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In Vivo Animal Model Evaluation of a Powerful Oral Nanomedicine for Treating Breast Cancer in BALB/c Mice Using 4T1 Cell Lines without Chemotherapy

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Advances in Nanoparticles 2022年第3期11卷 73-109页

作者： Zahra Fakhroueian Alireza Massiha Pegah Esmaeilzadeh Mehdi Assmar Afshin Zahedi Pouriya Esmaeilzadeh sara rezaei Shahab Rabiei Lalehdasht School of Chemical Engineering (Nanomedicine) College of Engineering University of Tehran Tehran Iran Department of Biotechnology Lahijan Branch Islamic Azad University Lahijan Iran Institute of Pharmacy Martin Luther University Halle Wittenberg Halle (Saale) Germany Department of Microbiology Lahijan Branch Islamic Azad University Lahijan Iran Department of Veterinary Pathology Islamic Azad University Rasht Branch Rasht Iran Department of Chemical Engineering Sharif University of Technology Tehran Iran Research Department Production and Laboratory Company ZFP Rasht Iran Department of Biology Faculty of Science Rasht Branch Islamic Azad University Guilan Iran

Nanopharmaceuticals containing quantum dot nanoparticles (Q-Dot NPs) for treating serious cancers such as breast cancer have made fantastic proposals. In this study, ZnO quantum dot NPs are formulated via ZnO@PVP nanopolymer as co-assistants coordinating with efficacious suitable wetting agents, PEG-binding compound, and W/O emulsifier for producing eco-friendly water-based nanodrug. Several characterization techniques containing SEM, TEM, FTIR, photoluminescence, zeta potential, and UV-Vis absorption were employed for ZnO Q-Dot NPs in nanodrug. This work aims to investigate the anti-tumor effects of such nanomedicine on the 4T1 breast cancer cell line in BALB/c mice, being elaborated through intraperitoneal, injection (IVP) and oral therapy. The impressive findings showed that ZnO nanodrug caused changes in blood factors, having the most effectiveness at 40 μg/ml concentration after two weeks of oral treatments. The significant increase in white blood cells (WBC) neutrophils and meaningful decreases in lymphocytes and especially cholesterol were powerful simultaneous impacts, successfully treating malignant breast cancer masses. In this significant animal model research for breast cancer, the sick mice recovered entirely and even had a safe space to mate. Histopathological results showed no evidence of breast tumor formation or metastasis in the group treated with nanodrug and their children. This nanomedicine has a therapeutic effect, and is ready to be applied for treating volunteer breast cancer patients. However, its prevention (inhibitory) effect can also be analyzed and added to current data in future studies.

关键词： Nanomedicine Nanodrug ZnO Q-Dot NPs In Vivo Breast Cancer BALB/c Mice 4T1 Cell Lines Metastasis Oral Treatment

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Primary oral and nasal transmissible venereal tumor in a mix-breed dog

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 443-445页

作者： Mahdieh rezaei Shahrzad Azizi Shima Shahheidaripour sara Rostami Department of Clinical Science Faculty of Veterinary MedicineShahid Bahonar University Department of Pathobiology Faculty of Veterinary MedicineShahid Bahonar University Faculty of Veterinary Medicine Shahid Bahonar University

Transmissible venereal tumor(TVT) is a coitally transmitted tumor of dogs with widespread distribution. The present study describes the occurrence of the primary oral and nasal TVT in a 10-year-old, female, mix-breed dog. The case was presented with a history of anorexia, inability to swallow and dyspnea. Clinical examinations revealed the emaciation, muzzle deformity due to the presence of a friable, fleshy, cauliflower-like mass in the oral cavity and submandibular lymphadenopathy. TVT was diagnosed based on histopathological findings. The dog was discharged with therapeutic intervention with vincristine. Unfortunately, the case died before readmission because of the progressive worsening of the general condition. Our findings highlight the need for considering TVT for the differential diagnosis of the extragenital masses in dogs.

