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Differential effects of environmental climatic variables on parasite abundances in blue tit nests during a decade

Integrative Zoology 2022年第4期17卷 511-529页

作者： Francisco CASTAÑO-VÁZQUEZ santiago merino Evolutionary Ecology Museo Nacional de Ciencias Naturales CSICMadridSpain

Models on climate change have predicted an increase of temperature over the earth’s surface with potential drastic effects on living *** analyzed the relationships between climatic conditions(temperature,rainfall,and wind speed)and the abundance of blood-sucking flying insects(biting midges and blackflies)and nest-dwelling ectoparasites(mites,fleas,and blowflies)collected from blue tit nests during bird breeding seasons for a period of 10 *** temperature,rainfall,and wind speed showed significant differences among *** and wind speed increased during the period of study while rainfall *** midge,blackfly,and blowfly abundances increased across years but not flea and mite *** date decreased and brood size increased across *** of year variation,parasites were related to climatic *** example,biting midge,blowfly,mite,and flea abundances were positive and significantly related to average *** also found a positive and significant relationship between abundances of Haemoproteus infections and biting midge abundances during the first year of life of birds out of ***,abundance and prevalence of Lankesterella infections in yearlings were positive and significantly related to mite abundances during the year of birth of *** and Lankesterella infections were also significantly related to climatic variables and Haemoproteus and Lankesterella infections increased across *** addition,body condition of adult females and males were negatively related to flea larvae and blowfly abundance *** body condition was also negatively related to biting midge *** in climatic conditions across years could therefore affect several parasites of birds but also to birds themselves.

关键词： biting midges blackfly blowfly Haemoproteus Lankesterella rainfall temperature

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Manipulation of parasite load induces significant changes in the structural-based throat color of male iberian green lizards

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Current Zoology 2018年第3期64卷 293-302页

作者： Rodrigo MEGiA-PALMA Javier MARTiNEZ santiago merino Dept Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSIC J. Gutierrez Abascal 2 E-28006 Madrid Spain Area Parasitologia Dept Biomedicina y Biotecnologia Area de Parasitologia. Facultad de Farmacia Universidad de Alcala de Henares Alcala de Henares E-28871 Madrid Spain

The honesty of structural-based ornaments is controversial. Sexual selection theory predicts that the honesty of a sexual signal relies on its cost of production or maintenance. Therefore, environmental factors with negative impact on individuals could generate high costs and affect the expression of these sexual signals. In this sense, parasites are a main cost for their hosts. To probe the effect of parasites on the structural-based coloration of a lacertid species , we have experimentally removed ticks from a group of male Iberian green lizards using an acaricide treatment (i.e., the broad-use insecticide fipronil). All individuals were radio-tracked and recaptured after 15 days to study changes in coloration in both the ultraviolet (UV)-blue (structural-based) and UV-yellow (structural and pigment-based) ornamentations after manipulation, as well as changes in endo- and ectoparasitic load and body condition. Additionally, after the experiment, we measured the skin inflammatory response to a mitogen. The fipronil treatment was effective in reducing ticks and it was associated with a significant reduction of hemoparasite load. Throughout the season, individuals treated with fipronil tended to maintain the brightness of the UV-blue throat coloration while control lizards tended to increase it. However, individuals treated with fipronil that were not infected with hemoparasites significantly reduced the brightness of the UV-blue throat coloration. Individuals with a higher initial tick load exhibited a lower UV saturation increment (UV-blue) and a higher brightness increment (UV-yellow) during the experiment. Overall these results experimentally support the idea that parasites adversely influence the expression of the structural-based coloration of male Iberian green lizards. This adds evidence to the hypothesis that sexual ornaments in lizards function as honest signals.

