检索结果-南通市图书馆

Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food science and Human Wellness 2024年

作者： Emily P.Laveriano-santos sara Castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón Estruch Patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria santos-Beneit Juan M.Fernández-Alvira Rodrigo Fernández-Jiménez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute， Icahn school of Medicine at Mount sinai Department de Nutrició， Ciències de l'Alimentació I Gastronomia， XIA， Facultat de Farmàcia i Ciències de l'alimentació， Institut de Recerca en Nutrició i seguretat Alimentària (INsA-UB)， Universitat de Barcelona Department of Internal Medicine， Hospital Clínic， Institutd'Investigacions Biomèdiques August Pi I sunyer (IDIBAPs)， University of Barcelona Consorcio CIBER， M.P.Fisiopatología de la Obesidad y Nutrición (CIBERObn)， Instituto de salud Carlos III (IsCIII) Mediterranean Diet Foundation 5. Foundation for science， Health and Education (sHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico san Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the sI! Program for secondary schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend st quintile of stilbene intake with lower BG (β=-1.83， 95%CI= -3.103;-0.64， P-for trend st quintile. Conclusion: A higher intake of (poly)phenols， espe

关键词：

负载二氢杨梅素的玉米醇溶蛋白-阿拉伯胶纳米粒子的制备及分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

食品工业科技 2024年

作者：常大伟曹佳怡任娜王虎玄孙玉娇沈文 sara.sendi 陕西科技大学食品科学与工程学院

本研究将二氢杨梅素（Dihydromyricetin，DMY）作为核心来构建纳米粒子，并借助纳米粒子对DMY予以包封，旨在解决其水溶性差以及稳定性欠佳的难题，从而提高其利用率与生物活性。采用反溶剂沉淀法，以DMY为芯材，以玉米醇溶蛋白（Zein... 详细信息

本研究将二氢杨梅素（Dihydromyricetin，DMY）作为核心来构建纳米粒子，并借助纳米粒子对DMY予以包封，旨在解决其水溶性差以及稳定性欠佳的难题，从而提高其利用率与生物活性。采用反溶剂沉淀法，以DMY为芯材，以玉米醇溶蛋白（Zein）为载体，构建Zein-阿拉伯胶（GA）纳米营养递送体系，以粒径、多分散指数（PDI）、zeta电位、包封率为指标优化了Zein/GA-DMY纳米粒子的制备条件。同时，采用傅里叶红外光谱（FT-IR）和X射线衍射（XRD）探讨了Zein、GA和DMY之间的相互作用，利用扫描电子显微镜（sEM）观察了该体系的微观形貌。结果表明，当Zein与阿拉伯胶的质量比为1:2，Zein与DMY质量比为10:1时，制备的纳米粒子粒径较小（191.04 nm），PDI为0.164，zeta电位为-17.70 mV，包封率为76.17%。氢键、静电和疏水相互作用是使该纳米粒子形成的主要驱动力，DMY以非晶体状态成功包埋在Zein/GA-DMY纳米粒子中，复合物呈球形，且分布均匀。GA的包覆使纳米粒子在一定条件下具备pH、加热、盐离子及储藏稳定性，扩展了其应用范围；体外抗氧化和模拟胃肠道消化实验表明经复合纳米粒子包封后DMY仍具备较强的抗氧化活性，同时呈现缓释特性。因此，本研究可为DMY在功能性食品领域的应用提供一定的理论基础。

关键词：二氢杨梅素玉米醇溶蛋白阿拉伯胶纳米粒子稳定性生物利用度壳-核结构

挤压过程中AA6xxx铝合金型材的再结晶行为模拟（英文）

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals society of China 2024年第10期 3170-3184页

作者： Marco NEGOZIO Antonio sEGATORI Riccardo PELACCIA Barbara REGGIANI sara Di DONATO Lorenzo DONATI University of Parma-Department of Engineering and Architecture Hydro Innovation and Technology DIsMI Department of sciences and Methods for Engineering University of Modena and Reggio Emilia InterMech-MO.RE–University of Modena and Reggio Emilia DIN Department of Industrial Engineering–University of Bologna

