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谷香满溢的阳光早餐

中外食品工业（贝太厨房） 2011年第7期 17-17页

作者：编辑（杨涛） sara 马俨（摄影） zhumei（版式设计）

阳光明媚的早晨，怎能少了谷香浓郁的营养早餐呢？谷类，纯天然的健康食物，含有丰富的营养素，不仅能在晨起时为我们的身体提供充足的养分，而且低热量零胆固醇，对身体无负担，还能加速肠道蠕动，当然是早餐的最佳选择。

关键词：早餐阳光满溢营养素纯天然胆固醇低热量身体

Cryoglobulinemia in elderly patients with HCV-related chronic hepatitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第2期1卷 72-74页

作者： Francesco Giuseppe Foschi Anna Chiara Dall'Aglio Arianna Lanzi Giorgio Marano sara Savini Pietro Andreone Mauro Bernardi Giuseppe Francesco Stefanini Department of Internal Medicine Faenza Hospital Department of Clinical Medicine Bologna University

Hepatitis C virus(HCV) infection affects about 3% of the world's population and often leads to chronic liver *** some industrialized countries,HCV prevalence increases with age,but the optimal management of older patients has not been accurately *** infection can also lead to lymphoproliferative disorders,the most common being mixed cryoglobulinemia(MC),and also for this condition that frequently affects elderly patients,the optimal therapeutic strategy is still *** report the case of a 77-year-old Caucasian woman with HCV-related chronic hepatitis and cutaneous manifestations consisting of urticaria and pruritus related to MC resistant to *** patient underwent a treatment with interferon and *** a treatment led to early biochemical and virological response associated with the resolution of cryoglobulinemia and cutaneous *** the end of treatment,HCV replication relapsed,but cryoglobulinemia and cutaneous symptoms did not *** the absence of definite treatment guidelines in this particular context,our experience suggests that the presence of symptoms related to HCV-infection that deeply affect patient quality of life warrants antiviral therapy even beyond the age limits that currently exclude patients from treatment.

关键词： Cryoglobulinemia Elderly patients Hepatitis C virus chronic hepatitis Antiviral treatment

利用基因敲出鼠模型研究Gab2连接蛋白在造血调控中的作用

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利用基因敲出鼠模型研究Gab2连接蛋白在造血调控中的作用

A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species

第11次中国实验血液学会议

作者：张毅 Ernesto Diaz-Flores Geqiang Li zhengqi Wang Zizhen Kang Eleonora Haviernikova sara Rowe Cheng-Kui Qu William Tse Kevin M.Shannon Kevin D.Bunting 军事医学科学院基础医学研究所二室 Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Reserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA

＜正＞Gab2作为细胞信号通路中一重要的连接蛋白,主要是通过一些细胞因子刺激酪氨酸磷酸化参与信号通路的调节作用。已有文献报道显示, Gab2可激活 PI-3K 和 MAPK 信号通路,调节造血细胞的迁移。利用 Gab2基因敲除鼠模型研究其生物学功... 详细信息

＜正＞Gab2作为细胞信号通路中一重要的连接蛋白,主要是通过一些细胞因子刺激酪氨酸磷酸化参与信号通路的调节作用。已有文献报道显示, Gab2可激活 PI-3K 和 MAPK 信号通路,调节造血细胞的迁移。利用 Gab2基因敲除鼠模型研究其生物学功能,结果表明 Gab2的缺失可导致严重的过敏反应;且可改变肥大细胞的发育。另

关键词： Gab2连接蛋白造血调控基因敲除动物模型

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Horticulture Research 2016年第1期3卷 30-42页