关键词：寄生虫结构蜥蜴负担喉咙操作颜色着色法

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Multiple color patches and parasites in Sceloporus occidentalis:differential relationships by sex and infection

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Current Zoology 2018年第6期64卷 703-711页

作者： Rodrigo MEGIA-PALMA Dhanashree PARANJPE Senda REGUERA Javier MARTINEZ Robert D COOPER Pauline BLAIMONT santiago merino Barry SINERVO Department of Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSICJose Gutierrez Abascal 2.Madrid E-28006Spain Departrnent of Ecology and Evolutionary Biology University of CaliforniaSanta Cruz1156High StSanta CruzCA 95064USA Department of Zoologia Facultad de CienciasUniversidad de GranadaGranada E-18071Spain Area Parasitologia Department of Biomedicina y BiotecnologiaArea de ParasitologiaFacultad de FarmaciaUniversidad de Alcala de HenaresAlcala de HenaresMadrid E-28871Spain

Parasites generally have a negative influence on the color expression of their *** selection theory predicts resistant high-quality individuals should show intense coloration,whereas susceptible low-quality individuals would show poor ***,intensely colored males of different species of Oid and New World lizards were more often infected by *** results suggest that high-quality males,with intense coloration,would suffer higher susceptibility to *** hypothesis remains poorly understood and contradicts general theories on sexual *** surveyed a population of Sceloporus occidentalis for parasites and found infections by the parasite genera Lankesterella and *** this population,both males and females express ventral blue and yellow color *** was almost exclusively infecting *** body size of the males significantly predicted the coloration of both blue and yellow *** males showed darker (lower lightness)blue ventral patches and more saturated yellow patches that were also ***,these males were more often infected by Lankesterella than smaller *** intestinal parasite Acroeimeria infected both males and *** infection by intestinal parasites of the genus Acroeimeria was the best predictor for the chroma in the blue patch of the males and for hue in the yellow patch of the *** males infected by Acroeimeria expressed blue patches with significantly lower chroma than the uninfected ***,the hue of the yellow patch was not significantly different between infected and uninfected *** results suggest a different effect of Lankesterella and Acroeimeria on the *** the one hand,the intense coloration of male lizards infected by Lankesterella suggested high-quality male lizards may tolerate *** the other hand,the low chroma of the blue coloration of the infected males suggested that this coloration could honest

关键词： animal communication coloration Hamilton and Zuk parasites sexual selection

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Organic matter quality of forest floor as a driver of C and P dynamics in acacia and eucalypt plantations established on a Ferralic Arenosols, Congo

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Forest Ecosystems 2020年第3期7卷 511-525页

作者： Lydie-Stella Koutika Lorenzo Cafiero Annamaria Bevivino Agustín merino Research Centre on the Durability and the Productivity of Industrial Plantations(CRDPI) Av.Ma Loango Moe Poaty BP 1291Pointe-NoireRepublic of the Congo Department for Sustainability Biotechnologies and Agroindustry DivisionLaboratory for AgriFood SustainabilityQuality and SafetyItalian National Agency for New TechnologiesEnergy and Sustainable Economic DevelopmentENEACasaccia Research CentreVia Anguillarese301-00123RomeItaly Department for Sustainability Division Resource EfficiencyLaboratory Technologies for the ReuseRecyclingRecovery and valorisation of Waste and MaterialsItalian National Agency for New TechnologiesEnergy and Sustainable Economic DevelopmentENEACasaccia Research Centre00123RomeItaly Department of Soil Science and Agricultural Chemistry University of Santiago de Compostela2702LugoSpain