介绍了一种开发AA6063铝合金再结晶模型的创新方法。该方法结合了基于回归分析的材料常数测定技术，并引入了评估晶粒尺寸演变的新方程。该方法的校准和验证结合了从3种AA6063铝合金型材的挤压实验中获得的显微组织数据和使用Qform Extr... 详细信息

介绍了一种开发AA6063铝合金再结晶模型的创新方法。该方法结合了基于回归分析的材料常数测定技术，并引入了评估晶粒尺寸演变的新方程。该方法的校准和验证结合了从3种AA6063铝合金型材的挤压实验中获得的显微组织数据和使用Qform Extrusion UK有限元代码模拟的结果。结果表明，显微组织演化的实验结果与数值模拟的预测结果相吻合。该方法准确模拟了动态再结晶和静态再结晶后晶粒尺寸随不同工业参数变化的趋势，在几乎整个抽样计算中，误差都小于25%。

关键词：再结晶模拟铝合金挤压有限元法显微组织预测

Magnetic resonance spectroscopy findings of brain olfactory areas in patients with COVID-19-related anosmia:A preliminary comparative study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck surgery 2024年第2期10卷 105-112页

作者： shadman Nemati Mohammad Haghani Dogahe Alia saberi Naghi Ramezani Pejman Kiani Tofigh Yaghubi Kalurazi Ehsan Kazemnejad Leili sara.seddighi Abbas Monsef Department of Otolaryngology and Head and Neck surgery School of MedicineOtorhinolaryngology Research CenterGuilan University of Medical SciencesRashtIran Guilan Road Trauma Research Center Guilan University of Medical SciencesRashtGuilanIran Department of Neurology Neuroscience Research CenterPoursina HospitalGuilan University of Medical SciencesRashtIran Department of Radiology Pars International HospitalGuilan ProvinceIran Department of Neuroscience and Addiction studies School of Advanced Technologies in MedicineTehranIran Department of Infectious Diseases Razi Clinical Research Development UnitRazi HospitalGuilan University of Medical SciencesRashtIran Center of Magnetic Resonance Research Department of Radiation OncologyUniversity of Minnesota Medical SchoolMinneapolisMinnesotaUSA

Objectives:2019 novel coronavirus disease(COVID-19)infection is commonly associated with olfactory dysfunctions,but the basic pathogenesis of these complications remains *** study seeks to evaluate the value of magnetic resonance spectroscopy(MRs)in determining the molecular neurometabolite alterations within the main brain olfactory areas in patients with COVID-19-related ***:In a cross-sectional study,seven patients with persistent COVID-19-related anosmia(mean age:29.57 years)and seven healthy volunteers(mean age:27.28 years)underwent MRs in which N-acetyl-aspartate(NAA),choline(Cho),creatine(Cr),and their ratios were measured in the anterior cingulate cortex,dorsolateral prefrontal cortex,orbitofrontal cortex(OFC),insular cortex,and ventromedial prefrontal *** were analyzed using TARQUIN software(version 4.3.10),and the results were compared with an independent sample t-test and nonparametric Mann-Whitney test based on the normality of the MRs data ***:The mean duration of anosmia before imaging was 8.5 months in COVID-19-related anosmia *** analysis elucidated a significant association between MRs findings within OFC and COVID-19-related anosmia(P_(disease)s among the most important neurometabolites(P_(interaction)=0.006).Reduced levels of NAA(Ps study emphasizes that MRs can be illuminating in COVID-19-related anosmia and indicates a possible association between central nervous system impairment and persistent COVID-19-related anosmia.

