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Molecular Plant 2016年第4期9卷 601-614页

作者： Ana Marta Pereira Margarida Sofia Nobre sara Cristina pinto Ana Lucia Lopes Mario Luis Costa Simona Masiero Silvia Coimbra Departamento de Biologia Faculdade de Ciencias da Universidade do Porto Rua do Campo Alegre 4169-007 Porto Portugal Plant Functional Genomics Group Biosystems and Integrative Sciences Institute (BiolSI) 4169-007 Porto Portugal Dipartimento di BioScienze Universita degli Studi di Milano 20133 Milan Italy Present address: Institute of Plant Biology and ZUrich-Basel Plant Science Center University of ZUrich Zolikerstrasse 107 8008 Zurich Switzerland

Successful double fertilization and subsequent seed development in flowering plants requires the delivery of two sperm cells, transported by a pollen tube, into the embryo sac of an ovule. The embryo sac cells tightly control synergid cell death, and as a result the polyspermy block. Arabinogalactan proteins are highly glycosylated proteins thought to be involved in several steps of the reproductive process. We show that JAGGER, Arabinogalactan Protein 4, is an important molecule necessary to prevent the growth of multiple pollen tubes into one embryo sac in Arabidopsis thaliana. In jagger, an AGP4 knockout mutant, the pistils show impaired pollen tube blockage as a consequence of the survival of the persistent synergid. JAGGER seems to be involved in the signaling pathway that leads to a blockage of pollen tube attraction. Our results shed light on the mechanism responsible for preventing polyspermy in Arabidopsis and for safe- guarding successful fertilization of all ovules in one pistil, ensuring seed set and the next generation.

关键词： Polytubey persistent synergid arabinogalactan proteins polyspermy

Posterior corneal astigmatism modifications after cataract surgery and its role on total corneal astigmatism

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Annals of Eye Science 2018年第1期3卷 267-275页

作者： Diana Silva Mafalda Mota Catarina Pedrosa Peter Pêgo sara pinto Cristina Vendrell Isabel Prieto Ophthalmology Department Hospital Prof.Dr.Fernando Fonseca E.P.E.AmadoraPortugal

Background:In recent years posterior corneal astigmatism and its effect on total corneal astigmatism has been studied,with research showing that this can impact total *** study aims to ascertain if there is significant change in the posterior corneal astigmatism after cataract surgery and its impact on the total ***:Analysis of 76 eyes that underwent cataract surgery with monofocal intraocular lens *** topography was performed with Pentacam(OCULUS®)pre-and *** corneal astigmatism was calculated with the algorithm of vergence *** compared preoperative and postoperative changes in the magnitude and axis differences of anterior corneal curvature astigmatism,posterior corneal curvature astigmatism and the calculated total corneal *** calculated the correlation between the total preoperative astigmatism and the difference between total corneal astigmatism and anterior corneal ***:The mean preoperative and postoperative posterior astigmatism was 0.31±0.02 D,showing no significant differences before and after surgery(P=0.989).Statistically significant differences between the calculated total corneal astigmatism and anterior corneal astigmatism were registered preoperatively and postoperatively in the with-the-rule anterior(WTR)corneal astigmatism(P=0.004,P<0.0001);against-the-rule(ATR)anterior corneal astigmatism(P<0.0001,P<0.0001)and in the oblique(P=0.026,P=0.019)*** posterior corneal astigmatism and the total corneal astigmatism correlated positively with the differences between the total corneal and anterior corneal astigmatism(R=0.378,P=0.001).Conclusions:There were statistically significant differences between the magnitude of the total astigmatism and anterior corneal astigmatism,underlining the impact of posterior corneal astigmatism.A positive correlation between the preoperative posterior astigmatism and the difference between the total corneal and the ant

关键词： Astigmatism cataract surgery intraocular lens posterior corneal curvature total corneal astigmatism

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宁波华茂艺术教育博物馆

现代装饰 2021年第4期 80-85页

作者： Jorge Santos Joana Soeiro sara pinto Susana Oliveira Francesca Tiri Rita Ferreira Diana Vasconcelos Inês Bastos Luisa Felizardo 侯博文范嘉苑 HouPictures

外在小巧,内在丰盈。一间博物馆的内部空间必须广阔。一间博物馆的内部空间必须明亮。华茂艺术教育博物馆是一间体量小而内部宽广的博物馆。它倚靠小山坡,以波浪状的起伏姿态立于地面之上,以其优雅而迷人的特征吸引着人们。在这座小建...

