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Discovery of highly immunogenic spleen-resident FCGR3^(+)CD103^(+)cDC1s differentiated by IL-33-primed ST2^(+)basophils

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Cellular & Molecular Immunology 2023年第7期20卷 820-834页

作者： Myeong-Ho Kang JungHyub Hong Jinjoo lee Min-Suk Cha sangho lee Hye-Young Kim Sang-Jun Ha Yong Taik Lim Yong-Soo Bae Department of Biological Sciences Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Center for Immune Research on Non-Lymphoid Organs Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyounggi-do 16419Republic of Korea Laboratory of Mucosal Immunology Department of Biomedical SciencesSeoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Institute of Allergy and Clinical Immunology Seoul National University Medical Research CenterSeoulRepublic of Korea Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of Nano Engineering and School of Chemical Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea.

Recombinant interleukin-33(IL-33)inhibits tumor growth,but the detailed immunological mechanism is still ***-33-mediated tumor suppression did not occur in Batf3^(−/−)mice,indicating that conventional type 1 dendritic cells(cDC1s)play a key role in IL-33-mediated antitumor immunity.A population of CD103^(+)cDC1s,which were barely detectable in the spleens of normal mice,increased significantly in the spleens of IL-33-treated *** newly emerged splenic CD103^(+)cDC1s were distinct from conventional splenic cDC1s based on their spleen residency,robust effector T-cell priming ability,and surface expression of *** and DC precursors did not express Suppressor of Tumorigenicity 2(ST2).However,recombinant IL-33 induced spleen-resident FCGR3^(+)CD103^(+)cDC1s,which were found to be differentiated from DC precursors by bystander ST2+immune *** immune cell fractionation and depletion assays,we found that IL-33-primed ST2^(+)basophils play a crucial role in the development of FCGR3^(+)CD103^(+)cDC1s by secreting IL-33-driven extrinsic *** GM-CSF also induced the population of CD103^(+)cDC1s,but the population neither expressed FCGR3 nor induced any discernable antitumor *** population of FCGR3^(+)CD103^(+)cDC1s was also generated in vitro culture of Flt3L-mediated bone marrow-derived DCs(FL-BMDCs)when IL-33 was added in a pre-DC stage of ***-BMDCs generated in the presence of IL-33(FL-33-DCs)offered more potent tumor immunotherapy than control Flt3L-BMDCs(FL-DCs).Human monocyte-derived DCs were also more immunogenic when exposed to IL-33-induced *** findings suggest that recombinant IL-33 or an IL-33-mediated DC vaccine could be an attractive protocol for better tumor immunotherapy.

关键词： Recombinant interleukin-33(IL-33) Highly immunogenic Spleen residency FCGR3^(+)CD103^(+)cDC1s ST2^(+)basophils Antitumor immunity

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腰椎间盘突出症的经皮内窥镜激光椎间盘切除术

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中华骨科杂志 2007年第4期27卷 254-258页

作者：杨波金大地 lee sangho 王吉兴南方医科大学南方医院脊柱骨病科广州510515 韩国首尔Wooridul脊柱医院神经外科

目的报告经皮内窥镜激光椎间盘切除手术（percutaneous endoscopic laser—assisted discectomy，PELD）治疗腰椎间盘突出症的效果和并发症。方法患者包括腰椎间盘原发性突出、再突出、椎管内突出和椎管外突出者。回顾性研究PELD后至... 详细信息

目的报告经皮内窥镜激光椎间盘切除手术（percutaneous endoscopic laser—assisted discectomy，PELD）治疗腰椎间盘突出症的效果和并发症。方法患者包括腰椎间盘原发性突出、再突出、椎管内突出和椎管外突出者。回顾性研究PELD后至少1年的6522例患者，手术效果按照Oswestry功能障碍指数（Oswestry disability index，ODI）、疼痛视觉类比评分（Visual Analogue scale，VAS）和改良的Macnab标准评定。按Yeung等标准：中央型1329例（20．4％），旁正中型4186例（64．2％），椎间孔型433例（6．6％），椎间孔外侧型574例（8．8％）。结果患者平均年龄40．9岁，平均随访时间283个月，平均手术时间55min，平均出血量12ml。按照Macnab标准评定，优2805例（43．0％），良2902例（44．5％），可371例（5．7％），差444例（6．8％），其中成功率（优良率）为87．5％。患者问卷满意率为89．1％。术后并发症发生率4．6％，翻修率为6．8％。术后ODI、VAS与术前比较明显改善（P〈0．05）。结论 PELD治疗腰椎间盘突出症的手术效果与传统开放经椎管显微椎间盘切除术一致，椎管内和椎管外椎间盘突出及伴发侧隐窝狭窄的患者均可获得有效治疗。

