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Robotic ultrasound:An initial feasibility study

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World Journal of Methodology 2022年第4期12卷 274-284页

作者： Sheragaru Hanumanthappa Chandrashekhara Krithika Rangarajan Ayushi agrawal sanjay Thulkar Shivanand Gamanagatti Deepak Raina Subir Kumar Saha Chetan Arora Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Mechanical Engineering Indian Institute of TechnologyDelhi 110016India Department of Computer Science Indian Institute of TechnologyDelhi 110016India

BACKGROUND Performing ultrasound during the current pandemic time is quite *** reduce the chances of cross-infection and keep healthcare workers safe,a robotic ultrasound system was developed,which can be controlled *** will also pave way for broadening the reach of ultrasound in remote distant rural areas as *** To assess the feasibility of a robotic system in performing abdominal ultrasound and compare it with the conventional ultrasound *** A total of 21 healthy volunteers were *** was performed in two settings,using the robotic arm and conventional hand-held *** acquired were analyzed by separate *** Our study showed that the robotic arm model was feasible,and the results varied based on the organ *** liver images showed no significant *** other organs,the need for repeat imaging was higher in the robotic arm,which could be attributed to the radiologist’s learning curve and ability to control the haptic *** doctor and volunteer surveys also showed significant comfort with acceptance of the technology and they expressed their desire to use it in the *** study shows that robotic ultrasound is feasible and is the need of the hour during thepandemic.

关键词： Robotic ultrasound Telemedicine Ultrasonography Haptic device Pandemic

Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/β-catenin in urinary bladder cancer patients

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World Journal of Clinical Oncology 2019年第4期10卷 166-182页

作者： Niharika Maurya Rinni Singh Apul Goel Atin Singhai Uday Pratap Singh Vinita agrawal Minal Garg Department of Biochemistry Lucknow University Department of Urology King George Medical University Department of Pathology King George Medical University Department of Urology and Renal Transplantation Sanjay Gandhi Post Graduate Institute of Medical Sciences Department of Pathology Sanjay Gandhi Post Graduate Institute of Medical Sciences

BACKGROUND Aberrant activation of phosphorylated form of glycogen synthase kinase-3β[pS9 GSK-3β(Serine 9 phosphorylation)] is known to trigger Wnt/β-catenin signal cascade but its clinicohistopathological implications in bladder carcinogenesis remain *** To investigate the diagnostic and prognostic relevance of expressions of pS9 GSK-3β, β-catenin and its target genes in the pathobiology of bladder *** Bladder tumor tissues from ninety patients were analyzed for quantitative expression and cellular localization of pS9 GSK-3β by immunohistochemical(IHC) staining. Real time-quantitative polymerase chain reaction and IHC were done to check the expression of β-catenin, Cyclin D1, Snail and Slug at transcriptome and protein level respectively. Clinicohistopathological variables were obtained from histology reports, follow up and OPD visits of *** of the markers were statistically correlated with these variables to determine their significance in clinical setting. Results were analysed using SPSS20.0 *** Aberrant(low or no membranous/high nuclear/high cytoplasmic) expression of pS9 GSK-3β was noted in 51% patients and found to be significantly associated with tumor stage and tumor grade(P = 0.01 and 0.04; Mann Whitney U test).Thirty one percent tumors exhibited aberrant co-expression of pS9 GSK-3β andβ–catenin proteins and showed strong statistical association with tumor stage,tumor type, smoking/tobacco chewing status(P = 0.01, 0.02 and 0.04, MannWhitney U test) and shorter overall survival probabilities of patients(P = 0.02;Kaplan Meier test). Nuclear immunostaining of Cyclin D1 in tumors with altered pS9 GSK-3β/β–catenin showed relevance with tumor stage, grade and ***β–catenin and pS9 GSK-3β proteins are identified as markers of diagnostic/prognostic significance in disease pathogenesis. Observed histopathological association of Cyclin D1 identifies it as marker of potential relevance in tumors with altered

