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Determining the utility of standard hospital microbiology testing: Comparing standard microbiology cultures with DNA sequence analysis in patients with chronic sinusitis

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第2期5卷 82-87页

作者： sarah K.Rapoport Alyssa j.Smith Maxwell Bergman Kelly A.Scriven Itzhak Brook Suzette K.Mikula Medstar Georgetown University Hospital Department of OtolaryngologyHeadεt Neck SurgeryWashington DCUSA Mayo Clinic Department of OtolaryngologyHeadεt Neck SurgeryRochesterMNUSA Georgetown University Medical School Washington DCUSA Medstar Georgetown University Hospital Department of Pediatricsεt Infectious DiseasesWashington DCUSA

Objective:To demonstrate DNA sequencing analysis (DNAsa) of sinus cultures in patients with CRS is a reliable method of detecting pathogens in polymicrobial CRS ***:After obtaining Institutional Review Board approval for this prospective cohort study,we selected a random sample of 50 patients with CRS at Medstar Georgetown University Hospital between September 2016 and March *** defined CRS as a history of rhinosinusitis refractory to maximal medical therapy and prior endoscopic sinus *** demonstrating active purulence in a sinus cavity were prospectively selected to undergo standard hospital cultures (SHC) and DNAsa *** identified in both methods were compared for each ***:Specimens were obtained from 29 female and 16 male patients with a mean age of 50 years.A total of 45 cultures were included in our final analysis;five cultures were excluded after inappropriate laboratory *** from these patients were compared and ***'s weighted kappa analysis showed agreement between the two testing methods in identifying predominant *** detected 31.9% more microorganisms compared to SHC (P < 0.05).When multiple microorganisms were detected,DNAsa yielded more positive results compared to SHC (P < 0.05).Conclusions:DNAsa detects all microorganisms identified by SHC as well as predominant microorganisms not detected by *** molecular pathogen identification may be more reliable for identifying multiple microorganisms as compared to standard culture techniques that identify only one or two *** recalcitrant cases of CRS,DNAsa may provide better guidance in selection of appropriate antimicrobial treatment.

关键词： Chronic rhinosinusitis (CRS) DNA sequencing analysis (DNAsa) Microbiome Molecular sequencing Microbiology culture

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使用各类模型学习高程图帮助学生理解流域概念

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中国科技教育 2017年第5期 30-37页

作者： sarah j.Fick jonathan Baek 姜景一美国维克森林大学美国密歇根州Ann Arbor市Honey Creek社区学校中国科协青少年科技中心竞赛活动处

初中阶段有一个关于地表径流的学习单元，学生要用不同模型说明流域内影响径流的各种因素。本文主要介绍在这个单元中如何结合各种工具（包括模型、数字和纸质地图）帮助学生理解“使用多元的数据源”的含义。这个单元也鼓励学生更加灵... 详细信息

初中阶段有一个关于地表径流的学习单元，学生要用不同模型说明流域内影响径流的各种因素。本文主要介绍在这个单元中如何结合各种工具（包括模型、数字和纸质地图）帮助学生理解“使用多元的数据源”的含义。这个单元也鼓励学生更加灵活地理解径流的概念。

关键词：学习单元模型概念流域生理助学高程地表径流

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职来职往——企业如何通过员工福利留住和吸引人才

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中国会展 2015年第8期 76-78页

作者： sarah j.F.Braley 韩舒宁

会议人的完美工作是一种怎样的体验？会议企业如何留住员工是一个经久不衰的话题，对现有员工好点的话，会吸引更多人才加人你的公司。在筛选了《财富》杂志评选出2015年的“最适合工作的公司”前100名以及求职网站***评选的2015年度“... 详细信息

会议人的完美工作是一种怎样的体验？会议企业如何留住员工是一个经久不衰的话题，对现有员工好点的话，会吸引更多人才加人你的公司。在筛选了《财富》杂志评选出2015年的“最适合工作的公司”前100名以及求职网站***评选的2015年度“最适合服务公司”之后，我们或许可以发现他们的经营之道。

关键词：员工福利吸引人才企业服务公司《财富》杂志 .com 求职网站经营之道

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Individual and Gender Information from Ferret: A Chemical Investigation of Urine in Comparison with Anal Gland Secretion

Individual and Gender Information from Ferret: A Chemical In...

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中国动物学会兽类学分会第六届会员代表大会暨学术讨论会

作者： Helena Soini Kevin Bruce Donald Weisler sarah K. Woodley Micheal j. Baum Milos Novotny titute for Pheromone Research at Department of Chemistry Indiana University Bloomington IN 47405 nstitute of Zoology Chinese Academy of Sciences Beijing 100080 China titute for Pheromone Research at Department of Chemistry Indiana University Bloomington IN 47405 nstitute of Zoology Chinese Academy of Sciences Beijing 100080 China titute for Pheromone Research at Department of Chemistry Indiana University Bloomington IN 47405 nstitute of Zoology Chinese Academy of Sciences Beijing 100080 China Department of Biology Boston University Boston MA 02215 USA titute for Pheromone Research at Department of Chemistry Indiana University Bloomington IN 47405 titute for Pheromone Research at Department of Chemistry Indiana University Bloomington IN 47405

＜正＞In this study, the novel quantitative stir bar sorptive extraction （SBSE） and thermal desorption gas chromatography-mass spectrometry （GC-MS） method was used to investigate urinary volatiles in comparison wi...