关键词：椎间盘切除术,经皮激光手术内窥镜检查椎间盘移位

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Vlodulation of ABA Signaling by Altering VxGФL Vlotif of PP2Cs in Oryza sativa

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Molecular Plant 2017年第9期10卷 1190-1205页

作者： Seungsu Han

The abscisic acid （ABA） signaling pathway is regulated by clade A type 2C protein phosphatases （PP2CAs） in plants. In the presence of ABA, PP2Cs release stress/ABA-activated protein kinases by binding to ABA-bound receptors （PYL/RCARs） for activation. Although the wedging tryptophan in PP2Cs is critical in the interaction with PYL/RCARs in Arabidopsis and rice, it remains elusive as to how other interface regions are involved in the interaction. Here, we report the identification of a conserved region on PP2Cs, termed the VxG4ФL motif, which modulates the interaction with PYL/RCARs through its second and fourth residues. The effects of the second and fourth residues on the interaction of OsPP2CS0 with several OsPYIJRCAR proteins were investigated by systematic mutagenesis. One OsPP2C50 mutant, VFGML （＂FM＂） mutant, lowered the affinity to OsPYL/RCAR3 by Ф15-fold in comparison with the wUd-type. Compar- ison of the crystal structures of wild-type OsPP2C50：ABA：OsPYI./RCAR3 with those composed of FM mutant revealed local conformational changes near the VxGФL motif, further supported by hydrogen-deute- rium exchange mass spectrometry. In rice protoplasts, ABA signaling was altered by mutations in the VxGФL motif. Transgenic Arabidopsis plants overexpressing OsPP2C50 and OsPP2C5OFM showed altered ABA sensitivity. Taken together, the VxGФL motif of PP2Cs appears to modulate the affinity of PP2Cs with PYL/RCARs and thus likely to alter the ABA signaling, leading to the differential sensitivity to ABA in planta.

关键词： ABA receptor type 2C protein phosphatase VxGФL motif Oryza sativa

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经皮椎板间隙入路L_5S_1椎间盘切除术

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中华骨科杂志 2005年第5期25卷 289-292页

作者：杨波刘尚礼 lee sangho TSANG Yisheng 李斯明广州市第十二人民医院骨科 510620 中山大学附属第二医院骨科韩国汉城Wooridul脊柱医院神经外科

目的探讨经皮椎板间隙入路内窥镜激光辅助椎间盘切除术治疗L5S1椎间盘突出症的疗效。方法回顾性研究2002年5月至2003年12月收治的L5S1椎间盘突出症病例168例,全部采用局麻下经皮椎板间隙入路内窥镜激光辅助椎间盘切除术,男92例,女76例;... 详细信息

目的探讨经皮椎板间隙入路内窥镜激光辅助椎间盘切除术治疗L5S1椎间盘突出症的疗效。方法回顾性研究2002年5月至2003年12月收治的L5S1椎间盘突出症病例168例,全部采用局麻下经皮椎板间隙入路内窥镜激光辅助椎间盘切除术,男92例,女76例;年龄18～73岁,平均42.8岁。依据Yeung分型,中央型22例、旁正中型120例、椎间孔型23例、椎间孔外侧型3例。其中钙化突出椎间盘8例,游离椎间盘19例。骶髂间距平均38.6mm。结果随访5～19个月,平均8.3个月。手术时间30￣90min,平均45min;平均住院时间1.3d。临床结果以MacNab标准评定,优73例(43.5%),良79例(47.0%),可8例(4.8%),差8例(4.8%);优良率90.5%。1例发生术中显微髓核钳断裂,8例术后MRI显示病变椎间盘减压不彻底、症状体征未改善,1例发生椎间盘炎,26例出现术后一过性感觉麻木。无一例发生死亡、硬脊膜破裂及脑脊液漏、血管损伤。结论L5S1的椎间盘突出可以采用经皮椎板间隙入椎管途径的内窥镜激光辅助椎间盘切除术,特别适用于髂嵴较高的患者。

