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Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis

World Journal of Gastroenterology 2016年第12期22卷 3486-3495页

作者： Li-Jun Du Bin-Rui Chen John J kim sarah kim Jin-Hua Shen Ning Dai Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Hangzhou 310020 Zhejiang Province China Division of Gastroenterology Loma Linda University Loma Linda CA 92354 United States

AIM: To evaluate whether Helicobacter pylori (H. pylori) eradication therapy benefits patients with functional dyspepsia (FD).METHODS: Randomized controlled trials (RCTs) investigating the efficacy and safety of H. pylori eradication therapy for patients with functional dyspepsia published in English (up to May 2015) were identified by searching PubMed, EMBASE, and The Cochrane Library. Pooled estimates were measured using the fixed or random effect model. Overall effect was expressed as a pooled risk ratio (RR) or a standard mean difference (SMD). All data were analyzed with Review Manager 5.3 and Stata ***: This systematic review included 25 RCTs with a total of 5555 patients with FD. Twenty-three of these studies were used to evaluate the benefits of H. pylori eradication therapy for symptom improvement; the pooled RR was 1.23 (95%CI: 1.12-1.36, P < 0.0001). H. pylori eradication therapy demonstrated symptom improvement during long-term follow-up at ≥ 1 year (RR = 1.24; 95%CI: 1.12-1.37, P < 0.0001) but not during short-term follow-up at < 1 year (RR = 1.26; 95%CI: 0.83-1.92, P = 0.27). Seven studies showed no benefit of H. pylori eradication therapy on quality of life with an SMD of -0.01 (95%CI: -0.11 to 0.08, P = 0.80). Six studies demonstrated that H. pylori eradication therapy reduced the development of peptic ulcer disease compared to no eradication therapy (RR = 0.35; 95%CI: 0.18-0.68, P = 0.002). Eight studies showed that H. pylori eradication therapy increased the likelihood of treatment-related side effects compared to no eradication therapy (RR = 2.02; 95%CI: 1.12-3.65, P = 0.02). Ten studies demonstrated that patients who received H. pylori eradication therapy were more likely to obtain histologic resolution of chronic gastritis compared to those who did not receive eradication therapy (RR = 7.13; 95%CI: 3.68-13.81, P < 0.00001).CONCLUSION: The decision to eradicate H. pylori in patients with functional

关键词： Functional dyspepsia Helicobacter pylori eradication Symptom improvement Quality of life Peptic ulceration Meta-analysis

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Osteoblastic glucocorticoid signaling exacerbates high-fat-diet-induced bone loss and obesity

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Bone Research 2021年第4期9卷 537-548页

作者： sarah kim Holger Henneicke Lauryn L.Cavanagh Eugenie Macfarlane Lee Joanne Thai Daphne Foong Sylvia J.Gasparini Colette Fong-Yee Michael M.Swarbrick Markus J.Seibel Hong Zhou Bone Research Program ANZAC Research InstituteThe University of SydneySydneyNSWAustralia Concord Clinical School The University of SydneySydneyNSWAustralia Department of MedicineⅢ Technische University Dresden Medical CenterDresdenGermany Center for Healthy Aging Technische Universitat Dresden Medical CenterDresdenGermany Center for Regenerative Therapies Dresden Technische University DresdenDresdenGermany Department of Endocrinology and Metabolism Concord Repatriation General HospitalThe University of SydneySydneyNSWAustralia

Chronic high-fat diet(HFD)consumption not only promotes obesity and insulin resistance,but also causes bone loss through mechanisms that are not well ***,we fed wild-type CD-1 mice either chow or a HFD(43%of energy from fat)for 18 weeks;HFD-fed mice exhibited decreased trabecular volume(-28%)and cortical thickness(-14%)compared to chow-fed *** HFD-fed mice,bone loss was due to reduced bone formation and mineral apposition,without obvious effects on bone *** feeding also increased skeletal expression of sclerostin and caused deterioration of the osteocyte lacunocanalicular network(LCN).In mice fed HFD,skeletal glucocorticoid signaling was activated relative to chow-fed mice,independent of serum corticosterone *** therefore examined whether skeletal glucocorticoid signaling was necessary for HFD-induced bone loss,using transgenic mice lacking glucocorticoid signaling in osteoblasts and osteocytes(HSD2^(OB/OCY)-tg mice).In HSD2^(OB/OCY)-tg mice,bone formation and mineral apposition rates were not suppressed by HFD,and bone loss was significantly ***,in HSD2^(OB/OCY)-tg mice fed HFD,both Wnt signaling(less sclerostin induction,increased P

