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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

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Bioactive Materials 2022年第2期7卷 267-295页

作者： Amal George Kurian Rajendra ksingh Kapil DPatel Jung-Hwan Lee Hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Department of Nanobiomedical Science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Biomaterials and Tissue Engineering UCL Eastman Dental InstituteLondonWC1X8LDUK Department of Biomaterials Science School of DentistryDankook UniversityCheonan31116Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre Dankook UniversityCheonan31116Republic of Korea Cell&Matter Institute Dankook UniversityCheonan31116Republic of Korea Department of Regenerative Dental Medicine College of DentistryDankook UniversityCheonan31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan31116Republic of Korea

Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules and *** others,methacrylated gelatin(GelMA)has become a representative hydrogel formulation,finding various biomedical *** efforts on GelMA-based hydrogels have been devoted to combining them with bioactive and functional nanomaterials,aiming to provide enhanced physicochemical and biological properties to *** benefits of this approach are multiple:i)reinforcing mechanical properties,ii)modulating viscoelastic property to allow 3D printability of bio-inks,iii)rendering electrical/magnetic property to produce electro-/magneto-active hydrogels for the repair of specific tissues(e.g.,muscle,nerve),iv)providing stimuli-responsiveness to actively deliver therapeutic molecules,and v)endowing therapeutic capacity in tissue repair process(e.g.,antioxidant effects).The nanomaterial-combined GelMA systems have shown significantly enhanced and extraordinary behaviors in various tissues(bone,skin,cardiac,and nerve)that are rarely observable with *** we systematically review these recent efforts in nanomaterials-combined GelMA hydrogels that are considered as next-generation multifunctional platforms for tissue *** approaches used in GelMA can also apply to other existing polymeric hydrogel systems.

关键词： GelMA hydrogel Nanomaterials Multifunctional Therapeutics Tissue repair

Can non-standard recombination resolve the Hubble tension?

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Science China(Physics,Mechanics & Astronomy) 2020年第9期63卷 30-34页

作者： MiaoXin Liu ZhiQi Huang XiaoLin Luo HaiTao Miao Naveen ksingh Lu Huang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082 China

The inconsistent Hubble constant values derived from cosmic microwave background(CMB) observations and from local distance-ladder measurements may suggest new physics beyond the standard ΛCDM paradigm. It has been found in earlier studies that, at least phenomenologically, non-standard recombination histories can reduce the ≥4σ Hubble tension to ~ 2σ.Following this path, we vary physical and phenomenological parameters in RECFAST, the standard code to compute ionization history of the universe, to explore possible physics beyond standard recombination. We find that the CMB constraint on the Hubble constant is sensitive to the hydrogen ionization energy and 2 s → 1 s two-photon decay rate, both of which are atomic constants, and is insensitive to other details of recombination. Thus, the Hubble tension is very robust against perturbations of recombination history, unless exotic physics modifies the atomic constants during the recombination epoch.

关键词： cosmology Hubble recombination CMB

A Heuristic Approach to Fast NOVCA （Near Optimal Vertex Cover Algorithm）

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Computer Technology and Application 2014年第2期5卷 83-90页

作者： sanj aya Gajurel Roger Bielefeld ITS Advanced Research Computing CWR U Cleveland 44106 USA

This paper describes an extremely fast polynomial time algorithm, the NOVCA （Near Optimal Vertex Cover Algorithm） that produces an optimal or near optimal vertex cover for any known undirected graph G （V, E）. NOVCA is based on the idea of（l） including the vertex having maximum degree in the vertex cover and （2） rendering the degree of a vertex to zero by including all its adjacent vertices. The three versions of algorithm, NOVCA-I, NOVCA-II, and NOVCA-random, have been developed. The results identifying bounds on the size of the minimum vertex cover as well as polynomial complexity of algorithm are given with experimental verification. Future research efforts will be directed at tuning the algorithm and providing proof for better approximation ratio with NOVCA compared to any available vertex cover algorithms.