Background: Land-use change and forest management may alter soil organic matter(SOM) and nutrient dynamics,due in part to alterations in litter input and quality. Acacia was introduced in eucalypt plantations established in the Congolese coastal plains to improve soil fertility and tree growth. Eucalypt trees were expected to benefit from N2 fixed by acacia. However, some indicators suggest a perturbation in SOM and P dynamics might affect the sustainability of the system in the medium and long term. In tropical environments, most of the nutrient processes are determined by the high rates of organic matter(OM) mineralization. Therefore, SOM stability might play a crucial role in regulating soil-plant processes. In spite of this, the relationship between SOM quality, C and other nutrient dynamics are not well understood. In the present study, OM quality and P forms in forest floor and soil were investigated to get more insight on the C and P dynamics useful to sustainable management of forest ***: Thermal analysis(differential scanning calorimetry(DSC) and thermogravimetry(TGA)) and nuclear magnetic resonance(solid state13 C CPMASS and NMR and31 P-NMR) spectroscopy have been applied to partially decomposed forest floor and soils of pure acacia and eucalypt, and mixed-species acacia-eucalypt ***: Thermal analysis and13 C NMR analysis revealed a more advanced stage of humification in forest floor of acacia-eucalypt stands, suggesting a greater microbial activity in its litter. SOM were related to the OM recalcitrance of the forest floor, indicating this higher microbial activity of the forest floor in this stand might be favouring the incorporation of C into the mineral ***: In relation with the fast mineralization in this environment, highly soluble orthophosphate was the dominant P form in both forest floor and soils. However, the mixed-species forest stands immobilized greater P in organic forms, preventing the P losses by lea

关键词： Mixed-species plantations Soil chemical stability Organic P Forest ecosystems Potential climate change mitigation

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Topical Calendula officinalis *** inflammatory pain through antioxidant,anti-inflammatory and peripheral opioid mechanisms

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Journal of Integrative Medicine 2023年第1期21卷 34-46页

作者： Bárbara B.Garrido-Suárez Gabino Garrido Addis Bellma Menéndez Nelson merino Odalys Valdés Nilia de la Paz Aylema Romero Livan Delgado Miguel D.Fernández Octavio Piñeros RenéDelgado-Hernández Pharmacology and Toxicology Chemical Analytic and Pharmaceutical Technology LaboratoriesCenter for Pharmaceutical Research and Development(CIDEM)Havana 10600Cuba Department of Pharmacology Institute of Marine Science(ICIMAR)Havana 10300Cuba Department of Pharmaceutical Sciences Faculty of SciencesCatholic University of the NorthAntofagasta 1240000Chile Research Department University of Santiago de CaliCali 760032Colombia Center for Research and Biological Evaluations Institute of Pharmacy and FoodUniversity of HavanaHavana 17100Cuba

Objective The present study evaluated the antinociceptive activity of Calendula officinalis L.(Ca)cream on inflammatory *** Creams with different Ca concentrations were tested for their ability to ameliorate pain-related behavior and edema in rats using formalin test,carrageenan(Cg)-induced acute inflammation model,bradykinin(BK)-induced acute inflammation model,and complete Freund’s adjuvant(CFA)-induced chronic inflammation *** the formalin test,we also examined the implication of peripheral opioid receptors in the antinociceptive mechanisms of Ca cream,by means of Q-naloxone,a peripherally acting nonselective opioid ***,the effects of Ca cream compared with diclofenac on BK-induced edema were examined when the kininase II in tissue was preserved or inhibited by *** local production of redox biomarkers in formalin model,tumor necrosis factor-α(TNF-α)in Cg model and histopathological changes in CFA model were also *** A single application of Ca cream at a dose of 10%or 30%(w/w)decreased the formalin-induced licking/biting behavior during both phases of this test in a Q-naloxone-sensitive *** effect was associated with the reduction of oxidative stress in the injured paw and the edema associated with the later phase of formalin-induced pain.A single application of Ca cream(10%or 30%)reduced paw edema and thermal hypernociception in Cg-induced acute inflammation,corresponding with a local decrease in TNF-α.Ca cream also inhibited BK-induced spontaneous nociceptive behavior and paw inflammation in both paradigms *** applications of Ca cream also decreased CFA-induced chronic inflammation,mechanical hypernociception and histopathological changes in the *** These results reveal the topical antinociceptive and antiedematogenic effects of Ca cream.A modulatory action on peripheral opioid receptors associated with its antioxidant mechanism may be involved,at least in par

关键词： Calendulaofficinalis L. Formalintest Pain Hyperalgesia Inflammation

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Photo-thermionic emission and photocurrent dynamics in low crystallinity carbon nanotubes

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Journal of Materiomics 2021年第2期7卷 271-280页

