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World Journal of Gastroenterology 2014年第44期20卷 16443-16451页

作者： sara Ceccarelli Valerio Nobili Anna Alisi Hepato-Metabolic Disease Unit and Liver Research Unit Bambino Gesù Children’s Hospital IRCCS

Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease(ALD). Currently, ALD is considered to be one of the major causes of death worldwide. An impaired intestinal barrier with related endotoxemia is among the various pathogenetic factors. This is mainly characterized by circulating levels of lipopolysaccharide(LPS), considered critical for the onset of intra-hepatic inflammation. This in turn promotes hepatocellular damage and fibrosis in ALD. Elevated levels of LPS exert their effects by binding to Toll-like receptors(TLRs) which are expressed by all liver-resident cells. The activation of TLR signaling triggers an overproduction and release of some cytokines, which promote an autocatalytic cascade of other proinflammatory signals. In this review, we provide an overview of the mechanisms that sustain LPS-mediated activation of TLR signaling, reporting current experimental and clinical evidence of its role during inflammation in ALD.

关键词： Alcoholic liver disease Toll-like receptors Inflammation Cirrhosis Nuclear factor-κ B Cytokines

Microphysiological systems for solid tumor immunotherapy:opportunities and challenges

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Microsystems & Nanoengineering 2023年第6期9卷 77-106页

作者： sara Abizanda-Campo María Virumbrales-Muñoz Mouhita Humayun Ines Marmol David J.Beebe Ignacio Ochoa sara Oliván Jose M.Ayuso Department of Dermatology University of Wisconsin-MadisonMadisonWIUSA University of Wisconsin Carbone Cancer Center MadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Tissue Microenvironment lab(TME lab) Aragón Institute of Engineering Research(I3A)University of ZaragozaZaragozaSpain Instituto de Investigación Sanitaria Aragón(IISA) ZaragozaSpain Centro Investigación Biomédica en Red.Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)ZaragozaSpain Department of Obstetrics and Gynecology University of Wisconsin-MadisonMadisonWIUSA Department of Biological Engineering Massachusetts Institute of Technology CambridgeCambridgeMAUSA Department of Pathology&laboratory Medicine University of WisconsinMadisonWIUSA

Immunotherapy remains more effective for hematologic tumors than for solid *** of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate,which limits the cytotoxic capabilities of immune effector cells(e.g.,cytotoxic T and natural killer cells).This microenvironment is characterized by hypoxia,nutrient starvation,accumulated waste products,and acidic ***-hijacked cells,such as fibroblasts,macrophages,and T regulatory cells,also contribute to this inhospitable microenvironment for immune cells by secreting immunosuppressive cytokines that suppress the antitumor immune response and lead to immune ***,there is a strong interest in developing new drugs and cell formulations that modulate the tumor microenvironment and reduce tumor cell immune *** systems(MPSs)are versatile tools that may accelerate the development and evaluation of these therapies,although specific examples showcasing the potential of MPSs remain *** in microtechnologies have led to the development of sophisticated microfluidic devices used to recapitulate tumor *** resulting models,also known as microphysiological systems(MPSs),are versatile tools with which to decipher the molecular mechanisms driving immune cell antitumor cytotoxicity,immune cell exhaustion,and immune cell exclusion and to evaluate new targeted ***,we review existing microphysiological platforms to study immuno-oncological applications and discuss challenges and opportunities in the field.

关键词： immunotherapy versatile solid

Organosolv Lignin for Non-Isocyanate Based Polyurethanes (NIPU) as Wood Adhesive

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Journal of Renewable Materials 2021年第5期9卷 881-907页

作者： Jaša saražin Antonio Pizzi Siham Amirou Detlef Schmiedl MilanŠernek Biotechnical Faculty University of LjubljanaLjubljana1000Slovenia LERMAB-ENSTIB Universitéde LorraineEpinal88000France Fraunhofer Institute for Chemical Technology Pfinztal76327Germany

A non-isocyanate-based polyurethane(NIPU)wood adhesive was produced from organosolv lignin,which is a bio-sourced raw material,available in large quantities and produced as a by-product of the paper *** formulation of this new lignin-based NIPU adhesive,which is presented,was chemically characterised by Matrix-Assisted laser Desorption Ionization Time of Flight(MALDI ToF)mass spectrometry and by Fourier Transform Infra-Red(FTIR)spectrometry *** oligomers formed were determined and showed that the three species involved in the NIPU adhesive preparation were formed by the co-reaction of the three reagents used:lignin,dimethyl carbonate,and hexamethylene *** and branched structures were both *** properties of the adhesive were determined using the Automated Bonding Evaluation System(ABES)and internal bond(IB)strength test of the laboratory particleboard bonded with *** adhesive has shown satisfactory mechanical properties after hot pressing at 230℃.Such a temperature is used industrially in the most modern particleboard factories,but since it is hardly feasible for more conventional wood bonding equipment,the reactivity of the NIPU adhesive was successfully increased with the addition of a small percentage of a silane coupling *** the addition of the silane,the proposed NIPU adhesive could also be used at a hot-pressing temperature lower than 200℃.