关键词： glucocorticoid obesity matched

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Long-term olfactory loss post-COVID-19:Pathobiology and potential therapeutic strategies

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 148-155页

作者： sarah kim John B.Finlay Tiffany Ko Bradley J.Goldstein Department of Head and Neck Surgery&Communication Sciences Duke UniversityDurhamNorth CarolinaUSA Medical Scientist Training Program Duke UniversityDurhamNorth CarolinaUSA Department of Neurobiology Duke UniversityDurhamNorth CarolinaUSA

An acute loss of smell emerged as a striking symptom present in roughly half of the people infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus in the early phases of the COVID-19 *** most COVID-19 patients,olfaction recovers over the course of a few ***,a lasting partial or complete loss of smell,often associated with distorted olfactory perceptions termed parosmia,has emerged as a widespread problem impacting at least 5%-10%of those who experience anosmia due to *** inability to offer effective therapies to this hyposmic or anosmic population,comprising millions of patients,highlights an enormous unmet need for the medical ***,we summarize the current understanding of the pathobiology causing acute olfactory loss due to SARS-CoV-2 infection,focusing on how the virus interacts with the peripheral olfactory system,a major site of viral *** also explore the problem of long-COVID olfactory dysfunction,which may accompany other persistent systemic disorders collectively termed postacute sequelae of ***,we discuss an emerging model focused on unresolved immune cell activity driving ongoing ***,we review current and future therapeutic approaches aimed at restoring olfactory function.

关键词： hyposmia inflammation long-COVID parosmia

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Visit Report:Shanghai Spring Shows in the eye of the overseas students

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China Textile 2015年第5期 31-35页

作者： Salma Abaoubida Mohamed Mouhib Annika Hanel sarah kim Zhao Zihan Engineering School ENSAIT Textile and Design Reutlingen University

The co-location Spring Shows, including Intertextile Shanghai Apparel Fabrics - Spring Edition, Yarn Expo Spring, PH Value and China International Fashion Fair （CHIC）, shined in Shanghai this March, bringing apparel fabrics, yarns and fibers, knitwear and other fashion garments under one roof. Taking this good opportunity, Xiao Lan, Teacher of College of Textiles, Donghua Universily, organized the overseas students to altend the show and asked them to write visit reports. Though the same show they visited, different perspectives and focuses were expressed through reports. The editor of China Textile selected four of them as a representative to share with the readers.

关键词：中国国际服装服饰博览会上海学生海外眼睛服装面料协同定位时尚服装

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Low-protein diet accelerates wound healing in mice post-acute injury

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Burns & Trauma 2021年第1期9卷 339-350页

作者： Jonathan J.Hew Roxanne J.Parungao Craig P.Mooney Julian K.Smyth sarah kim Kevin H.-Y.Tsai Huaikai Shi Cassandra Chong Renee C.F.Chan Beba Attia Caroline Nicholls Zhe Li Samantha M.Solon-Biet David G.Le Couteur Stephen J.Simpson Marc G.Jeschke Peter K.Maitz Yiwei Wang Burns Research and Reconstructive Surgery ANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Bone Biology Group ANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Adrenal Steroids Laboratory ANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Electron Microscopy Unit Anatomical PathologyConcord HospitalSydneyAustralia 2139 Burns Unit Concord Repatriation General HospitalConcordAustralia 2139 Ageing and Alzheimer Institute and ANZAC Research Institute Concord HospitalUniversity of SydneySydneyAustralia 2139 Charles Perkins Centre and School of Life and Environmental Sciences University of SydneyAustralia 2006 Sunnybrook Research Institute TorontoOntarioCanadaM4N 3M5 School of Pharmacy Nanjing University of Chinese MedicineNanjingPR China 210023