作者： Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg Department of Biosciences University of MilanMilan20133Italy Plant Breeding Wageningen University and ResearchWageningen6700AJThe Netherlands Research and Innovation Centre Edmund Mach FoundationSan Michele all’Adige38010Italy Biometris Wageningen University and ResearchWageningen6700AAThe Netherlands IRHS INRAAGROCAMPUS-OuestUniversitéd’AngersSFR 4207 QUASAVBeaucouzé49071France Department of Agricultural Sciences University of BolognaBologna40127Italy Department of Molecular Biology Laimburg Research Centre for Agriculture and ForestryOra39040Italy Department of Plant Breeding Swedish University of Agricultural SciencesAlnarp23053Sweden Hendrix Genetics Research Technology&ServicesBoxmeer 5830 ACThe Netherlands

Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome *** apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of *** approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of *** map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 ***,chromosome 5 was oriented according to its homoeologous chromosome *** map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL *** collinearity with the genome sequences v1 and v3 are *** our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and *** result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species.

关键词： breeding linkage mapping

理解并修正英国国家医疗卫生服务体系的产科模式重要的是选择正确的指标、使用高质量的数据、动员所有利益相关者

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英国医学杂志中文版 2013年第4期16卷 200-202页

作者： sara Kenyon clinical senior lectttrer in maternal fetalmedicine Catherine Calderwood rkatiorud clinwal direcWr for maternity women's health, NHS England senior lecturere ElizabethSraper professorofperbutta alutpaediatri epidemiology MarianKnight NationaIInstituteforHeahhResearchprofessorinpublk.heahh 梁立智(译) 杨孜(校) Wflrnen’sHealthAcadetficCentre Kitlg’SCollegeLondonLondonSEl7EH.UK NHSEngland POBox16738.RedditchUK hoolofHealthandPopulations’ie㈤es.UniversityofBirmingham BirminghamUK DepartmentofHealthSciences UniversityofLeicesterLeicesterUK NationalPefina1EpidemiologyUnit Universityof0Xford.0xford.UKlucy.chappell@kcl.aeUK 首都医科大学卫生管理与教育学院北京大学第三医院妇产科

本周，英国皇家妇产科学院发表了一份有关英格兰国家医疗卫生服务体系（NHS）2011_2012年产科模式的报告。。报告的目的是“检验潜在绩效指标的有效性，以及确定如何利用现有的数据，将这些指标成功地用于不同产科病房的绩效比较。”数... 详细信息

本周，英国皇家妇产科学院发表了一份有关英格兰国家医疗卫生服务体系（NHS）2011_2012年产科模式的报告。。报告的目的是“检验潜在绩效指标的有效性，以及确定如何利用现有的数据，将这些指标成功地用于不同产科病房的绩效比较。”数据来源于英国NHS信托机构通过医院阶段统计（HES）定期收集的住院患者信息和日病历，在分析这些数据的基础上，该报告初步提出11项绩效指标，均与分娩息息相关（框图）。该报告指出这些用于风险调整的数据可以在一个代表全国平均水平的漏斗图里推测每个产科病房的情况。如果随机发生任何变化，那么预计仅有1／20或1／500的产科病房分别位于2个标准差（漏斗图的内限）或3个标准差.

关键词：医疗卫生服务体系产科病房数据来源利益相关者英国质量绩效指标住院患者

Addition of Inhalation Training Devices and Smartphone Application to Verbal Counseling for Asthmatic Patients

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Journal of Clinical and Nursing Research 2022年第2期6卷 76-79页

作者： Rania AA Mahmoud sara M Tony Marian S Boshra Mona A Abdelrahman Haitham Saeed Hasnaa Osama Marwa O Elgendy Mohamed EA Abdelrahim Clinical Pharmacy Department Faculty of PharmacyBeni-Suef UniversityBeni-SuefEgypt Beni-Suef Specialized Hospital Beni-SuefEgypt Technical Office of Deputy Minister of Health in Beni-Suif Directorate of Health Affairs Beni-SuefEgypt Department of Clinical Pharmacy Teaching Hospital of Faculty of MedicineFaculty of MedicineBeni-Suef UniversityBeni-SuefEgypt Department of Clinical Pharmacy Faculty of PharmacyNahda University(NUB)Egypt

