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Cellular & Molecular Immunology 2023年第8期20卷 861-863页

作者： Sabine Stegemann-Koniszewski sarah Frentzel Dunja Bruder Experimental Pneumology Department of PneumologyUniversity Hospital Magdeburg/Medical FacultyHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Institute of Medical Microbiology and Hospital Hygiene Infection Immunology GroupHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Immune Regulation Group Helmholtz Centre for Infection ResearchBraunschweigGermany

In their recent article in Nature Immunology, Wang et al. showed that influenza A virus (IAV) infection trained alveolar macrophages (AMs) for sustained antitumor immunity in the lung [1], extending the concept of trained immunity and pointing out benefits of viral respiratory infection in the context of pulmonary antitumor immune surveillance.

关键词： immunity sustained respiratory

The brain–immune cells axis controls tissue specific immunopathology

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Cellular & Molecular Immunology 2019年第2期16卷 101-103页

作者： Maxi Heyner sarah Schreier Andrea Kröger Institute for Medical Microbiology and Hospital Hygiene Otto-von-Guericke University MagdeburgMagdeburgGermany Innate Immunity and Infection Group Helmholtz Centre for Infection ResearchBraunschweigGermany

During viral infections,cell death can be induced as a direct result of cytopathic virus replication in various cell types and tissues or as an immune response of the host to the infectious *** leads to an infiltration of inflammatory cells,causing subsequent tissue *** balance between effective elimination of the pathogen and prevention of fatal tissue damage is decisive for *** host has developed various mechanisms to inhibit excessive immune responses.

关键词： prevention damage death

3D Printing of Ceramic Biomaterials

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Engineered Regeneration 2022年第1期3卷 41-52页

作者： Michael Ly sarah Spinelli Shayne Hays Donghui Zhu Department of Biomedical Engineering Stony Brook University100 Nicolls RdStony BrookNY 11794United States

Bioceramics are a popular class of materials used in biomedical applications due to their mechanical stability and *** exist in a variety of fields including hip joints for orthopedics,tooth fillings for dentistry,and scaffolds for tissue engineering;however,the standard processes currently used to manufacture these ce-ramic products can be time-consuming and *** response,current literature alternatively proposes additive manufacturing(3D printing)strategies to fabricate bioceramic materials in a cost-effective and efficient ***,we briefly cover five common processes and materials used in additive manufacturing bioceramics:fused deposition modeling,material jetting,binder jetting,powder bed fusion,and vat ***-thermore,we discuss the potential of these 3D printed ceramic structures when applied to different biomedical technologies such as bone tissue scaffolds and structural implants.

关键词： Extrusion Binder jetting Material jetting Powder bed fusion Vat photopolymerization

Endo-β-1,4-glucanases impact plant cell wall development by influencing cellulose crystallization

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Journal of Integrative Plant Biology 2015年第4期57卷 396-410页

作者： Magdalena Glass sarah Barkwill Faride Unda Shawn D.Mansfield Department of Wood Science University of British Columbia

Cell walls are vital to the normal growth and development of plants as they protect the protoplast and provide rigidity to the stem. Here, two poplar and Arabidopsis orthologous endoglucanases, which have been proposed to play a role in secondary cell wall development, were examined. The class B endoglucanases, Pt GH9B5 and At GH9B5, are secreted enzymes that have a predicted glycosylphosphatidylinositol anchor, while the class C endoglucanases, Pt GH9C2 and At GH9C2, are also predicted to be secreted but instead contain a carbohydrate-binding *** poplar endoglucanases were expressed in Arabidopsis using both a 35 S promoter and the Arabidopsis secondary cell wall-specific Ces A8 promoter. Additionally, Arabidopsis t-DNA insertion lines and an RNAiconstruct was created to downregulate At GH9C2 in Arabidopsis. All of the plant lines were examined for changes in cell morphology and patterning, growth and development, cell wall crystallinity, micro fibril angle, and proportion of cell wall carbohydrates. Misregulation of Pt GH9B5/At GH9B5 resulted in changes in xylose content, while misregulation of Pt GH9C2/At GH9C2 resulted in changes in crystallinity, which was inversely correlated with changes in plant height and rosette diameter. Together, these results suggest that these endoglucanases affect secondary cell wall development by contributing to the cell wall crystallization process.