Background:Wound healing processes are influenced by macronutrient intake(protein,carbohydrate and fat).The most favourable diet for cutaneous wound healing is not known,although highprotein diets are currently favoured *** experimental study investigates the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework,a nutrient modelling method,capable of analyzing the individual and interactive effects of a wide spectrum of macronutrient ***:Two adjacent and identical full-thickness skin excisions(1 cm^(2))were surgically created on the dorsal area of male C57BL/6 *** were then allocated to one of 12 high-energy diets that varied in protein,carbohydrate and fat *** select diets,wound healing processes,cytokine expression,energy expenditure,body composition,muscle and fat reserves were ***:Using the Geometric Framework,we show that a low-protein intake,coupled with a balanced intake of carbohydrate and fat is optimal for wound *** fed a low-protein diet progressed quickly through wound healing stages with favourable wound inflammatory cytokine expression and significantly accelerated collagen *** local processes were associated with an increased early systemic inflammatory response and a higher overall energy expenditure,related to metabolic changes occurring in key macronutrient reserves in lean body mass and fat ***:The results suggest that a low-protein diet may have a greater potential to accelerate wound healing than the current clinically used high-protein diets.

关键词： Wound healing Macronutrients Cutaneous Geometric Framework Mouse model Low-protein diet Nutrition

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Management of borderline resectable pancreatic cancer

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World Journal of Gastrointestinal Oncology 2015年第10期7卷 241-249页

作者： Amit Mahipal Jessica Frakes sarah Hoffe Richard kim Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute

Pancreatic cancer is the fourth most common cause of cancer death in the United States. Surgery remains the only curative option; however only 20% of the patients have resectable disease at the time of initialpresentation. The definition of borderline resectable pancreatic cancer is not uniform but generally denotes to regional vessel involvement that makes it unlikely to have negative surgical margins. The accurate staging of pancreatic cancer requires triple phase computed tomography or magnetic resonance imaging of the pancreas. Management of patients with borderline resectable pancreatic cancer remains unclear. The data for treatment of these patients is primarily derived from retrospective single institution experience. The prospective trials have been plagued by small numbers and poor accrual. Neoadjuvant therapy is recommended and typically consists of chemotherapy and radiation therapy. The chemotherapeutic regimens continue to evolve along with type and dose of radiation therapy. Gemcitabine or 5-fluorouracil based chemotherapeutic combinations are administered. The type and dose of radiation vary among different institutions. With neoadjuvant treatment, approximately 50% of the patients are able to undergo surgical resections with negative margins obtained in greater than 80% of the patients. Newer trials are attempting to standardize the definition of borderline resectable pancreatic cancer and treatment regimens. In this review, we outline the definition, imaging requirements and management of patients with borderline resectable pancreatic cancer.

关键词： Pancreatic cancer Surgery Chemotherapy Radiation B

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A plant-based diet and hypertension

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Journal of Geriatric Cardiology 2017年第5期14卷 327-330页

作者： sarah Alexander Robert J Ostfeld Kathleen Allen kim A Williams Rush University Medical Center Division of Cardiology Chicago IL USA Montefiore Medical Center Division of Cardiology Bronx NY USA New York University Department of Nutrition & Food Studies NY USA

Hypertension is an insidious, common, and deadly dis-ease, often detected incidentally at a routine doctor＇s visit orworkplace health screening. Worldwide, it is estimated thatone billion people have hypertension and... 详细信息

关键词： Hypertension Vegan Vegetarian Plant-based diet

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Green Synthesis of Silver Nanoparticles and Their Reduced Graphene Oxide Nanocomposites as Antibacterial Agents:A Bio-inspired Approach

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Acta Metallurgica Sinica(English Letters) 2017年第1期30卷 45-52页

作者： Edreese Alsharaeh sarah Alazzam Faheem Ahmed Nishat Arshi Mohammed Al-Hindawi Garwin kim Sing College of Science & General Studies Alfaisal UniversityRiyadhSaudi Arabia

In this paper, silver nanoparticles （AgNPs） and AgNPs/reduced graphene oxide （RGO） nanocomposites were prepared using lemon juice under microwave irradiation （MWI） and UV light irradiation. AgNPs with face-centered cubic structure RGO peaks were observed by X-ray diffraction. The UV-Vis spectrum showed modifications in the absorption peaks of the AgNPs with the concentration of the precursor solution and irradiation time, and the optimized condition was obtained for 20 min MWI and 60 s of UV light. Raman analysis confirmed the presence of RGO as D and G bands in the spectrum. Transmission electron microscopy analyses confirmed that the AgNPs of size ranging from 3 to 8 nm were anchored onto the RGO sheets. The antibacterial properties of the AgNPs/RGO nanocomposites were investigated using gram-negative bacteria. The results revealed that AgNPs/RGO nanocomposites consisting of approximately 5 wt% AgNPs can achieve antibacterial performance similar to that of neat AgNPS. This method can be useful for the applications of AgNPs-based nanocomposites, where minute amount of silver will be utilized.