关键词：椎板间隙入路椎间盘切除术经皮 L5S1椎间盘突出症 2002年5月 2003年回顾性研究硬脊膜破裂内窥镜切除术. 椎间孔型手术时间临床结果住院时间症状体征椎间盘炎脑脊液漏血管损伤平均激光中央型外侧型优良率

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经皮内窥镜激光椎间盘纤维环成型术治疗腰椎间盘突出症

经皮内窥镜激光椎间盘纤维环成型术治疗腰椎间盘突出症

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第八届全国脊柱脊髓损伤学术会议

作者：杨波金大地 lee sangho 王吉兴广州南方医科大学南方医院脊柱骨病外科广州南方医科大学南方医院脊柱骨病外科广州南方医科大学南方医院脊柱骨病外科广州南方医科大学南方医院脊柱骨病外科

目的探讨经皮内窥镜激光椎间盘纤维环成型术治疗腰椎间盘突出症的疗效。方法回顾性研究1999年1月至 2005年5月,包容的较小和中等大小的腰椎间盘突出症病例1259例,全部为局麻经皮后外侧入路内窥镜激光椎间盘纤维环成型术患者,男772例,女... 详细信息

目的探讨经皮内窥镜激光椎间盘纤维环成型术治疗腰椎间盘突出症的疗效。方法回顾性研究1999年1月至 2005年5月,包容的较小和中等大小的腰椎间盘突出症病例1259例,全部为局麻经皮后外侧入路内窥镜激光椎间盘纤维环成型术患者,男772例,女487例,年龄17～88 岁,平均39.8岁。结果随访6-71个月, 平均44.4月,住院时间平均1.1d。临床结果以 MacNab 标准评定,优542例（43.1%）, 良625例（49.6%）,可14例（1.1%）,差78 例（6.2%）。成功率（优+良）92.7%（1167/1259 例）。并发症73/1259（5.8%）例:一过性感觉减退49（3.9%）,一过性感觉麻木 13（1.0%）,一过性肌力降低11（0.9%）。差的病例全部作了翻修手术。结论包容的较小和中等大小的腰椎间盘突出可以采用经皮内窥镜激光椎间盘纤维环成型术微创的方法有效治疗。

关键词：经皮激光手术内窥镜外科手术椎间盘移位

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经皮内窥镜激光椎间盘纤维环成型术治疗腰椎间盘突出症

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实用医学杂志 2007年第22期23卷 3483-3486页

作者：杨波金大地 lee sangho 王吉兴南方医科大学南方医院脊柱骨病外科广州市510515 Wooridul脊柱医院神经外科

目的:探讨经皮内窥镜激光椎间盘纤维环成型术治疗腰椎间盘突出症的疗效。方法:回顾性研究1999年1月至2005年5月,包容的较小和中等大小的腰椎间盘突出症病例1259例,全部为局麻经皮后外侧入路内窥镜激光椎间盘纤维环成型术患者,男772例,女... 详细信息

目的:探讨经皮内窥镜激光椎间盘纤维环成型术治疗腰椎间盘突出症的疗效。方法:回顾性研究1999年1月至2005年5月,包容的较小和中等大小的腰椎间盘突出症病例1259例,全部为局麻经皮后外侧入路内窥镜激光椎间盘纤维环成型术患者,男772例,女487例,年龄17～88岁,平均39.8岁。结果:随访6～71个月,平均44.4个月,住院时间平均1.1d。临床结果以MacNab标准评定,优542例(43.1%),良625例(49.6%),可14例(1.1%),差78例(6.2%),成功率(优+良)92.7%。并发症73例:一过性感觉减退49例(3.9%),一过性感觉麻木13例(1.0%),一过性肌力降低11例(0.9%)。差的病例全部作了翻修手术。结论:包容的较小和中等大小的腰椎间盘突出可以采用经皮内窥镜激光椎间盘纤维环成型术微创的方法有效治疗。

关键词：椎间盘移位激光手术内窥镜外科手术

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Positional functionalizations of metal–organic frameworks through invasive ligand exchange and additory MOF-on-MOF strategies:A review

Smart Molecules

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Smart Molecules 2024年第2期2卷 63-84页

作者： Daeyeon lee sangho lee Isaac Choi Min Kim Department of Chemistry Chungbuk National UniversityCheongjuRepublic of Korea