关键词： Cellulose cell walls crystallinity endoglucanase expansion glucose xylose

Effects of Plasmodium falciparum—infected erythrocytes on matrix metalloproteinase-9 regulation in human microvascular endothelial cells

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Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 195-199页

作者： sarah D' Alessandro Nicoletta Basilico Mauro Prato Dipartimento di Sanita Pubblica-Microbiologia-Virologia Universita di MilanoMilanoItaly Dipartimento di Genetica Biologia e BiochimicaFacolta di Medicina e ChirurgiaUniversita di TorinoTorinoItaly

Objective:To investigate the regulation of matrix metalloproteinases(MMPs) and tissue inhibitors of melalloproleinases(TIMPs) in human microvascular endothelium(HMEC-1) exposed to erythrocytes infected by different strains of Plasmodium falciparum(***).Methods: HMEC—1 eells were co—incubated for 72 h with erythrocytes infected by late stage trophozoite of D10(chloroquine-sensilive) or W 2(chloroquine-resistant) *** *** supernatants were then collected and the levels of pro- or active gelatinases MMP-9 and MMP-2 were evaluated by gelatin zymograpln and *** release of pro-MMP-9,***-1 and TIMP-1 proteins was analyzed by western blotting and ***:Infected erythrocytes induced de novo proMMP-9 and MMP-9 *** basal levels of proMMP-2 were altered,nor active MMP-2 was ***-3 and MMP-1 secretion was significant!) enhanced,whereas basal TIMP-1 was *** effects were similar for both strains. Conclusions:*** parasites,either chloroquine-sonsitive or -resistant,induce the release of active MMP-9 protein from human microvascular endothelium,by impairing balances between proMMP-9 and its inhibitor,and by enhancing the levels of its *** work provides new evidence on MMP involvement in malaria,pointing at MMP-9 as a possible target in adjuvant therapy.

关键词： Plasmodium falciparum Malaria Endothelial cells Matrix metalloproteinases Tissue inhibitors of metalloproteinases Gelatinases

Neuro-optimized numerical treatment of HIV infection model

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International Journal of Biomathematics 2021年第5期14卷 199-220页

作者： Anas Bilal Guangmin Sun sarah Mazhar Zhang Junjie Faculty of Information Technology Beijing University of TechnologyChaoyang District Beijing 100124P.R.China

In this paper,a neuro-optimized numerical method is presented for approximation of HIV virus progression model in the human *** model is composed of coupled nonlinear system of differential equations(DEs)containing healthy and infected T-Cells and HIV free virus *** coupled system is transformed into feedforward artificial neural network(ANN)with Mexican hat wavelet function in the hidden *** meta-heuristic algorithms based on chaotic particle swarm optimization(CPSO)and its hybrid version with local search technique are exploited to tune the parameters of ANN in an unsupervised manner of error function.A comprehensive testbed is established to observe the virus growth per day with performance metric containing fitness value,computational time complexity and *** proposed solutions are compared with state of art Runge-Kutta method and Legendre Wavelet Collocation Method(LWCM).The core advantages of the proposed scheme are getting the solution on continuous grid,consistent convergence,simplicity in implementation and handling strong nonlinearity effectively.

关键词： HIV infection Mexican hat wavelet artificial neural network chaotic particle swarm optimization hybrid computational method Monte Carlo simulations

Management of borderline resectable pancreatic cancer

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World Journal of Gastrointestinal Oncology 2015年第10期7卷 241-249页

作者： Amit Mahipal Jessica Frakes sarah Hoffe Richard Kim Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute

Pancreatic cancer is the fourth most common cause of cancer death in the United States. Surgery remains the only curative option; however only 20% of the patients have resectable disease at the time of initialpresentation. The definition of borderline resectable pancreatic cancer is not uniform but generally denotes to regional vessel involvement that makes it unlikely to have negative surgical margins. The accurate staging of pancreatic cancer requires triple phase computed tomography or magnetic resonance imaging of the pancreas. Management of patients with borderline resectable pancreatic cancer remains unclear. The data for treatment of these patients is primarily derived from retrospective single institution experience. The prospective trials have been plagued by small numbers and poor accrual. Neoadjuvant therapy is recommended and typically consists of chemotherapy and radiation therapy. The chemotherapeutic regimens continue to evolve along with type and dose of radiation therapy. Gemcitabine or 5-fluorouracil based chemotherapeutic combinations are administered. The type and dose of radiation vary among different institutions. With neoadjuvant treatment, approximately 50% of the patients are able to undergo surgical resections with negative margins obtained in greater than 80% of the patients. Newer trials are attempting to standardize the definition of borderline resectable pancreatic cancer and treatment regimens. In this review, we outline the definition, imaging requirements and management of patients with borderline resectable pancreatic cancer.