Background:One of the main issues with pressurized metered dose inhalers(pMDI)is that some patients find it difficult to use it ***:This study was carried out to compare the effect of traditional verbal counseling and that of adding an inhalation training device,such as Flo-Tone or Clip-Tone,along with a smartphone application on the incidence of inhalation technique mistakes and the pulmonary function of asthmatic adults and ***:The lung function of those in the advanced counseling group significantly improved on the second visit(p<0.001),whereas for those in the verbal counseling group,their lung function only improved on the third visit(p<0.001).For both the groups,the mean number of mistakes in regard to the steps in inhalation technique decreased significantly(p<0.001),with an overall higher percentage in the advanced counseling ***:The use of training devices and smartphone applications in addition to traditional verbal counseling for teaching asthmatic adults and children the correct inhalation technique steps using pMDI resulted in a significant improvement in pulmonary function and a significant reduction in the number of inhalation technique mistakes,compared to traditional verbal counseling alone.

关键词： Flo-Tone Clip-Tone Counseling Asthma in adults and children Inhalation technique MDI,FEV1 PEF Smartphone application

输尿管支架用镁合金丝材在模拟尿液中的腐蚀行为

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输尿管支架用镁合金丝材在模拟尿液中的腐蚀行为

运动皮质的磁敏感加权成像定量评分有助于区分肌萎缩侧索硬化症的临床表型

第十一届全国腐蚀与防护大会

作者：梅迪王成 Maria Nienaber Margarida Pacheco Alexandre Barros sara Neves Rui L.Reis 朱世杰 Jan Bohlen Dietmar Letzig 关绍康 Mikhail.L.Zheludkevich Sviatlana V.Lamaka 郑州大学 University of Minho

可生物降解的金属材料是用于制造生物医学植入装置的有前途的材料[1-2]。近年来,可降解镁合金作为输尿管支架的适用性和体内相容性已通过动物试验得到初步证实[3]。尽管初步结果表明镁合金是制造输尿管支架的有前途的候选材料之一[4-5]... 详细信息

可生物降解的金属材料是用于制造生物医学植入装置的有前途的材料[1-2]。近年来,可降解镁合金作为输尿管支架的适用性和体内相容性已通过动物试验得到初步证实[3]。尽管初步结果表明镁合金是制造输尿管支架的有前途的候选材料之一[4-5],但相关的研究基础尚不牢固。镁在尿道环境中的降解行为仍然没有被完全理解。本工作研究了人造尿液中镁合金的腐蚀机理,有助于更好地理解镁合金作为输尿管植入物的降解行为。经模拟尿液浸泡72小时后纯Mg和Mg-Zn丝材腐蚀后的横截面形貌如图1所示。Mg-1Zn丝材表现出严重的局部腐蚀(图1中的箭头所指(a1-a3))。纯Mg丝材中也存在局部腐蚀,但不如Mg-1Zn丝材明显。连续EIS测试是分析形成的腐蚀产物层的演变和屏障保护能力的有效方法。Mg-1Zn丝材和纯Mg丝材在模拟尿液中浸泡72小时的Bode图如图2所示。两个样品的初始Bode图(浸泡15分钟后)非常相似,由中频和低频时间常数组成。两个样本的低频阻抗模量在整个浸没期间逐渐增加。随着时间的增加,浸入24小时(纯Mg丝材)或48小时(Mg-1Zn丝材)后,在高频范围(10 kHz至100kHz内)会出现一个附加的时间常数。此后高频阻抗模量也随着高频时间常数的增加而逐渐增加。连续EIS证实了浸入模拟尿液期间两种Mg丝材上腐蚀产物的层状结构。输尿管支架是可生物降解镁合金的一个相对较新的应用领域。在这项研究中发现经模拟尿液浸泡后的Mg表面腐蚀产物具有两层结构:外层MgNHPO·6HO和内层Mg(OH)。具有一定保护性的外层MgNHPO·6HO产物减缓了Mg的腐蚀,但这一现象显示了裸Mg支架在泌尿系统环境中的结壳风险。

