(PCO) and compare with foldable designs.· METHODS: Phacoemulsification and IOL implantation was done in one eye of 24 New Zealand White rabbits, with IOL of two different designs (Square edged or round edge) and two different materials(PMMA or HEMA). After three months, the animals were sacrificed and enucleated. Evaluation of PCO included posterior view, migration of anterior capsular epithelial cells to the posterior capsule following epithelial-mesenchymal transition were assessed by staining the histological sections of posterior capsule by hematoxylin-eosin(HE) and Periodic acid- Schiff (PAS). The IOLs were extracted and stained with HE to evaluate the presence of adherent cells on the lens surface. · RESULTS: PCO was highest with round edged rigid lens. There was no significant difference in the PCO between the square edged PMMA and square edged foldable lens.· CONCLUSION: It is the design of the IOL not the material that offers protection on PCO formation.

关键词： design material of intraocular lens posterior capsular opacification

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Evolving provenance in the Proterozoic Pranhita-Godavari Basin,India

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Geoscience Frontiers 2015年第3期6卷 453-463页

作者： Udeni Amarasinghe Asru Chaudhuri Alan S.Collins Gautam Deb sarbani Patranabis-Deb Centre for Tectonics Resources and Exploration(TRaX)School of Earth and Environmental SciencesThe University of Adelaide Department of Geology Presidency College Geological Studies Unit(GSU) Indian Statistical Institute

The Pranhita-Godavari Basin in central eastern India is one of the Proterozoic ＂Purana＂ basins of cratonic India. New geochronology demonstrates that it has a vast depositional history of repeated basin reactivation from the Palaeoproterozoic to the Mesozoic. U-Pb laser ablation inductively coupled plasma mass spectrometry dating of detrital zircons from two samples of the Somanpalli Group--a member of the oldest sedimentary cycle in the valley--constrains its depositional age to - 1620 Ma and demonstrates a tripartite age provenance with peaks at - 3500 Ma, - 2480 Ma and - 1620 Ma, with minor age peaks in the Eoarchaean （ - 3.8 Ga） and at - 2750 Ma. These ages are consistent with palaeocurrent data suggesting a southerly source from the Krishna Province and Enderby Land in East Antarctica. The similarity in the maximum depositional age with previously published autbigenic glauconite ages suggest that the origin of the Pranhita-Godvari Graben originated as a rift that formed at a high angle to the coeval evolving late Meosproterozoic Krishna Province as Enderby Land collided with the Dharwar craton of India. In contrast, detrital zircons from the Cycle III Sullavai Group red sandstones yielded a maximum depositional age of 970 - 20 Ma and had age peaks of -2550 Ma, -1600 Ma and then a number of Mesoproterozoic detrital zircons terminating in three analyses at - 970 Ma. The provenance of these is again consistent with a southerly source from the Eastern Ghats Orogen and Antarctica. Later cycles of deposition include the overlying Albaka/Usur Formations and finally the late Palaeozoic to Mesozoic Gondwana Supergroup.

关键词： LA-icpms U-Pb zircon geochronology Godavari Purana Gondwana

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Spontaneous Resolution of Cataract and Medical Management of Corneal Opacity in an Indian Parrot—<i>Psittacula krameri manillensis</i>

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Open Journal of Veterinary Medicine 2013年第2期3卷 184-186页

作者： sarbani Hazra Department of Veterinary Surgery & Radiology West Bengal University of Animal & Fishery Sciences Kolkata India

A 35-year-old Indian parrot (Psittacula krameri manillensis) was presented to the Department of Veterinary Surgery & Radiology, West Bengal University of Animal and Fishery Sciences with a history of blepharospasm and corneal lesion OS. Test with fluorescein dye was negative. The dense corneal opacity (macula) was identified as involving the posterior corneal layer. The further ophthalmic examination was done and hypermature phacolytic cataract was diagnosed. No other abnormality was detected. Medical management with topical nepafenac prednisolone and triple antibiotic was instituted. The corneal lesion subsided completely within one week followed by spontaneous resorption of the cataract. The treatment protocol was successfully eliminated the discomfort and intraocular lesions in the senile parrot.

关键词： Medical Management Senile Cataract Parrot

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用于白内障超声乳化训练的活体白内障动物模型(英文)

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国际眼科杂志 2008年第6期8卷 1091-1094页

作者： sarbani Hazra Dipak K De Arup K Bose Biswarup Roy 印度加尔各答市西孟加拉动物与水产科学大学兽医外科学与放射学系印度西孟加拉邦眼显微外科和激光中心印度西孟加拉邦加尔各答市 R.G.Kar医学院及医院眼科

目的：制备用于白内障超声乳化训练的活体白内障动物模型。方法：狗在全身麻醉下用26号带有斜面的针刺破左眼的晶状体前囊，制备白内障模型，形成白内障后，行超声乳化手术。结果：眼部检查显示晶状体后部皮质混浊开始于穿刺术后5～7d... 详细信息

目的：制备用于白内障超声乳化训练的活体白内障动物模型。方法：狗在全身麻醉下用26号带有斜面的针刺破左眼的晶状体前囊，制备白内障模型，形成白内障后，行超声乳化手术。结果：眼部检查显示晶状体后部皮质混浊开始于穿刺术后5～7d，并于术后75d白内障全部形成，在所有的白内障形成的眼上行超声乳化手术，并植入人工晶状体，所有的狗均恢复了视力。结论：考虑到无经验的眼科医生在行白内障超声乳化手术的初始阶段引起的巨大损失，我们认为这个活的动物模型明显优于目前用于训练超声乳化手术的尸体眼。

关键词：白内障训练模型超声乳化狗

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局部麻醉对兔眼心反射和眼角膜愈合的影响(英文)

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国际眼科杂志 2009年第12期9卷 2255-2259页

作者： Jay Singh Subhasis Roy Prasenjit Mukherjee Debajyoti Konar Aditya Konar sarbani Hazra 西孟加拉动物与水产科学大学印度加尔各答 ESIC医院及职业病防治中心印度加尔各答印度化学生物学研究所印度加尔各答

目的:在兔模型中利用局部麻醉来研究两种麻醉剂的眼心反射发生率及其预防,同时我们还研究了局部麻醉对角膜愈合的影响。方法:健康的成年新西兰白兔(雌雄皆有)48只,分成两组(A组和B组),分别用氯胺酮(A组,24例)、异丙酚(B组,24例)麻醉。... 详细信息

目的:在兔模型中利用局部麻醉来研究两种麻醉剂的眼心反射发生率及其预防,同时我们还研究了局部麻醉对角膜愈合的影响。方法:健康的成年新西兰白兔(雌雄皆有)48只,分成两组(A组和B组),分别用氯胺酮(A组,24例)、异丙酚(B组,24例)麻醉。在此双盲研究中,通过用或不用局部麻醉(40g/L利多卡因,5g/L盐酸丙美卡因,5g/L布比卡因)对眼睛的不同干预,记录各组眼心反射发生率。应用每种局部麻醉后,通过对眼睛的临床检查,组织病理学,胶原染色以及投射电子显微等方法对术后1d长达7d角膜毒性和愈合进行评估。结果:在氯胺酮的麻醉下未出现眼心反射,而在异丙酚的麻醉下,心率显著下降(P<0.01)。因此,局部麻醉可以成功地防止眼心反射的发生并且不影响角膜愈合。结论:局部麻醉没有任何局部副作用,可以被推荐用来预防眼心反射。

关键词：眼心反射局部麻醉角膜愈合氯胺酮异丙酚

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