Low-protein diet accelerates wound healing in mice post-acute injury

作     者：Jonathan J.Hew Roxanne J.Parungao Craig P.Mooney Julian K.Smyth Sarah Kim Kevin H.-Y.Tsai Huaikai Shi Cassandra Chong Renee C.F.Chan Beba Attia Caroline Nicholls Zhe Li Samantha M.Solon-Biet David G.Le Couteur Stephen J.Simpson Marc G.Jeschke Peter K.Maitz Yiwei Wang 

作者机构：Burns Research and Reconstructive SurgeryANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Bone Biology GroupANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Adrenal Steroids LaboratoryANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Electron Microscopy UnitAnatomical PathologyConcord HospitalSydneyAustralia 2139 Burns UnitConcord Repatriation General HospitalConcordAustralia 2139 Ageing and Alzheimer Institute and ANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Charles Perkins Centre and School of Life and Environmental SciencesUniversity of SydneyAustralia 2006 Sunnybrook Research InstituteTorontoOntarioCanadaM4N 3M5 School of PharmacyNanjing University of Chinese MedicineNanjingPR China 210023 

出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)

年 卷 期：2021年第9卷第1期

页      面：339-350页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the ANZAC Research Institute Seed Fund 

主　　题：Wound healing Macronutrients Cutaneous Geometric Framework Mouse model Low-protein diet Nutrition 

摘      要：Background:Wound healing processes are influenced by macronutrient intake(protein,carbohydrate and fat).The most favourable diet for cutaneous wound healing is not known,although highprotein diets are currently favoured *** experimental study investigates the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework,a nutrient modelling method,capable of analyzing the individual and interactive effects of a wide spectrum of macronutrient ***:Two adjacent and identical full-thickness skin excisions(1 cm^(2))were surgically created on the dorsal area of male C57BL/6 *** were then allocated to one of 12 high-energy diets that varied in protein,carbohydrate and fat *** select diets,wound healing processes,cytokine expression,energy expenditure,body composition,muscle and fat reserves were ***:Using the Geometric Framework,we show that a low-protein intake,coupled with a balanced intake of carbohydrate and fat is optimal for wound *** fed a low-protein diet progressed quickly through wound healing stages with favourable wound inflammatory cytokine expression and significantly accelerated collagen *** local processes were associated with an increased early systemic inflammatory response and a higher overall energy expenditure,related to metabolic changes occurring in key macronutrient reserves in lean body mass and fat ***:The results suggest that a low-protein diet may have a greater potential to accelerate wound healing than the current clinically used high-protein diets.