关键词：镁丝输尿管支架模拟尿液腐蚀行为

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国际医学放射学杂志 2021年第3期44卷 364-364页

作者： C.Giorgio S.sara M.Claudia C.Silvia C.Luca C.V.Elisa 于海蛟

摘要目的分析磁敏感加权成像(SWI)上初级运动皮质的铁相关性低信号,区分肌萎缩侧索硬化症(ALS)及其亚型、类ALS以及健康对照者。方法纳入64例临床怀疑ALS且

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前列腺特异性膜抗原（PSMA）靶向18F-DCFPyL在外周神经节的摄取模式

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中华核医学与分子影像杂志 2018年第5期38卷 379-380页

作者：李慧玲兰晓莉 Rudolf A.Werner sara Sheikhbahaei Krystyna M.Jones Mehrbod S.Javadi Lilja B.Solnes Ashley E.Ross Mohamad E.Allaf Kenneth J.Pienta Constantin Lapa ANDreas K.Buck Takahiro Higuchi Martin G.Pomper Michael A.Gorin Steven P.Rowe 华中科技大学同济医学院附属协和医院核医学科 Division of Nuclear Medicine and Molecular Imaging The Russell H.Morgan Department of Radiology and Radiological ScienceJohns Hopkins University School of Medicine Department of Nuclear Medicine University Hospital Würzburg

目的靶向前列腺特异性膜抗原（PSMA）的放射性显像剂在许多正常结构、解剖变异和非前列腺癌组织中有摄取。该研究探讨PSMA靶向显像剂18F-DCFPyL在外周神经节PET显像的摄取频次和程度。方法回顾性分析98例接受18F-DCFPyL PET/CT显像的患... 详细信息

目的靶向前列腺特异性膜抗原（PSMA）的放射性显像剂在许多正常结构、解剖变异和非前列腺癌组织中有摄取。该研究探讨PSMA靶向显像剂18F-DCFPyL在外周神经节PET显像的摄取频次和程度。方法回顾性分析98例接受18F-DCFPyL PET/CT显像的患者,包括76例前列腺癌（PCa）男性患者和22名肾细胞癌（RCC）患者（男13例、女9例）。评估颈、星状、腹腔、腰、骶神经节的摄取。记录所有放射性摄取高于背景的神经节的摄取值,包括最大标准摄取值(SUVmax)和用瘦体质量校准的SULmax。计算SUVmax和SULmax除以升主动脉平均摄取(Aortamean)和右臀肌肉平均摄取(Gluteusmean),得到神经节/背景比值。结果 98例患者中有95例（96.9%）在至少1个外周神经节中有摄取。在PCa病例中,最常见的放射性聚集部位是腰交感神经节（55/76,72.4%）,其次是颈神经节（51/76,67.1%）。大多数患者是双侧摄取[腰椎44/55（80%）和颈椎30/51（58.8%）]。此外,星状神经节、腹腔神经节、骶神经节有明显放射性摄取者比例分别为65.8%（50/76）、59.2%（45/76）、6.6%（5/76）。RCC患者也有类似的发现,最常见的放射摄取部位是腰神经节（90.9%,20/22）和颈神经节（86.4%,19/22）。这2个部位的PSMA配体平均摄取量在PCa和RCC中均无差异。结论随着靶向PSMA显像剂的广泛应用,必须了解其在肿瘤不直接相关的组织结构中的摄取方式。该研究首次系统评价18F-DCFPyL在神经节中的摄取,结果显示其在腰椎、颈椎、星状神经节、腹腔神经节和骶神经节中的摄取频率呈下降趋势。然而,导致PSMA靶向放射性显像剂在外周神经节中摄取出现差异的生物学原因目前尚不清楚,需进一步研究。

关键词： 18F-DCFPyL 显像误区前列腺癌 PSMA 神经节