关键词： Transmissible venereal tumor Primary Oral Nasal Dog

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The effect of activity and face masks on exhaled particles in children

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Pediatric Investigation 2023年第2期7卷 75-85页

作者： Peter P.Moschovis Jesiel Lombay Jennifer Rooney sara R.Schenkel Dilpreet Singh Shawheen J.rezaei Nora Salo Amanda Gong Lael M.Yonker Jhill Shah Douglas Hayden Patricia L.Hibberd Philip Demokritou T.Bernard Kinane Department of Pediatrics Massachusetts General Hospital and Harvard Medical SchoolBostonMassachusettsUSA Department of Environmental Health Harvard T.H.Chan School of Public HealthBostonMassachusettsUSA Department of Mechanical and Aerospace Engineering Rutgers University School of Public HealthNew BrunswickNew JerseyUSA David Geffen School of Medicine the University of California Los AngelesLos AngelesCaliforniaUSA Department of Global Health Boston University School of Public HealthBostonMassachusettsUSA

Importance:Despite the high burden of respiratory infections among children,the production of exhaled particles during common activities and the efficacy of face masks in children have not been sufficiently studied.Objective:To determine the effect of type of activity and mask usage on exhaled particle production in children.Methods:Healthy children were asked to perform activities that ranged in intensity(breathing quietly,speaking,singing,coughing,and sneezing)while wearing no mask,a cloth mask,or a surgical mask.The concentration and size of exhaled particles were assessed during each activity.Results:Twenty-three children were enrolled in the study.Average exhaled particle concentration increased by intensity of activity,with the lowest particle concentration during tidal breathing(1.285 particles/cm^(3)[95%CI 0.943,1.627])and highest particle concentration during sneezing(5.183 particles/cm^(3)[95%CI 1.911,8.455]).High-intensity activities were associated with an increase primarily in the respirable size(≤5μm)particle fraction.Surgical and cloth masks were associated with lower average particle concentration compared to no mask(P=0.026 for sneezing).Surgical masks outperformed cloth masks across all activities,especially within the respirable size fraction.In a multivariable linear regression model,we observed significant effect modification of activity by age and by mask type.Interpretation:Similar to adults,children produce exhaled particles that vary in size and concentration across a range of activities.Production of respirable size fraction particles(≤5μm),the dominant mode of transmission of many respiratory viruses,increases significantly with coughing and sneezing and is most effectively reduced by wearing surgical face masks.

关键词： Aerosol Face masks Respiratory particles

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Pituitary-dependent hyperadrenocorticism in a terrier dog:A case report

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Journal of Coastal Life Medicine 2016年第6期4卷 502-504页

作者： Mahdieh rezaei sara Rostami Mehdi Saberi Dariush Vosugh Department of Clinical Science Faculty of Veterinary MedicineShahid Bahonar UniversityKermanIran Faculty of Veterinary Medicine Shahid Bahonar UniversityKermanIran

We report a case of pituitary-dependent hyperadrenocorticism in a 10-year-old,female,terrier dog.The animal was admitted due to polyphagia,weight gain,polyuria,polydipsia,hair loss,exercise intolerance and panting at rest.On physical examination,abdominal distention,truncal and bilaterally symmetric alopecia,thin hypotonic skin,comedones,bruising,hyperpigmentation and calcinosis cutis on the dorsal midline were observed.Hematologic investigations showed stress leukogram,high serum alkaline phosphatase activity,mild to moderate alanine aminotransferase activity,hypercholesterolemia,hypertriglyceridemia and hyperglycemia.Mild generalized interstitial lung patterns and hepatomegaly were detected in the radiographs.Bilaterally symmetric normal-sized adrenal glands were also diagnosed in ultrasonography.Diagnosis of pituitary-dependent hyperadrenocorticism was confirmed with low-dose dexamethasone suppression test.The dog was successfully treated with mitotane.

关键词： Hyperadrenocorticism Cushing’s syndrome Pituitary-dependent hyperadrenocorticism Low-dose dexamethasone suppression test Mitotane Dog

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