作者： J.A.García-merino L.Fernandez-Izquierdo R.Villarroel S.A.Hevia Instituto de Física Pontificia Universidad Catolica de ChileAv.Vicuna Mackenna4860SantiagoChile Centro de Investigacion en Nanotecnología y Materiales Avanzados(CIEN-UC) Av.Vicuna Mackenna4860SantiagoChile Department of Material Science&Engineering The University of Texas at DallasRichardsonTXUSA

Within this work,it is studied the photo-thermionic and photocurrent behavior of two kinds of carbon nanotube arrays,grown by chemical vapor *** kind is fabricated by using a co-catalyst bilayer approach and other by a catalyst-free route by using a porous alumina membrane as a *** carbon nanotubes fabricated by both approaches exhibit low *** compute the thermal properties of the nanomaterials,a photothermal experiment was measured at 1064 nm wavelength,and numerical simulations were conducted to analyze the photo-thermionic emission *** high absorbance of the carbon nanotubes leads to reach temperatures above 1500 K,with time response in the millisecond order and emission currents in the nanoampere *** the other hand,the photodetector behavior was confirmed by a single pulse experiment that induces fast photocurrent recognition associated to a *** results highlighted the coexistence of stable states related to high-power and high-speed electronic conversion energy dependent on the growth mechanism of carbon nanotubes.

关键词： Carbon nanotubes Porous alumina membrane Photodetector Photothermal conversion Photo-thermionic effect

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Effectiveness of infliximab after adalimumab failure in Crohn's disease

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World Journal of Gastroenterology 2012年第37期18卷 5219-5224页

作者： María Chaparro Montserrat Andreu Manuel Barreiro-de Acosta Esther García-Planella Elena Ricart Eugeni Domènech María Esteve Olga merino Pilar Nos Mireia Pealva Javier P Gisbert Department of Gastroenterology Hospital Universitario de La PrincesaInstituto de Investigación Princesa(IP)and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD)28006 MadridSpain Americio 17 portal E 2℃28021 Madrid Department of Gastroenterology Hospital del Mar Department of Gastroenterology Hospital Clínico Universitario de Santiago Department of Gastroenterology Hospital Santa Creui Sant Pau Department of Gastroenterology Hospital ClínicBarcelonaand Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas Department of Gastroenterology Hospital Germans Triasi Pujol and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD) Department of Gastroenterology Hospital Mutua de Terrassa Department of Gastroenterology Hospital de Cruces Department of Gastroenterology Hospital Universitario La Fe and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD) Department of Gastroenterology Hospital de Bellvitge Department of Gastroenterology Hospital Universitario de La PrincesaInstituto de Investigación Princesa(IP)and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD)

AIM:To evaluate the effectiveness of infliximab as a second-line therapy in Crohn's disease patients after adalimumab failure. METHODS:A historical cohort study in a community-based gastroenterology practice evaluated Crohn's disease patients treated with infliximab (induction plus maintenance) after adalimumab failure. Patients were identified using a large Spanish database (ENEIDA). RESULTS:We included 15 Crohn's disease patients who received infliximab after adalimumab failure. Five patients discontinued adalimumab due to loss of response, 3 due to adverse events and 7 due to partial response. After infliximab therapy was started, all patients who had interrupted adalimumab due to loss of efficacy regained response. All patients who discontinued adalimumab due to adverse events responded to infliximab and maintained this response; one of these patients had an uneventful course on infliximab, but 2 developed adverse events. None of the 7 patients who interrupted adalimumab due to partial response reached remission with infliximab. CONCLUSION:Switching from adalimumab to infliximab may be useful in patients who develop adverse effects or loss of response, however, the benefit of infliximab in primary nonresponders was not established.

