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Anticoagulation in frail older people

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Journal of Geriatric Cardiology 2019年第11期16卷 844-846页

作者： sarah Damanti Simon Braham Luca Pasina Geriatric Unit IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly Nutritional Sciences PhD Univeristy of MilanMilanItaly Angelo Bianchi Bonomi Hemophilia and Thrombosis Center IRCCS CàGranda Maggiore Hospital FoundationMilanItaly Pharmacotherapy and Appropriateness of Drug Prescription Unit Istituto Di Ricerche Farmacologiche Mario Negri IRCCSVia Giuseppe La MasaMilanItaly

Frailty is a multidimensional dynamic condition characterized by decreased physiological reserves. Therefore,frail people are more vulnerable to ***,minor stimuli,like a new drug prescription,can alter their homeostatic equilibrium determining adverse clinical outcomes(i.e.,falls,institutionalization,disability,and death).[1,2]Since the risk of atrial fibrillation[3]and venous thromboembolism[4]increase with ageing,frail people might require long term anticoagulation.

关键词： Anticoagulation Frailty The elderly

First Pig-to-Live Human Xenotransplant Produces Mixed Results

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Engineering 2022年第9期16卷 6-8页

作者： sarah C.P.Williams Senior Technology Writer

On 7 January 2022,a 57-year-old man with terminal heart disease became the first living human to receive a genetically modified pig organ—a heart—transplanted into his chest during a 8 h surgery at the University of Maryland Medical Center in Baltimore,MD,USA(Fig.1)[1].The pig heart,provided by the biotechnology company Revivicor(Blacksburg,VA,USA),had ten gene modifications intended to boost the chances of a successful pig-to-human transplant.

关键词： Maryland Human boost

luminating Crop Adaptation Using Population Genomics

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Molecular Plant 2019年第1期12卷 27-29页

作者： Rod J.Snowdon sarah Schiessl Department of Plant Breeding IFZ Research Centre for BiosystemsLand Use and Nutrition Justus Liebig University GiessenNeinrich-Buff-Ring 26-3235392 GiessenGermany

In this issue,Wu et al.(2019)describe the largest whole-genome resequencing dataset published to date for rapeseed (Brassica napus),an allopolyploid crop species that originated just a few thousand years ago under anthropogenic influence and rapidly evolved into one of the world's most important oilseed crops. In almost 1000 *** spanning species-wid.e germplasm for oilseed rape,a comprehensive analysis of sequence diversity related to flowering-related traits uncovered selective sweeps associated with eco-geographic adaptation and human selection,attributable particularly to divergence among homoeologs of key flowering-time regulation and ethylene synthesis/signaling genes.

关键词： issue Brassica napus

An Unusual Cause of Irritability in a Single Ventricle Patient after Bidirectional Glenn Shunt

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Congenital Heart Disease 2021年第4期16卷 393-396页

作者： sarah Pradhan Eileen Broomall Russel Hirsch The Heart Institute Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOhioUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterDepartment of PediatricsUniversity of Cincinnati College of MedicineCincinnatiOhioUSA

The differential diagnosis for irritability in children is *** patients with congenital heart disease,one must strongly consider cardiac etiologies such as low cardiac output or elevated central venous pressure(CVP).In patients with single-ventricle physiology,the second stage of palliation includes bidirectional Glenn,which involves anastomosis of the superior vena cava to the pulmonary artery resulting in volume offloading of the single systemic ***,early in the post-operative period,patients may experience a headache due to the acute increase in CVP,and symptoms improve over *** intracranial hypertension(IIH),also known as pseudotumor cerebri,is a rare neurologic disorder in children,characterized by raised intracranial pressure(ICP)in the absence of brain parenchymal lesions or cerebrospinal fluid(CSF)*** the pathogenesis of IIH is unknown,early recognition and treatment of IIH are important to prevent permanent vision *** are only rare reports of IIH in patients with Fontan *** our knowledge,we report the first case of IIH in a 2-year-old female after bidirectional Glenn.

