检索结果-南通市图书馆

In-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 530-540页

作者： Smrutipragnya Samal Rajesh kumar Meher Debasmita Dubey Showkat Ahmad Mir Binata Nayak Mahesh Chandra Sahu Pradeep kumar Naik Goutam Rath santosh kumar swain Department of Otorhinolaryngology and Head and Neck Surgery IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Medical Research Laboratory IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia School of Life Sciences Sambalpur UnivesityJyotiviharBurlaSambalpurOdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023India School of Pharmaceutical Sciences Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswar-751030India

Objective:To investigate the interaction of p53 with docetaxel and berberine and their anticancer activities against oral squamous cell ***:The interaction between p53 with docetaxel and berberine was investigated and their mechanisms of action against oral squamous cell carcinoma were *** studies were performed to determine any toxic impact of the drugs on the vital organs of tested ***:In silico results revealed the molecular interaction of docetaxel and berberine with p53 and the molecules were found to be potential p53 *** and berberine inhibited the proliferation of cancer cells in a concentration-dependent *** cytometry analysis revealed that docetaxel and berberine at IC50 concentrations upregulated the expression of p53 in oral squamous cell carcinoma cells,thus triggering apoptotic cell *** addition,no toxicity was observed in the liver and kidney tissues of mice after docetaxel and berberine ***:Docetaxel and berberine significantly suppressed the proliferation of oral cancer cells by activating p53 expression and causing apoptotic cell *** compounds can be potential agents for the treatment of oral cancer,with little to no toxicity at the tissue level.

关键词： Docetaxel Berberine PC-3 OVCAR-3 OSCC SCC-29B p53 Anticancer Apoptosis

Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第2期5卷 88-94页

作者： Mahesh Chandra Sahu santosh kumar swain IMS and SUM Hospital Siksha'O'Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia Department of Otorhinolaryngology IMS and SUM HospitalSiksha'O'Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia

Introduction:Chronic suppurative otitis media (CSOM) is a common problem in worldwide and untreated CSOM leads to fatal complications like facial nerve paralysis,lateral sinus thrombosis,labyrinthitis,meningitis and brain abscess in developing country like ***:To isolate causative bacteria and antibiotic sensitivity pattern for CSOM and to know the prevalence of extended spectrum beta lactamases (ESBL) and Metallobetalactamases (MBL) in CSOM ***:A total of 500 ear swabs of clinical suspected CSOM patients were cultured on specific cultured medium and identified the bacteria with conventional *** all the identified bacteria were subjected with specific antibiotics by the Kirby-Bauer's method to know the resistance pattern of *** and MBL strains were detected by double disc diffusion ***:A total of 384 bacteria were isolated from 500 CSOM patients,among them 86 *** (22.40%),112 Staphylococcus aureus (29.17%),53 *** (13.80%),32 *** (18%),26 *** (6.77%),24 *** (6.25%),23 *** (5.99%),18 *** (4.69%) and 10 *** (2.60%) identified with conventional *** antibiotic disc diffusion methods 74.22% ESBL strains and 9.90%MBL strains were *** resistant strains of *** (86/384,22.40%) were more prevalent than those of *** (112/384,29.17%) and other bacteria in ear *** and vancomicin could control to gram negative bacteria and gram positive bacteria ***:Continuous and periodic evaluation of microbiological profile and antimicrobial sensitivity pattern of bacterial is essential for optimum management of CSOM patients.

关键词： Antibiotics Chronic suppurative otitis media Gram negative bacteria ESBL MBL

A scoping review of vestibular paroxysmia: An acute disabling clinical entity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Acute Disease 2020年第6期9卷 248-252页

作者： santosh kumar swain Nibi Shajahan Satybrata Acharya Department of Otorhinolaryngology IMS and SUM HospitalSiksha"O"Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia

The pathogenesis of vestibular paroxysmia(VP)is the neurovascular cross-compression of cranial nerveⅧwith short episodes of vertigo as the common *** exact etiological and clinical profiles of the patients with VP are uncertainly reported in *** is general thought that loop of the anterior inferior cerebellar artery and posterior inferior cerebellar artery(less commonly),vertebral artery,or a vein is involved in compressing cranial nerveⅧ.Ephaptic neural discharges at the proximal end of cranial nerveⅧ,which is covered by oligodendrocytes,are thought to be the mechanism for *** with VP often suffer from brief vertiginous attacks of several episodes in a single day,and nystagmus is seen during the vertiginous *** magnetic resonance imaging could reveal the arterial compression of cranial nerveⅧ.The important differential diagnosis of VP includes vestibular migraine,Meniere's disease,benign paroxysmal positional vertigo,superior canal dehiscence syndrome,epileptic vertebral aura,paroxysmal brainstem attacks(in multiple sclerosis or after brainstem stroke),transient ischemic attacks and panic *** vertiginous attacks can be ceased by administration of a low dose of *** or oxcarbazepine,even in low doses,can be efficient to relieve VP,and they have the same efficiency both in adults and in children.