关键词： Pathobiology Target genes Tumor stage and grade Wnt/β–catenin signal cascade Urothelial carcinoma of bladder

Changes in gene expression in liver tissue from patients with fulminant hepatitis E

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World Journal of Gastroenterology 2015年第26期21卷 8032-8042页

作者： Anshu Naik Amit Goel Vinita agrawal Aditya N Sarangi Nanda Chhavi Vineeta Singh Shahid Jameel Rakesh Aggarwal Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Department of Pathology Sanjay Gandhi Postgraduate Institute of Medical Sciences Sandor Proteomics Pvt Ltd Virology Group International Centre for Genetic Engineering and Biotechnology

AIM: To study host gene expression and numberof immune cells in liver tissues from patients with fulminant hepatitis E(FH-E).METHODS: Microarray-based expression profiling was done using Illumina Human WG-6_v3_Bead Chip arrays on post-mortem liver tissue from 5 patients with FH-E,and compared with similar tissue from 6 patients with fulminant hepatitis B(FH-B; disease controls) and normal liver tissue from 6 *** expression was defined as ≥ 2.0-fold change with Benjamini-Hochberg false discovery rate below 0.05 using t-test in liver tissue from FH-B and FH-E,than healthy liver *** some genes that showed differential expression in FH-E,microarray data were validated using quantitative reverse transcription *** expressed gene lists were then subjected to "Gene Ontology" analysis for biological processes,and pathway analysis using Bio Carta database on the DAVID *** addition,tissue sections were stained for CD4+,CD8+ and CD56+ cells using indirect immunohistochemistry; cells staining positive for each of these markers were counted and compared between ***: Compared to normal livers,those from patients with FH-E and FH-B showed differential expression of 3377 entities(up-regulated 1703,downregulated 1674) and 2572 entities(up 1164,down 1408),*** included 2142(up 896,down 1246) entities that were common between the two sets; most of these belonged to metabolic,hemostatic and complement pathways,which are active in normal *** expression data from livers of patients with FH-E but not those of FH-B showed activation of several immune response pathways,particularly those involving cytotoxic T *** fold-change values of m RNA for selected genes in livers from FH-E than in normal liver tissue determined using quantitative reverse transcription PCR showed excellent concordance with microarray *** immunohistochemistry,CD8+ T cells showed an increase in liver biopsies from both FH-E [median

关键词： Cytotoxic T cells Gene expression HepatitisE Hepatitis E virus Immune response Liver biopsy Microarray Natural killer cells Pathogenesis

Genetics of coronary heart disease with reference to ApoAICⅡI-AIV gene region

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World Journal of Cardiology 2014年第8期6卷 755-763页

作者： Suraksha agrawal Sarabjit Mastana Department of Medical Genetics Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow UP 226014India Human Genomics Lab School of SportExercise and Health SciencesLoughborough UniversityLoughborough LE11 3TUUnited Kingdom

Cardiovascular diseases are affected by multiple factors like genetic as well as environmental hence they reveal factorial nature. The evidences that genetic factors are susceptible for developing cardiovascular diseases come from twin studies and familial aggregation. Different ethnic populations reveal differences in the prevalence coronary artery disease(CAD) pointing towards the genetic susceptibility. With progression in molecular techniques different developments have been made to comprehend the disease physiology. Molecular markers have also assisted to recognize genes that may provide evidences to evaluate the role of genetic factors in causation of susceptibility towards CAD. Numerous studies suggest the contribution of specific "candidate genes", which correlate with various roles/pathways that are involved in the coronary heart disease. Different studies have revealed that there are large numbers of genes which are involved towards the predisposition of CAD. However, these reports are not consistent. One of the reasons could be weak contribution of genetic susceptibility of these genes. Genome wide associations show different chromosomal locations which dock, earlier unknown, genes which may attribute to CAD. In the present review different ApoAI-CⅡI-AIV gene clusters have been discussed.

关键词： ApoAI-CⅡI-AIV gene cluster Haplotype analysis Single nucleotide polymorphism Candidate gene study Genome wide association studies