关键词： anosmia COVID-19 magnetic resonance spectroscopy neuroimaging olfaction

维普期刊数据库

海藻酸钠-低脂果胶-刺槐豆胶三元复合膜的制备及其在香菇压差膨化干燥中的应用

在线全文

学校读者我要写书评

暂无评论

食品工业科技 2024年

作者：常大伟任娜曹佳怡王虎玄孙玉娇沈文 sara.sendi 支晓红陕西科技大学食品科学与工程学院咸阳市食品药品检验检测中心

本研究以海藻酸钠（sA）、低脂果胶（LMPs）和刺槐豆胶（LBG）为成膜材料，通过优化各组分的质量比，成功制备了一种海藻酸钠-低脂果胶-刺槐豆胶三元复合可食膜（sPL）。系统研究了复合膜液的流变学特性，测量了膜的机械性能（包括抗拉... 详细信息

本研究以海藻酸钠（sA）、低脂果胶（LMPs）和刺槐豆胶（LBG）为成膜材料，通过优化各组分的质量比，成功制备了一种海藻酸钠-低脂果胶-刺槐豆胶三元复合可食膜（sPL）。系统研究了复合膜液的流变学特性，测量了膜的机械性能（包括抗拉强度和断裂伸长率）、水蒸气透过系数、水溶性、透光率以及水接触角等关键性能指标，利用扫描电镜（sEM）和傅里叶红外光谱（FTIR）技术对复合膜的表面形貌、内部结构及其组分间的相互作用进行表征。此外，本研究还探索了sPL三元复合膜涂膜预处理在香菇压差膨化干燥（EPD）工艺中的应用效果。实验结果显示，当sA、LMPs和LBG的质量比为50:20:30时，所制备的sPL三元复合膜的综合性能较优，抗拉强度为13.54±0.95 MPa，断裂伸长率为58.15%±4.32%，同时在600 nm波长下的透光率为79.70%±2.31%，表现出良好的机械强度和光学性能。复合膜表面平滑，内部结构均匀致密，sA、LMPs和LBG三者之间具有良好的相互作用及分子相容性。与未处理和仅使用sA膜液涂膜预处理的EDP香菇产品相比，采用sPL三元复合膜液结合Ca2+交联涂膜预处理后的EPD香菇产品，其产品品质得到了明显提升。

关键词：多糖可食用膜香菇压差膨化干燥涂膜预处理

新奥尔良当代艺术中心共享办公室美国新奥尔良

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界建筑导报 2024年第1期39卷 74-78页

作者：无 Neil Alexander(摄影) sara Essex Bradley(摄影) EDR建筑事务所不详

The shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮... 详细信息

The shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮店,70年代中期被用作当代艺术中心。顶部两层在过去40年中一直没有被充分利用,The shop的开发标志着对这一空间的第一次大规模整修。

关键词：联合办公当代艺术中心新奥尔良市美国新奥尔良 shop 冷饮店办公室杂货

维普期刊数据库

Influence of statins and Fibrates Drugs on Bone Health and Regeneration

在线全文

学校读者我要写书评

暂无评论

Journal of Biomaterials and Nanobiotechnology 2024年第1期15卷 1-24页

作者： Octavio santiago Ivan Nadir Camal Ruggieri Marina Ribeiro Paulini Valéria Paula sassoli Fazan João Paulo Mardegan Issa sara Feldman LABOATEM Laboratory of Bone Biology and Tissue Engineering School of Medicine Rosario National University Ros&#225rio Argentina school of Dentistry of Ribeirã o Preto University of S&#227o Paulo (FORP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil school of Medicine of Ribeirã o Preto University of S&#227o Paulo (FMRP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil

In the medical and dental field, the importance and need for the study of materials and drugs for use as bone grafts or regeneration in injured areas due to the presence of fractures, infections or tumors that cause extensive loss of bone tissue is observed. Bone is a specialized, vascularized and dynamic connective tissue that changes throughout the life of the organism. When injured, it has a unique ability to regenerate and repair without the presence of scars, but in some situations, due to the size of the defect, the bone tissue does not regenerate completely. Thus, due to its importance, there is a great development in therapeutic approaches for the treatment of bone defects through studies that include autografts, allografts and artificial materials used alone or in association with bone grafts. Pharmaceuticals composed of biomaterials and osteogenic active substances have been extensively studied because they provide potential for tissue regeneration and new strategies for the treatment of bone defects. statins work as specific inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoAreductase). They represent efficient drugs in lowering cholesterol, as they reduce platelet aggregation and thrombus deposition;in addition, they promote angiogenesis, reduce the β-amyloid peptide related to Alzheimer’s disease and suppress the activation of T lymphocytes. Furthermore, these substances have been used in the treatment of hypercholesterolemia and coronary artery disease. By inhibiting HMG-CoAreductase, statins not only inhibit cholesterol synthesis, but also exhibit several other beneficial pleiotropic effects. Therefore, there has been increasing interest in researching the effects of statins, including simvastatin, on bone and osteometabolic diseases. However, statins in high doses cause inflammation in bone defects and inhibit osteoblastic differentiation, negatively contributing to bone repair. Thus, different types of studies with different conc

关键词： Bone statins Rosuvastatin sinvastatin Fibrates Fenofibrate Bone Regeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

野性之路往自然深处走，探索山巅每一面

环球人文地理 2024年第13期 24-33页

作者： sara 俞浩洋(JmT) 放眼无忌李永男加拿大BC省旅游局

从温哥华出发，沿着天海公路一路前行，从海平面到山巅，从峡谷到冰川……探索BC省的野性，用车轮丈量与罗布森山的距离。惠斯勒滑雪场“教父”，也是骑行天堂李宗盛说：“风，声响，潮汐，天光，让寂寞变得有意义起来。”坐落在加拿大...

从温哥华出发，沿着天海公路一路前行，从海平面到山巅，从峡谷到冰川……探索BC省的野性，用车轮丈量与罗布森山的距离。惠斯勒滑雪场“教父”，也是骑行天堂李宗盛说：“风，声响，潮汐，天光，让寂寞变得有意义起来。”坐落在加拿大西海岸的温哥华，确实如他所言，充满浪漫活力。

关键词：

Effectiveness of Wastewater-Based Epidemiology as an Early Warning Tool to Detect sARs-CoV-2 (COVID-19)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Health 2024年第7期16卷 635-656页

作者： Rakib Ahmed Chowdhury Daniel E. Meeroff sumaiya sharmin Alamgir Kabir sara Hollenbeck Valerie Dalencourt Thu Nguyen Zack Farmer Frederick Bloetscher Waseem Asghar stacey Volnick College of Engineering and Computer science Florida Atlantic University Boca Raton FL USA

Medical diagnostic tests to detect severe Acute Respiratory syndrome Coronavirus-2 (sARs-CoV-2) for individuals in the United states were initially limited to people who were traveling or symptomatic to track disease incidence due to the cost of providing testing for all people in a community on a routine basis. As an alternative to randomly sampling large groups of people to track disease incidence at significant cost, wastewater-based epidemiology (WBE) is a well-established and cost-effective technique to passively measure the prevalence of disease in communities without requiring invasive testing. WBE can also be used as a forecasting tool since the virus is shed in individuals prior to developing symptoms that might otherwise prompt testing. This study applied the WBE approach to understand its effectiveness as a possible forecasting tool by monitoring the sARs-CoV-2 levels in raw wastewater sampled from sewer lift stations at a large public university campus setting including dormitories, academic buildings, and athletic facilities. The WBE analysis was conducted by sampling from building-specific lift stations and enumerating target viral copies using RT-qPCR analysis. The WBE results were compared with the 7-day rolling averages of confirmed infected individuals for the following week after the wastewater sample analysis. In most cases, changes in the WBE outcomes were followed by similar trends in the clinical data. The positive predictive value of the applied WBE approach was 86% for the following week of the sample collection. In contrast, positive correlations between the two data with spearmen correlation (rs) ranged from 0.16 to 0.36. A stronger correlation (rs = 0.18 to 0.51) was observed when WBE results were compared with COVID-19 cases identified on the next day of the sampling events. The P value of 0.007 for Dorm A suggests high significance, while moderate significance was observed for the other dormitories (B, C, and D). The outcomes of this in

关键词： sARs-CoV-2 Wastewater Detection Wastewater-Based Epidemiology (WBE)