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Addition of Thiourea Host Monomer to Polymer Flocculants to Improve Selectivity of Phosphate Sorption

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journal of Agricultural Chemistry and Environment 2020年第3期9卷 147-158页

作者： Timothy S. Goebel Kevin j. McInnes Scott A. Senseman Robert j. Lascano Alex M. Cullen Timothy j. Fuhrer sarah Pickle Netochi O. Adeolokun Todd A. Davis USDA Wind Erosion and Water Conservation Unit Lubbock TX USA Department of Soil and Crop Sciences Texas A & M University College Station TX USA Department of Plant Sciences University of Tennessee Knoxville TN USA Department of Chemistry United States Air Force Academy USAF Academy Colorado Springs CO USA Department of Chemistry Radford University Radford VA USA Department of Chemistry Idaho State University Pocatello ID USA

Inorganic phosphate is a common nutrient that is applied as a fertilizer to both agricultural fields as well as urban settings such as private yards, public parks and other urban landscaping. While phosphate typically binds tightly to soil, movement of phosphate off of application sites can occur through soil erosion. The soil and its bound phosphate can then end up in surface waters such as rivers and lakes. Phosphate found in surface water bodies exists both as bound to the suspended clay as well as that free in solution. Elevated phosphate concentration in surface waters can lead to algal blooms and eutrophication. While the phosphate bound to clay in suspension in surface water bodies can be removed by commercially available polymer flocculants, the phosphate that is free in solution is more challenging as it is usually found in low concentrations and other anionic salts are generally present in higher concentrations. To remove phosphate from contaminated water systems, where other anions exist at higher concentrations, it is favorable to have a method of removal that is selective for phosphate. As a proof of principle, thiourea derivatized polymer flocculants were examined for the selective removal of phosphate in the presence of competing anions. The polymer flocculants exhibited selectivity for phosphate through hydrogen bonding and were effective at removing up to 43% of phosphate from simulated wastewater. Computational studies and 1H NMR were used to investigate the selectivity of the thiourea monomer for phosphate over competing anions such as chloride and sulfate.

关键词： Molecular Recognition Thiourea Polymers Flocculants Phosphate

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The exploitation of epichloae endophytes for agricultural benefit

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Fungal Diversity 2013年第3期60卷 171-188页

作者： Linda j.johnson Anouck C.M.de Bonth Lyn R.Briggs john R.Caradus sarah C.Finch Damien j.Fleetwood Lester R.Fletcher David E.Hume Richard D.johnson Alison j.Popay Brian A.Tapper Wayne R.Simpson Christine R.Voisey Stuart D.Card AgResearch Ltd Grasslands Research CentreTennent DrivePalmerston North 4442New Zealand AgResearch Ltd Ruakura Research CentreEast StreetHamilton 3214New Zealand AgResearch Ltd Lincoln Research CentreCorner Springs Road and Gerald StreetLincoln 8140New Zealand AgResearch Laboratory of Structural Biology School of Biological SciencesUniversity of Auckland3a Symonds StreetAuckland 1142New Zealand Grasslanz Technology Ltd Tennent DrivePalmerston North 4474New Zealand

Epichloae endophytes of family Clavicipitaceae(comprising genera Epichloëand Neotyphodium)are fungal symbionts of Pooideae *** associations formed,range from mutually beneficial to antagonistic and the nature of this relationship is dependent upon the importance of vertical(via host seeds)versus horizontal(ascospore mediated)transmission of the *** endophytes can enhance their hosts’survival through protection from abiotic and biotic stresses and can thus be utilized in an agricultural ***-safe grass-endophyte associations that confer bio-protective properties for increased pasture persistence and productivity have been developed and *** of the crucial drivers underpinning the selection of epichloae strains for commercial development is endophyte derived *** potential of next generation endophytes is determined by testing a number of attributes such as agronomic fitness,animal and food safety as well as compatibility with host plants of *** research supports these activities by focusing on elucidating mechanisms of compatibility between host and fungal symbiont,as well as investigating other molecular drivers of symbiosis such as siderophore mediated iron-uptake,fungal signalling,fungal growth in host plants and fungal secondary *** review weaves together the different strands of multidisciplinary research aimed at ultimately exploiting epichloae endophytes for increased pasture performance.

