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Advances in Enzyme Research 2022年第4期10卷 83-100页

作者： Silvia Alejandra Meza-Ireta blanca Colin-Lozano Penélope Merino-Montiel José Luis Vega-báez sara Montiel-Smith Facultad de Ciencias Químicas Ciudad Universitaria Benemérita Universidad Autónoma de Puebla Puebla México

Hormone Receptor positive (HR+) breast cancer is the most common malignancy in women. New strategies in the treatments have targeted the estrogen biosynthesis pathways including the inhibition of the aromatase and 17β-HSD1 enzymes. The present work, describes the study of a new family of 9 hybrid compounds derived from estrone attached to a coumarin fragment, linked through different lengths of hydrocarbon chains. The activity of these compounds was evaluated by molecular docking with two relevant enzymes in breast cancer (HR+). It has been proposed nine compounds as 17β-HSD1 inhibitors and six as aromatase inhibitors. We found important interactions with key amino acids at the orthosteric site of each enzyme and their score values compared to the crystallographic ligand. The in silico analysis showed good score values in the proposed compounds, where the steroidal portion presented important interactions with Met374 and Tyr155 in aromatase and in 17β-HSD1 respectively. Highlighting Compounds 2, 5 and 8 with an aromatic ring at the C4 position of the coumarin moiety, which favored arene-H type interactions essential for protein-ligand recognition. In addition, the results related to the 17β-HSD1 enzyme demonstrated how the length of the linker influences the interaction;the best score was found for derivative 8 with a chain of 8 methylenes.

关键词： Estrone Coumarins Aromatase Inhibitors 17β-HSD1 Inhibitors Molecular Docking

Effect of Melt Scan Rate on Microstructure and Macrostructure for Electron beam Melting of Ti-6Al-4V

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Materials Sciences and Applications 2012年第5期3卷 259-264页

作者： Karina Puebla Lawrence E. Murr sara M. Gaytan Edwin Martinez Francisco Medina Ryan b. Wicker University of Texas at El Paso El Paso USA

Microstructure and variations in porosity in Ti-6Al-4V samples built with electron beam melting (EbM) over a range of melt scan speeds, ranging from 100 mm·s-1 to 1000 mm·s-1 were examined. Microstructure was characterized by refinement of α-phase and transformation to α′-martensite. Light optical microscopy, scanning electron microscopy, and transmission electron microscopy were used to observe these phenomena, while corresponding tensile testing and associated macro and microindentation hardness measurements were used to define the microstructural variations. Relative stiffness was observed to be linearly log-log related to relative density, corresponding to ideal porosity associated with open-cellular structures.

关键词： Electron beam Melting Additive Manufacturing α-Phase and α′-Martensite Optical and Electron Microscopy Melt-Scan Rate

Lower limb balance,ankle dorsiflexion,orofacial tissue pressure,and occlusal force of rugby players

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Sports Medicine and Health Science 2024年第2期6卷 173-178页

作者： Rafael R.Machado Marcelo Palinkas Paulo b.de Vasconcelos sara Gollino Veridiana W.Arnoni Marcos Vinicios R.Prandi Isabela H.Regalo Selma Siessere Simone C.H.Regalo School of Dentistry of Ribeirao Preto University of Sao PauloBrazil National Institute for Translational Medicine(INCT-TM) Ribeirao PretoBrazil

This cross-sectional study examined the lower limb balance,ankle dorsiflexion,orofacial tissue pressure,and occlusal strength of rugby ***-six participants were divided into groups:rugby players(n=13)and healthy sedentary adults(n=13).Participants underwent an analysis of lower limb balance using a composite score(Y-balance Test).Ankle dorsiflexion was measured using the Lunge *** Iowa Oral Performance Instrument was employed to measure orofacial tissue *** force was measured with a dynamometer,and T-Scan assessed occlusal contact *** were analyzed using the t-test(pble to verify that these factors did not influence the results *** differences were observed in the balance of the right(p=0.07)and left(p=0.02)lower limbs,where rugby players had lower composite *** were significant differences in the right(p=0.005)and left(p=0.004)lunges,with rugby players showing lower values,as well as lower tongue pressure(p=0.01)and higher lip pressure(p=0.03),with significant differences to sedentary *** was no significant difference in molar bite force and distribution occlusal contacts between *** seems to reduce lower limb displacement,cause ankle hypomobility,lead to changes in orofacial tissues,particularly the tongue and *** study is significant for identifying significant differences between rugby players and sedentary individuals,providing new insights into the impact of rugby on health and performance,which can benefit sports training and injury prevention.