外在小巧,内在丰盈。一间博物馆的内部空间必须广阔。一间博物馆的内部空间必须明亮。华茂艺术教育博物馆是一间体量小而内部宽广的博物馆。它倚靠小山坡,以波浪状的起伏姿态立于地面之上,以其优雅而迷人的特征吸引着人们。在这座小建筑之中,任何东西都是举重若轻。环绕建筑外延探索至内嵌于低矮屋檐下的公共入口,推开不起眼的大门将进入一个广阔的空间,挑高的建筑映入眼帘,沿蜿蜒的斜坡能到达不同楼层。这种介于"压缩"与"释放"之间的空间体验恒定地存在于参访的过程之中。多样化的参观流线以及相互连接的空间让这座小建筑的内部看起来开阔宽敞。

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嘉卿会所-台丰高尔夫俱乐部

现代装饰 2022年第4期 14-21页

作者： álvaro Siza Carlos Castanheira Elisabete Queirós Catarina Araújo Erika Musci Filipe Mota Joana Soeiro Jo?o Alves Jorge Pinheiro Mariana Mendes Nuno Campos Nuno Rodrigues Pedro Afonso Rita Saturnino sara pinto Sofia Concei??o Carlos Castanheira 范嘉苑

在高尔夫球运动中,力量与优雅的完美平衡是衡量其水平的一个基本准则。同样的,在建筑设计与建造的表达过程中,除了回应技术问题与基本需求以外,还需要考虑其他或简单或复杂的因素。衡量一个项目不仅只是看基本要素,即使它仅需要回应基...

在高尔夫球运动中,力量与优雅的完美平衡是衡量其水平的一个基本准则。同样的,在建筑设计与建造的表达过程中,除了回应技术问题与基本需求以外,还需要考虑其他或简单或复杂的因素。衡量一个项目不仅只是看基本要素,即使它仅需要回应基础功能。好的设计应该经过谨慎的思考,由此承载巨大能量,传达优雅气息。“经验分析”能够帮助我们辨别设计的第一步,它可能源自于一种态度、概念,或者一些难以解释的想法。

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腺苷受体是调节大脑内侧前额叶皮质星形胶质细胞大麻素1型(CB1)受体对突触可塑性作用的开关

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神经损伤与功能重建 2024年第4期19卷 250-250页

作者： Joana Gon?alves-Ribeiro Oksana K Savchak sara Costa-pinto Joana I Gomes Rafael Rivas-Santisteban Alejandro Lillo Javier Sánchez Romero Ana M Sebasti?o Marta Navarrete Gemma Navarro Rafael Franco Sandra H Vaz Instituto de Farmacologia e Neurociencias Faculdade de MedicinaUniversidade de Lisboa Instituto de Medicina Molecular Joao Lobo Antunes Faculdade de MedicinaUniversidade de Lisboa Department of Biochemistry and Physiology School of Pharmacy and Food ScienceUniversitat de Barcelona CiberNed Network Center for Neurodegenerative DiseasesNational Spanish Health Institute Carlos Ⅲ 5. Instituto CajalCSIC PhD Program in Neuroscience Universidad Autonoma de Madrid-Instituto Cajal Institut de Neurociencies Universitat de Barcelona Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFaculty of Biology School of Chemistry Universitat de Barcelona

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1R)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与... 详细信息

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1R)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与腺苷受体之间的交流。我们在这里展示,通过CB1R-A2AR或CB1R-A1R异源二聚体,星形胶质细胞Ca2+信号传递发生了进一步的调节,最终影响mPFC突触可塑性。当A1R和A2AR被激活时,CB1R介导的Ca2+瞬变出现增加或减少,揭示了腺苷受体可能是星形胶质细胞CB1R的调节器。CB1R的激活导致mPFC的长时程增强(LTP)增强,受A1R控制,但不受A2AR控制。值得注意的是,在IP3R2KO小鼠中,由于没有显示出星形胶质细胞Ca2+水平升高,CB1R的激活减少了LTP,这种效果不受A1R或A2AR的调节。本研究表明,CB1R在mPFC LTP上具有稳态作用,受到A1R的控制,可能是由于这些受体在星形胶质细胞中的交流,最终改变了CB1R Ca2+信号传递。

关键词： CB1受体腺苷受体星形胶质细胞内侧前额叶皮质突触可塑性

促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施: 整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 46-56页

作者： Bruna F.Sebastiao Raquel M.Hortelao sara S.Granadas Jose M.Faria Joana R.pinto Helga Rafael Henriques Nursing School of Lisbon LisbonPortugal Hospital Center of Central Lisbon Portugal CUF Tejo Hospital LisbonPortugal University Hospital Center of Northern Lisbon LisbonPortugal Nursing Research Innovation and Development Centre of Lisbon(CIDNUR)LisbonPortugal