关键词： Epichloë Neotyphodium Pooideae Symbiosis Secondary metabolite Toxicology

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Clinical and scientific innovations in auditory brainstem implants

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World journal of Otorhinolaryngology-Head and Neck Surgery 2021年第2期7卷 109-115页

作者： Kunal R.Shetty sarah E.Ridge Vivek Kanumuri Angela Zhu M.Christian Brown Daniel j.Lee Department of Otorhinolaryngology Head and Neck Surgery McGovern Medical School at the University of Texas Health Science Center at HoustonHoustonTXUSA Eaton-Peabody Laboratories Massachusetts Eye and Ear InfirmaryHarvard Medical SchoolBostonMAf USA

The auditory brainstem implant(ABI)was originally developed to provide rehabilitation of retrocochlear deafness caused by neurofibromatosis type 2(NF2).Recent studies of the ABI have investigated outcomes in non-NF2 cohorts,such as patients with cochlear nerve aplasia or cochlear ossification and more recently,intractable *** technologies that improve the ABI-neural tissue interface are being explored as means to improve performance and decrease side *** discoveries in optogenetics and bioengineering present opportunities to continually evolve this technology into the future,enhancing spatial selectivity of neuronal activation in the cochlear nucleus and preventing side effects through reduction in activation of non-target neuronal *** advances will improve surgical planning and ultimately improve patients1 audiological *** research has rapidly increased in the 21st century and applications of this technology are likely to continually ***,we aim to characterize ongoing clinical,basic science,and bioengineering advances in ABIs and discuss future directions of this technology.

关键词： Auditory brainstem implant Cochlear nucleus Neurofibromatosis type 2 Optogenetics ABI Conformable electrode array Otology Neurotology

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更真实更高效的投票——前沿听众反馈技术解读

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中国会展 2011年第16期 52-54页

作者： sarah j.F.Braley 佟岳（编译）

听众反馈技术是应用于会议活动投票环节的～项技术，和以往举手投票等方式相比，今天的参会者能够通过电子投票工具发表自己的意见。随着电子科技的发展，今天的听众反馈技术能够应用于智能手机、便携式电脑等移动平台，让参会者更快捷... 详细信息

听众反馈技术是应用于会议活动投票环节的～项技术，和以往举手投票等方式相比，今天的参会者能够通过电子投票工具发表自己的意见。随着电子科技的发展，今天的听众反馈技术能够应用于智能手机、便携式电脑等移动平台，让参会者更快捷、简单并真诚地参与讨论，技术手段的实现让会议投票更具分析价值和意义。

关键词：电子投票技术反馈听众解读便携式电脑会议活动电子科技

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感应电动机电流传感器故障诊断研究

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电气传动 2018年第4期48卷 3-7页

作者：孙凯何柏娜 sarah Odofin 谷雨山东理工大学电气与电子工程学院山东淄博255049 诺森比亚大学工程与环境学院北京信息科技大学自动化学院北京100192

提出一种基于扩张状态观测器和遗传算法的电流传感器故障诊断方法。首先,建立了包含系统模型误差、未知扰动和传感器故障的电动机状态空间数学模型。其次,设计了一个基于电动机状态数学模型的扩张状态观测器。再次,通过闭环系统特征值... 详细信息

提出一种基于扩张状态观测器和遗传算法的电流传感器故障诊断方法。首先,建立了包含系统模型误差、未知扰动和传感器故障的电动机状态空间数学模型。其次,设计了一个基于电动机状态数学模型的扩张状态观测器。再次,通过闭环系统特征值配置和遗传优化算法搜寻闭环反馈增益矩阵的最优值。最后,建立了基于Matlab的故障诊断系统仿真模型。仿真结果表明,该故障诊断方法可以准确地诊断出传感器故障,并且对系统扰动具有很强的鲁棒性。

关键词：故障诊断遗传算法传感器故障感应电动机扩张状态观测器矢量控制

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Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management

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World journal of Gastrointestinal Pathophysiology 2020年第2期11卷 20-31页

作者： Adithya M Pathanki joseph A Attard Elizabeth Bradley sarah Powell-Brett Bobby V M Dasari john R Isaac Keith j Roberts Nikolaos A Chatzizacharias Department of HPB and Liver Transplantation Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152THUnited Kingdom Department of Nutrition and Dietetics Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152THUnited Kingdom

Pancreaticoduodenectomy(PD)is the commonest procedure performed for pancreatic *** exocrine insufficiency(PEI)may be caused or exacerbated by surgery and remains underdiagnosed and *** aim of this review was to ascertain the incidence of PEI,its consequences and management in the setting of PD for indications other than chronic pancreatitis.A literature search of databases(MEDLINE,EMBASE,Cochrane and Scopus)was carried out with the MeSH terms“pancreatic exocrine insufficiency”and“Pancreaticoduodenectomy”.Studies that analysed PEI and its complications in the setting of PD for malignant and benign disease were *** reporting PEI in the setting of PD for chronic pancreatitis,conference abstracts and reviews were *** incidence of PEI approached 100%following PD in some *** pre-operative incidence varied depending on the characteristics of the patient cohort and it was higher(46%-93%)in series where pancreatic cancer was the predominant indication for *** was also recorded with regards to the method used for the diagnosis and evaluation of pancreatic function and *** enzyme replacement therapy is the mainstay of the *** is common and remains undertreated after *** studies are required for the identification of a welltolerated,reliable and reproducible diagnostic test in this setting.

关键词： Pancreatic exocrine insufficiency Pancreaticoduodenectomy Pancreatic enzyme replacement therapy Pancreatic cancer Malabsorption Steatorrhoea

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