关键词： Vertigo Vestibular paroxysmia Neurovascular cross-compression Carbamazepine

Clinical characteristics and treatment of acute epiglottitis: A retrospective study of 28 cases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Acute Disease 2020年第3期9卷 109-113页

作者： santosh kumar swain Bulu Nahak Priyanka Debta Department of Otorhinolaryngology IMS and SUM HospitalSiksha“O”Anusandhan UniversityK8KalinganagarBhubaneswar-751003OdishaIndia Department of Oral Pathology and Microbiology IDS and SUM HospitalSiksha“O”Anusandhan UniversityK8KalinganagarBhubaneswar-751003OdishaIndia

Objective:To evaluate the clinical profiles,diagnosis,and treatment of patients with acute epiglottitis at a tertiary care teaching hospital of eastern ***:This is a retrospective study in which 28 patients of acute epiglottitis *** study was conducted between January 2016 and October *** diagnosis of acute epiglottitis was based on the clinical presentations and fiberoptic laryngoscopic examinations of the larynx and *** of age,gender,personal history,clinical symptoms,treatment,and hospital stay were ***:Out of the 28 patients with acute epiglottitis,17(60.71%)were male and 11(39.29%)were female with age ranged from 4 years to 62 years and a mean age of 23.45 *** median duration from the onset to resorting to physicians is 3 *** the 28 patients,4 patients(14.29%)were under the treatment for diabetes *** cases(14.29%)required airway management with intubation and ***:Acute epiglottitis is an acute infectious condition of the supraglottis and may lead to airway *** presentations alone are insufficient for the diagnosis of acute *** nasopharyngolaryngoscopic examination should be performed as soon as possible for confirmation of the disease.

关键词： Acute epiglottitis Airway obstruction Supraglottis Odynophagia

Pseudo-Differential Operators of Homogeneous Symbol Class Associated with the Weinstein Transform

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第6期40卷 1533-1562页

作者： santosh kumar UPADHYAY Mohd SARTAJ Department of Mathematical Sciences Indian Institute of Technology(BHU)VaranasiIndia

In this paper,pseudo-differential operators with homogeneous symbol classes associated with the Weinstein transform are *** boundedness of pseudo-differential operators and commutator between two pseudo-differential o... 详细信息

关键词： Pseudo-Differential Operators Homogeneous Symbol Class Weinstein Operator Sobolev space Weinstein transform

Acute otitis media with facial nerve palsy: our experiences at a tertiary care teaching hospital of eastern India

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Acute Disease 2019年第5期8卷 204-207页

作者： santosh kumar swain Alok Das Jatindra Nath Mohanty Department of Otorhinolaryngology IMS and SUM hospitalSiksha'O'Anusandhan UniversityK8KalinganagarBhubaneswar-751003OdishaIndia Medical Research Laboratory IMS and SUM hospitalSiksha'O'Anusandhan UniversityK8Kalinga nagarBhubaneswar-751003OdishaIndia

Objective:To assess acute otitis media with facial nerve paralysis,its prognosis,and ***:It is a retrospective *** patients of acute otitis media associated with facial nerve paralysis attended the outpatient department of otorhinolaryngology between May 2017 and April *** patients were clinically assessed with appropriate investigations,prognosis,and ***:Out of 13 patients,2 were identified with complete facial paralysis and the remaining 11 patients presented with incomplete *** treatment including antibiotics and corticosteroids failed,while myringotomy and facial nerve decompression were done with a favorable *** patients recovered to grade-Ⅰ (House-Brackmann) and 2 cases to grade-Ⅱ (House-Brackmann).Conclusion:Peripheral facial nerve paralysis in acute otitis media is *** and steroids yield good outcome as conservative *** case of failure by conservative treatment,facial nerve decompression yields a favorable outcome.