关键词： Organosolv lignin NIPU MALDI ToF FTIR ABES

Health effects of air pollution:a Southern European perspective

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Chinese Medical Journal 2020年第13期133卷 1568-1574页

作者： Giovanni Viegi Sandra Baldacci sara Maio Salvatore Fasola Isabella Annesi-Maesano Francesco Pistelli laura Carrozzi Stefania la Grutta Francesco Forastiere National Research Council(NCR)Institute for Biomedical Research and Innovation(IRB) 90146 PalermoItaly National Research Council(NCR)Institute of Clinical Physiology(IFC) 56126 PisaItaly Department of Epidemiology of Allergic and Respiratory Diseases Sorbonne Universite and INSERMInstitut Pierre Louis d'fpidemiologie et de Sante PubliqueF75012 ParisFrance Department of Cardiothoracic and Vascular University Hospital of Pisa56124 PisaTuscanyItaly Department of Surgical MedicalMolecular Pathology and Critical AreaUniversity of Pisa56126 PisaTuscanyItaly

Objective:To summarize the main updated evidence about the health effects of air pollution,with a special focus on Southern *** sources:Literature was obtained through PubMed Central and the official websites of European Agencies and Scientific *** selection:Recent shreds of evidence about the health effects of air pollution coming from international reports and original research were collected and described in this ***:Air pollution is an avoidable risk factor that causes a huge burden for society,in terms of death,health disorders,and huge socio-economic *** southern European countries face a more threatening problem because they experience the effects of both anthropogenic pollutants and natural dusts(particulate matter[PM]).The European Environment Agency reported the number of premature deaths in the 28 countries of the European Union attributable to air pollutant exposure in the year 2016:374,000 for PM2.5,68,000 for nitrogen dioxide,and 14,000 for *** Italy,time series and analytical epidemiological studies showed increased cardiorespiratory hospital admissions and mortality,as well as increased risk of respiratory diseases in people living in urban ***:Based on abundant evidence,the World Health Organization,which hosts the Global Alliance against Chronic Respiratory Diseases(GARD),the scientific respiratory societies,and the patients’associations,as well as others in the health sector,must increase their engagement in advocacy for clean air policies.

关键词： Environment Respiratory disorders Epidemiology

Extracellular and intracellular functions of coiled-coil domain containing 3

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Journal of Molecular Cell Biology 2023年第6期15卷 1-10页

作者： sara Omari Hyemin Lee Jieqiong Wang Shelya X.Zeng Hua Lu Department of Biochemistry&Molecular Biology Tulane University School of MedicineNew OrleansLA 70112USA Tulane Cancer Center Tulane University School of MedicineNew OrleansLA 70112USA

Coiled-coil domain containing 3(CCDC3,also called Favine)is a highly conserved protein initially identified as a protein secreted from adipocytes and endothelial cells in the vascular system with endocrine-like ***,CCDC3 was also found to function as a nuclear tumor suppressor in breast *** it is still understudied,CCDC3,since its discovery,has been shown to play multiple roles in lipid metabolism,fatty liver,abdominal obesity,anti-inflammation,atherosclerosis,and *** essay is thus composed to offer an overview of these extracellular endocrine-like and intracellular(nuclear)functions of *** also discuss the possible underlying cellular and molecular mechanisms of CCDC3,the implications for clinical translation,and the remaining puzzles about this special molecule.

关键词： CCDC3 p53 MDM2 lipid metabolism p63 fatty liver(steatosis) tumor suppressor

Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish

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Animal Nutrition 2022年第4期11卷 293-308页

作者： Anna Rita Angotzi Esther Leal sara Puchol José M. Cerdá-Reverter Sofia Morais Department of Fish Physiology and Biotechnology Instituto de Acuicultura de Torre de la SalIATS-CSICTorre la Sal s/nRibera de Cabanes12595 CastellonSpain Lucta S.A. Innovation DivisionAnimal Science UnitUAB Research Park08193 BellaterraSpain

