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第十五届全国光散射学术会议

作者： James R.Durig sarah xiaohua zhou Joshua Klaassen Arindam Ganguly University of Missouri-Kansas City 5110 Rockhill Rd Kansas CityMO 64110 USA

When a silyl or an organosilyl moiety is attached to an OY or NZ species the SiOY or SiNZ angle becomes relatively large which results in many such molecules having very low barriers to linearity. Because of the low b...

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New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells

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Open Journal of Medicinal Chemistry 2022年第1期12卷 1-13页

作者： Edward C. Lisic sarah N. Grossarth sarah B. Bowman Jessica L. Hill Michael W. Beck Joseph E. Deweese xiaohua Jiang Department of Chemistry Tennessee Technological University Cookeville TN USA Department of Biological Physical and Human Sciences Freed Hardeman University Henderson TN USA

The new ligand, 2-acetylpyrazine-tertbutylthiosemicarbazone (APZ-tBTSC), and its Cu(II), Pd(II) and Pt(II) complexes have been synthesized. This ligand coordinates to the metal ions in a tridentate monoanionic fashion forming monometallic complexes with the formula [M(APZ-tBTSC)Cl]. The ligand and the three metal complexes [Cu(APZ-tBTSC)Cl], [Pd(APZ-tBTSC)Cl], and [Pt(APZ-tBTSC)Cl] were tested for anti-proliferative biological behavior with a panel of seven microbes, and the copper and palladium complexes were found to be highly active against Gram positive bacteria. The 4 compounds were also tested in human topoisomerase IIα DNA relaxation assays and all three metal complexes had topoisomerase inhibition at a concentration between 4 - 6 micro-molar. The 4 compounds were also tested for activity with the HEK293T cell line and also the breast cell cancer line, MDA-MB-231. The most effective compound for activity against the HEK293T cell line was the [Cu(APZ-tBTSC)Cl] complex, and the MDA-MB-231 breast cancer cell line was the [Pt(APZ-tBTSC)Cl] complex.

关键词： Topoisomerase Breast Cancer α-(N)-Heterocyclic Thiosemicarbazones

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Repeated stimulation of the posterior parietal cortex in patients in minimally conscious state:a sham-controlled randomized clinical trial

Repeated stimulation of the posterior parietal cortex in pat...

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作者： Wangshan Huang Aurore Thibaut sarah Wannez Felipe Fregni xiaohua Hu Shan Jing Geraldine Martens Minhui He Haibo Di Steven Laureys Hangzhou Normal University International Vegetative State and Consciousness Science Institute University of Liege and University Hospital of LiegeCyclotron Research Center and Neurology DepartmentComa Science Group Spaulding Rehabilitation Hospital/Harvard Medical School Spaulding Neuro--modulation Center Hangzhou Wujing Hospital Department of Rehabilitation

Objective:We assessed the effects of transcranial direct current stimulation(tDCS) targeted to posterior parietal cortex in patients in minimally conscious state(MCS).Methods:In a randomized double-blind sham-controlled crossover study,MCS patients at least 1 month after traumatic or nontraumatic insult received one sham and one real tDCS session(2 mAduring 20 minutes once a day for five days) in a randomized order separated by five days of washout over the posterior parietal *** Recovery Scale-Revised(CRS-R) assessments were performed directly on enrollment,before the first session and after each real and sham tDCS as well as five days ***-up outcome data were acquired 1,3,6,12 months after inclusion using the ***:33 MCS patients were enrolled(mean age:57±11 years;interval 6±5 months;20 traumatic).Atreatment effect(p=0.012;effect size:0.31) was observed after real tDCS session but did not last for 5 days after the end of the session(p=0.135).We identified 9(27%)tDCS-responders(i.e.,showing new sign(s) of consciousness that was never observed before,lasting at least 5 days after the end of the stimulation).Conclusion:Five days of tDCS over the posterior parietal cortex has a small and short-lasted beneficial effect on consciousness in MCS.

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