关键词： Rugby Y-balance test Lunge test Orofacial tissues Occlusal force

Corrigendum to Mercury photoreduction and photooxidation in lakes:effects of filtration and dissolved organic carbon *** of Environmental Sciences 68(2018)151-159

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Journal of Environmental Sciences 2021年第5期33卷 347-350页

作者： Nelson J.O'Driscol Emma Vost Erin Mann sara Klapstein Robert Tordon Matthew Lukeman Department o f Earth&Environmental Science.Acadia University WolfuilleNova ScotiaCanada B4P 2R62 Environment Canada DartmouthNova Scotia Department of Chemistry Acadia UniversityWolfuilleNova ScotiaCanada B4P 2R6

"Filtered(0.2μm)and unfiltered samples were analyzed for gross photoreduction,gross photooxidation,and net reduction rates of mercury using pseudo first-order curves.

关键词： lakes Mercury dissolved

What factors influence patient experience in orthopedic oncology office visits?

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World Journal of Clinical Oncology 2020年第3期11卷 136-142页

作者： Alan T blank sara Shaw Connor J Wakefield Yue Zhang Wei J Liu Kevin b Jones R Lor Randall Department of Orthopedic Surgery Division of OncologyRush University Medical CenterChicagoIL 61011United States Department of Orthopedics University of UtahSalt Lake CityUT 84122United States Department of Family&Preventive Medicine University of UtahSalt Lake CityUT 84108United States Scientific Computing and Image Institute University of UtahSalt Lake CityUT 84108United States Department of Orthopaedic Surgery University of California-Davis Medical CenterSacramentoCA 95817United States

bACKGROUND Patient satisfaction and reported outcomes are becoming increasingly important in determining the efficacy of clinical *** date no study has evaluated the patient experience in the orthopedic oncology outpatient setting to determine which factors of the encounter are priorities to the *** To evaluate what factors impact patient experience and report satisfaction in an outpatient orthopedic oncology *** Press Ganey®patient surveys from a single outpatient orthopedic oncology clinic at a tertiary care setting were prospectively collected per routine medical *** orthopedic oncology patients who were seen in clinic and received electronic survey were *** survey responses were submitted within one month of clinic *** approval was obtained to retrospectively collect survey responses from 2015 to *** demographic data along with survey category responses were collected and statistically *** One hundred sixty-two patient surveys were *** patient age was 54.4 years(SD=16.2 years)and were comprised of 51.2% female and 48.4%male.64.2%of patients were from *** of state residents were more likely to recommend both the practice and attending *** likelihood to recommend attending physician was positively associated with MD friendliness/courtesy(OR=14.4,95%CI:2.5-84.3),MD confidence(OR=48.2,95%CI:6.2-376.5),MD instructions follow-up care(OR=2.5,95%CI:0.4-17.4),and sensitivity to needs(OR=16.1,95%CI:1-262.5).Clinic operations performed well in the categories of courtesy of staff(76%)and cleanliness(75%)and less well in ease of getting on the phone(49%),information about delays(36%),and wait time(37%).CONCLUSION Orthopedic specialties can utilize information from this study to improve care from the patient *** studies may be directed at how to improve these areas of care which are most valued by the patient.

关键词： Press Ganey^(█) survey Orthopedic oncology Outpatient clinic Patient experience Patient satisfaction Patient reported outcomes

National Comprehensive Cancer Network guidelines compliance of a sarcoma service:A retrospective review

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World Journal of Clinical Oncology 2020年第6期11卷 389-396页

作者： Alan T blank brandon Michael Larson sara Shaw Connor J Wakefield Tricia King Kevin b Jones R Lor Randall Department of Orthopedic Surgery Division of OncologyRush University Medical CenterChicagoIL 60612United States Department of Orthopedics University of UtahSalt Lake CityUT 84108United States Department of Orthopedic Surgery University of California-Davis Medical CenterSacramentoCA 95817United States

bACKGROUND Clinical workup and treatment guidelines have been published by the National Comprehensive Cancer Network(NCCN)to ensure patients are treated uniformly and *** study sought to retrospectively review patients with a new diagnosis of sarcoma who were treated in a National Cancer Institute(NCI)designated center and determine compliance rates with guidelines for *** To evaluate our compliance of NCCN sarcoma guidelines at a major NCI designated center and to report instances of deviation that could be used for future studies to improve patient *** Data was collected retrospectively as an internal review and quality assessment of 35 newly diagnosed and treated *** data were recorded and information concerning whether patients had appropriate imaging,biopsy and *** of interest were expressed as raw numbers and *** Primary site imaging was obtained in 100%of *** and full-body imaging were obtained in 97%and 100%of indicated cases,*** was obtained preoperatively in 97%of *** was reviewed at multidisciplinary Treatment Planning Conference(TPC)in 97%of *** was reviewed in 94%of cases in *** tumor,node,metastasis staging and plan of care were reviewed in 100%of cases in *** guidelines were followed in 94%of cases *** This study evaluated the workup and treatment provided by a single NCI designated sarcoma service to a series of patients with pathologies defined with the NCCN sarcoma treatment *** adherence to NCCN was reported to be very high future prospective studies are required to investigate whether NCCN guidelines impact patient outcomes.

