Repeated stimulation of the posterior parietal cortex in patients in minimally conscious state:a sham-controlled randomized clinical trial
作者单位：Hangzhou Normal UniversityInternational Vegetative State and Consciousness Science Institute University of Liegeand University Hospital of LiegeCyclotron Research Center and Neurology DepartmentComa Science Group Spaulding Rehabilitation Hospital/Harvard Medical SchoolSpaulding Neuro--modulation Center Hangzhou Wujing HospitalDepartment of Rehabilitation
会议日期：2016年
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
摘 要：Objective:We assessed the effects of transcranial direct current stimulation(tDCS) targeted to posterior parietal cortex in patients in minimally conscious state(MCS).Methods:In a randomized double-blind sham-controlled crossover study,MCS patients at least 1 month after traumatic or nontraumatic insult received one sham and one real tDCS session(2 mAduring 20 minutes once a day for five days) in a randomized order separated by five days of washout over the posterior parietal *** Recovery Scale-Revised(CRS-R) assessments were performed directly on enrollment,before the first session and after each real and sham tDCS as well as five days ***-up outcome data were acquired 1,3,6,12 months after inclusion using the ***:33 MCS patients were enrolled(mean age:57±11 years;interval 6±5 months;20 traumatic).Atreatment effect(p=0.012;effect size:0.31) was observed after real tDCS session but did not last for 5 days after the end of the session(p=0.135).We identified 9(27%)tDCS-responders(i.e.,showing new sign(s) of consciousness that was never observed before,lasting at least 5 days after the end of the stimulation).Conclusion:Five days of tDCS over the posterior parietal cortex has a small and short-lasted beneficial effect on consciousness in MCS.