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Multifunctional FeCo-Graphitic Carbon Nanocrystals for Combined Imaging, Drug Delivery and Tumor-Specific Photothermal Therapy in Mice

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Nano Research 2011年第12期4卷 1248-1260页

作者： sarah P. sherlock Hongjie Dai Department of Chemistry Stanford University Stanford CA 94305 USA

Ultrasmall FeCo-graphitic carbon shell nanocrystals （FeCo/GC） are promising multifunctional materials capable of highly efficient drug delivery in vitro and magnetic resonance imaging in vivo. In this work, we demonstrate the use of FeCo/GC for highly effective cancer therapy through combined drug delivery, tumor-selective near-infrared photothermal therapy, and cancer imaging of a 4T1 syngeneic breast cancer model. The graphitic carbon shell of the ~4 nm FeCo/GC readily loads doxorubicin （DOX） via π-π stacking and absorbs near-infrared light giving photothermal heating. When used for cancer treatment, intravenously administrated FeCo/GC-DOX led to complete tumor regression in 45% of mice when combined with 20 min of near-infrared laser irradiation selectively heating the tumor to 43-45 ℃. In addition, the use of FeCo/GC-DOX results in reduced systemic toxicity compared with free DOX and appears to be safe in mice monitored for over 1 yr. FeCo/GC-DOX is shown to be a highly integrated nanoparticle system for synergistic cancer therapy leading to tumor regression of a highly aggressive tumor model.

关键词： Nanocrystals photothermal therapy doxorubicin hyperthermia magnetic resonance imaging

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Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared

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Nano Research 2010年第3期3卷 222-233页

作者： Zhuang Liu Scott Tabakman sarah sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai Functional Nano&Soft Materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Department of Chemistry Stanford UniversityStanfordCA 94305USA Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center Tsinghua UniversityBeijing 100084China

Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular *** Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of *** vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor *** is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser *** zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species.

关键词： Carbon nanotubes Raman scattering biomedicine multiplexed imaging

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High Performance In Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes

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Nano Research 2010年第11期3卷 779-793页

作者： Joshua T.Robinson Kevin Welsher Scott M.Tabakman sarah P.sherlock Hailiang Wang Richard Luong Hongjie Dai Department of Chemistry Stanford UniversityStanfordCA 94305USA Department of Comparative Medicine Stanford University School of MedicineStanfordCA 94305USA

Short single-walled carbon nanotubes(SWNTs)functionalized by PEGylated phospholipids are biologically non-toxic and long-circulating nanomaterials with intrinsic near infrared photoluminescence(NIR PL),characteristic Raman spectra,and strong optical absorbance in the near infrared(NIR).This work demonstrates the first dual application of intravenously injected SWNTs as photoluminescent agents for in vivo tumor imaging in the 1.0-1.4μm emission region and as NIR absorbers and heaters at 808 nm for photothermal tumor elimination at the lowest injected dose(70μg of SWNT/mouse,equivalent to 3.6 mg/kg)and laser irradiation power(0.6 W/cm2)reported to *** vivo resonance Raman imaging revealed the SWNT distribution within tumors at a high spatial *** tumor elimination was achieved for large numbers of photothermally treated mice without any toxic side effects after more than six months ***,side-by-side experiments were carried out to compare the performance of SWNTs and gold nanorods(AuNRs)at an injected dose of 700μg of AuNR/mouse(equivalent to 35 mg/kg)in NIR photothermal ablation of tumors in *** effective tumor elimination with SWNTs was achieved at 10 times lower injected doses and lower irradiation powers than for *** results suggest there are significant benefits of utilizing the intrinsic properties of biocompatible SWNTs for combined cancer imaging and therapy.

关键词： Photothermal cancer SWNT imaging treatment

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Uplift, climate and biotic changes at the Eocene-Oligocene transition in south-eastern Tibet

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National Science Review 2019年第3期6卷 495-504页

作者： Tao Su Robert A.Spicer Shi-Hu Li He Xu Jian Huang sarah sherlock Yong-Jiang Huang Shu-Feng Li Li Wang Lin-Bo Jia Wei-Yu-Dong Deng Jia Liu Cheng-Long Deng Shi-Tao Zhang Paul J.Valdes Zhe-Kun Zhou Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Paleobiology and Stratigraphy Nanjing Institute of Geology and Paleontology Chinese Academy of Sciences School of Environment Earth and Ecosystem Sciences The Open UniversityMK7 6AA UK Guangdong Provincial Key Laboratory of Geodynamics and Geohazards School of Earth Sciences and Engineering Sun Yat-sen University Institute of Geology and Paleontology Linyi University Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Faculty of Land Resource Engineering Kunming University of Science and Technology School of Geographical Sciences and Cabot Institute University of Bristol

The uplift history of south-eastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas. Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernization of the highly diverse, but threatened, Asian biota. Here, with new radiometric dating and newly collected plant-fossil archives, we quantify the surface height of part of the south-eastern margin of Tibet in the latest Eocene(～34 Ma) to be ～3 km and rising, possibly attaining its present elevation(3.9 km) in the early Oligocene. We also find that the Eocene–Oligocene transition in south-eastern Tibet witnessed leaf-size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate, likely reflective of both uplift and secular climate change, and that, by the latest Eocene, floral modernization on Tibet had already taken place, implying modernization was deeply rooted in the Palaeogene.

关键词： biodiversity Eocene Oligocene plant fossil Qinghai-Tibetan Plateau uplift

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