关键词： Single ventricle bidirectional Glenn shunt idiopathic intracranial hypertension pseudotumor cerebri

Elderly male with blurry vision

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World Journal of Emergency Medicine 2019年第1期10卷 59-60页

作者： Anthony Maselli sarah E.Frasure Department of Emergency Medicine Brigham and Women's Hospital

Dear editor,We present a case of an elderly gentleman who was punched in the face and subsequently diagnosed by an emergency physician with acute angle closure glaucoma secondary to a posterior lens *** lamp evaluatio... 详细信息

关键词：小学英语课外阅读阅读材料

Orthostatic hypertension and adverse clinical outcomes in adults and older people

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Journal of Geriatric Cardiology 2021年第9期18卷 779-782页

作者： sarah Damanti Paolo D Rossi Matteo Cesari Unit of General Medicine and Advanced Care IRCCS San Raffaele InstituteMilanItaly Geriatric Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanoItaly Department of Clinical Sciences and Community Health University of MilanMilanItaly Geriatric Unit IRCCS Istituti Clinici Scientifici MaugeriMilanItaly

Orthostatic hypertension(OHT)is a condition characterized by an increase in blood pressure after assuming the standing position.[1]Nowadays no consensus definition exists,thus OHT prevalence varies among studies(4%-20... 详细信息

关键词： hypertension clinical prevalence

Virus-like nanoparticle vaccines for inducing long-lasting immunity against infectious diseases

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National Science Review 2024年第4期11卷 13-15页

作者： Yi-Nan Zhang sarah Auclair Jiang Zhu Department of Integrative Structural and Computational Biology The Scripps Research Institute Department of Immunology and Microbiology The Scripps Research Institute

Prophylactic vaccines that can generate long-lasting protective immune responses are needed for many infectious diseases. Efficient vaccination requires vaccine antigens to be retained and presented to B cells in lymp... 详细信息

关键词： against diseases immunity inducing infectious long-lasting nanoparticle vaccines virus-like

Response to the white paper on MHA reform:marginalisation of patients detained under part III of the MHA

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General Psychiatry 2021年第3期34卷 175-178页

作者： sarah Markham Biostatistics and Health Informatics Department Institute of PsychiatryPsychology and NeuroscienceLondonUK

In England and Wales,the Mental Health Act(MHA)1983 provides the legal framework for the detention of individuals suffering from a mental disorder if they are judged to present a risk of harm to self or *** MHA removes from certain psychiatric patients civil liberties otherwise inherent in our legal *** both statute and common law,it balances a patient’s right to autonomy with psychiatrists'duty of care by reference to the health and safety of the *** also balances the civil rights of individual patients against the right of society to protection1.

关键词： patients legal Wales

Bi-material strip based temperature sensor design and optimization through thermo-mechanical multi-physics modeling

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International Journal of Smart and Nano Materials 2019年第1期10卷 1-10,I0001页

作者： Baobao Tang sarah Kathryn Collings Hai Xiao Huijuan Zhao Department of Mechanical Engineering Clemson UniversityClemsonSCUSA Holcombe Department of Electrical and Computer Engineering Clemson UniversityClemsonSCUSA

With the capability of additive manufacturing,complex structures are easily fabricated to achieve various design *** this work,a bi-material strip temperature sensor with complex periodic pattern design is purposed and investigated through both the analytical modeling and multi-physics finite element *** design patterns are considered:standard,E-shape and *** the standard solid strip design,the curvature of the bi-material strip under temperature variation is in a linear relationship with the coefficient of thermal expansion(CTE)difference,but in a reciprocal relationship with the strip *** curvature of the bi-material strip depends on the Young’s modulus ratio and layer thickness ratio of the two materials,but is independent of the magnitude of the materials’Young’s *** on analytical derivation and numerical validation,the optimized design parameters can be *** to S-shape pattern design,E-shape pattern design can significantly increase the temperature sensitivity of the bi-material *** analytical prediction of the E-shape pattern’s temperature sensitivity is introduced and *** work proves the concept that new design space becomes available with the capability of additive manufacturing,and provides the general design guideline for a bi-material strip based temperature sensor with possible design patterns.

关键词： Bi-material temperature sensing optimization finite element analysis