Metal–organic frameworks(MOFs)represent a unique class of porous materialswith tremendous potential for diverse applications.A key factor contributing totheir versatility is their ability to precisely introduce functional groups at specificpositions within pores and *** review explores two prominent strategiesfor achieving the positional functionalization of MOFs:post-synthetic ligand exchange(PSE)and *** PSE,the existing ligands within solid-stateMOFs can be selectively replaced by the desired functional groups in solutionthrough ligand *** invasive functionalization provides a flexibleapproach to fine-tuning the surface of the MOFs with the target ***,MOF-on-MOF strategies are additive methodologies involving thecontrolled growth of one MOF layer onto *** functionality of the core andshell(or surface)can be independently *** review critically examinesthe examples,strengths,limitations,and applications of these strategies,emphasizingtheir significance in advancing the field of MOF functionalization andpaving the way for tailored multifunctional materials with precise and specificproperties.

关键词： metal–organic frameworks(MOFs) MOF-on-MOF multifunctional materials porous coordination polymers(PCPs) post-synthetic exchanges(PSEs)

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Stability of hypersurface sections of quadric threefolds

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Science China Mathematics 2015年第3期58卷 479-486页

作者： BYUN sangho lee YongNam Department of Mathematical Sciences

Let S be a complete intersection of a smooth quadric 3-fold Q and a hypersurface of degree d in *** analyze GIT stability of S with respect to the natural G=SO(5,C)-*** prove that if d 4 and S has at worst semi-log canonical singularities then S is ***,we prove that if d 3 and S has at worst semi-log canonical singularities then S is G-semistable.

关键词： quadric threefold hypersurface section stability geometric invariant theory

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Process of establishing design requirements and selecting alternative configurations for conceptual design of a VLA

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Chinese Journal of Aeronautics 2017年第2期30卷 738-751页

作者： Bo-Young Bae sangho Kim Jae-Woo lee Nhu Van Nguyen Bong-Cheul Chung Department of Aerospaee Information Engineering Konkuk University Seoul 143-701 Republic of Korea Konkuk Aerospace Design Airworthiness Research Institute Konkuk University Seoul 143-701 Republic of Korea

In this study,a process for establishing design requirements and selecting alternative configurations for the conceptual phase of aircraft design has been *** proposed process uses system-engineering-based requirement-analysis techniques such as objective tree,analytic hierarchy process,and quality function deployment to establish logical and quantitative ***,in order to perform a logical selection of alternative aircraft configurations,it uses advanced decision-making methods such as morphological matrix and technique for order preference by similarity to the ideal *** addition,a preliminary sizing tool has been developed to check the feasibility of the established performance requirements and to evaluate the flight performance of the selected *** present process has been applied for a two-seater very light aircraft（VLA）,resulting in a set of tentative design requirements and two families of VLA configurations：a high-wing configuration and a low-wing *** resulting set of design requirements consists of three categories：customer requirements,certification requirements,and performance *** performance requirements include two mission requirements for the flight range and the endurance by reflecting the customer *** flight performances of the two configuration families were evaluated using the sizing tool developed and the low-wing configuration with conventional tails was selected as the best baseline configuration for the VLA.

关键词： Aircraft configuration Conceptional design Design requirements Requirement analysis Very light aircraft (VLA)

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Genetic Algorithm to Optimize the Design of Main Combustor and Gas Generator in Liquid Rocket Engines

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Journal of Thermal Science 2014年第3期23卷 259-268页

作者： Min Son sangho Ko Jaye Koo Graduate Student Korea Aerospace University School of Aerospace and Mechanical Engineering Korea Aerospace University

A genetic algorithm was used to develop optimal design methods for the regenerative cooled combustor and fuel-rich gas generator of a liquid rocket engine. For the combustor design, a chemical equilibrium analysis was applied, and the profile was calculated using Rao's method. One-dimensional heat transfer was assumed along the profile, and cooling channels were designed. For the gas-generator design, non-equilibrium properties were derived from a counterflow analysis, and a vaporization model for the fuel droplet was adopted to calculate residence time. Finally, a genetic algorithm was adopted to optimize the designs. The combustor and gas generator were optimally designed for 30-tonf, 75-tonf, and 150-tonf engines. The optimized combustors demonstrated superior design characteristics when compared with previous non-optimized results. Wall temperatures at the nozzle throat were optimized to satisfy the requirement of 800 K, and specific impulses were maximized. In addition, the target turbine power and a burned-gas temperature of 1000 K were obtained from the optimized gas-generator design.

关键词： Liquid Rocket Engine Main Combustor Gas Generator Optimization Genetic Algorithm

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