关键词： Acute otitis media Facial nerve paralysis Myrigotomy Facial nerve decompression

Hybrid Approach for Cost Efficient Application Placement in Fog-Cloud Computing Environments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第6期79卷 4127-4148页

作者： Abdulelah Alwabel Chinmaya kumar swain Department of Computer Sciences College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia Department of Computer Science and Engineering Institute of Management and Information TechnologyCuttackBPUTOdishaIndia

Fog computing has recently developed as a new paradigm with the aim of addressing time-sensitive applications better than with cloud computing by placing and processing tasks in close proximity to the data ***,the majority of the fog nodes in this environment are geographically scattered with resources that are limited in terms of capabilities compared to cloud nodes,thus making the application placement problem more complex than that in cloud *** approach for cost-efficient application placement in fog-cloud computing environments that combines the benefits of both fog and cloud computing to optimize the placement of applications and services while minimizing *** approach is particularly relevant in scenarios where latency,resource constraints,and cost considerations are crucial factors for the deployment of *** this study,we propose a hybrid approach that combines a genetic algorithm(GA)with the Flamingo Search Algorithm(FSA)to place application modules while minimizing *** consider four cost-types for application deployment:Computation,communication,energy consumption,and *** proposed hybrid approach is called GA-FSA and is designed to place the application modules considering the deadline of the application and deploy them appropriately to fog or cloud nodes to curtail the overall cost of the *** extensive simulation is conducted to assess the performance of the proposed approach compared to other state-of-the-art *** results demonstrate that GA-FSA approach is superior to the other approaches with respect to task guarantee ratio(TGR)and total cost.

关键词： Placement mechanism application module placement fog computing cloud computing genetic algorithm flamingo search algorithm

Acute onset of massive epistaxis due to post-traumatic cavernous internal carotid artery pseudoaneurysm: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Acute Disease 2021年第1期10卷 39-41页

作者： santosh kumar swain Alok Das Satyabrata Acharya Nibi Shajahan Rohit Agrawala Department of Otorhinolaryngology IMS and SUM HospitalSiksha"O"Anusandhan University(Deemed to be)K8Kalinga NagarBhubaneswar-751003OdishaIndia

Rationale:Cavernous internal carotid artery(ICA)pseudoaneurysm caused by non-penetrating head trauma is a rare cause of massive *** sudden onset of epistaxis due to such a fatal aneurysm protruding into the sphenoid sinus is extremely rare in clinical *** management is often challenging because of anatomical inaccessibility of the bleeding ***'s concern:A 42-year-old man with a history of head trauma showing an ICA aneurysm eroding the sphenoid sinus followed by massive ***:A computerized tomography(CT)scan showed a fracture in the sphenoid *** angiogram revealed cavernous ICA ***:Endovascular coil ***:The patient recovered well and was discharged without any neurological deficits Lessons:Cavernous ICA pseudoaneurysm may lead to a life-threatening *** a patient has a history of head trauma,post-traumatic cavernous ICA pseudoaneurysm should be considered a differential diagnosis of massive epistaxis.

关键词： Massive epistaxis Pseudoaneurysm Internal carotid artery Coil embolization

Intrusion detection systems for wireless sensor networks using computational intelligence techniques

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cybersecurity 2024年第2期7卷 81-95页

作者： Vaishnavi Sivagaminathan Manmohan Sharma santosh kumar Henge Lovely Professional University PhagwaraIndia

Network Intrusion Detection Systems(NIDS)are utilized to find hostile network *** can be accom-plished by looking at traffic network activity,but it takes a lot of *** NIDS heavily utilizes approaches for data extraction and machine learning to find *** terms of feature selection,NIDS is far more *** is accurate since anomaly identification uses a number of time-consuming *** of this,the feature selec-tion method influences how long it takes to analyze movement patterns and how clear it *** goal of the study is to provide NIDS with an attribute selection *** has been used for that *** Network Intrusion Detection System that is being developed will be able to identify any malicious activity in the network or any unusual behavior in the network,allowing the identification of the illegal activities and safeguarding the enormous amounts of confidential data belonging to the customers from being *** the research,datasets were produced utilising both a network infrastructure and a simulation *** is used to gather data packets whereas Cisco Packet Tracer is used to build a network in a simulated ***,a physical network consisting of six node MCUs connected to a laptop and a mobile hotspot,has been built and communication packets are being recorded using the Wireshark *** train several machine learning models,all the datasets that were gatheredcre-ated datasets from our own studies as well as some common datasets like NSDL and UNSW acquired from Kaggle-were ***,PsO,which is an optimization method,has been used with these ML algorithms for feature *** the research,KNN,decision trees,and ANN have all been combined with PSO for a specific case *** it was found demonstrated the classification methods PSO+ANN outperformed PSO+KNN and PSO+DT in this case study.

关键词： Network intrusion detection systems(NIDS) Cisco packet tracer Wireshark tool Machine learning PSO Cybersecurity Optimization