In Vivo Animal Model Evaluation of a Powerful Oral Nanomedicine for Treating Breast Cancer in BALB/c Mice Using 4T1 Cell Lines without Chemotherapy
In Vivo Animal Model Evaluation of a Powerful Oral Nanomedicine for Treating Breast Cancer in BALB/c Mice Using 4T1 Cell Lines without Chemotherapy作者机构：School of Chemical Engineering (Nanomedicine) College of Engineering University of Tehran Tehran Iran Department of Biotechnology Lahijan Branch Islamic Azad University Lahijan Iran Institute of Pharmacy Martin Luther University Halle Wittenberg Halle (Saale) Germany Department of Microbiology Lahijan Branch Islamic Azad University Lahijan Iran Department of Veterinary Pathology Islamic Azad University Rasht Branch Rasht Iran Department of Chemical Engineering Sharif University of Technology Tehran Iran Research Department Production and Laboratory Company ZFP Rasht Iran Department of Biology Faculty of Science Rasht Branch Islamic Azad University Guilan Iran
出 版 物：《Advances in Nanoparticles》 (纳米粒子（英文）)
年 卷 期：2022年第11卷第3期
页 面：73-109页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Nanomedicine Nanodrug ZnO Q-Dot NPs In Vivo Breast Cancer BALB/c Mice 4T1 Cell Lines Metastasis Oral Treatment
摘 要：Nanopharmaceuticals containing quantum dot nanoparticles (Q-Dot NPs) for treating serious cancers such as breast cancer have made fantastic proposals. In this study, ZnO quantum dot NPs are formulated via ZnO@PVP nanopolymer as co-assistants coordinating with efficacious suitable wetting agents, PEG-binding compound, and W/O emulsifier for producing eco-friendly water-based nanodrug. Several characterization techniques containing SEM, TEM, FTIR, photoluminescence, zeta potential, and UV-Vis absorption were employed for ZnO Q-Dot NPs in nanodrug. This work aims to investigate the anti-tumor effects of such nanomedicine on the 4T1 breast cancer cell line in BALB/c mice, being elaborated through intraperitoneal, injection (IVP) and oral therapy. The impressive findings showed that ZnO nanodrug caused changes in blood factors, having the most effectiveness at 40 μg/ml concentration after two weeks of oral treatments. The significant increase in white blood cells (WBC) neutrophils and meaningful decreases in lymphocytes and especially cholesterol were powerful simultaneous impacts, successfully treating malignant breast cancer masses. In this significant animal model research for breast cancer, the sick mice recovered entirely and even had a safe space to mate. Histopathological results showed no evidence of breast tumor formation or metastasis in the group treated with nanodrug and their children. This nanomedicine has a therapeutic effect, and is ready to be applied for treating volunteer breast cancer patients. However, its prevention (inhibitory) effect can also be analyzed and added to current data in future studies.
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