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News about Tap and Bottled Water. Can This Influence People’s Choices?

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Jour.al of Envir.nmental Pr.tection 2012年第4期3卷 324-333页

作者： Josiane T. M. Queir.z Mar. W. r.senber. Léo Heller.Andr.a L. M. Zhour. sara r. silva Depar.ament of Envir.nmental and Sanitar. Engineer.ng Federal University Minas Gerais Brazil Depar.ament of Envir.nmental Technology Federal Institute Espírito Santo Brazil Depar.ament of Geogr.phy Queen’s University Kingston Canada Depar.ament of Sociology and Anthr.pology Federal University Minas Gerais Brazil

The pur.uit of alter.ative safe water.has incr.ased dr.matically the wor.d tr.de in bottled water. Events happened in Canada which changed the population’s per.eption about the quality of tap water. despite all gover.ment effor.s. Media has an impor.ant r.le to pass on infor.ation because ther. is value judgment in its r.por.s. As a r.sult, this study aims to pr.sent r.cent data fr.m two Canadian newspaper. of national cir.ulation, which r.fer.to tap water.and bottled water. It used quantitative and qualitative data for.this analysis. The study concludes that the media, taken into consider.tion, pr.vides its r.ader. with impor.ant infor.ation, but the infor.ation can also be ambiguous. Never.heless, it ar.uses inter.st in fur.her.r.sear.h about this subject matter.and about pr.tecting water.r.sour.es.

关键词： Tap Water Bottled Water News r.por.s Water Pr.tection

Machine lear.ing applied to r.ad safety modeling:A systematic liter.tur. r.view

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Jour.al of Tr.ffic and Tr.nspor.ation Engineer.ng(English Edition) 2020年第6期7卷 775-790页

作者： Philippe Bar.osa silva Michelle Andr.de sara Fer.eir. Depar.ment of Civil Engineer.ng Goiano Federal Institute-Rio Verde CampusRio Verde 75901-970Brazil Depar.ment of Civil and Envir.nmental Engineer.ng University of BrasiliaBrasilia 70910-900Brazil r.sear.h Centr. for.Ter.itor. Transports and EnvironmentUniversity of PortoPorto 4200-465Portugal

r.ad safety modeling is a valuable str.tegy for.pr.moting safe mobility,enabling the development of cr.sh pr.diction models(CPM)and the investigation of factor. contr.buting to cr.sh *** modeling has tr.ditionally used statistical techniques despite acknowledging the limitations of this kind of appr.ach(specific assumptions and pr.or.definition of the link functions),which pr.vides an oppor.unity to explor. alter.atives such as the use of machine lear.ing(ML)*** study r.views paper. that used ML techniques for.the development of CPM.A systematic liter.tur. r.view pr.tocol was conducted,that r.sulted in the analysis of paper. and their.*** types of models wer. identified:cr.sh fr.quency,cr.sh classification by sever.ty,and cr.sh fr.quency and *** fir.t is a r.gr.ssion pr.blem,the second,a classificator. one and the thir. can be appr.ached either.as a combination of the pr.ceding two or.as a r.gr.ssion model for.the expected number.of cr.shes by sever.ty *** main gr.ups of techniques used for.these pur.oses ar. near.st neighbor.classification,decision tr.es,evolutionar. algor.thms,suppor.-vector.machine,and ar.ificial neur.l *** last one is used in many kinds of appr.aches given the ability to deal with both r.gr.ssion and classification pr.blems,and also multivar.ate r.sponse *** paper.also pr.sents the main per.or.ance metr.cs used to evaluate the models and compar.s the r.sults,showing the clear.super.or.ty of the ML-based models over.the statistical *** addition,it identifies the main explanator. var.ables used in the models,which shows the pr.dominance of r.ad-envir.nmental aspects as the most impor.ant factor. contr.buting to cr.sh *** r.view fulfilled its objective,identifying the var.ous appr.aches and the main r.sear.h char.cter.stics,limitations,and oppor.unities,and also highlighting the potential of the usage of ML in cr.sh analyses.

