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挤压过程中AA6xxx铝合金型材的再结晶行为模拟（英文）

Advances in Microbiology（微生物学） 2023年第1期

作者： Uchenna B.Iloghalu sara E.miller Akamu J.Ewunkem Janak R.Khatiwada Shurrita S.Davis Leonard L.Williams

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Transactions of Nonferrous Metals Society of China 2024年第10期 3170-3184页

作者： Marco NEGOZIO Antonio SEGATORI Riccardo PELACCIA Barbara REGGIANI sara Di DONATO Lorenzo DONATI University of Parma-Department of Engineering and Architecture Hydro Innovation and Technology DISMI Department of Sciences and Methods for Engineering University of Modena and Reggio Emilia InterMech-MO.RE–University of Modena and Reggio Emilia DIN Department of Industrial Engineering–University of Bologna

介绍了一种开发AA6063铝合金再结晶模型的创新方法。该方法结合了基于回归分析的材料常数测定技术，并引入了评估晶粒尺寸演变的新方程。该方法的校准和验证结合了从3种AA6063铝合金型材的挤压实验中获得的显微组织数据和使用Qform Extr... 详细信息

介绍了一种开发AA6063铝合金再结晶模型的创新方法。该方法结合了基于回归分析的材料常数测定技术，并引入了评估晶粒尺寸演变的新方程。该方法的校准和验证结合了从3种AA6063铝合金型材的挤压实验中获得的显微组织数据和使用Qform Extrusion UK有限元代码模拟的结果。结果表明，显微组织演化的实验结果与数值模拟的预测结果相吻合。该方法准确模拟了动态再结晶和静态再结晶后晶粒尺寸随不同工业参数变化的趋势，在几乎整个抽样计算中，误差都小于25%。

关键词：再结晶模拟铝合金挤压有限元法显微组织预测

Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

Magnetic resonance spectroscopy findings of brain olfactory areas in patients with COVID-19-related anosmia:A preliminary comparative study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 105-112页

作者： Shadman Nemati Mohammad Haghani Dogahe Alia Saberi Naghi Ramezani Pejman Kiani Tofigh Yaghubi Kalurazi Ehsan Kazemnejad Leili sara Seddighi Abbas Monsef Department of Otolaryngology and Head and Neck Surgery School of MedicineOtorhinolaryngology Research CenterGuilan University of Medical SciencesRashtIran Guilan Road Trauma Research Center Guilan University of Medical SciencesRashtGuilanIran Department of Neurology Neuroscience Research CenterPoursina HospitalGuilan University of Medical SciencesRashtIran Department of Radiology Pars International HospitalGuilan ProvinceIran Department of Neuroscience and Addiction Studies School of Advanced Technologies in MedicineTehranIran Department of Infectious Diseases Razi Clinical Research Development UnitRazi HospitalGuilan University of Medical SciencesRashtIran Center of Magnetic Resonance Research Department of Radiation OncologyUniversity of Minnesota Medical SchoolMinneapolisMinnesotaUSA

Objectives:2019 novel coronavirus disease(COVID-19)infection is commonly associated with olfactory dysfunctions,but the basic pathogenesis of these complications remains *** study seeks to evaluate the value of magnetic resonance spectroscopy(MRS)in determining the molecular neurometabolite alterations within the main brain olfactory areas in patients with COVID-19-related ***:In a cross-sectional study,seven patients with persistent COVID-19-related anosmia(mean age:29.57 years)and seven healthy volunteers(mean age:27.28 years)underwent MRS in which N-acetyl-aspartate(NAA),choline(Cho),creatine(Cr),and their ratios were measured in the anterior cingulate cortex,dorsolateral prefrontal cortex,orbitofrontal cortex(OFC),insular cortex,and ventromedial prefrontal *** were analyzed using TARQUIN software(version 4.3.10),and the results were compared with an independent sample t-test and nonparametric Mann-Whitney test based on the normality of the MRS data ***:The mean duration of anosmia before imaging was 8.5 months in COVID-19-related anosmia *** analysis elucidated a significant association between MRS findings within OFC and COVID-19-related anosmia(P_(disease)<0.01),and NAA was among the most important neurometabolites(P_(interaction)=0.006).Reduced levels of NAA(P<0.001),Cr(P<0.001)and^(NAA)/Cho ratio(P=0.007)within OFC characterize COVID-19-related ***:This study emphasizes that MRS can be illuminating in COVID-19-related anosmia and indicates a possible association between central nervous system impairment and persistent COVID-19-related anosmia.