In this study,we investigated the transcriptional spatio-temporal dynamics of the taste 1 receptor(T1R)gene family repertoire in seabream(Sparus aurata[sa]),during larval ontogeny and in adult *** early larval development,sa T1R expression arises heterochronously,*** extraoral taste-related perception in the gastrointestinal tract(GIT)anticipates first exogenous feeding(at 9 days post hatching[dph]),followed by the buccal/intraoral perception from 14 dph onwards,supporting the hypothesis that the early onset of the molecular machinery underlying sa T1R expression in the GIT is not induced by food but rather genetically *** adulthood,we characterized the expression patterns of sa T1R within specific tissues(n=4)distributed in oropharingeal,GIT and brain regions substantiating their functional versatility as chemosensory signaling players to a variety of biological functions beyond oral taste ***,we provided for the first time direct evidences in fish for m RNA coexpression of a subset of sa T1R genes(mostly sa T1R3,*** common subunit of the heterodimeric T1R complexes for the detection of“sweet”and“umami”substances),with the selected gut peptides ghrelin(ghr),cholecystokinin(cck),hormone peptide yy(pyy)and proglucagon(pg).Each peptide defines the enteroendocrine cells(ECCs)identity,and establishes on morphological basis,a direct link for T1R chemosensing in the regulation of fish digestive ***,we analyzed the spatial gene expression patterns of 2 taste signaling components functionally homologous to the mammalian G(i)a subunit gustducin,namely sa G(i)a1 and sa G(i)a2,and demonstrated their co-localization with the sa T1R3in EECs,thus validating their direct involvement in taste-like transduction mechanisms of the fish *** conclusion,data provide new insights in the evolutionary conservation of gut sensing in fish suggesting a conserved role for nutrient sensors modulating entero-endocrine secretion.

关键词： Taste 1 receptor Fish larvae Gut nutrient sensing Gut peptides G(i)alpha protein subunits 1 and 2

Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1584-1606页

作者： Rodolfo Daniel Cervantes-Villagrana Damaris Albores-García Alberto Rafael Cervantes-Villagrana sara Judit García-Acevez Department of Pharmacology Center for Research and Advanced Studies of the National Polytechnic Institute(CINVESTAV-IPN)07360 Mexico CityMexico Department of Environmental Health Sciences Florida International University(FIU)MiamiFlorida 33199USA laboratorio de investigación en Terapéutica Experimental Unidad Académica de Ciencias QuímicasÁrea de Ciencias de la SaludUniversidad Autónoma de Zacatecas(UAZ)ZacatecasMéxico Dirección de Proyectos e Investigación Grupo Diagnóstico Médico Proa06400 CDMX CuauhtémocMéxico

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and *** the well characterized angiogenic effect of some tumor-derived factors;others,such as BDNF,recruit peripheral nerves and *** neurogenic switch,activated by tumor-derived neurotrophins and extracellular vesicles,attracts adjacent peripheral fibers(autonomic/sensorial)and neural progenitor ***,tumor-associated nerve fibers can guide cancer cell ***,IL-1β,CCL2,PGE2,among other chemotactic factors,attract natural immunosuppressive cells,including T regulatory(Tregs),myeloid-derived suppressor cells(MDSCs),and M2 macrophages,to the tumor *** leukocytes further exacerbate the aberrant communication circuit releasing factors with neurogenic ***,cancer cells directly evade immune surveillance and the antitumoral actions of natural killer cells by activating immunosuppressive mechanisms elicited by heterophilic complexes,joining cancer and immune cells,formed by PD-L1/PD1 and CD80/CTla-4 plasma membrane ***,nervous and immune cells,together with fibroblasts,endothelial,and bone-marrow-derived cells,promote tumor growth and enhance the metastatic properties of cancer *** by the demonstrated,but restricted,power of anti-angiogenic and immune cell-based therapies,preclinical studies are focusing on strategies aimed to inhibit tumor-induced *** we discuss the potential of anti-neurogenesis and,considering the interplay between nervous and immune systems,we also focus on anti-immunosuppression-based *** molecules,antibodies and immune cells are being considered as therapeutic agents,aimed to prevent cancer cell communication with neurons and leukocytes,targeting chemotactic and neurotransmitter signaling pathways linked to perineural invasion and metastasis.

关键词： PD1 therapies invasion

Development of new cowpea(Vigna unguiculata)mutant genotypes,analysis of their agromorphological variation,genetic diversity and population structure

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BIOCELL 2021年第2期45卷 345-362页

作者： MADE DIOUF sara DIALLO FRANÇOIS ABAYE BADIANE OUMAR DIACK DIAGA DIOUF laboratoire Campus de Biotechnologies Végétales Département de Biologie VégétaleFacultédes Sciences et TechniquesUniversitéCheikh Anta DiopDakar-FannDakar10700Sénégal Facultédes Sciences et Technologies de l’Education et de la Formation UniversitéCheikh Anta DiopDakar-FannDakar10700Sénégal