关键词： Soft tissue sarcoma bony sarcoma Orthopedic Oncology Sarcoma guidelines National Comprehensive Cancer Network

Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis

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World Journal of Gastroenterology 2010年第24期16卷 3016-3024页

作者： Edmondo Falleti Davide bitetto Carlo Fabris Annarosa Cussigh Elisabetta Fontanini Ezio Fornasiere Elisa Fumolo sara bignulin sara Cmet Rosalba Minisini Mario Pirisi Pierluigi Toniutto Laboratory Medicine University of Udine Department of Medical Sciences Clinical and Experimental Medical Liver Transplant UnitUniversity of Udine Department of Clinical and Ex-perimental Medicine University of Eastern Piedmont "A. Avoga-dro"

AIM: To assess the relationship between vitamin D re-ceptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC). METHODS: Two-hundred forty patients who underwent liver transplantation were studied. The etiologies of liver disease were hepatitis C (100 patients), hepatitis b (37) and alcoholic liver disease (103). A group of 236 healthy subjects served as controls. HCC in the explanted liver was detected in 80 patients. The following single nucle-otide gene polymorphisms of the VDR were investigatedby polymerase chain reaction and restriction fragment length polymorphism: FokI C>T (F/f), bsmI A>G (b/b), ApaI T>G (A/a) and TaqI T>C (T/t) (bAT). RESULTS: The frequencies of genotypes in patients without and with HCC were for FokI F/F = 69, F/f = 73, f/f = 18 and F/F = 36, F/f = 36, f/f = 8; bsmI b/b = 45, b/b = 87, b/b = 28 and b/b = 33, b/b = 35, b/b = 12; for ApaI A/A = 53, A/a = 85, a/a = 22 and A/A = 27, A/a = 38, a/a = 15; for TaqI T/T = 44, T/t = 88, t/t = 28 and T/T = 32, T/t = 38, t/t = 10. Carriage of the b/b genotype of bsmI and the T/T genotype of TaqI was signif icantly associated with HCC (45/160 vs 33/80, P bsence of the A-T-C protective allele of bAT was signif i-cantly associated with the presence of HCC (46/80 vs 68/160, P bserved between carriage of the bAT A-T-C and G-T-T haplotypes and HCC only in alcoholic liver disease (7/46 vs 12/36 vs 11/21, P < 0.002, respectively).CONCLUSION: VDR genetic polymorphisms are sig-nificantly associated with the occurrence of HCC in patients with liver cirrhosis. This relationship is more specific for patients with an alcoholic etiology.

关键词： Alcohol Hepatocellular carcinoma Liver cirrhosis Vitamin D receptor polymorphisms

Diagnostic strategy for occult hepatitis b virus infection

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World Journal of Gastroenterology 2011年第12期17卷 1553-1557页

作者： sara Ocana Maria Luisa Casas Ingrid buhigas Jose Luis Lledo Service of Clinical Laboratory Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadrid 28036Spain Service of biochemistry Hospital Universitario Fundación Alcorcón.Av Budapest-1.28922 AlcorcónMadrid 28036Spain Service of Gastroenterology Hospital Universitario Fundación Alcorcón.Av Budapest-1.28922 AlcorcónMadrid 28036Spain Navarro Service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-1.28922 AlcorcónMadrid 28036Spain

In 2008,the European Association for the study of the liver(EASL) defined occult hepatitis b virus infection (ObI) as the"presence of hepatitis b virus(HbV) DNA in the liver(with detectable or undetectable HbV DNA in the serum) of individuals testing hepatitis b surface antigen(HbsAg) negative by currently available assays".Several aspects of occult HbV infection are still poorly understood,including the definition itself and a standardized approach for laboratory-based detection,which is the purpose of this *** clinical significance of ObI has not yet been established;however,in terms of public health,the clinical importance arises from the risk of HbV ***,it is important to detect high-risk groups for occult HbV infection to prevent *** main issue is,perhaps,to identify the target population for screening *** is very low or undetectable in occult HbV infection,even when the most sensitive methods are used,and the detection of the viral DNA reservoir in hepatocytes would provide the best evaluation of occult HbV prevalence in a defined set of ***,this diagnostic approach is obviously unsuitable:blood detection of occult hepatitis b requires assays of the highest sensitivity and specificity with a lower limit of detectionbV DNA andbsAg.