关键词： Vertex cover problem combinatorial problem NP-complete problem approximation algorithm optimization algorithms.

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

Morphoanatomic, physicochemical, and phytochemical standardization with HPTLC fingerprinting of aerial parts of Aerva lanata (Linn) Juss ex Schult

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Journal of Traditional Chinese Medical Sciences 2015年第1期2卷 39-44页

作者： yuhao Zhao Deepak Kumar D.N.Prasad Rajesh ksingh yanxu Ma School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Shivalik College of Pharmacy NangalRoparPunjab 140126India Department of Orthopedics Beijing Traditional Chinese Medicine HospitalCapital Medical UniversityBeijing 100010China

Objective:Aerva lanata (Linn) Juss ex Schult,family Amaranthaceae,is a common wayside *** herb is accepted by the Ayurvedic Formulary of *** study was undertaken to establish morphoanatomic and physiochemical standards of ***:Leaf constants and high-performance thin layer chromatography fingerprint profiles of *** were *** and conclusion:The physico-chemical,morphologic,and histologic parameters presented in this paper may be proposed as standards to establish the authenticity of *** and help differentiate it from other species such as Aerva tomentosa.

关键词： Aerva lanata Amaranthaceae Phytochemical Physicochemical Morphoanatomic

Molecular Dynamics Simulation of Behaviours of Non-Polar Droplets Merging and Interactions with Hydrophobic Surfaces

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Journal of Bionic Engineering 2008年第4期5卷 271-281页

作者： y.y. yan C.y. Ji School of the Built Environment University of Nottingham Nottingham NG7 2RD UK

This paper presents a molecular dynamics simulation of the behaviours of non-polar droplets merging and also the fluid molecules interacting with a hydrophobic surface. Such behaviours and transport phenomena are popular in general microchannel flow boiling and two-phase flow. The droplets are assumed to be composed of Lennards-Jones type molecules. Periodic boundary conditions are applied in three coordinate directions of a 3-D system, where there exist two liquid droplets and their vapour. The two droplets merge when they come within the prescribed small distance. The merging of two droplets apart from each other at different initial distances is tested and the possible larger （or critical） non-dimensional distance, in which droplets merging can occur, is discussed. The evolution of the merging process is simulated numerically by employing the Molecular Dynamics （MD） method. For interactions with hydrophobic solid wall, a system with fluid confined between two walls is used to study the wetting phenomena of fluid and solid wall. The results are compared with those of hydrophilic wall to show the unique characteristics of hydrophobic interactions by microscopic methods.

关键词： molecular dynamics simulation mist flow droplets merging hydrophobic wetting

Simulation of plastic deformation induced texture evolution using the crystallographic homogenization finite element method

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Acta Mechanica Solida Sinica 2017年第1期30卷 51-63页

作者： y.P.Chen y.y.Cai Department of Mechanics Huazhong University of Science and Technology

A semi-implicit elastic/crystalline viscoplastic finite element（FE） method based on a ＂crystallographic homogenization＂ approach is formulated for a multi-scale analysis. In the formulation, the asymptotic series expansion is introduced to define the displacement in the micro-continuum. This homogenization FE analysis is aimed at predicting the plastic deformation induced texture evolution of polycrystalline materials, the constituent microstructure of which is represented by an assembly of single crystal grains. The rate dependent crystal plasticity model is adopted for the description of microstructures. Their displacements are decomposed into two parts： the homogenized deformation defined in the macrocontinuum and the perturbed one in the micro-continuum. This multi-scale formulation makes it possible to carry out an alternative transition from a representative micro-structure to the macro-continuum. This homogenization procedure satisfies both the compatibility and the equilibrium in the micro-structure. This developed code is applied to predict the texture evolution, and its performance is demonstrated by the numerical examples of texture evolution of FCC polycrystalline metals.

关键词： Homogenization Local periodicity Crystalline plasticity Texture Finite element