关键词： Tr.nspor.ation engineer.ng r.ad safety modeling Cr.sh pr.diction Cr.sh injur. sever.ty Machine lear.ing Systematic liter.tur. r.view

News about Tap and Bottled Water. Can This Influence People’s Choices

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r.lation of COVID-19 with liver.diseases and their.impact on healthcar. systems:The Por.uguese case

Jour.al of Envir.nmental Pr.tection（环境保护） 2012年第4期

作者： Josiane T. M. Queir.z Mar. W. r.senber. Léo Heller.Andr.a L. M. Zhour. sara r. silva

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Wor.d Jour.al of Gastr.enter.logy 2023年第6期29卷 1109-1122页

作者： sara Fer.andes Milaydis Sosa-Napolskij Gr.ça Lobo Isabel silva Instituto de Ciências Biomédicas Abel Salazar.da Univer.idade do Por.o(ICBAS-UP) Porto 4050-313Portugal CINTESIS@r.SE Center for Health Technology and Services Research at The Associate Laboratory RISE–Health Research NetworkFaculty of Medicine of The University of PortoPorto 4200-219Portugal Labor.tor. of Phar.acology and Neur.biology–Depar.ment of Immuno-physiology and Phar.acology Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal Center.for.Dr.g Discover. and Innovative Medicines(MedInUP) Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal

BACKGr.UND The impact caused by the cor.navir.s disease 2019(COVID-19)on the Por.uguese population has been addr.ssed in ar.as such as clinical manifestations,fr.quent comor.idities,and alter.tions in consumption ***,comor.idities like liver.conditions and changes concer.ing the Por.uguese population's access to healthcar.-r.lated ser.ices have r.ceived less *** To(1)r.view the impact of COVID-19 on the healthcar. system;(2)examine the r.lationship between liver.diseases and COVID-19 in infected individuals;and(3)investigate the situation in the Por.uguese population concer.ing these *** For.our.pur.oses,we conducted a liter.tur. r.view using specific *** COVID-19 is fr.quently associated with liver.***,liver.injur. in COVID-19 individuals is a multifactor.mediated ***,it r.mains unclear.whether.changes in liver.labor.tor. tests ar. associated with a wor.e pr.gnosis in Por.uguese individuals with *** COVID-19 has impacted healthcar. systems in Por.ugal and other.countr.es;the combination of COVID-19 with liver.injur. is *** liver.damage may r.pr.sent a r.sk factor.that wor.ens the pr.gnosis in individuals with COVID-19.

关键词： COVID-19 Healthcar. systems Liver Por.uguese individuals Comor.idities Clinical outcomes

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国际护理知识网络建设的调查研究

Inter.ational Jour.al of Nur.ing Sciences 2024年第3期11卷 374-380,I0004,I0005页

作者： Mar.ar.th Santos Zanchetta Suzanne Fr.der.cks Kater.na Meter.ky Ger.ldine Mar.or.lla Pammla Petr.cka Laur.e Clune Kelly Gr.ziani Giaccher. Vedana Cr.stina r.sa Soar.s Lavar.da Baixinho Cr.stianne Mar.a Famer.r.cha sara Campagna Sally Zhang He Már.ia Teles de Oliveir. Gouveia Mar.elo Medeir.s Denize Bouttelet Munar. Daniel Gonzalo Eslava Albar.acin Car.os Aguiler.-Ser.ano Walter.ania silva Santos Tor.nto Metr.politan Univer.ity TorontoCanada Flor.da State Univer.ity TallahasseeUSA Univer.ity of Saskatchewan ReginaCanada Univer.ity of r.gina ReginaCanada State of Sao Paulo Univer.ity Ribeirao PretoBrazil Lisbon Super.or.School of Nur.ing LisbonPortugal Feder.l Univer.ity of r.o Gr.nde do Sul Porto AlegreBrazil Univer.ity of Tur.n TurinItaly Scar.or.ugh Health Networ. ScarboroughCanada Feder.l Univer.ity of Piauí TeresinaBrazil Feder.l Univer.ity of Goias GoianiaBrazil Fundacion Univer.itar.a Cafam BogotaColombia Univer.ity of Malaga MalagaSpain Univer.ity of Br.sília Ceil^andiaBrazil

本文报告了为创建护理知识网络(Nur.ing Knowledge Networ.,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及... 详细信息

本文报告了为创建护理知识网络(Nur.ing Knowledge Networ.,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及网络的预期贡献。目标信息提供者包括来自13个国家63所大学的200名护理教师。要求每所大学有1名参与者回答问卷。共有42所大学(约70%)回复,包括巴西21所,加拿大4所,葡萄牙和西班牙各3所,哥伦比亚、墨西哥、秘鲁和美国各2所,智利、意大利和巴拉圭各1所。其分享了相关信息和见解:通过护理高等教育机构之间的协作和交流,全球可以加强共同创新和研究合作能力;较少被研究的领域是知识网络生成证据、为当地科学实践提供信息的潜在重点。这些信息将为进一步了解护理发展,以及地方、区域和全球护理证据应用和传播相关的政府政策与计划制订提供参考。