Cowpea is one of the most important legume grains in the sub-Saharan region of Africa used for human consumption and animal feed,but its production is hampered by biotic and abiotic constraints raising the need to broaden its genetic *** this purpose,seeds of two cowpea varieties Melakh and Yacine were irradiated with 300 and 340 Gy of gamma-ray,*** developed mutant populations were agromorphologically characterized from M5 to M7,while the genetic diversity of the latter was evaluated using 13 ISSR *** on the agromorphological characterization,variation of flower color,pod length,seed coat color,and seed weight with 78.01,68.29,94.48,and 57.58%heritability,respectively,were recorded in the mutant *** analyses allowed to identify the elite mutants based on their agromorphological traits,while Pearson’s correlation results revealed a positive correlation between yield and yield component *** subpopulations were identified through STRUCTURE analyses,but the assignment of the individuals in each group was improved using DAPC(Discriminant Analysis of Principal Components)*** of Molecular Variance revealed that the majority(85%)of the variance rather existed within groups than among(15%)***,our study allowed us to select new promising mutant genotypes that could be tested for multi-locational trials to evaluate their agronomic performance.

关键词： Agromorphological characterization Induced mutagenesis ISSR Plant breeding

Differences and similarities between mesenchymal stem cell and endothelial progenitor cell immunoregulatory properties against T cells

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World Journal of Stem Cells 2021年第8期13卷 971-984页

作者： Mehdi Razazian Maryam Khosravi Sheyda Bahiraii Georges Uzan sara Shamdani Sina Naserian Institut national de la santéet de la recherche médicale(Inserm)UnitéMixte de Recherche-Inserm-Ministère de la Défense 1197 Hôpital Paul BrousseVillejuif 94800France Microenvironment&Immunity Unit Institut PasteurParis 75724France Institut national de la santéet de la recherche médicale(Inserm)Unit 1224 Paris 75724France Department of Pharmacognosy University of ViennaVienna 1090Austria Paris-Saclay University Villejuif 94800France CellMedEx Saint Maur Des Fossés 94100France

Bone-marrow-derived mesenchymal stem cells and endothelial progenitor cells have some interesting biological properties that make them unique for cell therapy of degenerative and cardiovascular *** both cell populations have been already studied and used for their regenerative potentials,recently their special immunoregulatory features have brought much more *** stem cells and endothelial progenitor cells have both proangiogenic functions and have been shown to suppress the immune response,particularly T cell proliferation,activation,and cytokine *** makes them suitable choices for allogeneic stem cell ***,these two cells do not have equal immunoregulatory *** elements including their extraction sources,age/passage,expression of different markers,secretion of bioactive mediators,and some others could change the efficiency of their immunosuppressive ***,to our knowledge,no publication has yet compared mesenchymal stem cells and endothelial progenitor cells for their immunological interaction with T *** review aims to specifically compare the immunoregulatory effect of these two populations including their T cell suppression,deactivation,cytokine production,and regulatory T cells induction ***,it evaluates the implications of the tumor necrosis factor alpha-tumor necrosis factor receptor 2 axis as an emerging immune checkpoint signaling pathway controlling most of their immunological properties.

关键词： Endothelial Progenitor Cells Mesenchymal Stem Cells T cells Immunosuppression Immunoregulation TNFα-TNFR2 signaling pathway

Endowing a plain fluidic chip with micro-optics: a holographic microscope slide

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Light(Science & Applications) 2017年第1期6卷 528-539页

作者： Vittorio Bianco Biagio Mandracchia Valentina Marchesano Vito Pagliarulo Federico Olivieri sara Coppola Melania Paturzo Pietro Ferraro Institute of Applied Sciences and Intelligent Systems-Italian National Research Council(ISASI-CNR) Via Campi Flegrei 34PozzuoliNapoli 80078Italy Universitàdegli Studi di Napoli‘Federico II’ P.le Tecchio 80Napoli 80100Italy

lab-on-a-Chip(LoC)devices are extremely promising in that they enable diagnostic functions at the *** this scope,an important goal is to design imaging schemes that can be used out of the *** this paper,we introduce and test a pocket holographic slide that allows digital holography microscopy to be performed without an interferometer ***,a commercial off-the-shelf plastic chip is engineered and functionalized with this *** microfluidic chip is endowed with micro-optics,that is,a diffraction grating and polymeric lenses,to build an interferometer directly on the chip,avoiding the need for a reference arm and external bulky optical *** to the single-beam scheme,the system is completely integrated and robust against vibrations,sharing the useful features of any common path ***,it becomes possible to bring holographic functionalities out of the lab,moving complexity from the external optical apparatus to the chip ***-free imaging and quantitative phase contrast mapping of live samples are demonstrated,along with flexible refocusing ***,a liquid volume can be analyzed in one single shot with no need for mechanical scanning systems.

关键词： diffraction gratings digital holography lab-on-a-Chip micro-optics optical devices polymer printing