关键词： Silver nanoparticles (AgNPs) Nanocomposites Reduced graphene oxide Antibacterial

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Arabidopsis CAMTA Transcription Factors Regulate Pipecolic Acid Biosynthesis and Priming of Immunity Genes

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Molecular Plant 2020年第1期13卷 157-168页

作者： Yongsig kim sarah J.Gilmour Lumen Chao Sunchung Park Michael F.Thomashow MSU-DOE Plant Research Laboratory Michigan State UniversityEast LansingMl 48824USA MSU Plant Resilience Institute Michigan State UniversityEast LansingMl 48824USA Department of Plant Soil and Microbial SciencesMichigan State UniversityEast LansingMl 48824USA Present address:U.S.Department of Agriculture Agricultural Research Service1636 East Alisal St.SalinasCA 93905USA

The Arabidopsis thaliana Calmodulin-binding Transcription Activator(CAMTA)transcription factors CAMTA1,CAMTA2,and CAMTA3(CAMTA123)serve as master regulators of salicylic acid(SA)-mediated immunity,repressing the biosynthesis of SA in healthy ***,we show that CAMTA123 also repress the biosynthesis of pipecolic acid(Pip)in healthy *** of CAMTA123 function resulted in the induction of AGD2-like defense response protein 1(ALD1),which encodes an enzyme involved in Pip *** of ALD1 resulted in the accumulation of high levels of Pip,which brought about increased levels of the SA receptor protein NPR1 without induction of NPR1 expression or requirement for an increase in SA ***-mediated induction of ALD1 and genes regulating the biosynthesis of SA—CBP60g,SARD1,PAD4,and EDS1—was largely dependent on ***,Pip-mediated increase in NPR1 protein levels was associated with priming of Pip and SA biosynthesis genes to induction by low levels of *** together,our findings expand the role for CAMTA123 in regulating key immunity genes and suggest a working model whereby loss of CAMTA123 repression leads to the induction of plant defense genes and initiation of SAR.

关键词： Arabidopsis thaliana pipecolic acid salicylic acid plant immunity priming CAMTA transcription factors

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Ig SF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95

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Bone Research 2020年第1期8卷 97-106页

作者： Hyunsoo kim Noriko Takegahara Matthew CWalsh sarah AMiddleton Jiyeon Yu Jumpei Shirakawa Jun Ueda Yoshitaka Fujihara Masahito Ikawa Masaru Ishii Junhyong kim Yongwon Choi Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of MedicinePhiladelphiaPA 19104USA Department of Biology Department of Computer and Information ScienceSchool of Arts and SciencesProgram in Single Cell BiologyUniversity of PennsylvaniaPhiladelphiaPA 19104USA Research Institute for Microbial Diseases Osaka UniversitySuitaOsaka 565-0871Japan Department of Immunology and Cell Biology Graduate School of Medicine and Frontier BiosciencesOsaka UniversitySuitaOsaka 565-0871Japan

Osteoclasts are multinucleated, giant cells derived from myeloid progenitors. While receptor activator of NF-κB ligand(RANKL)stimulation is the primary driver of osteoclast differentiation, additional signaling further contributes to osteoclast ***, we demonstrate that immunoglobulin superfamily member 11(Ig SF11), whose expression increases during osteoclast differentiation, regulates osteoclast differentiation through interaction with postsynaptic density protein 95(PSD-95), a scaffold protein with multiple protein interaction domains. Ig SF11 deficiency in vivo results in impaired osteoclast differentiation and bone resorption but no observed defect in bone formation. Consequently, Ig SF11-deficient mice exhibit increased bone *** in vitro osteoclast culture systems, we show that Ig SF11 functions through homophilic interactions. Additionally, we demonstrate that impaired osteoclast differentiation in Ig SF11-deficient cells is rescued by full-length Ig SF11 and that the Ig SF11-PSD-95 interaction requires the 75 C-terminal amino acids of Ig SF11. Our findings reveal a critical role for Ig SF11 during osteoclast differentiation and suggest a role for Ig SF11 in a receptor-and signal transduction molecule-containing protein complex.

关键词： SF11 osteoclast impaired

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