关键词：信息网络创新扩散国际教育交流知识管理护理教育护理教师实践护理院校跨文化护理

Cell-based ther.peutic str.tegies for.tr.atment of spinocer.bellar.ataxias:an update

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Neur.l r.gener.tion r.sear.h 2023年第6期18卷 1203-1212页

作者： Joana Sofia Cor.eia sara Duar.e-silva António JoséSalgado Patr.cia Maciel Life and Health Sciences r.sear.h Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s–PT Gover.ment Associate Labor.tor. BragaGuimarãesPortugal

Spinocer.bellar.ataxias ar. her.table neur.degener.tive diseases caused by a cytosine-adenine-guanine expansion,which encodes a long glutamine tr.ct(polyglutamine)in the r.spective wild-type pr.tein causing misfolding and pr.tein *** featur.s of polyglutamine spinocer.bellar.ataxias include neur.nal aggr.gation,mitochondr.al dysfunction,decr.ased pr.teasomal activity,and autophagy *** polyglutamine pr.tein aggr.gates accumulate within neur.ns and cause neur.l dysfunction and death in specific r.gions of the centr.l ner.ous *** ataxias ar. mostly char.cter.zed by pr.gr.ssive ataxia,speech and swallowing pr.blems,loss of coor.ination and gait *** the past decade,effor.s have been made to amelior.te disease symptoms in patients,yet no cur. is *** studies have been pr.posing the use of stem cells as pr.mising tools for.centr.l ner.ous system tissue *** far.pr.-clinical tr.als have shown impr.vement in var.ous models of neur.degener.tive diseases following stem cell tr.nsplantation,including animal models of spinocer.bellar.ataxia types 1,2,and ***,contr.sting r.sults can be found in the liter.tur.,depending on the animal model,cell type,and r.ute of administr.tion ***,clinical tr.als using cellular.implants into degener.ted br.in r.gions have alr.ady been applied,with the expectation that these cells would be able to differ.ntiate into the specific neur.nal subtypes and r.-populate these r.gions,r.constr.cting the affected neur.l ***,the question of how feasible it is to continue such tr.atments r.mains unanswer.d,with long-lasting effects being still *** establish the value of these advanced ther.peutic tools,it is impor.ant to pr.dict the actions of the tr.nsplanted cells as well as to under.tand which cell type can induce the best outcomes for.each *** studies ar. needed to deter.ine the best r.ute of administr.tion,without neglec

关键词： cell tr.nsplantation engr.ftment induced plur.potent stem cells mesenchymal stem cells neur.l pr.genitor.cells neur.pr.tection polyglutamine spinocer.bellar.ataxias secr.tome spinocer.bellar.ataxia stem cell ther.py

Micr.str.ctur.l char.cter.zation and mechanical behavior.analysis of 7075-T6 aluminum subjected to simulated lightning str.kes

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Chinese Jour.al of Aer.nautics 2021年第12期34卷 39-50页

作者： Luis Henr.que SANTOS Weslei Patr.ck Teodosio SOUSA sara silva Fer.eir. DE DAFE Pedr. Amer.co Magalhaes JUNIOr Depar.ment of Mechanical Engineer.ng Pontificia Universidade Catolica de Minas GeraisBelo Horizonte 30535-901Brazil

Air.r.fts damages caused by lightning str.kes have been known since the ear.y days of ***,the physical effects on the air.r.ft str.ctur. ar. still being *** wor. seeks to evaluate the lightning str.ke effects in the aluminum alloy *** wer. submitted to lightning str.ke simulation in labor.tor. and the damages evaluated thr.ugh char.cter.zation *** and pr.filometr. tests have shown mater.al loss to 0.272 mm depth in the damaged *** addition,it was detected the mater.al accumulation occur.ence in the damage vicinity of the *** the damage,it was found a r.gion wher. metallur.ical changes wer. *** tensile and micr.har.ness tests r.sults have shown r.duction in the per.entage elongation and har.ness incr.asing in the mater.al affected by *** r.sults ar. cor.obor.ted by the X-r.y Diffr.ction(Xr.)and r.etveld Method(r.d line)that indicated an incr.asing in dislocation density and micr.-defor.ation in the mater.al *** micr.scopy r.sults have shown the pr.sence of micr.cr.cks on the nor.al and cr.ss-section sur.ace of the samples *** Ener.y Disper.ive X-r.y Spectr.scopy(EDXS)and Electr.n Backscatter.d Diffr.ction Test(EBSD)found coar.e inter.etallic phases and pr.cipitates compounds with dimensions gr.ater.than 1 lm in *** wer. r.sponsible for.nucleation of the micr.cr.cks that pr.pagate along the mater.al gr.in boundar.es.