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法2023年3月 ,系统检索CINAHL、Medline、Academie Search Complete .Scopus、WebofScience、Cochrane图书馆、乔安娜布里格斯研究所(JoannaBriggsInstitute,JBI)循证实践数据库,以及GoogleScholar。对纳人研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素) ,教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队.提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进--步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施:整合性综述（英文）

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International Journal of Nursing Sciences 2024年第1期 46-56页

作者： Bruna F.Sebasti?o Raquel M.Hortel?o sara S.Granadas José M.Faria Joana R.pinto Helga Rafael Henriques Nursing School of Lisbon Hospital Center of Central Lisbon CUF Tejo Hospital University Hospital Center of Northern Lisbon Nursing Research Innovation and Development Centre of Lisbon (CIDNUR)

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法 2023年3月,系统检索CINAHL、Medline、Academic Search Complete、Scopus、Web of Science、Cochrane图书馆、乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)循证实践数据库,以及Google Scholar。对纳入研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素),教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队、提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进一步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

The Influence of Keratometry on Visual and Refractive Outcomes after Myopic LASER <i>in Situ</i>Keratomileusis

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Open Journal of Ophthalmology 2018年第2期8卷 84-90页

作者： sara Frazã o Pedro Rodrigues Samuel Alves Ana Maria Carvalho José Maia Sê co Hugo Nogueira Instituto de Oftalmologia Dr. Gama pinto Lisbon Portugal

To evaluate the effect of preoperative keratometry on visual and refractive outcomes after Myopic LASER in Situ Keratomileusis (LASIK) in eyes with preoperative spherical equivalent (SE) of -6.00D or less. Material and Methods: A retrospective study enrolling clinical records of 482 eyes of 275 patients with myopia who underwent LASIK between 2009 and 2016. Subjects were grouped according to the degree of preoperative mean keratometry (Km), into three groups: Group 1 (Flat Cornea): Km ≤ 42.00 diopters (D);Group 2: 42.00 46.00D;Group 3 (Steep Cornea): Km ≥ 46.00D. To evaluate the prognostic impact of keratometry in Myopic LASIK, we considered the results measured at 6 months postoperatively, including uncorrected distance visual acuity (UDVA), postoperative sphere, cylinder, SE and its variation. Results: The mean preoperative SE was -3.91 ± 1.54D, ranging between -0.88 and -6.00D. The percentage of eyes achieving a postoperative SE of ±0.50D was 39.5%, 31.8% and 26% in groups 1, 2 and 3 respectively. Moreover, in group 3, 14.3% of the eyes had a residual SE of -2.00D or greater, contrasting with the groups 1 and 2 with only 6% - 7%. These results were found to be statistically significant. Concerning UDVA, eyes achieving 20/25 or more were 81.5%, 81.8% and 71.5%, and 20/50 or less were 6.7%, 6.2% and 11.7% in groups 1, 2 and 3 respectively. Conclusions: Myopic eyes with steeper corneas seem to have greater tendency to undercorrection, also presenting worse visual outcomes.

关键词： Myopia Astigmatism LASER in Situ Keratomileusis Keratometry Spherical Equivalent Flat Cornea Steep Cornea

Production of Aflatoxins from Aspergillus flavus in Liquid Medium

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Journal of Life Sciences 2013年第4期7卷 377-381页

作者： Maria Edite Bezerra da Rocha Francisco das Chagas Oliveira Freire Icaro Gusmao pinto Vieira Jose Mariados Santos Filho Fabio Erlan Feitosa Maia Maria Izabel Florindo Guedes Davide Rondina Universidade Estadual do Ceara Avenida Paranjana 1700 CEP: 60740-000 Fortaleza Ceara Brasil Embrapa Agroindustria Tropical Rua Dra. Sara Mesquita 2270 CEP: 60.511-110 Fortaleza-CE Brasil

Aflatoxins are produced mainly by Aspergillus flavus and Aspergillus parasiticus, and can be found in many grains such as peanuts, soybeans and com. This study aimed to qualitatively and quantitatively evaluate the production of aflatoxin in liquid media using strains of Aspergillus flavus obtained from peanuts marketed in the city of Fortaleza, CEo Strains of Aspergillus flavus were inoculated into a liquid medium malt extract and after 2 days inoculated into a second medium containing sucrose 5%, MgSO4·7H20 0.1%, KH2PO4 1%, ZnSO4·7H2O 0.0176 g, and cultured for 3 more days. The media were kept at room temperature ranging from 24°C to 32 °C with agitation of 130 rpm and aeration of 4.17 Llmin. Qualitative analysis was performed by thin layer chromatography and quantitatively by high performance liquid chromatography with fluorescence detection, demonstrating the production of aflatoxin B I （588 mg/L） and B2 （929 mg/L）.

关键词： Peanut fungi micotoxins chromatography.