关键词： Occult hepatitis b virus infection Hepatitis b surface antigen Hepatitis b virus DNA Anti-Hbc

Risk of hepatitis b virus reactivation in rheumatoid arthritis patients undergoing biologic treatment: Extending perspective from old to newer drugs

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World Journal of Hepatology 2015年第3期7卷 344-361页

作者： Francesca De Nard Monica Todoerti Vittorio Grosso sara Monti Silvia breda Silvia Rossi Carlomaurizio Montecucco Roberto Caporali IRCCS Policlinico San Matteo Foundation Chair and Division of Rheumatology University of Pavia

Hepatitis b virus(HbV) reactivation in rheumatoid arthritis(RA) patients undergoing biological therapy is not infrequent. This condition can occur in patients with chronic hepatitis b as well as in patients with resolved HbV infection. Current recommendations are mainlyfocused on prevention and management strategies of viral reactivation under tumor necrosis factor-α inhibitors or chimeric monoclonal antibody rituximab. In recent years, growing data concerning HbV reactivation in RA patients treated with newer biological drugs like tocilizumab and abatacept have cumulated. In this review, epidemiology, pathogenesis and natural history of HbV infection have been revised first, mainly focusing on the role that specific therapeutic targets of current biotechnological drugs play in HbV pathobiology; finally we have summarized current evidences from scientific literature, including either observational studies and case reports as well, concerning HbV reactivation under different classes of biological drugs in RA patients. Taking all these evidences into account, some practical guidelines for screening, vaccination, prophylaxis and treatment of HbV reactivation have been proposed.

关键词： Rheumatoid arthritis Hepatitis b virus biologics Anti-TNF Rituximab Tocilizumab Abatacept

Control programs for strongyloidiasis in areas of high endemicity: an economic analysis of different approaches

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Infectious Diseases of Poverty 2021年第3期10卷 72-81页

作者： Dora buonfrate Lorenzo Zammarchi Zeno bisoffi Antonio Montresor sara boccalin Department of Infectious Tropical Diseases and Microbiology IRCCS Sacro Cuore Don Calabria HospitalNegrarVeronaItaly Department of Experimental and Clinical Medicine University of FlorenceFlorenceItaly Referral Center for Tropical Diseases of Tuscany Infectious and Tropical Diseases UnitCareggi University HospitalFlorenceItaly. Department of Diagnostics and Public Health University ofVeronaVeronaItaly Department of Control of Neglected Tropical Diseases World Health OrganizationGenevaSwitzerland Department of Health Sciences University of FlorenceFloreneeItaly.

background:Implementation of control programmes for Strongyloides stercoralis infection is among the targets of the World Health Organization Roadmap to *** ofthis work was to evaluate the possible impact in terms of economic resources and health status of two different strategies of preventive chemotherapy(PC)compared to the current situation(strategy A,no PC):administration of ivermectin to school-age children(SAC)and adults(strategy b)versus ivermectin to SAC only(strategy C).Methods:The study was conducted at the IRCCS Sacro Cuore Don Calabria hospital,Negrar di Valpolicella,Verona,Italy,at the University of Florence,Italy,and at the WHO,Geneva,Switzerland,from May 2020 to April *** for the model were extracted from literature.A mathematical model was developed in Microsoft Excel to assess the impact of strategies b and C in a standard population of 1 million subjects living in a strongyloidiasis endemic *** a case base seenario,15%prevalence of strongyloidiasis was considered;the 3 strategies were then evaluated at different thresholds of prevalenee,ranging from 5 to 20%.The results were reported as number of infected subjects,deaths,costs,and Incremental-Effectiveness Ratio(ICER).A 1-year and a 10-year horizons were ***:In the case base seenario,cases of infections would reduce dramatically in the first year of implementation of PC with both strategy b and C:from 172500 cases to 77040 following strategy b and 146700 following strategy *** additional cost per recovered person was United States Dollar(USD)2.83 and USD 1.13 in strategy b and C,respectively,compared to no treatment in the first *** both strategies,there was a downtrend in costs per recovered person with increasing *** number of adverted deaths was larger for strategy b than C,but cost to advert one death was lower for strategy C than ***:This analysis permits to estimate the impact of two PC strategies for the control of strongyloidiasis in

关键词： Strongyloides stercoralis Strongyloidiasis Control programme Preventive chemotherapy Ivermectin Economic Adverted death Adverted infection