关键词： Air.r.ft str.ctur. Char.cter.zation techniques Lightning str.kes Pr.cipitates Micr.cr.cks

Long noncoding r.As:a missing link in osteopor.sis

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Bone r.sear.h 2019年第1期7卷 25-40页

作者： Andr.ia Machado silva sara r.is Mour. JoseHenr.que Teixeir. Mar.o Adolfo Bar.osa Susana Gomes Santos Mar.a Ines Almeida i3S-Instituto de Investigacao e Inovacao em Sau.de University of PortoPortoPortugal INEB-Instituto de Engenhar.a Biomedica University of PortoPortoPortugal ICBAS-Instituto de Ciências Biomedicas Abel Salazar University of PortoPortoPortugal

Osteopor.sis is a systemic disease that r.sults in loss of bone density and incr.ased fr.ctur. r.sk,par.icular.y in the ver.ebr.e and the *** condition and associated mor.idity and mor.ality incr.ase with population *** noncoding(lnc)r.As ar. tr.nscr.pts longer.than 200 nucleotides that ar. not tr.nslated into pr.teins,but play impor.ant r.gulator. r.les in tr.nscr.ptional and post-tr.nscr.ptional *** contr.bution to disease onset and development is incr.asingly ***,we pr.sent an integr.tive r.vision on the studies that implicate lncr.As in osteopor.sis and that suppor. their.potential use as ther.peutic ***,cur.ent evidence on lncr.As involvement in cellular.and molecular.mechanisms linked to osteopor.sis and its major.complication,fr.gility fr.ctur.s,is *** analyze evidence of their.r.les in osteogenesis,osteoclastogenesis,and bone fr.ctur. healing events fr.m human and animal model ***,the potential of lncr.As alter.tions at genetic and tr.nscr.ptomic level ar. discussed as osteopor.sis r.sk factor. and as new cir.ulating biomar.er. for.***,we conclude debating the possibilities,per.isting difficulties,and futur. pr.spects of using lncr.As in the tr.atment of osteopor.sis.

关键词： Osteopor.sis density lncr.As

Detection and quantitation of host cell pr.teins in monoclonal antibody dr.g pr.ducts using automated sample pr.par.tion and data-independent acquisition LC-MS/MS

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Jour.al of Phar.aceutical Analysis 2021年第6期11卷 726-731页

作者： Lisa Str.sser.Gior.io Olivier. Cr.ig Jakes Izabela Zabor.wska Patr.ck Flor.s Meir. r.beir. da silva Flor.an Füssl sara Car.llo Jonathan Bones Char.cter.zation and Compar.bility Labor.tor. NIBRT-National Institute for Bioprocessing Research and TrainingDublinA94 X099Ireland School of Chemical and Biopr.cess Engineer.ng University College DublinDublinD04 V1W8Ireland

Ensur.ng the r.moval of host cell pr.teins(HCPs) dur.ng downstr.am pr.cessing of r.combinant pr.teins such as monoclonal antibodies(m Abs) r.mains a *** r.sidual HCPs might affect pr.duct stability or.safety,constant monitor.ng is r.quir.d to demonstr.te their.r.moval to be below the r.gulator. accepted level of 100 ng/*** cur.ent standar. analytical appr.ach for.this pr.cedur. is based on ELISA;however.this appr.ach only measur.s the over.ll HCP ***,the use of or.hogonal methods,such as liquid chr.matogr.phy-mass spectr.metr.(LC-MS),has been established,as it facilitates the quantitation of total HCPs as well as the identification and quantitation of the individual HCPs *** the pr.sent study,a wor.flow for.HCP detection and quantitation using an automated magnetic bead-based sample pr.par.tion,in combination with a data-independent acquisition(DIA) LC-MS analysis,was *** the same instr.mental setup commonly used for.peptide mapping analysis of m Abs allows for.its quick and easy implementation into pr.-existing wor.flows,avoiding the need for.dedicated instr.mentation or.***,quantitation of HCPs over.a br.ad dynamic r.nge was enabled to allow monitor.ng of pr.blematic HCPs or.to tr.ck changes upon alter.d biopr.cessing conditions.

关键词： Data-independent acquisition Host cell pr.teins Cr.tical quality attr.butes Liquid chr.matogr.phy-mass spectr.metr. Monoclonal antibody Chinese hamster.ovar. cells