关键词： Pancreatic cancer Surgery Chemotherapy Radiation B

Nanodiamonds as nanomaterial for biomedical field

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Frontiers of Materials Science 2021年第3期15卷 334-351页

作者： sarah GARIFO Dimitri STANICKI Gamze AYATA Robert NMULLER Sophie LAURENT General Organic and Biomedical Chemistry UnitNuclear Magnetic Resonance(NMR)and Molecular Imaging LaboratoryUniversity of Mons(UMONS)Avenue Maistriau 197000 MonsBelgium Center for Microscopy and Molecular Imaging(CMMI) Rue Adrienne Bolland 86041 GosseliesBelgium

Recent advances in nanotechnology have attracted significant attention to nanodiamonds(NDs)in both industrial and research areas thanks to their remarkable intrinsic properties:large specific area,poor cytotoxicity,chemical resistance,magnetic and optical properties,ease of large-scale production,and surface reactivity make them suitable for numerous applications,including electronics,optics,sensors,polishing materials,and more recently,biological *** interest in diamond platforms for bioimaging and chemotherapy is *** the outstanding features of these particles and their ease of tuning,current and future applications in medicine have the potential to display innovative imaging applications and to be used as tools for monitoring and tracking drug delivery in vivo.

关键词： nanodiamond scale-up synthesis bioimaging hyperpolarization drug delivery

Comparative analysis of the biodiversity of fungal endophytes in insect-induced galls and surrounding foliar tissue

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Fungal Diversity 2014年第3期66卷 89-97页

作者： sarah P.Lawson Natalie Christian Patrick Abbot Department of Biological Sciences Vanderbilt UniversityNashvilleTN 37235USA Department of Biology Indiana University1001 E.3rd St.BloomingtonIN 47405-7005USA

Insect-induced galls are abnormal plant growths that can provide food and shelter to their inhabitants,resulting in stressed plant tissue that may alter the conditions for the colonization or proliferation of endophytic *** investigated the effect gall formation has on fungal endophyte communities and *** three closely-related gallforming aphid species that specialize on poplars,we characterized fungal endophyte diversity in galls and surrounding petiole and leaf lamina tissue.A total of 516 fungal endophyte samples were isolated from 272 tissue samples(32 leaves,31 petioles,and 209 galls),resulting in 23 distinct *** sharing a common host plant and often forming spatially contiguous galls,the endophyte profiles within the galls of each aphid species were distinct,not only from the galls of the other species,but also from surrounding plant *** results suggest that insect galls can affect the composition of fungal endophyte species in plant tissues,by altering either the colonization or proliferation of their endophytic ***,fungal endophytes may be important in the ecology and evolution of insect galls.

关键词： Insect-induced galls Fungal endophytes Fungal endophyte-insect interactions Pemphigus aphids Poplar trees

PEX16 contributions to peroxisome import and metabolism revealed by viable Arabidopsis pex16 mutants

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Journal of Integrative Plant Biology 2019年第7期61卷 853-870页

作者： sarah E.Burkhart Roxanna J.Llinas Bonnie Bartel Department of BioSciences Rice University

Peroxisomes rely on peroxins(PEX proteins) for biogenesis, importing membrane and matrix proteins, and fission. PEX16, which is implicated in peroxisomal membrane protein targeting and forming nascent peroxisomes from the endoplasmic reticulum(ER), is unusual among peroxins because it is inserted co-translationally into the ER and localizes to both ER and peroxisomal membranes. PEX16 mutations in humans, yeast, and plants confer some common peroxisomal defects; however, apparent functional differences have impeded the development of a unified model for PEX16 action. The only reported pex16 mutant in plants, the Arabidopsis shrunken seed1 mutant, is inviable,complicating analysis of PEX16 function after embryogenesis. Here, we characterized two viable Arabidopsis pex16 alleles that accumulate negligible PEX16 protein levels. Both mutants displayed impaired peroxisome function-slowed consumption of stored oil bodies, decreased import of matrix proteins, and increased peroxisome size. Moreover,one pex16 allele exhibited reduced growth that could be alleviated by an external fixed carbon source, decreased responsiveness to peroxisomally processed hormone precursors, and worsened or improved peroxisome function in combination with other pex mutants. Because the mutations impact different regions of the PEX16 gene, these viable pex16 alleles allow assessment of the importance of Arabidopsis PEX16 and its functional domains.

关键词： pex16 mutants peroxisome metabolism