关键词： anosmia COVID-19 magnetic resonance spectroscopy neuroimaging olfaction

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海藻酸钠-低脂果胶-刺槐豆胶三元复合膜的制备及其在香菇压差膨化干燥中的应用

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食品工业科技 2024年

作者：常大伟任娜曹佳怡王虎玄孙玉娇沈文 sara Sendi 支晓红陕西科技大学食品科学与工程学院咸阳市食品药品检验检测中心

本研究以海藻酸钠（SA）、低脂果胶（LMPs）和刺槐豆胶（LBG）为成膜材料，通过优化各组分的质量比，成功制备了一种海藻酸钠-低脂果胶-刺槐豆胶三元复合可食膜（SPL）。系统研究了复合膜液的流变学特性，测量了膜的机械性能（包括抗拉... 详细信息

本研究以海藻酸钠（SA）、低脂果胶（LMPs）和刺槐豆胶（LBG）为成膜材料，通过优化各组分的质量比，成功制备了一种海藻酸钠-低脂果胶-刺槐豆胶三元复合可食膜（SPL）。系统研究了复合膜液的流变学特性，测量了膜的机械性能（包括抗拉强度和断裂伸长率）、水蒸气透过系数、水溶性、透光率以及水接触角等关键性能指标，利用扫描电镜（SEM）和傅里叶红外光谱（FTIR）技术对复合膜的表面形貌、内部结构及其组分间的相互作用进行表征。此外，本研究还探索了SPL三元复合膜涂膜预处理在香菇压差膨化干燥（EPD）工艺中的应用效果。实验结果显示，当SA、LMPs和LBG的质量比为50:20:30时，所制备的SPL三元复合膜的综合性能较优，抗拉强度为13.54±0.95 MPa，断裂伸长率为58.15%±4.32%，同时在600 nm波长下的透光率为79.70%±2.31%，表现出良好的机械强度和光学性能。复合膜表面平滑，内部结构均匀致密，SA、LMPs和LBG三者之间具有良好的相互作用及分子相容性。与未处理和仅使用SA膜液涂膜预处理的EDP香菇产品相比，采用SPL三元复合膜液结合Ca2+交联涂膜预处理后的EPD香菇产品，其产品品质得到了明显提升。

关键词：多糖可食用膜香菇压差膨化干燥涂膜预处理

新奥尔良当代艺术中心共享办公室美国新奥尔良

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世界建筑导报 2024年第1期39卷 74-78页

作者：无 Neil Alexander(摄影) sara Essex Bradley(摄影) EDR建筑事务所不详

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮... 详细信息

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮店,70年代中期被用作当代艺术中心。顶部两层在过去40年中一直没有被充分利用,The Shop的开发标志着对这一空间的第一次大规模整修。

关键词：联合办公当代艺术中心新奥尔良市美国新奥尔良 Shop 冷饮店办公室杂货

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Influence of Statins and Fibrates Drugs on Bone Health and Regeneration

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Journal of Biomaterials and Nanobiotechnology 2024年第1期15卷 1-24页

作者： Octavio Santiago Ivan Nadir Camal Ruggieri Marina Ribeiro Paulini Valéria Paula Sassoli Fazan João Paulo Mardegan Issa sara Feldman LABOATEM Laboratory of Bone Biology and Tissue Engineering School of Medicine Rosario National University Ros&#225rio Argentina School of Dentistry of Ribeirã o Preto University of S&#227o Paulo (FORP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil School of Medicine of Ribeirã o Preto University of S&#227o Paulo (FMRP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil

In the medical and dental field, the importance and need for the study of materials and drugs for use as bone grafts or regeneration in injured areas due to the presence of fractures, infections or tumors that cause extensive loss of bone tissue is observed. Bone is a specialized, vascularized and dynamic connective tissue that changes throughout the life of the organism. When injured, it has a unique ability to regenerate and repair without the presence of scars, but in some situations, due to the size of the defect, the bone tissue does not regenerate completely. Thus, due to its importance, there is a great development in therapeutic approaches for the treatment of bone defects through studies that include autografts, allografts and artificial materials used alone or in association with bone grafts. Pharmaceuticals composed of biomaterials and osteogenic active substances have been extensively studied because they provide potential for tissue regeneration and new strategies for the treatment of bone defects. Statins work as specific inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoAreductase). They represent efficient drugs in lowering cholesterol, as they reduce platelet aggregation and thrombus deposition;in addition, they promote angiogenesis, reduce the β-amyloid peptide related to Alzheimer’s disease and suppress the activation of T lymphocytes. Furthermore, these substances have been used in the treatment of hypercholesterolemia and coronary artery disease. By inhibiting HMG-CoAreductase, statins not only inhibit cholesterol synthesis, but also exhibit several other beneficial pleiotropic effects. Therefore, there has been increasing interest in researching the effects of statins, including Simvastatin, on bone and osteometabolic diseases. However, statins in high doses cause inflammation in bone defects and inhibit osteoblastic differentiation, negatively contributing to bone repair. Thus, different types of studies with different conc

关键词： Bone Statins Rosuvastatin Sinvastatin Fibrates Fenofibrate Bone Regeneration

The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

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Current Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles Medina Inés Laso García Fernando González Tello sara Álvarez Rodríguez Manuel Hevia Palacios Marina Mata Alcaraz César Mínguez Ojeda Fernando Arias Funez Victoria Gómez Dos Santos Francisco Javier Burgos Revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of Radiology Hospital Universitario Ramón y CajalMadridSpain

Background:Malignant ureteral obstruction(MUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November ***,clinical,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-Meier method,and univariate and multivariate Cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to MUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing MUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).Recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:Cancer patients with MUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival Prognosis

促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施: 整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 46-56页

作者： Bruna F.Sebastiao Raquel M.Hortelao sara S.Granadas Jose M.Faria Joana R.Pinto Helga Rafael Henriques Nursing School of Lisbon LisbonPortugal Hospital Center of Central Lisbon Portugal CUF Tejo Hospital LisbonPortugal University Hospital Center of Northern Lisbon LisbonPortugal Nursing Research Innovation and Development Centre of Lisbon(CIDNUR)LisbonPortugal

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法2023年3月 ,系统检索CINAHL、Medline、Academie Search Complete .Scopus、WebofScience、Cochrane图书馆、乔安娜布里格斯研究所(JoannaBriggsInstitute,JBI)循证实践数据库,以及GoogleScholar。对纳人研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素) ,教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队.提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进--步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

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野性之路往自然深处走，探索山巅每一面

环球人文地理 2024年第13期 24-33页

作者： sara 俞浩洋(JmT) 放眼无忌李永男加拿大BC省旅游局

从温哥华出发，沿着天海公路一路前行，从海平面到山巅，从峡谷到冰川……探索BC省的野性，用车轮丈量与罗布森山的距离。惠斯勒滑雪场“教父”，也是骑行天堂李宗盛说：“风，声响，潮汐，天光，让寂寞变得有意义起来。”坐落在加拿大...

从温哥华出发，沿着天海公路一路前行，从海平面到山巅，从峡谷到冰川……探索BC省的野性，用车轮丈量与罗布森山的距离。惠斯勒滑雪场“教父”，也是骑行天堂李宗盛说：“风，声响，潮汐，天光，让寂寞变得有意义起来。”坐落在加拿大西海岸的温哥华，确实如他所言，充满浪漫活力。

关键词：