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A flexible magnetoelectric field-effect transistor with magnetically responsive nanohybrid gate dielectric layer

Nano Research 2015年第10期8卷 3421-3429页

作者： Nguyen Minh Triet Tran Quang Trung Nguyen Thi Dieu Hien saqib siddiqui Do-ll Kim Jai Chan Lee Nae-Eung Lee SchoolofAdvancedMaterialsScienceandEngineering SungkyunkwanUniversitySuwonKyunggi-do440-746RepublicofKorea SungkyunkwanUniversity(SKKU)AdvancedInstituteofNanotechnology(SAINT) 5ungkyunkwanUniversitySuwonKyunggi-do440-746RepublicofKorea SamsungAdvancedInstituteforHealthSciencesandTechnology(SAIHST) SungkyunkwanUniversitySuwonKyunggi-do440-746RepublicofKorea

Flexible magnetoelectric （ME） materials have been studied for new applications such as memory, energy harvesters, and magnetic field sensors. Herein, with the widely studied and progressive advantages of ME phenomena in the multiferroic field, we demonstrate a new approach for utilizing flexible ME materials as gate dielectric layers in ME organic field-effect transistors （ME-OFET） that can be used for sensing a magnetic field and extracting the ME properties of the gate dielectric itself. The magnetoelectric nanohybrid gate dielectric layer comprises sandwiched stacks of magnetostrictive CoFe2O4 nanoparticles and a highly piezoelectric poly（vinylidene fluoride-co-trifluoroethylene） layer. While varying the magnetic field applied to the ME gate dielectric, the ME effect in the functional gate dielectric modulates the channel conductance of the ME-OFET owing to a change in the effective gate field. The clear separation of the ME responses in the gate dielectric layer of ME-OFET from those of the other parameters was demonstrated using the AC gate biasing method and enabled the extraction of the ME coefficient of ME materials. Additionally, the device shows high stability after cyclic bending of 10,000 cycles at a banding radius of 1.2 cm. The device has significant potential for not only the extraction of the intrinsic characterization of ME materials but also the sensing of a magnetic field in integrated flexible electronic systems.

关键词： magnetoelectric magnetostriction CoFe2O4 nanoparticles P(VDF-TrFE) organic field-effecttransistor magnetic sensor

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Comprehensive genetic screening reveals wide spectrum of genetic variants in monogenic forms of diabetes among Pakistani population

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World Journal of Diabetes 2021年第11期12卷 1957-1966页

作者： Ibrar Rafique Asif Mir Shajee siddiqui Muhammad Arif Nadeem saqib Asher Fawwad Luc Marchand Muhammad Adnan Muhammad Naeem Abdul Basit Constantin Polychronakos Department of Biological Sciences International Islamic UniversityIslamabad 44000Pakistan Departments of Pediatrics and Human Genetics McGill University Health Centre Research InstituteMontreal H4A 3J1Canada Research Development and Coordination Pakistan Health Research CouncilIslamabad 44000Pakistan Department of Medicine Pakistan Institute of Medical SciencesIslamabad 44000PakistanPakistan Department of Medical Laboratory Technology National Skills UniversityIslamabad44000Pakistan Department of Biochemistry Baqai Institute of Diabetology and EndocrinologyBaqai Medical UniversityKarachi 74600SindhPakistan PHRC Research Centre FJMUPakistan Health Research CouncilLahore 54000Pakistan Department of Biotechnology Quaid-I-Azam UniversityIslamabad 44000Pakistan Department of Medicine Baqai Institute of Diabetology and EndocrinologyBaqai Medical UniversityKarachi 74600SindhPakistan

BACKGROUND Monogenic forms of diabetes(MFD)are single gene *** diagnosis is challenging,and symptoms overlap with type 1 and type 2 *** To identify the genetic variants responsible for MFD in the Pakistani population and their *** A total of 184 patients suspected of having MFD were *** inclusion criterion was diabetes with onset below 25 years of *** demographic and clinical information were taken from the *** maturity-onset diabetes of the young(MODY)probability score was calculated,and glutamate decarboxylase ELISA was *** negative patients and features resembling MODY were selected(n=28)for exome sequencing to identify the pathogenic *** A total of eight missense novel or very low-frequency variants were identified in 7 *** variants were found in genes for MODY,***1A(c.169C>A,***57Met),KLF11(c.401G>C,***134Ala),and HNF1B(c.1058C>T,***353Leu).Five variants were found in genes other than the 14 known MODY genes,***6(c.919G>A,***307Lys),WFS1(c.478G>A,***160Lys)and WFS1(c.517G>A,***173Lys),RFX6(c.1212T>A,***404Gln)and ZBTB20(c.1049G>A,***350His).CONCLUSION The study showed wide spectrum of genetic variants potentially causing MFD in the Pakistani *** MODY genes prevalent in European population(GCK,HNF1A,and HNF4a)were not found to be common in our *** of novel variants will further help to understand the role of different genes causing the pathogenicity in MODY patient and their proper management and diagnosis.

关键词： MODY Diabetes Genetics Monogenic diabetes Monogenic forms of diabetes

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