关键词：单抗胃肠病学队列研究开关频率患者治疗数据库西班牙

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为 cholangiocarcinoma 的化疗: 更改

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 171-176页

作者： Natalia Ramírez-merino santiago Ponce Aix Hernán Cortés-Funes Department of Medical Oncology Clinica La Luz28003 MadridSpain

Cholangiocarcinomas(bile duct cancers) are a heterogeneous group of malignancies arising from the epithelial cells of the intrahepatic,perihilar and extrahepatic bile *** diagnosed with cholangiocarcinoma must be evaluated by a multidisciplinary team and be treated with individualized *** of all,it is very important to define the potential resectability of the tumor because surgery is the main therapeutic option for these ***,cholangiocarcinomas have a very poor *** 5 year survival rate is 5%-10%.In cases with a potentially curative surgery,5 year survival rates of 25%-30% are ***,it is necessary to increase the cure rate from surgery,exploring the survival benefit of any adjuvant *** is difficult to clarify the role of adjuvant treatment in localized and locally advanced *** are limited data and the role of adjuvant chemotherapy/chemoradiation in patients with resected biliary tract cancer is poorly *** most relevant studies in the adjuvant setting are one from Japan,the well known ESPAC-3 and BILCAP from the United Kingdom and a *** show the results of these *** to medical oncology guidelines,postoperative adjuvant therapy is widely recommended for all patients with intrahepatic or extrahepatic cholangiocarcinoma who have microscopically positive resection margins,as well as for those with a complete resection but node-positive *** trials are *** locally advanced cholangiocarcinoma setting includes a heterogeneous mix of patients:(1) patients who have had surgery but with macroscopic residual disease;(2) patients with locally recurrent disease after potentially curative treatment;and(3) patients with locally unresectable disease at *** these patients,surgery is not an option and chemoradiation therapy can prolong overall survival and provide control of symptoms due to local tumor ***,no neoadjuv

关键词： Chemotherapy Cholangiocarcinoma Review Oncology Gemcitabine

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Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions

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World Journal of Clinical Oncology 2019年第10期10卷 318-339页

作者： Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Clinical Department Faculty of BiomedicineUniversidad EuropeaMadrid 28223Spain Department of Radiation Oncology Hospital Fundación Jiménez DíazMadrid 28040Spain Department of Medical Oncology Hospital La LuzMadrid 28003Spain Department of Radiation Oncology Complexo Hospitalario Universitario Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology Hospital Universitario Puerta del MarCádiz 11009Spain Department of Medical Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain

Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated *** stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor ***,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease *** approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative *** optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain *** the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify *** classification will allow us to select the most appropriate therapeutic strategy on an individualized *** the future,the molecular or microRNA profiles will likely improve the treatment selection *** objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and *** also discuss areas of controversy and future directions.

关键词： Non-small cell lung cancer Metastasectomy Oligometastases Stereotactic ablative radiotherapy Stereotactic body radiation therapy Radiosurgery

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丹麦国家海事博物馆

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城市环境设计 2019年第2期118卷 142-159页

作者： John Pries Jensen Henrik Kania Ariel Joy Norback Wallner Rasmus Pedersen Annette Jensen Dennis Rasmussen Jan Magasanik Jeppe Ecklon Karsten Hammer Hansen Rasmus Rodam Rune Hansen Alina Tamosiunaite Alysen Hiller Ana merino Armen Menendian Andy Yu Andreas Johansen Baptiste Blot Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Eskild Nordbud Felicia Guldberg Finn N?rkj?r Gül Ertekin Jan Borgstr?m James Schrader Johan Cool Jonas M?nster Kirstine Ragnhild Malte Kloe Michael Andersen Michal Kristof Marc Jay Maria Mavriku Masatoshi Oka Oana Simionescu Pablo Labra Peter Rieff Qianyi Lim Sara Sosio Sebastian Latz Tina Lund H?jgaard Tina Troster Todd Bennet Xi Chen Xing Xiong Xu Li Zoltan Kalaszi Iwan Baan Rasmus Hjortshoj Luca santiago Mora Dragoer Luftfoto Jens Lindhe Lorenzon Boddi Thiks Wolzak 陈子钰

丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强... 详细信息

丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强有力的结构作为海事博物馆中心。将博物馆这样设置,使它在成为与克伦堡城堡和邻近的文化庭院相联系的文化环境的一部分的同时,彰显自身,成为一个独立

关键词：海事博物馆铝覆层 Section 重钢结构

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